Proefschrift Jansen Klomp

Chapter 3
Formula S1. Net Reclassification Improvement
(1) NRI = [P(up | D=1) - P(down | D=1)] - [P(up | D=0) - P(down | D=0)],
where P is the proportion of patients, “up” and “down” denote a reclassification into
a higher or lower risk-class respectively, and D is the disease status (0 = atherosclerosis
grade £2, 1 = atherosclerosis grade ³3).
Formula S2. Integrated discrimination Improvement
(2) IDI = (P new, atherosclerosis - P old, atherosclerosis) - (P new, no atherosclerosis - P old, no atherosclerosis),
where P is the mean probability per category
Figure S1. Receiver Operating Characteristic Curves for the three models in patients with complete data.
Model 1 = Patient characteristics, Model 2 = Patient characteristics + TOE, model 3 = Patient characteristics
+ TOE + A-View method. TOE = Transoesophageal echocardiography, AUC = Area under the receiver
operating curve
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