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BIO UMBERTO VERONESI- 28 NOVEMBER 1925: Born in Milan - 1976-1994: Director of the National Cancer Institute in MilanSINCE 1994: Scientific Director of the European Institute of Oncology (of which he is also the founder) and Chairman of the EU Committeeof Cancer Experts - APRIL 2000 - JUNE 2001: Italian Minister for HealthPORTRAITUMBERTOVERONESIMr YouthExtend your life by a third: that’s whatresearchers at the Umberto VeronesiFoundation and the Genextra start-upare working on. Theirs is an exemplaryco-operative venture between researchand the biotech industry, but what exactlywill the benefits be? We discussed theissues with Professor Umberto Veronesi,the internationally renowned Italian oncologistwho will chair the 2004 Altran Foundation jury.It all began four years ago, when Pier GiuseppePellicci and Pier Paolo di Fiore of the EuropeanInstitute of Oncology (EIO) discovered thegene p66. “This gene encodes a protein withpowerful oxidising properties”, explainsProfessor Veronesi, the EIO’s Scientific Director. When thisgene is turned off in genetically modified mice, they live 30%longer. “p66 determines the length of our lives. If this genewere turned off in humans, they would live to 120!”, hecontinues. “Since that is impossible for obvious ethicalreasons, we must find another way of countering the actionof p66: by blocking the protein it codes, for example. Wewould then have a fantastic weapon for delaying the onsetof age-related illnesses, such as arteriosclerosis, neurodegenerativediseases and cancers”. But this type ofresearch is beyond the scope of a non profit-makinginstitute. “All too often, our discoveries get left in the drawer”,« If the p66 genewere turned off inhumans, we wouldlive to 120! »adds Professor Veronesi. Which is whatprompted him to contact FrancescoMicheli, businessman and founder ofGenextra. “Genextra will apply all itsexpertise to transform our idea into aneffective product for three years, ”. Which in practical terms,means a treatment to prevent, stabilise or combat agerelatedillnesses.“Our maximum lifespan hasn’t changed for2000 years; it’s just that the average lifespan grewsignificantly during the last century. That trend won’tchange: the aim will always be to get as close as possibleto our maximum lifespan. Society will have to change toaccommodate this new fact and people’s working lives willbe much longer…”. But, to come back to the present for amoment, this does not mean that we have discovered theelixir of youth yet. “We still have a long way to go”. It’s likevirtual reality!

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