Infectious Pancreatic Necrosis Virus (IPNV) in Atlantic Salmon (Salmo salar)
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Virulence<br />
VP5<br />
• 217 important, threon<strong>in</strong>e<br />
associated with high<br />
virulence, prol<strong>in</strong>e with<br />
low virulence<br />
• Scottish isolates with<br />
prol<strong>in</strong>e have high<br />
virulence<br />
• Other factors have an<br />
effect on virulence<br />
–Host species<br />
– Orig<strong>in</strong> and<br />
environmental<br />
conditions<br />
217 221 247 Virulence<br />
Thr Thr/ Ala High<br />
Ala<br />
Thr Thr/ Thr High<br />
Ala<br />
Pro Thr Ala Low<br />
Pro Ala Ala Low<br />
Pro Ala Ala HIGH ?<br />
Segment A ORF 1<br />
VP5<br />
5’ 3’<br />
Pre- VP2 NS VP3<br />
Segment B ORF 2<br />
5’ VP1 3’<br />
• Truncated VP5 -<br />
virulent<br />
• Apoptosis<br />
Host response<br />
Vacc<strong>in</strong>ation<br />
• Transcriptome/ Proteome<br />
• Fish immunology<br />
• Carrier state<br />
• Protection<br />
• Experimental challenge<br />
• Licens<strong>in</strong>g<br />
• Vertical transmission<br />
• Vacc<strong>in</strong>ation<br />
Landcatch Family Unit<br />
Rank<strong>in</strong>g families<br />
Shetland West Coast Scotland (2)<br />
Green –<br />
resistant<br />
Orange –<br />
<strong>in</strong>termediate<br />
Red -<br />
susceptible
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