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molecule<br />

material<br />

medicine


synthesis<br />

of the molecule<br />

developing more environmentally<br />

sustainable methods for drug<br />

manufacturing<br />

molecule<br />

isolation<br />

of the material<br />

increasing the range of medicines<br />

available to the public<br />

material<br />

formulation<br />

of the medicine<br />

reducing drug manufacturing costs<br />

medicine


CONTENTS<br />

P2<br />

NEXT<br />

GENERATION<br />

DRUG<br />

MANUFACTURE<br />

P6<br />

UNPARALLELED<br />

INDUSTRY<br />

ENGAGEMENT<br />

P10<br />

SCIENTIFIC<br />

EXCELLENCE<br />

P18<br />

WORLD<br />

LEADING<br />

INVESTIGATORS<br />

P24<br />

FUNDING &<br />

PARTNERSHIP<br />

P26<br />

DEVELOPING<br />

NEXT<br />

GENERATION<br />

SCIENTISTS


OUR MISSION<br />

TO POSITION IRELAND AS A GLOBAL<br />

HUB FOR PROCESS INNOVATION<br />

AND ADVANCED MANUFACTURING<br />

IN THE PHARMACEUTICAL INDUSTRY


<strong>SSPC</strong> IN NUMBERS<br />

€44<br />

MILLION<br />

INVESTMENT<br />

38<br />

POST-DOCTORAL<br />

RESEARCHERS<br />

21<br />

RESEARCH<br />

PROJECTS<br />

41<br />

INVESTIGATORS<br />

63<br />

PhD<br />

CANDIDATES<br />

43<br />

RESEARCH<br />

PERFORMING<br />

ORGANISATIONS<br />

& INDUSTRY<br />

PARTNERS<br />

www.sspc.ie


<strong>SSPC</strong><br />

GLOBAL<br />

PARTNERSHIPS<br />

Canada<br />

TORONTO<br />

IRELAND<br />

United States<br />

CALIFORNIA<br />

FLORIDA<br />

ILLINOIS<br />

INDIANA<br />

MASSACHUSETTS<br />

NEW JERSEY<br />

NEW YORK<br />

TEXAS<br />

TO POSITION IRELAND AS A GLOBAL HUB FOR PROCESS


Europe<br />

BELGIUM<br />

FRANCE<br />

ITALY<br />

NETHERLANDS<br />

SWITZERLAND<br />

UK<br />

Asia<br />

CHINA<br />

SINGAPORE<br />

INNOVATION AND ADVANCED MANUFACTURING IN THE PHARMACEUTICAL INDUSTRY


1<br />

NEXT GENERATION<br />

DRUG MANUFACTURE


Pharmaceutical manufacturing contributes significantly to Ireland’s<br />

economy. The industry employs over 25,000 individuals directly<br />

and 24,500 indirectly, and produces over 50% of all exports,<br />

making Ireland the second-largest pharmaceutical exporter in<br />

the world. Each pharmaceutical drug produced for the market<br />

is the culmination of at least a decade of sustained science<br />

and engineering research that transforms a molecule into a<br />

pharmaceutical material and, ultimately, into a medicine for the<br />

benefit of patients, society and the wider economy. Next generation<br />

drug manufacture will require a more integrated approach to<br />

manufacturing pharmaceuticals, aimed at reducing the time and cost<br />

to market and meeting the ever increasing regulatory requirements.<br />

Launched in July 2013, the <strong>SSPC</strong> research programme leads the way for next generation<br />

drug manufacture. The <strong>SSPC</strong> is the largest research collaboration in Ireland, and one of the<br />

largest globally, within the pharmaceutical area. The <strong>SSPC</strong> represents a significant combined<br />

Science Foundation Ireland and industry investment of €42 million. The <strong>SSPC</strong> builds upon the<br />

success and foundations of the Solid State Pharmaceutical Cluster (2007-2013), which was<br />

funded by Science Foundation Ireland’s Strategic Research Cluster programme. The Solid<br />

State Pharmaceutical Cluster research programme focused exclusively upon the crystallisation<br />

stage of the manufacturing process. Within the pharmaceutical industry, this stage is the<br />

most challenging aspect of manufacturing, as there is a significant lack of fundamental<br />

understanding of the science and engineering challenges at this stage of the process.<br />

Building upon this success, the <strong>SSPC</strong> research programme now spans the entire<br />

pharmaceutical production chain from synthesis of the molecule, to the isolation of the<br />

material, to the formulation of the medicine. <strong>SSPC</strong> research focuses upon developing more<br />

environmentally sustainable methods for drug manufacturing; increasing the range of<br />

medicines available to the public; and reducing drug manufacturing costs. The <strong>SSPC</strong> aims<br />

to deliver industry relevant solutions, which result in job growth and retention within the<br />

pharmaceutical industry in Ireland.<br />

3


The <strong>SSPC</strong>’s inclusive, equitable and collaborative<br />

model between our 22 industry partners, 9<br />

research performing organisations and 12<br />

international academic collaborators, successfully<br />

links experienced scientists and engineers, in<br />

both academia and the pharmaceutical industry,<br />

to address critical research challenges through<br />

the <strong>SSPC</strong> research programme. This collaborative<br />

model aims to build a strong pharmaceutical<br />

community and a pharma-friendly environment in<br />

Ireland, and is key to <strong>SSPC</strong> research innovations<br />

and future success.<br />

DEVELOPING<br />

more<br />

environmentally<br />

sustainable<br />

methods for drug<br />

manufacture<br />

Building upon our strong foundations, along with<br />

our successful collaborative model to attract<br />

new global industry and academic partners, the<br />

<strong>SSPC</strong> leads the way for next generation drug<br />

manufacture.<br />

Professor Kieran Hodnett<br />

<strong>SSPC</strong> Scientific Director<br />

INCREASING<br />

the range of<br />

medicines available<br />

to the public<br />

kieran.hodnett@ul.ie<br />

REDUCING<br />

drug<br />

manufacturing<br />

costs<br />

4


“<br />

The <strong>SSPC</strong> aims to deliver<br />

industry relevant solutions,<br />

which result in job growth<br />

and retention within the<br />

pharmaceutical industry<br />

in Ireland.<br />


2<br />

UNPARALLELED<br />

INDUSTRY<br />

ENGAGEMENT


Trust, a culture of inclusivity and equity, clear goals and objectives,<br />

commitment and mutual benefit are just some of the factors that<br />

the <strong>SSPC</strong> fosters within its successful industry-academia, and interindustry<br />

collaborations. The success of the <strong>SSPC</strong> model is evidenced<br />

by the fact that since its establishment, the <strong>SSPC</strong> has grown in<br />

membership to include 22 industry partners, 9 research performing<br />

organisations and 12 international academic collaborators.<br />

Since 2012, the scale of the <strong>SSPC</strong> has<br />

increased to over three fold its original size,<br />

and is now the largest research collaboration<br />

in Ireland, and one of the largest globally,<br />

within the pharmaceutical area.<br />

The <strong>SSPC</strong> is transforming the landscape for<br />

the multinational pharma sector in Ireland.<br />

Prior to the <strong>SSPC</strong>, Ireland was perceived as<br />

a predominately manufacturing jurisdiction.<br />

As a result of the <strong>SSPC</strong> this has changed.<br />

The <strong>SSPC</strong>’s ability to facilitate multi-company<br />

projects within the precompetitive space as<br />

well as capturing the knowledge of an entire<br />

community has led to a paradigm shift for the<br />

sector in Ireland. Sites in Ireland now deliver<br />

a greater value proposition to corporate. Irish<br />

sites are no longer viewed as an exporter<br />

of challenges to corporate; moreover an<br />

importer of challenges from global sister sites<br />

and an exporter of cutting edge solutions<br />

based on highly impactful scientific and<br />

engineering rigour.<br />

research services globally. As a result of the<br />

<strong>SSPC</strong> and companies like APC, companies<br />

can now take on development work, which<br />

they could not have before.<br />

The <strong>SSPC</strong> prides itself upon its inclusive,<br />

equitable and collaborative model between<br />

our 22 industry partners, 9 research<br />

performing organisations and 12 international<br />

academic collaborators.<br />

Jon O’Halloran<br />

<strong>SSPC</strong> General Manager<br />

jon.ohalloran@ul.ie<br />

In the SME space the <strong>SSPC</strong> has also delivered.<br />

In 2011, the Applied Process Company<br />

(APC), a current <strong>SSPC</strong> industry partner, was<br />

established by Principal Investigator Professor<br />

Brian Glennon and Post-Doctoral Researcher,<br />

Dr Mark Barrett, University College Dublin.<br />

APC provides contract pharmaceutical<br />

7


Optical micrograph<br />

showing different<br />

carbamazepine<br />

crystalline polymorphs<br />

produced from<br />

methanol using<br />

supercritical CO 2<br />

BY DR LUIS PADRELA, <strong>SSPC</strong>


BUILDING A STRONG PHARMACEUTICAL COMMUNITY AND<br />

A PHARMA-FRIENDLY ENVIRONMENT IN IRELAND<br />

Research Performing Organisations<br />

Industry Partners<br />

International Academic Collaborators<br />

9


3<br />

SCIENTIFIC<br />

EXCELLENCE


synthesis<br />

“ Bold, Ambitious,<br />

Wide Ranging and<br />

Highly Innovative...<br />

EXTERNAL REVIEW OF<br />

<strong>SSPC</strong> RESEARCH PROGRAMME<br />

”<br />

molecule<br />

The <strong>SSPC</strong> supports 38 Investigators, 34 Post-<br />

Doctoral Researchers and 60 PhD Candidates.<br />

In total, the <strong>SSPC</strong> supports over 250 active<br />

members across academia and industry on a<br />

national and international basis.<br />

The <strong>SSPC</strong> research programme spans the entire pharmaceutical<br />

production chain from synthesis of the molecule, to the isolation of<br />

the material, to the formulation of the medicine. The <strong>SSPC</strong> research<br />

programme focuses upon developing more environmentally<br />

sustainable methods for drug manufacture; increasing the<br />

range of medicines available to the public; and reducing drug<br />

manufacturing costs. The overarching objective is to better<br />

understand mechanisms, control processes and predict outcomes<br />

for the efficient and environmentally sustainable production of safe<br />

medicines. The <strong>SSPC</strong> research programme is organised into three<br />

interconnecting strands, which actively reflect the three distinct<br />

steps in the manufacture of modern medicines.<br />

STRAND 1<br />

New Frontiers in Pharmaceutical Synthesis:<br />

developing more environmentally sustainable<br />

methods for drug manufacturing<br />

isolation<br />

material<br />

STRAND 2<br />

Crystal Growth and Design:<br />

increasing the range of medicines available to the<br />

public<br />

rmulation<br />

medicine<br />

STRAND 3<br />

Drug Product Formulation and Manufacture:<br />

reducing drug manufacturing costs<br />

11


In total, the <strong>SSPC</strong> supports 20 state of the art research projects.<br />

The <strong>SSPC</strong> is structured to deliver two primary outputs: to achieve scientific excellence along<br />

with economic and societal impact in Ireland. To achieve these outputs the <strong>SSPC</strong> research<br />

programme is divided into platform research projects and targeted research projects.<br />

Platform Research<br />

The <strong>SSPC</strong> research programme<br />

supports nine platform projects,<br />

which are targeted towards the<br />

progression of scientific state of the<br />

art, driven by scientific challenges<br />

of the area and aimed at achieving<br />

scientific excellence.<br />

Targeted Projects<br />

The <strong>SSPC</strong> supports 9 targeted projects, which<br />

are driven by scientific challenges of specific<br />

industrial needs. Under targeted projects, the<br />

<strong>SSPC</strong> also supports 2 linker projects, which are<br />

the interactions between the three strands. Linker<br />

projects are vital in order to make progress in this<br />

area, as they concentrate effort at interfaces where<br />

the most important developments need to take<br />

place. The programme has been designed to pay<br />

particular attention to how attributes from each<br />

strand can impact upon each of the other strands.<br />

Optical micrograph<br />

image showing a Form<br />

II piracetam crystal<br />

undergoing a polymorphic<br />

transformation to a more<br />

stable Form III crystal in<br />

methanol at 25°C<br />

BY DR ANTHONY MAHER, <strong>SSPC</strong>,<br />

WINNER OF SFI<br />

RESEARCH IMAGE OF THE YEAR<br />

COMPETITION 2014.<br />

12


DEVELOPING MORE ENVIRONMENTALLY<br />

SUSTAINABLE METHODS FOR DRUG MANUFACTURE<br />

Strand 1: New Frontiers in Pharmaceutical Synthesis<br />

The focus of Strand 1 research is on enantioselective and efficient synthetic routes and<br />

processes.<br />

MAJOR THEMES INCLUDE:<br />

• New catalysts and systems for cleaner production with excellent selectivity in<br />

asymmetric synthesis, elimination of hazardous reagents and operation in benign<br />

conditions.<br />

• Innovative process technologies operating in flow conditions and where appropriate<br />

achieving multiple transformation steps in a single reactor.<br />

• New chemical methods for the efficient removal of impurities and side products.<br />

INCREASING THE RANGE OF<br />

MEDICINES AVAILABLE TO THE PUBLIC<br />

Strand 2: Crystal Growth and Design<br />

The focus of Strand 2 research is on science and process engineering underpinning the<br />

crystallisation of complex organic molecules with conformational flexibility and a multitude of<br />

functional groups. Impurities and solvent selection are central to this strand.<br />

MAJOR THEMES INCLUDE:<br />

• Study of the underlying molecular interactions in supersaturated solutions and at<br />

interfaces.<br />

• Understanding the mechanisms that control product crystal properties such as<br />

crystal structure, purity, shape and size.<br />

• Exploiting these mechanisms to tailor and control crystal properties; to scale up and<br />

scale down processes; and to develop model-based control for improved product<br />

quality in traditional batch crystallisations as well as in emerging technologies<br />

like continuous processing, cocrystallisation, nanocrystallisation and crystallisation<br />

into excipient matrices.<br />

13


REDUCING DRUG<br />

MANUFACTURING COSTS<br />

Strand 3: Drug Product Formulation<br />

The focus of Strand 3 research is on bringing stronger scientific and process engineering<br />

principles and knowledge into the domain of Solid State Pharmaceutics, which up to now<br />

has essentially been empiric. This improved approach is demanded by the Quality by<br />

Design knowledge-based approach to develop new products and formulations.<br />

MAJOR THEMES INCLUDE:<br />

• Understanding the nature and strength of interactions between APIs and excipients.<br />

• Identification of currently unknown critical attributes in APIs and excipients that lead<br />

to failures during formulation.<br />

• Development of new materials and technologies for the generation and<br />

stabilisation of the amorphous state, which is one approach to realising the<br />

potential of BSC Class II poorly soluble drugs.<br />

14


Butyl paraben<br />

crystals grown from<br />

acetonitrile solution<br />

BY DR LIJUN JIA, <strong>SSPC</strong>


CUTTING EDGE BIOPHARMACEUTICAL RESEARCH<br />

The <strong>SSPC</strong> is committed to conducting cutting edge<br />

biopharmaceutical research. The <strong>SSPC</strong> works with seven<br />

industry partners; Allergan Pharmaceuticals Ireland, BioMarin<br />

International Limited, Eli Lilly and Company, Genzyme Ireland Ltd<br />

- A Sanofi Company, Janssen Biologics, MSD and Pfizer Ireland<br />

Pharmaceuticals and three research performing organisations;<br />

the National Institute for Bioprocessing Research and Training<br />

(NIBRT), Trinity College Dublin (TCD) and Dublin City University<br />

(DCU) - as part of an Advanced Biopharmaceutical Technologies<br />

research collaboration.<br />

This collaboration received €1.05m in funding from the Department of Jobs, Innovation and<br />

Enterprise (DJEI) through Science Foundation Ireland’s (SFI) Spokes programme, coupled<br />

with €450,000 in cash contributions from industry partners.<br />

The manufacturing process of biotherapeutic drugs is complex and costly, with problems<br />

relating to formulation and protein instability often affecting the biological performance<br />

of these therapeutics. As a result of this Advanced Biopharmaceutical Technologies<br />

collaboration, Ireland’s leading scientists and engineers are working with industry partners<br />

to develop innovative single use bioprocessing solutions and to examine the effects of<br />

extractable and leachable agents on product quality. This research generates significant<br />

intellectual property for Irish universities and gains commercial advantage for Irish-based<br />

biopharma companies.<br />

16


“<br />

This research generates<br />

significant intellectual<br />

property for Irish<br />

universities and gains<br />

commercial advantage<br />

for Irish-based<br />

biopharma companies.<br />


4<br />

WORLD LEADING<br />

INVESTIGATORS


Professor Kieran Hodnett<br />

<strong>SSPC</strong> SCIENTIFIC DIRECTOR<br />

Email: kieran.hodnett@ul.ie<br />

Prof. Hodnett is the former Dean of the Faculty of Science<br />

and Engineering at the University of Limerick (2007-2013),<br />

having previously served as Head of the Department of<br />

Chemical and Environmental Sciences (1995-1998) and<br />

Director of the Materials and Surface Science Institute<br />

(1999-2003). Prof. Hodnett played a lead role in the<br />

Aughinish Alumina- University of Limerick 5 Year Research Collaboration, which provided the<br />

foundations for the Solid State Pharmaceutical Cluster (2007-2013). Prof. Hodnett has published<br />

over 120 papers in refereed journals, which have over 2800 ISI citations, and has supervised 30<br />

PhD students to completion. Prof. Hodnett’s current research interests are in the polymorphism<br />

in pharmaceutical compounds and active pharmaceutical crystallisation into excipient matrices.<br />

Professor Anita Maguire<br />

STRAND 1 LEADER AND<br />

PRINCIPAL INVESTIGATOR<br />

Email: a.maguire@ucc.ie<br />

Prof. Maguire undertook<br />

undergraduate and postgraduate<br />

studies in Chemistry at University<br />

College Cork (UCC) (B.Sc.<br />

1985, Ph.D. 1989). Following<br />

postdoctoral research first at<br />

Namur, Belgium then at the<br />

University of Exeter, Prof. Maguire<br />

returned to the Department of<br />

Chemistry in UCC in 1991, initially<br />

as a College Lecturer, then as<br />

Associate Professor in Organic<br />

Chemistry in 2002. In 2004,<br />

Prof. Maguire was appointed to<br />

the newly-established Chair of<br />

Pharmaceutical Chemistry, jointly<br />

in the Department of Chemistry<br />

and the School of Pharmacy,<br />

and has played a leading role in<br />

development of the School of<br />

Pharmacy in recent years. Since<br />

her appointment at UCC, Prof.<br />

Maguire has played a strategic<br />

role in the development of<br />

teaching and learning, including<br />

the introduction of Medicinal<br />

and Pharmaceutical Chemistry at<br />

undergraduate level for the first<br />

time. Over the past 23 years, Prof.<br />

Maguire has led an active research<br />

team focusing on synthetic organic<br />

and pharmaceutical chemistry,<br />

which interacts extensively<br />

with the pharmaceutical sector<br />

in Ireland and internationally.<br />

Prof. Maguire is committed to<br />

postgraduate education, ensuring<br />

research students gain the skills<br />

required to underpin their future<br />

careers. 37 PhD and five MSc<br />

students have graduated from her<br />

research team since 1997, most<br />

of whom have developed careers<br />

within the pharmaceutical industry<br />

both in Ireland and internationally.<br />

Prof. Maguire was appointed as<br />

Vice President for Research and<br />

Innovation in January 2011.<br />

19


Professor Pat Guiry<br />

STRAND 1 LEADER AND PRINCIPAL<br />

INVESTIGATOR<br />

Email: patrick.guiry@ucd.ie<br />

Prof. Pat Guiry is a Professor of Synthetic Organic<br />

Chemistry at University College Dublin. Prof. Guiry holds<br />

a PhD and a BSc (Hons), Chemistry from University<br />

College Dublin. In 2013 Prof. Guiry was elected as a<br />

Member of the Royal Irish Academy and in 2014, Prof.<br />

Guiry was appointed Royal Irish Academy Vice-Chair, Physical, Chemical and Mathematical<br />

Sciences and was awarded the Boyle-Higgins Medal by the Institute of Chemistry of Ireland.<br />

Prof. Guiry’s research specialises in synthetic organic chemistry, with interests in both the<br />

development of asymmetric synthetic methodology through the application of new chiral<br />

ligands in homogeneous metal-catalysed transformations and in the total synthesis of<br />

compounds of biological interest.<br />

Professor Åke C Rasmuson<br />

STRAND 2 LEADER AND PRINCIPAL INVESTIGATOR<br />

Email: Ake.Rasmuson@ul.ie<br />

Prof. Rasmuson is a Professor of Chemical Engineering and Industrial<br />

Chemistry at the University of Limerick (UL). Having received both an<br />

MSc and a PhD in Chemical Engineering from the Royal Institute of<br />

Technology (KTH), Stockholm, Sweden, Prof. Rasmuson went on to<br />

receive a chair at KTH before joining UL in 2008. Prof. Rasmuson’s main<br />

field of research is various aspects of crystallization and crystallization<br />

processes including: fundamentals of solubility, nucleation, growth and<br />

agglomeration; experimental determination of solution thermodynamics<br />

and crystallization kinetics; crystallization of organic molecules from<br />

solution; influence of hydrodynamics and mixing in crystallization<br />

processes; and batch crystallization process design. In addition, Prof.<br />

Rasmuson has experience of hydrodynamics and mixing in agitated<br />

tanks, recovery of methane from anaerobic digestion of sewage sludge<br />

and recovery of rare earth elements from mineral waste and spent car<br />

batteries. Prof. Rasmuson has been the adviser of 23 PhD programs, 23<br />

Licentiate theses and approximately 70 MSc theses.<br />

The research group at present<br />

has six postdoctoral researchers<br />

and six PhD students. Prof.<br />

Rasmuson has published 112<br />

papers in scientific journals,<br />

presented 54 conference papers<br />

and coauthored 30 reports for<br />

industrial cooperation projects.<br />

20


Professor Brian Glennon<br />

STRAND 2 LEADER AND PRINCIPAL INVESTIGATOR<br />

Email: brian.glennon@ucd.ie<br />

Prof. Glennon is a Professor of Chemical and Bioprocess Engineering<br />

in University College Dublin (UCD) and Director of Pharmaceutical<br />

Process Engineering Research Group. The main research interests of<br />

the group are in the development and application of measurement,<br />

modelling and control strategies for the design and optimization of<br />

pharmaceutical processes. Prof. Glennon is co-founder of APC Ltd.,<br />

a process engineering technologies and solutions company which works with the majority of the world’s<br />

leading pharmaceutical and biopharmaceutical companies. Prior to joining UCD, Prof. Glennon worked with<br />

pharmaceutical company Merck & Co., Inc.<br />

Professor Anne Marie Healy<br />

STRAND 3 LEADER AND PRINCIPAL INVESTIGATOR<br />

Email: healyam@tcd.ie<br />

Prof. Healy is Professor in Pharmaceutics and Pharmaceutical<br />

Technology in the School of Pharmacy and Pharmaceutical Sciences,<br />

Trinity College Dublin (TCD) and is currently Head of School. Prof.<br />

Healy is a registered pharmacist; she holds a B.Sc. in Pharmacy and a<br />

Ph.D. in Pharmaceutics, both from TCD. Prof. Healy joined the School<br />

of Pharmacy, TCD in 1992 as a Lecturer in Pharmaceutics. In 2010, Prof.<br />

Healy was elected Fellow of Trinity College. Prof. Healy has over 60<br />

peer reviewed publications and has given over 100 presentations at<br />

national and international conferences. Prof. Healy’s research interests<br />

include pharmaceutical material science, amorphous forms, formulating<br />

poorly soluble drugs and pulmonary drug delivery.<br />

21


Professor Gavin Walker<br />

STRAND 3 LEADER AND PRINCIPAL INVESTIGATOR<br />

Email: Gavin.Walker@ul.ie<br />

Prof. Walker was appointed as the Bernal Chair<br />

of Pharmaceutical Powder Engineering at the<br />

University of Limerick (UL) in 2012. Prof. Walker<br />

is also a Visiting Research Professor of Chemical<br />

Engineering at Queen’s University Belfast, UK. Prof.<br />

Walker’s research interests include particle/powder<br />

technology, granulation processes and materials<br />

engineering. Prof. Walker has published over<br />

130 international journal papers (>2500 citations,<br />

h-index 26) on various aspects of chemical and<br />

process engineering and is Associate Editor of<br />

Chemical Engineering Journal and Chemical<br />

Engineering Research and Design. Prof. Walker has<br />

been awarded two Royal Academy of Engineering<br />

(UK) fellowships: the ExxonMobil Fellowship in<br />

2002 and the Leverhulme Trust Senior Research<br />

Fellowship in 2009.<br />

Funded Investigators<br />

Title and Name: Institution: E-mail<br />

Professor Martin Albrecht University College Dublin martin.albrecht@ucd.ie<br />

Dr Niall Barron DCU Niall.barron@dcu.ie<br />

Dr Jonathan Bones NIBRT Jonathan.bones@nibrt.ie<br />

Dr Colin Clarke NIBRT Colin.clarke@nibrt.ie<br />

Professor Martin Clynes DCU Martin.clynes@dcu.ie<br />

Professor Stephen Connon Trinity College Dublin connons@tcd.ie<br />

Dr Abina Crean University College Cork a.crean@ucc.ie<br />

22


Funded Investigators (contd.)<br />

Title and Name: Institution: E-mail<br />

Professor Gavin Davey Trinity College Dublin gdavey@tcd.ie<br />

Professor Alan Dobson University College Cork a.dobson@ucc.ie<br />

Dr Andrea Erxleben NUI Galway andrea.erxleben@nuigalway.ie<br />

Dr Patrick Frawley University of Limerick patrick.frawley@ul.ie<br />

Dr Nick Gathergood Dublin City University nick.gathergood@dcu.ie<br />

Professor Declan Gilheany University College Dublin declan.gilheany@ucd.ie<br />

Dr Jerrard Hayes Trinity College Dublin jehayes@tcd.ie<br />

Dr Clement L. Higginbotham Athlone Institute of Technology chigginbotham@ait.ie<br />

Dr Sarah Hudson University of Limerick sarah.husdson@ul.ie<br />

Dr Simon E. Lawrence University College Cork s.lawrence@ucc.ie<br />

Professor Edmond Magner University of Limerick edmond.magner@ul.ie<br />

Dr Paula Meleady DCU Paula.meleady@dcu.ie<br />

Dr Andrew McDonald Trinity College Dublin amcdonald@tcd.ie<br />

Dr Gerard McGlacken University College Cork g.mcglacken@ucc.ie<br />

Dr Niaobh McLoughlin NIBRT Niaobh.mcloughlin@nibrt.ie<br />

Dr Peter McLoughlin Waterford Institute of Technology pmcloughlin@wit.ie<br />

Dr John Milne NIBRT John.milne@nibrt.ie<br />

Dr Ken Hun Mok Trinity College Dublin Mok1@tcd.ie<br />

Dr Humphrey Moynihan University College Cork h.moynihan@ucc.ie<br />

Professor Fergal O’Gara University College Cork f.ogara@ucc.ie<br />

Dr Francesca Paradisi University College Dublin francesca.paradisi@ucd.ie<br />

Dr Kevin M. Ryan University of Limerick kevin.m.ryan@ul.ie<br />

Dr Alan Ryder National University of Ireland, Galway alan.ryder@nuigalway.ie<br />

Dr Lidia Tajber Trinity College Dublin lidia.tajber@tcd.ie<br />

23


5<br />

FUNDING &<br />

PARTNERSHIP


THE <strong>SSPC</strong> IS DEDICATED TO OBTAINING<br />

EXTERNAL RESEARCH FUNDING<br />

INTERNATIONAL LEADING CENTRE OF EXCELLENCE<br />

The <strong>SSPC</strong> aims to be an internationally leading centre of excellence in synthesis<br />

and solid state pharmaceuticals. Acquiring funding and fostering collaboration with<br />

other leading international academics and centres is critical to achieving this aim. The<br />

objective of the <strong>SSPC</strong>’s collaboration strategy is to enhance the scientific, engineering<br />

and technical capital available to the centre. The <strong>SSPC</strong> team has strong track record in<br />

winning competitive funding.<br />

FORMAL INTERNATIONAL COLLABORATORS<br />

The <strong>SSPC</strong> team already has an extensive international collaboration portfolio. The <strong>SSPC</strong><br />

builds on and enhances the level of strategic international collaboration to deliver the<br />

research programme. The <strong>SSPC</strong> enhances knowledge exchange and supports funding<br />

diversification beyond the island of Ireland.<br />

FUNDING BIDS<br />

The nature of funding bids has become increasingly competitive and a significant part<br />

of the submission now involves project management experience. The <strong>SSPC</strong> has a<br />

dedicated Funding Project Manager to support researchers both in the preparation of<br />

bids and post-award project management. This is very beneficial, particularly for large<br />

bids involving multiple partners.<br />

HORIZON 2020<br />

The European Commission’s Horizon 2020 Programme is the biggest EU research<br />

and innovation programme to date; one of the biggest publicly funded worldwide<br />

and has a budget of nearly €80 billion over seven years. Horizon 2020 offers <strong>SSPC</strong><br />

researchers many opportunities to apply for funding under its three key pillars; Excellent<br />

Science, Industrial Leadership and Societal Challenges. The <strong>SSPC</strong> has a dedicated team<br />

responsible for supporting both national and international funding opportunities through<br />

the coordination of proposals, facilitating partner searches and navigating the myriad of<br />

open and forthcoming calls.<br />

25


6<br />

DEVELOPING<br />

NEXT GENERATION<br />

SCIENTISTS


The <strong>SSPC</strong> is tasked with delivering significant economic and societal<br />

impact, as well as research excellence, aligned with national strategic<br />

goals. The <strong>SSPC</strong> is dedicated to developing the next generation of<br />

scientists through its education, outreach and training programme.


EDUCATION<br />

The <strong>SSPC</strong> supports 60 PhD candidates. The <strong>SSPC</strong> structured PhD programme<br />

incorporates both structured and traditional research elements. The structured<br />

element is designed to be both flexible and adaptable, in order to meet the<br />

ever-changing requirements of the sector. The key facets of the structured<br />

element are credited assessment-based generic and transferrable skills and<br />

core discipline-specific modules. In addition, students are also required to<br />

develop and keep a Research and Professional Development Plan with their<br />

doctoral supervisory team. As employability is at the core of the student<br />

experience, industrial placement is a key feature of our approach.<br />

TRAINING<br />

The <strong>SSPC</strong> training programme is developed<br />

upon the existing suite of bespoke incompany<br />

training programmes that were<br />

established under the auspices of the<br />

Solid State Pharmaceutical Cluster (2007-<br />

2013). The <strong>SSPC</strong> training programme<br />

provides bespoke upskilling and reskilling<br />

opportunities within the pharmaceutical<br />

area for <strong>SSPC</strong> partners.<br />

OUTREACH<br />

The <strong>SSPC</strong>’s bespoke outreach strategy<br />

is aligned with Science Foundation<br />

Ireland’s overall outreach and public<br />

engagement strategy for research centres.<br />

The programme engages with, and<br />

communicates <strong>SSPC</strong> research to, pupils,<br />

parents, teachers and the general public.<br />

Outreach programmes are based upon<br />

teacher and scientist informed curriculum<br />

materials, which develop cutting edge<br />

activities suitable and appropriate to pupils<br />

and curricula at different stages of the Irish<br />

school system.<br />

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CONTACT US<br />

www.sspc.ie/contact_sspc


www.sspc.ie

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