Checkpoint Toxicity

Management of Checkpoint
Inhibitor-Related Toxicity
Friday, March 6, 2020
InterContinental Hotel
9801 Carnegie Avenue
Cleveland, Ohio
To register go to: www.ccfcme.org/toxicitymgmt

About the Course
Twelve immunotherapy agents have been approved sine 2011 in a wide variety of cancers.
Immune checkpoint blockade leads to a new spectrum of dysimmune toxicity requiring
collaboration between oncologists, providers, and specialists to improve the understanding
of the mechanism, diagnosis, and management of immune-related adverse events (irAEs).
The goal of the program is to bring together a multidisciplinary group of clinicians to share
expertise and improve the care of patients receiving immune checkpoint inhibitor therapies.
Specialists in dermatology, endocrinology, gastroenterology, oncology, internal medicine,
rheumatology/immunology, nurses, nurse practitioners, physician assistants and residents/
fellows are invited to attend.
Learning Objectives
As a result of attending the course, the participant will be able to:
• Describe the mechanism of action associated with checkpoint inhibitor therapies.
• Identify the spectrum of immune-related adverse events that can occur with immune
checkpoint inhibitor therapies.
• Implement assessment criteria, diagnostic testing, and interventions to improve early
identification and management of immune-related AEs.
• Recognize the importance and necessity of the multidisciplinary approach in treatment
of immune-related adverse events.
Program Location
InterContinental Hotel & Conference Center
9801 Carnegie Avenue
Cleveland, OH 44106
Hotel Information and Reservations
A block of rooms has been reserved at the InterContinental Hotel & Conference Center until
5:00 pm ET, February 4, 2020. Make your reservation by calling 855.765.8709. Please
identify yourself as being with the Cleveland Clinic Immunotherapy conference for a special
rate of $189 plus tax.
Parking
Parking is available in the E 100th Street visitor’s parking garage.
Faculty Disclosure
The Cleveland Clinic Foundation Center for Continuing Education has implemented a policy to
comply with the current Accreditation Council for Continuing Medical Education Standards for
Commercial Support requiring resolution of all faculty conflicts of interest. Faculty declaring
a relevant commercial interest will be identified in the activity syllabus.
Accreditation
The Cleveland Clinic Foundation Center for Continuing Education is accredited by the
Accreditation Council for Continuing Medical Education (ACCME) to provide continuing
medical education for physicians.
The Cleveland Clinic Foundation Center for Continuing Education designates this live activity
for a maximum of 6.25 AMA PRA Category 1 Credits. Physicians should claim only the
credit commensurate with the extent of their participation in the activity.
Participants claiming CME credit from this activity may submit the credit hours to the
American Osteopathic Association for Category 2 credit.
The Ohio Board of Nursing will accept at face value the number of contact hours awarded for
an educational activity that has been approved for CE by a nationally accredited system of
CE approval.

Nurses are able to obtain CE that has been approved or provided by a nationally recognized
accreditation system of continuing education.
Examples include:
• The American Nurses Credentialing Center (ANCC)
• The Accreditation Council for Continuing Medical Education (ACCME)
• The International Association for Continuing Education and Training (IACET)
Information
For further information about this activity, contact Sheryl Krall at
Local: 216.444.7924
Toll Free: 800.223.2273 x47924
Email: kralls2@ccf.org
Deadline for Registration & Cancellation
Register at www.ccfcme.org/toxicitymgmt. The deadline for registration is 5:00 pm
(EST), Wednesday, March 4, 2020. A request for refund must be received in writing by
February 26, 2020. No refunds will be given after March 6, 2020. A $50 cancellation fee will
be deducted from the refund for cancellations after February 26, 2020. For questions about
registrations, please call 216.448.8710 or email cmeregistration@ccf.org.
Faculty
Course Directors
Pauline Funchain, MD
Department of Hematology/Medical Oncology
Cleveland Clinic
Planning Committee
Cassandra M Calabrese, DO
Department of Rheumatologic and
Immunologic Disease
Cleveland Clinic
Cleveland Clinic Faculty
Joshua Arbesman, MD
Department of Dermatology
Leonard Calabrese, DO
Department of Rheumatologic and
Immunologic Disease
Bassam Estfan, MD
Department of Hematology/Medical Oncology
Elizabeth Kirchner, CNP
Department of Rheumatologic and
Immunologic Disease
Marisa McGinley, DO
Mellen Center
Rohit Moudgil, MD, PhD
Department of Cardiovascular Medicine
Christian Nasr, MD
Department of Endocrinology, Diabetes and
Metabolism
Manuel Lessa Ribeiro Neto, MD
Department of Pulmonary Medicine
Laura S. Wood, RN, MSN, OCN
Department of Hematology/Medical Oncology
Cleveland Clinic
Invited Faculty
Jason Bischof, MD
Department of Emergency Medicine
The Ohio State University Wexner Medical
Center
Columbus, OH
Moshe Ornstein, MD, MA
Department of Hematology/Medical Oncology
Jessica Philpott, MD, PhD
Department of Gastroenterology, Hepatology,
and Nutrition
Carlos Romero-Marrero, MD
Department of Gastroenterology, Hepatology,
and Nutrition
Jung-Min Song, CNS
Department of Hematology/Medical Oncology
Carolyn Stanek, RN
Department of Hematology/Medical Oncology
James Stevenson, MD
Department of Hematology/Medical Oncology
Arthi Venkat, MD
Department of Ophthalmology

Agenda
Friday, March 6, 2020
7:30 am Registration/Continental Breakfast
8:00 am Welcome/Introduction
Pauline Funchain, MD, Laura S. Wood, RN, MSN, OCN
SESSION # 1: COMMON BUT COMPLEX irAEs
MODERATOR: James Stevenson, MD
8:05 am Dermatologic irAEs – Joshua Arbesman, MD
8:25 am Endocrine irAEs – Christian Nasr, MD
8:45 am Ophthalmologic irAEs – Arthi Venkat, MD
9:05 am Case Presentations/Panel Discussion – Q & A
Dr. Arbesman, Dr. Nasr, Dr. Venkat, Jung-Min Song, CNS
9:35 am Break
SESSION # 2: IT ISN’T JUST JOINT PAIN
MODERATOR: Moshe Ornstein, MD, MA
10:05 am KEYNOTE ADDRESS
The Immunologic Basis of irAEs: Clinical Implications for irAE
Therapy and Tumor Response
Leonard Calabrese, DO
11:05 am Rheumatologic irAEs
Cassandra Calabrese, DO
11:25 am Case Presentations/Panel Discussion – Q & A
Dr. L. Calabrese, Dr. C. Calabrese, Elizabeth Kirchner, CNP
11:45 am LUNCH
SESSION # 3: COMMON AND EMERGENT irAEs
MODERATOR: Bassam Estfan, MD
12:45 pm Gastrointestinal irAEs – Jessica Philpott, MD, PhD
1:05 pm Hepatic irAEs – Carlos Romero-Marrero, MD
1:25 pm irAEs - What the Emergency Department Needs to Know
Jason Bischof, MD
1:45 pm Case Presentations/Panel Discussion – Q & A
Dr. Philpott, Dr. Romero-Marrero, Dr. Bischof, Carolyn Stanek, RN
2:15 pm BREAK
SESSION # 4: RARE AND FATAL irAEs
MODERATOR: Pauline Funchain, MD
2:30 pm Cardiologic irAEs – Rohit Moudgil, MD, PhD
2:50 pm Pulmonary irAEs – Manuel Lessa Ribeiro Neto, MD
3:10 pm Neurologic irAEs – Marisa McGinley, DO
3:30 pm Case Presentations/Panel Discussion – Q & A
Dr. Moudgil, Dr. Ribeiro Neto, Dr. McGinley
4:00 pm Adjourn

Registration
Management of Checkpoint Inhibitor-Related Toxicity
Friday, March 6, 2020 Course #02011405
InterContinental Hotel & Conference Center
Registration Fees
Before February 7, 2020 After February 7, 2020
Physician $199 $225
Advanced Practice Providers/Nurses $50 $75
Non Physician $50 $75
Resident/Fellow* $0* $25*
Corporate $199 $225
*Letter from program chairman or department chairman must accompany Resident/Fellow
registration.
Fee includes registration materials, continental breakfast, lunch, and breaks.
To register go to: www.ccfcme.org/toxicitymgmt
CCF employees should check fees and register online at the above web address.
Americans with Disabilities Act
The Cleveland Clinic Foundation Center for Continuing Education fully intends to comply
with the legal requirements of the Americans with Disabilities Act. If you need assistance,
please notify Cleveland Clinic at 216.444.7924 at least two weeks prior to the activity.

Management of Checkpoint
Inhibitor-Related Toxicity
Friday, March 6, 2020
InterContinental Hotel
9801 Carnegie Avenue
Cleveland, Ohio
The Cleveland Clinic Foundation
Cleveland Clinic Taussig Cancer Institute
9500 Euclid Ave. CA50
Cleveland, OH 44195