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How does avanafil work Side effect,dosage,Risks & Reveiws CAS 330784-47-9

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<strong>How</strong> <strong>does</strong> <strong>avanafil</strong> <strong>work</strong>? <strong>Side</strong> <strong>effect</strong>,<strong>dosage</strong>,<strong>Risks</strong> &<br />

Reviews <strong>CAS</strong> <strong>330784</strong>-<strong>47</strong>-9<br />

Reproduce from:<br />

https://www.phcoker.com/ask-yourself-before-taking-<strong>avanafil</strong>/<br />

1. What is Avanafil (<strong>330784</strong>-<strong>47</strong>-9)?........................................................................................................2<br />

2. Avanafil video..................................................................................................................................... 3<br />

3. What causes erectile dysfunction?.....................................................................................................3<br />

Physical causes of erectile dysfunction .......................................................................................... 4<br />

Psychological causes........................................................................................................................4<br />

4. Avanafil Works — What is <strong>avanafil</strong> used for?.....................................................................................4<br />

5. Avanafil Dosage – <strong>How</strong> much Avanafil should I take?........................................................................5<br />

6. Avanafil Results — <strong>How</strong> to take Avanafil for maximum benefits?..................................................... 6<br />

Take note of the following before taking the Avanafil dose:........................................................7<br />

Who should not use Avanafil?.........................................................................................................8<br />

Who should take Avanafil with caution?.........................................................................................9<br />

7. Avanafil side <strong>effect</strong>s – could Avanafil give me side <strong>effect</strong>s?...............................................................9<br />

8. Avanafil <strong>Risks</strong> — What other drugs will <strong>effect</strong> <strong>avanafil</strong>?..................................................................10<br />

9. Avanafil Reviews — Is Avanafil a safe ED drug?............................................................................... 12<br />

10. Storage and disposal safety............................................................................................................13<br />

11. Avanafil Powder Supplier — Where can I get the Avanafil (<strong>330784</strong>-<strong>47</strong>-9)?.................................. 14<br />

12. Avanafil Compared to Tadalafil and Sildenafil Citrate for ED Treatment....................................... 15<br />

So how fast are the drugs and how long is their <strong>effect</strong>?...............................................................15<br />

a. Avanafil (<strong>330784</strong>-<strong>47</strong>-9)................................................................................................... 15<br />

b. Sildenafil (139755-83-2)................................................................................................. 16<br />

c. Tadalafil (171596-29-5)................................................................................................... 16<br />

13. 【References】.............................................................................................................................16<br />

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Avanafil <strong>dosage</strong> is the latest medication in the medical field that treats erectile dysfunction in men.<br />

The cases of sexual impotence in men have been on the rise in recent years. The condition makes it<br />

hard for men to satisfy their partners since their sexual organs do not harden enough and if they do<br />

it’s only for a short time. Typically, when a man gets aroused, the blood will flow to the penis<br />

enlarging it for successful intercourse. <strong>How</strong>ever, when suffering from erectile dysfunction (ED), you<br />

will have difficulties in your sexual life. Avanafil <strong>work</strong>s by enhancing blood flow into your penis to<br />

sustain an erection for a reasonable time.<br />

Medical researchers have been trying to find various medications to help the situation which has<br />

resulted to development of multiple drugs such as Viagra, Tadalafil, Sildenafil and now Avanafil.<br />

Erectile dysfunction is a problem that lowers one’s self-esteem and has even been a significant<br />

cause of divorces in our society. Avanafil is the solution to all your erection problems. The drug will<br />

help you maintain your erection for a reasonable time by preserving blood flow into your penis.<br />

Nevertheless, for the drug to <strong>work</strong>, you must first get aroused and get the blood flowing to your<br />

penis. For those who have been using this drug after its approval, have given positive feedback and<br />

an excellent rating providing hope to those who are yet to try it.<br />

As a precaution, before purchasing any drug not only the Avanafil, you need to do some research<br />

and understand how it <strong>work</strong>s. Drugs react differently to different people, and a drug that helped<br />

your friend might cause health complication to your body. Therefore, it’s advisable to involve your<br />

doctor to help you get the right drug and proper <strong>dosage</strong> after examining your immunity.<br />

Interestingly, some people get an average erection while others get maximum results after using<br />

the Avanafil. There are also those who are forced to take high <strong>dosage</strong> for them to get the results<br />

they desire. Some medical conditions might limit the options you have for the erectile dysfunction<br />

drugs available on the market.<br />

1. What is Avanafil (<strong>330784</strong>-<strong>47</strong>-9)?<br />

Avanafil is an oral medicine that has proved to be useful in the treatment of erectile dysfunction.<br />

The drug belongs to phosphodiesterase inhibitors a class of drugs that have other medication such<br />

as Viagra, Cialis, and Levitra. Avanafil which sales in the united states of America as Stendra, was<br />

approved by the US Food and Drug Administration on April 27th, 2012 after some years of study.<br />

The Avanafil <strong>dosage</strong> strengths approved are of 50 mg, 100 mg, and 200 mg. <strong>How</strong>ever, a patient<br />

should be prescribed to use the lowest dose available at first to avoid severe side <strong>effect</strong>s. Avanafil<br />

was approved after being taken through three different trials where the drug proved to be ideal<br />

and <strong>work</strong>ed for all men used in the test. An application to market the drug in Europe was submitted<br />

to the European Union in March 2012. The medication is now selling in South Korea under a<br />

different brand after the state relevant agencies approved it.<br />

Determining the levels of erectile dysfunction can be a challenge due to the failure of the majority<br />

of men to report the problem during surveys. According to various studies, sexual impotence<br />

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increases with the increase in age. That means the older people are likely to experience the<br />

problem than the middle-aged and the young ones. For instance, men aged between 18 to 59 years<br />

have an impotence rate of 10%. Another similar study found out that men aged 50-59 had a 3.5%<br />

higher rate of erection dysfunction than individuals ranging between 18-29 years of age. The people<br />

aged 70 years and above have a 61% rate of erectile dysfunction.<br />

2. Avanafil video<br />

https://youtu.be/mvZDe7NFMvU<br />

3. What causes erectile dysfunction?<br />

Male sexual arousal is a process that involves the coordination of various body organs and tissues<br />

such as brain, emotions, hormones, muscles, nerves and blood vessels. In case one of the parts has<br />

a problem can result in erectile dysfunction. On the other hand, mental health problem or stress<br />

can worsen the situation, and it’s one of the leading causes of sexual difficulties in both men and<br />

women. In many cases, the combination of psychological and physical issues lead to erectile<br />

dysfunction. A small physical condition which slows down the sexual response can lead to anxiety<br />

making it difficult for you to maintain an erection. Sometimes people don’t notice the problems<br />

that lead to erection difficulties and opt to keep it a secret until the situation worsens.<br />

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Physical causes of erectile dysfunction<br />

Some physical body factors are responsible for the difficulties in erection, and they are as follows;<br />

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Heart disease, your heart is responsible for pumping blood to various parts of your body including your<br />

penis. In case the heart is not in good condition, you will have difficulties in maintaining your erection. For<br />

you to experience a proper erection, your heart must be healthy to keep a continuous flow of blood<br />

during sexual arousal.<br />

Atherosclerosis (clogged blood vessels), when your heart is pumping blood, and the vessels don’t allow it<br />

to reach various parts of your body; it can result to multiple problems apart from erectile dysfunction.<br />

Therefore, if your blood vessels are clogged or thin due to piling of fats on the walls, your penis will not<br />

receive enough blood to harden enough for successful sex. A proper health examination will be important<br />

to determine the real cause of your problem before the doctor recommends you to take Avanafil.<br />

Prostate cancer treatment or enlarged prostate, sometimes men feel that their male organ is not large<br />

enough and decide to go for manhood enlargement surgery or use supplements. Your heart can’t supply<br />

enough blood to an extra organ apart from the natural ones. Prostate cancer also affects the sexual organ<br />

veins and hormones that increase sexual stimulation.<br />

Substance abuse and alcoholism have been cited as another major cause of erectile dysfunction. You can<br />

<strong>work</strong> on reducing the intake of alcohol as you consider using Avanafil. Regular exercises are also an<br />

excellent remedy for burning the extra fats in the body and keeping your heart healthy.<br />

Psychological causes<br />

Your brain plays an essential role in initiating a series of events which lead to erection such as<br />

triggering feelings and sexual excitement. In case you’re thinking of something else, be sure it will<br />

interfere with your erection. Some of the psychological causes of arousal difficulties include<br />

depression, stress, and anxiety among other mental issues. If you are experiencing relationship<br />

problems, then you will have erectile difficulties either your partner since your mind is not in a good<br />

state. The moment your brain if focusing on other issues rather than thinking about your sexual<br />

experience with your partner, the erection will be a problem.<br />

4. Avanafil Works — What is <strong>avanafil</strong> used for?<br />

This drug <strong>work</strong>s by preventing the action of phosphodiesterase type 5. Erection is a product of a<br />

series of activities involving nervous system signals and release of chemical signals in the penis<br />

tissues. The chemical messengers in your penis include Cyclic GMP which causes the penis blood<br />

vessels to widen by relaxing the muscle layer in the blood vessel walls. Thus, allowing blood to flow<br />

into your sexual organ making it erect and become hard after the blood fills the penis blood vessels.<br />

The phosphodiesterase type 5 that is present in the penis breaks down the Cyclic GMP functioning,<br />

thus blocking the flow of more blood. That means the blood flow to your sexual organ will not be<br />

enough causing the penis to shrink. Avanafil (<strong>330784</strong>-<strong>47</strong>-9) stops the phosphodiesterase from<br />

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acting, to stop any cyclic GMP interference, thus improving the blood flow into your penis.<br />

Therefore, being able to have an erection for a longer time and satisfy yourself and your partner.<br />

The drug also enhances the proper functioning of chemical messengers that are responsible for<br />

facilitating erection. Avanafil will only be <strong>effect</strong>ive if the chemical messengers are present.<br />

Consequently, you have been sexually stimulated for the drug to help you maintain the erection.<br />

You should take the Avanafil dose thirty minutes before you intend to have sex for better results. In<br />

the United States of America, the Avanafil is sales under the brand Stendra. The product is just the<br />

same only that it has different brand names in different countries.<br />

5. Avanafil Dosage – <strong>How</strong> much Avanafil should I<br />

take?<br />

Just like any other medication, you should make sure you take the right Avanafil <strong>dosage</strong> to get the<br />

desired results. Consult your doctor before going to the market to purchase Avanafil. The drug<br />

comes in different forms such as powder and pills. It is advisable to take Stendra at least 30 minutes<br />

before you engage in sexual activity. You will start experiencing the Avanafil results after about<br />

20-40 minutes upon taking the Avanafil.<br />

In some cases, the results might delay depending on various factors or your body strength. When it<br />

happens, don’t rush to take another dose, consult your doctor to guide you on what to do next.<br />

Remember, it’s not advisable to take two doses a day, it can be risky or result to severe side <strong>effect</strong>s<br />

such as getting an erection for a very long time or headaches.<br />

The standard Stendra <strong>dosage</strong> is 100mg per day. <strong>How</strong>ever, if you feel it’s not <strong>effect</strong>ive, your doctor<br />

can increase it to the maximum <strong>dosage</strong> of 200mg. The doctor can recommend a reduction of the<br />

<strong>dosage</strong> by 50mg, in case you are experiencing side <strong>effect</strong>s with the main <strong>dosage</strong>s or you are under<br />

medication for other diseases. Avanafil should be taken before you take your meals for quick<br />

results. Taking the <strong>dosage</strong> after meals can delay its <strong>effect</strong> for some time which is normal.<br />

You should swallow your Stendra tablet with a glass of water. Avoid drinking grapefruit juice 24<br />

hours before taking the drug. It could increase the level of this drug in your blood leading to severe<br />

side <strong>effect</strong>s. Some people might decide to take medicine using other drinks such as soft drinks or<br />

milk which is not advisable. Stick to using water for <strong>effect</strong>ive results and to avoid any adverse<br />

<strong>effect</strong>s. As much as you need to have maximum sexual pleasure, stick to one <strong>dosage</strong> as prescribed<br />

by your doctor.<br />

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6. Avanafil Results — <strong>How</strong> to take Avanafil for<br />

maximum benefits?<br />

The drug guarantees excellent results so long as you follow your doctor’s prescription. Don’t<br />

purchase the drug without letting your doctor examine your health condition and allowing him/her<br />

to advise you accordingly. Taking extra dose than it’s recommended can lead to uncontrollable<br />

erections or other severe side <strong>effect</strong>s. Make sure you are always on the safe side by following the<br />

doctor’s advice and in case you feel the <strong>dosage</strong> is not enough, consult the doctor for further<br />

instructions. People react differently to drugs, and just because the drug manufacturer assures you<br />

of results in 20 minutes, it’s possible for the results to delay or even come early than you expect.<br />

Body strength is key in determining the <strong>effect</strong>iveness of the drug even if you follow all the doctor’s<br />

instructions. For instance, some people can get maximum results and long erections for just taking<br />

the 100mg dose while others will have to increase the dose to get the <strong>effect</strong>s they desire. In other<br />

cases, the doctor will be forced to reduce the standard <strong>dosage</strong> if the patient suffers from side<br />

<strong>effect</strong>s by taking the normal Avanafil dose of 100gm per day. In case you are under medication for<br />

other diseases go medical examination first to determine if the Avanafil will be safe to use with<br />

other drugs. The doctor will design the drug <strong>dosage</strong> that will be perfect according to your condition.<br />

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Watch out for counterfeit Avanafil drugs that might be available on the market since they can be<br />

riskier. They can cause more harm to your body instead of helping you achieve the erection levels<br />

you desire to save your sex life. Get the drug from a reputable seller or get it from your nearest<br />

clinic under the guidance of your doctor. Look for the quality label and read the usage instructions<br />

carefully for you to enjoy the maximum benefits.<br />

Take note of the following before taking the Avanafil dose:<br />

Avanafil can cause visual disturbances and dizziness. To be on safe side, you should be aware of this<br />

reactions although they vary from one person to another. In case you feel dizzy after taking the<br />

drug, sleep for some minutes, and the <strong>effect</strong>s will go away. Taking this medicine with alcohol<br />

increases the chances of dropping the blood pressure which may make you faint or feel dizzy.<br />

Drinking alcohol and then take your Avanafil dose might weaken your sexual performance.<br />

When your erections last for more than four hours after taking the drug, reach to your doctor<br />

immediately. The condition should be treated within six hours of erection since more delays can<br />

lead to damage of the penis erectile tissues or irreversible erectile problems. For those who<br />

experience loss of sight in either one or both eyes, should stop the intake of the drug and reach out<br />

to a doctor within the shortest time possible. There are other problems you might experience,<br />

especially if you are a first-time Avanafil user such as a slight headache, or even delay in getting<br />

results. These are common <strong>effect</strong>s due to the reaction of your body, but they go away after some<br />

minutes. In the event the <strong>effect</strong>s persist for more than 30 minutes, call your doctor to help in<br />

controlling the situation.<br />

Don’t take the drug while at <strong>work</strong> or when you are driving. The <strong>effect</strong>s could be severe and result in<br />

an accident. Always ensure your partner is near and is also ready for sex before taking the drug. The<br />

<strong>effect</strong>s can be severe if you take the Avanafil dose, get aroused and fail to have sex. You will be<br />

exposing your penis muscles to damage which can make your erectile problems worse. Remember,<br />

the drug enhances blood flow into your penis muscles, and if the organ <strong>does</strong>n’t do its <strong>work</strong>, the<br />

erectile tissues will be stretched beyond the maximum levels which are very dangerous. Your<br />

doctor can reverse the situation if you call him/her in time after you notice you might not engage in<br />

sex after using the Avanafil due to one reason or another.<br />

Some people think of taking another dose if they don’t get results within the 40 minutes time frame<br />

given by the experts. You should understand that the results might delay if you don’t get sexual<br />

arousal or you took the drug after meals. Your stomach should be empty, if you need fast results<br />

and also ensure you get sex arousal soon after taking your dose. Don’t expect any results when you<br />

are not in the sex mood. Your brain should be ready for the act together with other involved body<br />

hormones. The drug only helps in maintaining an erection for a more extended period by enhancing<br />

the blood flow into your sexual organ.<br />

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Who should not use Avanafil?<br />

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Although these generic ed drugs are excellent for helping men with erection problems, it should be<br />

used by specific people. Not everybody can use this drug; for instance, the Stendra is not made for<br />

women. <strong>How</strong>ever, it’s not clear when can happen if a woman uses the drug, but it’s only explicitly<br />

made to help men maintain their erection. Children are also not allowed to use Avanafil since their<br />

bodies are not strong enough to sustain the reaction of this drug. Those in adolescent or under 18<br />

years old are also prohibited from using the drug.<br />

Some men should not consider using this drug especially those suffering from complicated diseases<br />

such as kidney failure, unstable angina, low blood pressure, and high blood pressure among others.<br />

Your doctor should examine your health condition before recommending the right Avanafil <strong>dosage</strong>.<br />

If you have any condition that you were advised by a doctor to stay away from sex, then you should<br />

not use this drug as well. Heart problem is another disease that should stop you from using the<br />

drug. Avanafil enhances blood flow, which means your heart will be forced to pump the blood<br />

harder and if you have any heart disease, using Avanafil could worsen the condition.<br />

For men who have ever had an eye disease known as non-arteritic anterior ischemic optic<br />

neuropathy (NAION) should also stay away from this drug. The disease causes partial loss of sight<br />

since it damages the optic nerve. In some cases, the patients can lose vision in one or both eyes,<br />

and the condition can be permanent, or if you get quality treatment on time, the condition can be<br />

temporary. Inform your doctor if you once suffered from this sickness. One of the body reactions<br />

you will experience after taking Avanafil is a loss of vision for some time. Thus, if you had the<br />

problem before, it could revive the sickness or make it worse.<br />

Look at the ingredients if you are allergic to any, then try other erection dysfunction medication<br />

methods. Sometimes after taking the drug is when you experience the allergies, inform your doctor<br />

or pharmacist before getting another dose. It could be advisable to stop using the Stendra once you<br />

notice you’re allergic. <strong>How</strong>ever, some allergies can be controlled reach out to your doctor to know<br />

if the allergy can be controlled before you stop using the Avanafil completely. Additionally, ii in the<br />

last six months, you have been experiencing abnormal heartbeat, then consider other erectile<br />

dysfunction medications.<br />

Don’t take the Avanafil with other PDE5 inhibitors such as tadalafil, vardenafil or sildenafil. All the<br />

drugs <strong>work</strong> in almost the same way and taking them at once means you are overdosing which can<br />

increase the side <strong>effect</strong>s. The Stendra <strong>does</strong>n’t protect you from sexually transmitted diseases like<br />

HIV & AIDS. Therefore, use protective gears after taking the drug as it only enables you to erect for<br />

a longer time. Inform your doctor if you have had any surgery in the last few months since it might<br />

compromise the recovery progress.<br />

In summary, visit your doctor for a health examination and get professional advice on the right dose<br />

to use. Many people rush into pharmacies to purchase the drug even before consulting a doctor<br />

which is very risky. Majority of men who take the Avanafil without doctor’s advice, they have high<br />

chances of experiencing severe side <strong>effect</strong>s.<br />

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Who should take Avanafil with caution?<br />

<br />

<br />

<br />

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Avanafil is a powerful drug which demands to be taken with caution by some people. For instance, men<br />

above 70 years old should be cautious when using the drug. The body strength goes down as you age.<br />

Taking Avanafil dose that is beyond your body strength can be very dangerous, and the reactions can be<br />

severe than expected. Instead for getting the arousal you desire, you might end up spending some time in<br />

a hospital treating the side <strong>effect</strong>s.<br />

In case you have a liver problem then you need to watch the Avanafil doses you take. Let your doctor<br />

understand the problem and can reduce your dose by 50gm or more after health diagnosis.<br />

Men suffering from blood disorder such as hemophilia or those with an active peptic ulcer. Other<br />

conditions that require men to take Avanafil carefully is when one is suffering from leukemia which can<br />

lead to prolonged erections. And those with physically abnormal penises like the severe curvature, and<br />

scarring.<br />

Men who have suffered a stroke, a heart attack or arrhythmia (an irregular and life-threatening heartbeat)<br />

in the past six months. It should also not be consumed by men who are suffering from heart failure.<br />

7. Avanafil side <strong>effect</strong>s – could Avanafil give me side<br />

<strong>effect</strong>s?<br />

Medicine is a combination of chemicals and other substances that may not always agree with all<br />

bodies all the time. Most drugs have their side <strong>effect</strong>s, and Avanafil is not any different, and this is<br />

why we are informing you of the side <strong>effect</strong>s so you can be vigilant and prepared when using the<br />

drug. Some of the side <strong>effect</strong>s that come along with using Avanafil include those listed below and<br />

just because a side <strong>effect</strong> is named below it <strong>does</strong> not mean that it has to happen to you.<br />

<br />

<br />

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<br />

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Dizziness – the use of Avanafil could make you dizzy and sluggish therefore it is essential always to ensure<br />

that you are perfectly fine before attempting to operate any machine or driving. In the case where you<br />

feel woozy or faint after taking this drug, it is advisable that you lay down for a while until these<br />

symptoms go away.<br />

Priapism – this means that sometime the erection might last longer than it should. If your erection lasts<br />

for more than four hours, you should consult a medic immediately. Not seeking treatment in less than six<br />

hours of the priapism could be fatal. This is because it can cause severe damage to the erectile tissues<br />

found in the penis which in turn would cause permanent erectile dysfunction.<br />

Blurred vision – in rare occasions Avanafil may cause loss or decreased sense of sight in one eye or even<br />

both. If this occurs, you should cease using the drug and see your doctor immediately.<br />

Hearing problems – if you experience an abrupt reduction or loss of hearing you should discontinue using<br />

the drug and seek medical attention as soon as possible.<br />

Getting an erection without any sexual incentive whatsoever and passing urine more frequently than<br />

normal plus itching in the genital area. It may also cause premature ejaculation.<br />

Tummy issues – these issues range from problems with the gut and diarrhea, pain in the lower abdomen,<br />

inflammation in the stomach ‘gastritis’ and indigestion.<br />

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Increased levels of prostate-specific antigen (PSA) and bilirubin and creatinine in the blood.<br />

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Blood pressure – in people who use alcohol the drug will cause a decrease in the blood pressure while it<br />

may also increase the blood pressure in non-alcoholics.<br />

Peripheral edema – due to excess retention of fluids the legs and ankles may swell. It may also cause<br />

pain in the muscles and spasms.<br />

Other sides <strong>effect</strong>s include; chest pain, weight gain, heart murmurs, seasonal allergies, back pain<br />

muscle tightness, abnormal heart rhythm, sinus congestion and headache, increased liver enzymes,<br />

hot flushes, insomnia, sleepiness and fatigue, palpitations, tachycardia, and inflammation of the<br />

nose and throat, causing a blocked or running nose and sore throat.<br />

Avanafil may have other side <strong>effect</strong>s it is therefore imperative that you talk to your doctor if you<br />

start undergoing significant body transformations or discomfort while you are on the drug. Some<br />

patients experienced these symptoms after they took Avanafil and some who ignored them ended<br />

up having permanent problems such as loss of vision. Other people had the symptoms and stopped<br />

using Avanafil, and instead, they started using similar drugs which is not very healthy.<br />

8. Avanafil <strong>Risks</strong> — What other drugs will <strong>effect</strong><br />

<strong>avanafil</strong>?<br />

Like I said medicine are chemical substances and chemicals react with other compounds. The<br />

reaction could give positive or negative results this is why it is very important to inform your doctor<br />

or pharmacist about any other drugs that you may be taking and these include those that you<br />

bought over the counter or even herbal medicine. Similarly, before starting to take new<br />

medications while you are on Avanafil, it is vital to check with your doctor to ensure that the drugs<br />

are compatible.<br />

Avanafil is not compatible with any form of nitrate medicine, and this means that they must never<br />

be taken alongside each other. This is because mixing the two may lead to a severe fall in blood<br />

pressure which in turn will cause dizziness, fainting and in the worst of cases a heart attack. If a<br />

nitrate must be given to an individual who has taken Avanafil, it must not be before 12 hours have<br />

gone by after he consumed the dose of Avanafil. Nitrate combinations include:<br />

<br />

<br />

<br />

Amyl nitrate<br />

Nicorandil<br />

Glyceryl trinitrate, isosorbide mononitrate (Imdur, Ismo, Monoket), and isosorbide dinitrate (Isordil).<br />

These drugs are used to treat angina or heart failure. In the case where you get chest pains as a side<br />

<strong>effect</strong> of using Avanafil, you should not use any nitrate to treat it. Men who are using the drugs<br />

listed below should also avoid using Avanafil because they reduce the breakdown of Avanafil in the<br />

body hence increasing the chances of its side <strong>effect</strong>s occurring. These drugs include:<br />

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Atazanavir (Reyataz)<br />

Clarithromycin ( Biaxin)<br />

Indinavir (Crixivan)<br />

Itraconazole ( Sporanox)<br />

Ketoconazole (Nizoral)<br />

Nefazodone<br />

Nelfinavir (Viracept)<br />

Ritonavir (Norvir)<br />

Saquinavir (Invirase)<br />

Telithromycin (Ketek)<br />

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You should also avoid using Avanafil alongside other drugs used to treat erectile dysfunction. The<br />

safety of using this drugs together is yet to be proven. Also, people who are using alpha-blockers<br />

should avoid taking Avanafil as the combination may lead to higher chances of a fall in blood<br />

pressure which in turn will increase the chances of fainting and wooziness. People who take<br />

alpha-blockers must be put on a stable dose of alpha-blockers before the Avanafil is started. In such<br />

instances, the Avanafil must be started at a <strong>dosage</strong> of 50mg. If the person was already on Avanafil<br />

and there is a pressing need for the patient to be placed on alpha-blockers, then the alpha-blocker<br />

should be started on the lowest dose possible. The following are some of the alpha-blockers:<br />

<br />

<br />

<br />

<br />

<br />

<br />

Alfuzosin<br />

Doxazosin<br />

Indoramin<br />

Prazosin<br />

Tamsulosin<br />

Terazosin (Hytrin)<br />

People who are on medication for high blood pressure should also be vigilant when using Avanafil.<br />

Combining antihypertensive with Avanafil may lead to an additional drop in blood pressure. This<br />

drop may not be of much importance, but it has the potential of causing dizziness due to the<br />

increased drop in blood pressure. If this happens, it is essential to share the information with your<br />

doctor.<br />

The medicines listed below could raise the blood level of Avanafil. In case you are consuming any of<br />

these drugs it very critical that you do not have more than the 100mg intake of Avanafil and the<br />

doses should be consumed with time gaps of 48 hours between the doses. These drugs are:<br />

<br />

<br />

<br />

<br />

<br />

<br />

<br />

Amprenavir<br />

Aprepitant<br />

Diltiazem<br />

Erythromycin<br />

Fluconazole<br />

Fos<strong>amp</strong>renavir<br />

Verapamil<br />

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Some medications also can reduce the <strong>effect</strong>iveness of Avanafil. This is achieved by their ability to<br />

speed up the breakdown of Avanafil. These drugs include:<br />

<br />

<br />

<br />

<br />

<br />

Bosentan<br />

Carbamazepine<br />

Efavirenz<br />

Phenobarbital<br />

Rif<strong>amp</strong>icin<br />

Avanafil must also not be used together with other PDE5 inhibitors that are used to treat<br />

impotence. Ex<strong>amp</strong>les of such drugs include:<br />

<br />

<br />

Vardenafil also known as Levitra<br />

Sildenafil is commonly known as Viagra<br />

9. Avanafil Reviews — Is Avanafil a safe ED drug?<br />

On the 27th of April 2012, The FDA approved Avanafil as a safe drug to be used by men who are<br />

suffering from erectile dysfunction. “This approval expands the available treatment options to men<br />

experiencing erectile dysfunction, and enables patients, in consultation with their doctor, to choose<br />

the most appropriate treatment for their needs,” Victoria Kusiak, MD, deputy director of the Office<br />

of Drug Evaluation III in the FDA’s Center for Drug Evaluation and Research, stated in a news<br />

release.<br />

Clinical trials have been conducted to test the <strong>effect</strong>iveness of the drug and how safe it is to<br />

consume it. In the clinical trials, some men were reported to experience the efficacy of the drug in<br />

less than 20 minutes while others had to wait for up to 6 hours to get their erections. 77% of the<br />

men who were suffering from general erectile dysfunction in the clinical trials were able to get an<br />

erection. And of the men who were suffering from diabetes-related erectile dysfunction at least<br />

63% of the men got to experience an improved erection.<br />

The primary and most common downside <strong>effect</strong>s of Avanafil include pain in the back, a stuffy nose,<br />

flushing, and headache. It is very rare to hear cases of a prolonged erection, lasting to four or more<br />

hours, as a result of Avanafil. But in the case where this happens, it is essential to seek medical<br />

attention as soon as possible.<br />

Avanafil is not very safe for people who use alcohol. Both Avanafil and alcohol lower blood pressure<br />

thus mixing the two of them will lead to a drastic and excessive drop in blood pressure. This will, in<br />

turn, cause severe headaches, faintness, and an increased heart rate. Avanafil is a safe drug to use<br />

as long as you are within the allowed group of people medically. To ensure total safety do not use<br />

the drug if you are allergic to any of its ingredients. Let your doctor or pharmacist know if you have<br />

experienced an allergy.<br />

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Always follow the instructions given by your doctor or the drug manufacturer. Medical examination<br />

will be essential in determining whether the drug is safe for you or not. Don’t just rush to a<br />

pharmacy or purchase the Avanafil online without involving your doctor. If you have a health<br />

condition or you are undergoing medication of any disease, then the drug might not be safe for you<br />

or you will need to take small doses. For those who have adhered to doctor’s advice while using the<br />

drug, haven’t complained about any severe side <strong>effect</strong>s.<br />

Looking at different customer Avanafil reviews, you can see that the majority of the patients are<br />

happy with the results they get after using the drug. The excellent rating of this drug on various<br />

platforms is an indicator that it’s delivering and it has helped many people maintain their erections.<br />

The few people who have had issues with the drug can be the group that needs to be careful when<br />

using the drug which includes men with various medical conditions such as heart disease and strong<br />

among other chronic diseases.<br />

10. Storage and disposal safety<br />

It is also important that you keep the people around you and your surroundings safe from the drug.<br />

Store the medicine in a cool and dry place away from excessive heat and moisture. Ensure the<br />

container is always tightly closed and the medication should be kept out of reach for children at all<br />

times. Place your medication in locked drawers that are up very high out of the reach and sight of<br />

children.<br />

If you are done with the medication, and you no longer need it, you should dispose of it in a way<br />

that ensures that pets, children, and other people are not going to consume it. Talk to your<br />

pharmacist or doctor so you can be informed about the take-back program. The program gives you<br />

a chance to take back all medicine that you are not using. This protects humans, animals, and plants<br />

from poisoning.<br />

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11. Avanafil Powder Supplier — Where can I get the<br />

Avanafil (<strong>330784</strong>-<strong>47</strong>-9)?<br />

To get the Avanafil powder, you can visit your local pharmacist and make a purchase. Currently,<br />

there are dozens of suppliers selling Avanafil online; you can make an order while you are in the<br />

comfort of your home or office. The prices vary from one supplier to the next. <strong>How</strong>ever, do your<br />

research first to know the right dealer to avoid the risk of purchasing a counterfeit drug. The<br />

availability of many Avanafil sellers online makes it hard for many patients to determine the best.<br />

There are various factors that you should consider to get the right Avanafil vendor. Read the<br />

vendor-customer reviews; this will give you a glimpse of how the seller operates.<br />

The delivery timelines, Avanafil price, and reputation should guide you when looking for the best<br />

generic ed drugs online dealer. Customer helpdesk should also be quick enough in responding to<br />

your questions, and the call lines of a reputable Avanafil online seller should be open throughout.<br />

Take time to study various Avanafil powder suppliers<br />

before settling on the one you can trust. Your doctor<br />

can also help you get the best drug seller around<br />

maybe a friend or refer you to a reputable pharmacy.<br />

Some clinics also stock the Stendra on their pharmacy,<br />

which makes your <strong>work</strong> easier since the doctor will<br />

prescribe and you pick it from there.<br />

Before you decide to purchase the drug from any<br />

seller, make sure the vendor is certified to operate by<br />

relevant government agencies. Avanafil is a drug like<br />

any other on the market and should be sold by<br />

professionals that understand how it <strong>work</strong>s. The seller<br />

should be able to advise you in case of any concerns,<br />

and only a medical professional can be in a position to<br />

help you. Looking at the accreditation documents is<br />

the only most natural way to know if the seller is<br />

qualified to sell the drug.<br />

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12. Avanafil Compared to Tadalafil and Sildenafil<br />

Citrate for ED Treatment<br />

There are different perspectives that you can use to handle this topic. Many scholars and patients<br />

have different opinions when it comes to comparing these threes drugs. The drugs are almost the<br />

same since they all treat erectile dysfunction, and they almost <strong>work</strong> in the same way. Tadalafil,<br />

sildenafil and Avanafil, every drug has its fans. There are those who feel one drug is better than the<br />

other and others have a different opinion. Basically, human bodies react differently to various drugs,<br />

and that’s the reason why there is a debate about which drug is better. All these drugs aim at<br />

achieving the same three goals that include;<br />

<br />

<br />

<br />

Help men get an erection<br />

Maintain an erection for some time<br />

Help men get hard erections<br />

All erectile dysfunction oral such as sildenafil citrate, tadalafil, and Avanafil belong to<br />

phosphodiesterase inhibitors type 5. They all <strong>work</strong> by prolonging the nitric oxide molecule <strong>effect</strong> on<br />

the blood vessels walls in the penis. The nitric oxide presence in the blood vessels increases the<br />

blood flow into the penis and maintains the flow for some time resulting in hard, and prolonged<br />

erections. The significant difference between the three drugs is the duration and speed of their<br />

action. <strong>How</strong>ever, patients react differently to the drugs because of genetic differences. No single<br />

medicine can be said to be better and <strong>effect</strong>ive for every patient.<br />

So how fast are the drugs and how long is their <strong>effect</strong>?<br />

Generally, erectile dysfunction drugs that tend to <strong>work</strong> faster don’t stay on your body system for<br />

long. Which means, you will only feel the <strong>effect</strong> for some time and you go back to normalcy. Some<br />

men get erections faster than others, and this is the factor you should consider when choosing the<br />

right drug for you. For instance, if you can plan for sex within the shortest time then go for<br />

fast-acting drugs such as Stendra. For the patients who will take time long-acting medicine like<br />

tadalafil will be perfect since it stays in the body system for a few days.<br />

a. Avanafil (<strong>330784</strong>-<strong>47</strong>-9)<br />

This drug that sales under the brand name Stendra in the United States of America is among the<br />

fastest acting erectile dysfunction medicine. For many patients, the drug starts <strong>work</strong>ing in 15<br />

minutes time after taking your dose. Avanafil remains <strong>effect</strong>ive for around 6 to 8 hours after that<br />

your body returns to normal. That means if you need to have sex again after the 8 hours you will<br />

have to take another Avanafil <strong>dosage</strong>. The standard dose is 100mg, and the maximum is 200mg<br />

although it can be reduced or increased by your doctor after examination.<br />

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b. Sildenafil (139755-83-2)<br />

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Commonly known as Viagra, the drug gives a moderate action compared to Avanafil and Tadalafil. It<br />

<strong>work</strong>s in around 30-60 minutes after taking your dose. The <strong>effect</strong>s last for 6 to 12 hours depending<br />

on how your body responds to the drug. It’s advisable to take at least one dose a day if you are sure<br />

of having sex daily. Alternatively, only take your dose an hour before having sex with your partner.<br />

The doses range from 10mg, 20mg, 25mg, 50mg and maximum dose is 100mg.<br />

c. Tadalafil (171596-29-5)<br />

This drug is also known as Cialis, is a long-acting drug, normally after taking a dose, it will take an<br />

hour before you start feeling the <strong>effect</strong>. <strong>How</strong>ever, it stays in your body system for 2-3 days leading<br />

to the nickname “weekend drug.” The <strong>dosage</strong> is between 10mg to 20mg which you should only<br />

take once in three days. Alternatively, your doctor can advise you to take the small daily doses of<br />

2.5mg or 5ml.<br />

Generally, the drugs are <strong>effect</strong>ive in solving the erectile dysfunction in men. Determination of the<br />

best drug depends on the patient body reaction and preference. Some people need a short-acting<br />

drug, and other want long-acting medicine. Always consult your doctor before choosing the right<br />

prescription for your condition. Now that you understand how Avanafil <strong>work</strong>s, you can get it from<br />

your nearest pharmacy or online stores but remember to involve your doctor in the<br />

decision-making table.<br />

13. 【References】<br />

1. Ryan M Burke, Jeffery D Evans, Avanafil for treatment of erectile dysfunction: review of its potential,<br />

Vasc Health Risk Manag. 2012; 8: 517–523.<br />

2. DeRogatis LR, Burnett AL. The epidemiology of sexual dysfunctions. J Sex Med. 2008;5:289–300.<br />

3. Zhao C, Kim S, Yan D, et al. Efficacy and safety of <strong>avanafil</strong> for treating erectile dysfunction: results of a<br />

multicentre, randomized, double-blind, placebo-controlled trial. BJU Int. 2012 Mar 27;<br />

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