Robyn Bryson PharmD Kerri Hagedorn PharmD BCPS

Physiologic changes• Decline in Renal and Hepatic function• Reduced clearance• Accumulation• More severe side effects if doses are not adjusted• Reduced body weight, muscle mass, fluid• Altered drug distribution—abx, phenytoin• Increased fatty tissue• Prolonged half-life of lipophilic drugs, i.e. diazepam