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bpj-sce-august-2020

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suitability of antihypertensive used. Always consider whether<br />

the medicine selected will exacerbate pre-existing conditions<br />

or interact with medicines the patient is already taking. 1<br />

If an ACE inhibitor is selected, consider choosing an<br />

alternative to cilazapril. New Zealand has high rates of<br />

cilazapril use, however, it is used much less commonly<br />

overseas. 8 As such, we are vulnerable to supply issues.<br />

PHARMAC has secured stock of cilazapril until 2022 but they<br />

cannot guarantee supplies beyond this point. 8 Supply of the<br />

fixed-dose combination of cilazapril with hydrochlorothiazide<br />

has been discontinued and stocks are expected to run out in<br />

September, <strong>2020</strong>. 8<br />

For more information on prescribing ACE inhibitors, see<br />

“Prescribing ACE inhibitors: time to reconsider old habits”,<br />

https://bpac.org.nz/2018/ace.aspx<br />

Beta-blockers are not first-line in patients with<br />

uncomplicated hypertension. Beta-blockers do not reduce<br />

the risk of stroke as much as other antihypertensive medicines<br />

and are often poorly tolerated. 1 However, beta-blockers<br />

may be preferred early in treatment for patients with some<br />

co-morbidities, such as ischaemic heart disease or atrial<br />

fibrillation. 1<br />

Use individualised BP targets<br />

A target BP of

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