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Immunogenicity of a modified intradermal<br />
pre-exposure rabies vaccination schedule<br />
• Intradermal vaccination:<br />
– cheaper but<br />
– recommended only if there is sufficient time to perform<br />
serology 2 to 3 weeks post vaccination and confirm<br />
immunity prior to travel<br />
• Modified intradermal schedule TRID 2:<br />
– can be completed in a shorted time compared to standard<br />
intradermal schedule:<br />
– 2 ID of 0.1 ml of human diploid cell rabies vaccine<br />
administered on day 0 and 7<br />
• 420 travelers<br />
– seroconversion rate 94.3% at 21 days post-vaccination<br />
– Antibody levels were significantly lower in the older age<br />
groups (p=0.003)<br />
• This schedule is highly effective, with similar<br />
immunogenicity to the standard intradermal schedule
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