ARKANSAS BIOSCIENCES INSTITUTE

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Arkansas Biosciences Institute Arkansas Biosciences Institute, the agricultural and biomedical research program of the Arkansas Tobacco Settlement Proceeds Act of 2000, is a partnership of scientists from: • Arkansas Children’s Research Institute • Arkansas State University • University of Arkansas – Division of Agriculture • University of Arkansas, Fayetteville • University of Arkansas for Medical Sciences As outlined in the Act, the purpose of the Arkansas Biosciences Institute is to conduct: • Agricultural research with medical implications; • Bioengineering research that expands genetic knowledge and creates new potential applications in the agriculturalmedical fields; • Tobacco-related research that identifies and applies behavioral, diagnostic, and therapeutic knowledge to address the high level of tobacco-related illnesses in Arkansas; • Nutritional and other research that is aimed at preventing and treating cancer, congenital and hereditary conditions, or other related conditions; and • Other areas of developing research that are related or complementary to primary ABI-supported programs. COVER PHOTO shows a super-resolution immunohistochemistry micrograph of human kidney cells using a Zeiss LSM 880 Airyscan confocal microscope at 1000x magnification. The cells have been genetically engineered using CRISPR-Cas9 to create a non-functional mutant enzyme that normally glycosylates proteins in the Golgi complex. Fluorescently tagged antibodies reveal mutant proteins and cellular components. The magenta/pink reveals the subcellular localization of the genetically engineered mutant proteins. Other cellular organelles include the nuclei (blue), Golgi complex (green), and lysosomes (red). The image was taken by Jessica Bailey Blackburn, a PhD candidate in the Cellular Physiology and Molecular Biophysics graduate program at the University of Arkansas for Medical Sciences Graduate School. Jessica is conducting her dissertation research in the laboratory of Dr. Vladimir V. Lupashin, a member of the UAMS Graduate School faculty and a professor in the UAMS College of Medicine Department of Physiology and Biophysics. The Lupashin lab focuses on processing, secretion, and trafficking of protein through the Golgi in order to better understand the molecular mechanisms of many diseases such as inborn errors of metabolism, neurodegenerative disorders, and cancer. 2 ARKANSAS BIOSCIENCES INSTITUTE • 2016 ANNUAL REPORT
LETTER FROM THE EXECUTIVE DIRECTOR Fifteen Years of Discovery A decade and a half for any organization is quite an accomplishment. But it is not our longevity that makes this anniversary of the Arkansas Biosciences Institute so special. Instead it is the remarkable impact we have been able to make on the biomedical and agricultural landscape in the state of Arkansas. In this special issue of the ABI Annual Report, we want to highlight some of the key individuals from each of our member institutions who have helped make such a difference. We also have an interview with the Chairman of the ABI Board of Directors and President of the University of Arkansas System, Dr. Donald R. Bobbitt, who was here fifteen years ago when ABI first started and has seen it unfold and develop over the years. The ABI contributions to the research infrastructure of the state are also quite impressive. Each of our institutions provides support for core laboratories that are accessible across all our campuses. In this report, we have highlighted two core laboratories that have been very successful and have advanced discovery for a large number of investigators throughout ABI and the state. A key performance metric that we report annually is our leverage factor for extramural grant awards. This year, ABI received $10.18M which our investigators were able to leverage into $40.5M in additional dollars, or $3.99 for every dollar received. This is exceptional and comes during a time when federal funding agencies have had flat or diminishing budgets. In the last few years, many of these funding agencies, such as the National Institutes of Health, have funded below 10% of the grants they receive. Thus, a 4:1 leverage factor translates to a large pool of amazingly competitive scientists. This year, a comprehensive analysis was conducted on both our science as measured through publications and the overall impact ABI has had on the state’s economy. We commissioned TEConomy Partners, LLC, Cleveland Ohio, to conduct the study and the detailed report in its entirety is included here as well. The impact study has a lot of interesting data demonstrating that the investment made in ABI has made a significant difference to the state. Almost 21% of all scientific publications that come from Arkansas are from ABI Investigators, and within the top nine Web of Science categories, ABI investigators accounted for over 50% of all publications from Arkansas. These are the kind of metrics that put Arkansas on the national research map and make us a destination state. The economic analysis is equally as impressive and provides data supporting that in FY16 the direct investment of ABI has generated $7.91 of overall economic activity in the state for every $1 invested and has averaged $6.86 annually since 2001. Cumulatively, this has been a contribution of $1.27 billion to the state’s economy. Over our fifteen years, awards to ABI investigators have supported an annual average of 339 full-time knowledge-based jobs. According to the federal Small Business Administration, based on number of employees and total dollars generated, we are not a small business but a mid-size company, one that came to Arkansas in 2001 and has been contributing to Arkansas’s research infrastructure and economy ever since. So fifteen years ago, the citizens of Arkansas elected to use the revenue from the state’s tobacco settlement in part to establish the Arkansas Biosciences Institute. It is with the support of many citizens, legislators, former governors Huckabee and Beebe, and Governor Asa Hutchinson that we have been able to accomplish what we have. We take the responsibility seriously, and our unwavering commitment is to keep providing what is an enviable return on investment and improving the health of Arkansans through cutting edge, state-of-the-art biomedical and agricultural research. Robert E. McGehee, Jr., Ph.D. Executive Director, Arkansas Biosciences Institute Dean, UAMS Graduate School Professor, UAMS College of Medicine Department of Pediatrics, Division of Neonatology ARKANSAS BIOSCIENCES INSTITUTE • 2016 ANNUAL REPORT 3
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Shiver MB, Mahmoud F, Gao L. (2015)
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ARKANSAS BIOSCIENCES INSTITUTE

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