The Operating Theatre Journal November 2020

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New insight into neovessel formationshows promise in future treatmentof cardiovascular diseasesA new study by researchers at the University of Eastern Finland providesnovel insight into the previously unknown effects of factors regulatingblood vessel formation. In the study, bone morphogenetic factor 6,i.e. BMP6, was shown – for the first time - to regulate blood vesselformation via vascular endothelial growth factor receptor 2 (VEGFR2)and Hippo signalling pathway. The findings can be used in developingtreatments for cardiovascular diseases.Cardiovascular diseases are the leading cause of death in the Westernworld. In many of these diseases, blood circulation is decreased dueto narrowed blood vessels, leading to inadequate tissue perfusionand oxygen deprivation. The formation of new blood vessels offers anovel treatment option for these diseases. The development of thistreatment requires a thorough understanding of cellular signallingmechanisms that regulate neovessel formation.Bone morphogenetic proteins, BMPs, are growth factors originallydiscovered as regulators in bone formation. Later on, their regulatoryrole on the development and maintenance of a wide range of tissueshas become apparent. BMPs have a vital role in the development of thecardiovascular system. In addition, BMPs have been shown to regulateThis is Chelsea’s story.blood vessel formation but their exact mechanisms are unknown.Crosstalk of BMP-signalling with a well-known blood vessel formationregulator, VEGF, and its downstream effectors is poorly understood.8 Years This ago Chelsea is lost her Chelsea’s boyfriend in a tragic motorcycle Storyaccident. 8 Years She ago chose Chelsea to use lost her grief boyfriend as a driving in force to pursueThe new study now shows that VEGF gene transfer or oxygen deprivationof the tissue induce the expression of BMPs. Bone morphogenetic factornursing a tragic in an motorcycle attempt to accident. support others She chose as the nurses at Royalto use her grief as a driving force to6 ligand was further demonstrated, for the first time, to regulate bloodLondon pursue had nursing done for in her. an attempt She finally to support registered as a nurse aftervessel formation. BMP6 was shown to act in endothelial cells via VEGFR2studying others at as the the University nurses at of Royal Essex London the had 7 and Hippo signalling pathways by inducing nuclear localization of Hippodone for her. She finally This registered is as Chelsea’s th anniversary of hersignalling pathway mediator TAZ. Hippo signalling has an important roleloss, with her partner tightly holding her hand.a story.nurse after studying at the Universityin tissue size control and cell proliferation, and its malfunction hasof Essex on the 7th anniversary been associated with cancer.8 Years agoofChelseaherlost her boyfriend in a tragic motorcycleg career loss, in ICU with at the her Homerton partner tightly Hospital. holding Within her 6 months ofaccident. She chose to use her grief as a driving force to pursue The findings from this research improve our understanding ofe she was hand. thrown in the deep end nursing and in worked an attempt in ICU to support throughout others as the nurses at Royal multifactorial communication of cell signalling pathways in blood vesselemic. Throughout She began this her period nursing she career London shared in had ICU her done at personal for her. She experiencesfinally registered as a nurse formation. after The discoveries related to BMP6 and Hippo signalling canthe Homerton Hospital. Within 6 monthsbe used in the development of novel treatments for cardiovascularucate people about the struggles studying being at faced the University whilst dealing of Essex on with the the 7 anniversary of herof completing her degree diseases.loss, withsheherwaspartner tightly holding her hand.g days imaginable. thrown in the deep end and worked inICU throughout the coronavirus pandemic.The study, openly accessible in Angiogenesis, was carried out in theShe began her nursing career in ICU at the Homerton Hospital. Within 6 months of Vascular Biology junior research group of Academy Research Fellow,she never Throughout lost completing her care this her and period degree compassion she was shared thrown for her in others. personal deep There end experiences and are worked so on in ICU social throughout Adjunct Professor Johanna Laakkonen at the A.I. Virtanen Institute fors that have media been the to coronavirus shared educate about pandemic. people how about Throughout she the supported struggles this period being others. she shared faced When whilst her a personal dealing experiences Molecular Sciences. The main authors of the article, Heidi Pulkkinen,with the most difficult working days imaginable.MSc, and Miika Kiema, MSc, are Early Stage Researchers in the Doctorald with terminal on social cancer media his to partner educate people locked about herself the struggles in the toilet; being faced whilst dealing with theProgramme of Molecular Medicine at UEF. Understanding how theEvenmostthroughoutdifficult workingthis shedaysneverimaginable.door and joined her to comfort her. She lost was her care constantly and compassion checking for up others.cell types interact in vascular diseases is one of the central researchThere are so many fantastic stories that have been shared about howthat had interests of the Laakkonen junior research group. The group’s goal is toshe been Evensupported transferred throughout thisothers. to another she neverWhen a ward, lost herpatient even care andwas coming compassiondiagnosed into for work others. There are sowith terminalimplement these discoveries for improved treatment and diagnosis ofthere as cancer they many were his fantastic partner discharged stories locked that back herself have home. been in shared the toilet; about how Chelsea she supported unlocked others. When acardiovascular diseases.door patient and joined was diagnosed her to with comfort terminal her. cancer She his was partner constantly locked herself checking the up toilet;on previous Chelsea unlocked patients the that door had and been joined transferred her to comfort to her. another She was ward, constantly even checking The upospital and moved on to ICU at the Royal London to be able offernewly published study is supported by the Academy of Finland, thecoming on previous into work patients on her that days had been off to transferred be there to as another they ward, were even discharged coming into European work Research Council, Sigrid Juselius Foundation and the Finnishd compassion back on home. in her the days place off to that be there her as life they had were been discharged changed back by home. theFoundation for Cardiovascular Research. The article is part of a projectrking in the that has received funding from the European Union’s Horizon 2020She hardest left Homerton days of Hospital her life. and Unfortunately moved on to we ICU were at the unable Royal to LondonShe left Homerton Hospital and moved on to ICU at the Royal London to be able offer research and innovation programme under the Marie Skłodowska-Curiee things that to be she able was offer capable kindness, of achieving support and there compassion 3 weeks in the after place that hergrant agreement.lifekindness,had beensupportchangedandbycompassionthe incrediblein the placenursesthatworkingher life hadinbeenthe hardestchanged by theb Chelsea dieddays incredible in a tragicof her life. nurses motorcycleUnfortunately working in the accident.we hardest were days unable of her to life. witness Unfortunately the incredible we were unable toResearch article:things witness that the she incredible was capable things of that achieving she was capable there as of 3 achieving weeks after there starting as 3 weeks afterand familyPulkkinen HH, Kiema M, Lappalainen JP, Toropainen A, Beter M,her are starting dream trying her job to dream Chelsea follow job in died Chelsea her in path. died a tragic in She a tragic advocated motorcycle for accident. organTirronen A, Holappa L, Niskanen H, Kaikkonen MU, Ylä-Herttuala S,nd donated Her to partner, three air friends ambulance and family charities. are trying As a to result follow a in her path. She Laakkonen JP. BMP6/TAZ-Hippo signaling modulates angiogenesis andHer partner, friends and family are trying to follow in her path. She advocated for organhas been advocated created to for raise organ much and needed blood donation funds for and the donated Air to three air endothelial cell response to VEGF. Angiogenesis. 2020 Oct 6. doi:and blood donation and donated to three air ambulance charities. As a result aambulance charities. As a result a fundraising campaign has been 10.1007/s10456-020-09748-4. Epub ahead of print. PMID: 33021694.fundraising campaign has been created to raise much needed funds for the Aircreated to raise much needed funds for the Air Ambulance.Ambulance.We urge We you urge to you continue to continue to live to live by Chelsea’s by Chelsea’s legacy.Remember We the urge impact you to continue that you to live by Chelsea’slegacy. Remember the impact can have thatlegacy. on youRemember someone’s canthe lives impact that you canhave on someone’s lives when have they on someone’s comethrough lives when they comeyourthroughdoors.yourThedoors.kindnessthrough your doors. The kindness and The kindness andand compassion that youcompassion that you show compassion that you show daily canshow daily daily can can completelychange someone’s pathand provide some solace intheir darkest of days.many fantastic stories that have been shared about how she supported others. Whare There others. for compassion and care her lost never she this throughout EvenChelsea unlocked the door and joined her to comfort her. She was constantly checktoilet; the in herself locked partner his cancer terminal with diagnosed was patienton her days off to be there as they were discharged back home.intocoming even ward, another to transferred been had that patients previous onThis is Chelsea’s story.accident. She chose to use her grief as a driving force to pmotorcyctragic a in boyfriend her lost Chelsea ago Years 8London had done for her. She finally registered as a nurseR at nurses the as others support to attempt an in nursingloss, with her partner tightly holding her hand.anniversary o7ththe on Essex of University the at studyingcompleting her degree she was thrown in the deep end and worked in ICU throughof months 6 Within Hospital. Homerton the at ICU in career nursing her began Sheon social media to educate people about the struggles being faced whilst dealing wexperiepersonal her shared she period this Throughout pandemic. coronavirus themost difficult working days imaginable.She left Homerton Hospital and moved on to ICU at the Royal London to be able ofkindness, support and compassion in the place that her life had been changed by thwitness the incredible things that she was capable of achieving there as 3 weeks aftun were we Unfortunately life. her of days hardest the in working nurses incrediblestarting her dream job Chelsea died in a tragic motorcycle accident.and blood donation and donated to three air ambulance charities. As a result ao for advocated She path. her in follow to trying are family and friends partner, HerAmbulance.has been created to raise much needed funds for the Aircampaign fundraisinglegacy. Remember the impact that you canChelsea’sby live to continue to you urge Wethrough your doors. The kindness andcome they when lives someone’s on havecompassion that you show daily can14 THE OPERATING THEATRE JOURNAL www.otjonline.com
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The Operating Theatre Journal November 2020

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