The Gene Gateway Workbook
The Gene Gateway Workbook
The Gene Gateway Workbook
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U.S. Department of Energy Office of Science Updated: 10/05/2004<br />
<strong>The</strong> URL for the Homo sapiens genome view is: http://www.ncbi.nlm.nih.gov/mapview/map_search.cgi<br />
In Activity #1, we learned that the official symbol for the hereditary hemochromatosis gene is<br />
HFE, and its locus is 6p21.3. Let’s find this locus on chromosome 6.<br />
What is a locus?<br />
A locus describes the region of a chromosome where a<br />
gene is located. 6p21.3 is the locus for the HFE gene. 6<br />
is the chromosome number, p indicates the short arm of<br />
the chromosome, and 21.3 is the number assigned to a<br />
particular region on a chromosome. When<br />
chromosomes are stained in the lab, light and dark<br />
bands appear, and each band is numbered. <strong>The</strong> higher<br />
the number, the farther away the band is from the<br />
centromere.<br />
1. In the text box at the top of the page search for HFE as shown in the search box below.<br />
<strong>Gene</strong> <strong>Gateway</strong>: A Web Companion to the Human Genome Landmarks Poster<br />
www.DOEgenomes.org/genegateway<br />
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