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Anaphylactic Reactions<br />
<strong>to</strong> <strong>Arthropod</strong> <strong>Bites</strong><br />
<strong>and</strong> <strong>Stings</strong><br />
John H. Klotz, Jacob L. Pinnas, Stephen A. Klotz, <strong>and</strong> Justin O. Schmidt<br />
Two French scientists, Charles Richet <strong>and</strong> Paul Portier, codiscovered<br />
anaphylaxis in 1901. The lion’s share <strong>of</strong> the<br />
credit went <strong>to</strong> Richet, an eminent physician <strong>and</strong> Pr<strong>of</strong>essor <strong>of</strong><br />
Physiology at the University <strong>of</strong> Paris, while Portier was an assistant<br />
in the Labora<strong>to</strong>ry <strong>of</strong> Physiology at the Sorbonne. A his<strong>to</strong>ry <strong>of</strong> their<br />
discovery given from the perspective <strong>of</strong> Portier’s contributions is<br />
well covered by May (1985).<br />
Their collaboration began as guests on the oceanographic research<br />
vessel <strong>of</strong> Albert I, Prince <strong>of</strong> Monaco, as commemorated by a<br />
stamp (Fig. 1). The prince <strong>and</strong> his scientific direc<strong>to</strong>r suggested the<br />
<strong>to</strong>pic for their research on this scientifically his<strong>to</strong>ric cruise. They were<br />
<strong>to</strong> conduct experiments on the <strong>to</strong>xicity <strong>of</strong> venoms from the Portugese<br />
man-o-war, Physalia physalis.<br />
Figure 1. Postage stamp issued by Monaco in 1953 <strong>to</strong> commemorate<br />
the discovery <strong>of</strong> anaphylaxis. This figure was published in the Journal <strong>of</strong><br />
Allergy <strong>and</strong> Clinical Immunology, Vol. 110, Cohen, S.G. <strong>and</strong> M. Zelaya-<br />
Quesada: Portier, Richet, <strong>and</strong> the discovery <strong>of</strong> anaphylaxis: a centennial,<br />
p. 333, Copyright Elsevier (2002).<br />
In the definitive experiment conducted after they returned <strong>to</strong><br />
Paris, Richet <strong>and</strong> Portier exposed two dogs <strong>to</strong> weak doses <strong>of</strong> sea<br />
anemone actino<strong>to</strong>xin <strong>and</strong> then repeated the injection at various time<br />
intervals. No reaction was noted until an injection 26 days after the<br />
beginning <strong>of</strong> the experiment, when both dogs became extremely<br />
ill <strong>and</strong> died shortly thereafter. Richet (1913) proposed two fac<strong>to</strong>rs<br />
that were necessary <strong>and</strong> sufficient <strong>to</strong> cause an anaphylactic reaction:<br />
“increased sensitivity <strong>to</strong> a poison after previous injection <strong>of</strong> the same<br />
poison, <strong>and</strong> an incubation period necessary for this state <strong>of</strong> increased<br />
sensitivity <strong>to</strong> develop.”<br />
To name this reaction, Richet first proposed the term “aphylaxis,”<br />
later coining the term anaphylaxis (“without protection”) because it<br />
was more euphonious. For their studies on hypersensitivity reactions,<br />
Richet was awarded the 1913 Nobel Prize in Medicine or Physiology,<br />
while Portier, although his contribution was significant, did not<br />
share in the Prize <strong>and</strong> was barely mentioned in the Nobel address.<br />
Given the academic tradition at that time, it was not unusual for the<br />
more distinguished senior scientist <strong>to</strong> overshadow the lesser-known<br />
junior scientist, <strong>and</strong> Portier, a humble man, apparently did not feel<br />
slighted <strong>and</strong> remained friendly with Richet until the latter’s death<br />
in 1935. Portier made other important scientific contributions, including<br />
en<strong>to</strong>mological studies concerning the physiology <strong>of</strong> aquatic<br />
insects <strong>and</strong> a treatise on the biology <strong>of</strong> butterflies published in 1949,<br />
when he was 83.<br />
Anaphylaxis described. Current definitions <strong>of</strong> anaphylaxis<br />
reflect advances in our underst<strong>and</strong>ing <strong>of</strong> its physiological basis: an<br />
acute systemic allergic reaction resulting from the release <strong>of</strong> chemical<br />
media<strong>to</strong>rs following an immunologic reaction that is typically<br />
mediated by immunoglobulin E (IgE). IgE is one class <strong>of</strong> antibodies<br />
produced by the immune system in response <strong>to</strong> foreign substances.<br />
Individuals who suffer allergic reactions produce greater quantities<br />
134 <strong>America</strong>n En<strong>to</strong>mologist • Fall 2009
<strong>of</strong> IgE <strong>to</strong>ward allergens <strong>to</strong> which they have been sensitized <strong>and</strong> have<br />
poorer regulation <strong>of</strong> responses <strong>to</strong> those allergens.<br />
A sensitization phase in which the individual is “set up” for the<br />
reaction (Frazier <strong>and</strong> Brown 1980) directs lymphocytes <strong>to</strong> recognize<br />
invading allergens as foreign <strong>and</strong> activates them <strong>to</strong> produce IgEantibodies.<br />
The lymphocytes then release these antibodies, which<br />
subsequently bind <strong>to</strong> recep<strong>to</strong>r sites on mast cells <strong>and</strong> circulating<br />
basophils. The mast cells contain histamine <strong>and</strong> are located in body<br />
tissues such as the respira<strong>to</strong>ry <strong>and</strong> gastrointestinal tracts, the heart,<br />
<strong>and</strong> the mucous gl<strong>and</strong>s <strong>and</strong> skin.<br />
In the sensitized individual, re-exposure <strong>to</strong> the <strong>of</strong>fending allergen<br />
sets in motion a cascade <strong>of</strong> biochemical events. The allergen crosslinks<br />
neighboring IgE antibodies on mast cell <strong>and</strong> basophil surfaces,<br />
which alters the cell membrane <strong>and</strong> leads <strong>to</strong> the release <strong>of</strong> histamine<br />
<strong>and</strong> other chemical media<strong>to</strong>rs. These media<strong>to</strong>rs are capable <strong>of</strong><br />
contracting smooth muscle in the airways <strong>and</strong> intestines, as well as<br />
dilating blood vessels <strong>and</strong> increasing vascular permeability.<br />
These pathophysiological events may manifest as hives or skin<br />
swellings (angiodema), labored breathing, dizziness, or shock.<br />
The time interval between a bite or sting <strong>and</strong> appearance <strong>of</strong> these<br />
symp<strong>to</strong>ms is <strong>of</strong>ten short, usually only several minutes. Reactions <strong>to</strong><br />
stings by Hymenoptera, for example, vary within a continuum ranging<br />
from minor <strong>to</strong> severe. In most cases the reaction is limited <strong>to</strong> a<br />
welt (hive)—a reddened, tender area that causes burning <strong>and</strong> pain<br />
for an hour or two (Greene 2005). In a large local reaction, there is<br />
pronounced swelling; sometimes an entire leg or arm will swell from<br />
a sting on the <strong>to</strong>e or finger.<br />
The most common systemic reactions are cutaneous: the individual<br />
breaks out in hives or urticaria. There is the rare fatal anaphylactic<br />
reaction, in which the individual typically dies within 30<br />
<strong>to</strong> 60 minutes after the sting due <strong>to</strong> respira<strong>to</strong>ry <strong>and</strong> cardiovascular<br />
complications. These are not <strong>to</strong>xic reactions, but allergic reactions<br />
<strong>to</strong> proteins in the venom (<strong>to</strong>xic reactions take hours <strong>to</strong> days, unless<br />
several thous<strong>and</strong>s <strong>of</strong> stings are received).<br />
Causative agents <strong>of</strong> Anaphylaxis. Since its discovery in the early<br />
1900s, other causative agents <strong>of</strong> anaphylaxis in addition <strong>to</strong> venom<br />
have been implicated, including foods, which are the most common<br />
cause <strong>of</strong> anaphylaxis outside <strong>of</strong> the hospital setting (50-100 deaths/<br />
year), medications (especially antibiotics), latex, vaccines, hormones,<br />
<strong>and</strong> sometimes even exercise when associated with a particular food<br />
(Kemp 2001; Fireman 1999).<br />
<strong>Arthropod</strong>s are by far the most common cause <strong>of</strong> anaphylaxis<br />
due <strong>to</strong> animal bites or stings, <strong>and</strong> the insects (particularly Hymenoptera)<br />
make up the majority <strong>of</strong> these cases (see Table 1 for cases <strong>of</strong><br />
anaphylaxis caused by arthropods that have been determined <strong>to</strong> be<br />
IgE-mediated <strong>and</strong> Table 2 for other reported cases <strong>of</strong> anaphylacticlike<br />
reactions, so called because these reports lack the definitive in<br />
vitro or in vivo tests <strong>to</strong> demonstrate IgE-mediation).<br />
Insects<br />
Hymenoptera. It is speculated that the earliest case <strong>of</strong> an allergic<br />
reaction dates back <strong>to</strong> ancient Egypt (3300 <strong>to</strong> 2640 BCE), when the<br />
Pharaoh Menes supposedly suffered a fatal anaphylactic reaction<br />
when stung by a “kheb” during a journey <strong>to</strong> the “Western Isles”—possibly<br />
referring <strong>to</strong> Britain (Harper 1980). In ancient Egyptian, kheb<br />
means hornet or hippopotamus, <strong>and</strong> <strong>to</strong> the dismay <strong>of</strong> the allergists<br />
who favor this his<strong>to</strong>rical footnote as <strong>to</strong> the origin <strong>of</strong> their pr<strong>of</strong>ession,<br />
some Egyp<strong>to</strong>logists have implicated the hippo in the death <strong>of</strong> King<br />
Menes, especially given its abundance in the Nile (Harper 1980).<br />
Table 1. Anaphylactic reactions <strong>to</strong> arthropod bites <strong>and</strong> stings (evidence<br />
for IgE-mediation) (Klotz et al. 2008)<br />
Scientific Nomenclature (Common names in parentheses were reported<br />
<strong>to</strong> induce the reaction)<br />
Phylum: <strong>Arthropod</strong>a<br />
Class: Insecta<br />
Order: Hymenoptera<br />
Family: Vespidae<br />
Genus: Vespula (ground-nesting yellow jackets)<br />
Dolichovespula (aerial-nesting yellow jackets)<br />
Vespa (hornets)<br />
Polistes (paper wasps)<br />
Family: Apidae<br />
Genus: Apis (honey bees)<br />
Bombus (bumble bees)<br />
Family: Formicidae<br />
Genus: Solenopsis (fire ants)<br />
Pogonomyrmex (harvester ants)<br />
Tetramorium<br />
Myrmecia (bulldog ants)<br />
Pachycondyla (Asian needle <strong>and</strong> Samsum ants)<br />
Formica (wood ants)<br />
Order: Hemiptera<br />
Family: Reduviidae<br />
Genus: Tria<strong>to</strong>ma (kissing bugs)<br />
Order: Diptera<br />
Family: Tabanidae<br />
Genus: Chrysops (deer flies)<br />
Tabanus (horse flies)<br />
Family: Simuliidae (black flies)<br />
Culicidae (mosqui<strong>to</strong>es)<br />
Hippoboscidae (louse flies)<br />
Muscidae<br />
Genus: Glossina (tsetse flies)<br />
Order: Lepidoptera<br />
Family: No<strong>to</strong>dontidae<br />
Genus: Thaume<strong>to</strong>poea (pine processionary caterpillars)<br />
Class: Arachnida<br />
Order: Acari<br />
Family: Ixodidae<br />
Genus: Ixodes holocyclus (Australian paralysis ticks)<br />
Ixodes pacificus (western black-legged ticks)<br />
Ixodes ricinus<br />
Rhiphicephalus<br />
Family: Argasidae<br />
Genus: Argas (pigeon ticks)<br />
Order: Scorpiones<br />
Genus: Centruroides (bark <strong>and</strong> common striped scorpions)<br />
Class: Chilopoda (centipedes)<br />
About 1% <strong>of</strong> children <strong>and</strong> 3% <strong>of</strong> adults are allergic <strong>to</strong> stings <strong>of</strong><br />
Hymenoptera, <strong>and</strong> at least 40 fatalities occur each year in the United<br />
States, with many victims having no previous reactions <strong>to</strong> stings<br />
(Golden 2003). Sting allergies in the U.S. are most commonly due <strong>to</strong><br />
yellow jackets (Vespula <strong>and</strong> Dolichovespula) <strong>and</strong> honey bees (Apis),<br />
followed by fire ants (Solenopsis) <strong>and</strong> paper wasps (Polistes), <strong>and</strong> less<br />
frequently, harvester ants (Pogonomyrmex), hornets (Vespa), bumblebees<br />
(Bombus), <strong>and</strong> sweat bees (Halictidae) (Schmidt 1992).<br />
All <strong>of</strong> these insects, except some sweat bees, are social <strong>and</strong> most<br />
are characterized by central place foraging: worker bees, wasps, <strong>and</strong><br />
ants leave a nest <strong>to</strong> find food <strong>and</strong> then return with it <strong>to</strong> provide for<br />
the colony. The distance traveled <strong>to</strong> obtain food varies from a few<br />
meters for ants <strong>to</strong> several kilometers for bees. The daily range <strong>of</strong><br />
the colony’s forays defines its home range or terri<strong>to</strong>ry. As the colony<br />
grows in size, its terri<strong>to</strong>ry exp<strong>and</strong>s <strong>to</strong> accommodate the increasing<br />
<strong>America</strong>n En<strong>to</strong>mologist • Volume 55, Number 3 135
Table 2. Anaphylactic-like reactions <strong>to</strong> bites <strong>and</strong> stings <strong>of</strong> arthropods<br />
(lacking labora<strong>to</strong>ry evidence for IgE-mediation) (Klotz et al. 2008)<br />
Scientific Nomenclature (Common names in parentheses were reported<br />
<strong>to</strong> induce the reaction)<br />
Phylum: <strong>Arthropod</strong>a<br />
Class: Insecta<br />
Order: Hymenoptera<br />
Family: Halictidae (sweat bees)<br />
Formicidae<br />
Genus: Pseudomyrmex (twig ants)<br />
Hypoponera<br />
Rhytidoponera (green-head ants)<br />
Order: Hemiptera<br />
Family: Cimicidae<br />
Genus: Cimex (bed bugs)<br />
Order: Diptera<br />
Family: Cera<strong>to</strong>pogonidae<br />
Genus: Culicoides (punkies)<br />
Family: Rhagionidae<br />
Genus: Symphoromyia (snipe flies)<br />
Family: Therevidae<br />
Genus: Thereva (stilet<strong>to</strong> flies)<br />
Order: Lepidoptera<br />
Family: Anthelidae<br />
Genus: Chelepteryx (white-stemmed gum moths)<br />
Family: Megalopygidae<br />
Genus: Megalopyge (puss caterpillars)<br />
numbers <strong>of</strong> individuals. Their terri<strong>to</strong>rial defense is maximal at the<br />
nest, which they tenaciously defend against any intruder.<br />
In the aculeate Hymenoptera (wasps, bees, <strong>and</strong> ants), the oviposi<strong>to</strong>r<br />
<strong>of</strong> females has been modified in<strong>to</strong> a stinger, an adaptation that<br />
enables these insects <strong>to</strong> defend their nest against potential preda<strong>to</strong>rs<br />
that would exploit such a concentrated source <strong>of</strong> food (Schmidt<br />
1986). In many species <strong>of</strong> ants the stinger is absent or vestigial, but<br />
they still possess potent defensive secretions.<br />
Although ants are not generally appreciated as causes <strong>of</strong> anaphylaxis,<br />
there are a growing number <strong>of</strong> species in the U.S. that have been<br />
reported <strong>to</strong> cause this medical emergency (Table 3). Most no<strong>to</strong>rious<br />
is the red imported fire ant, Solenopsis invicta, which is widespread<br />
in the southeastern U.S. <strong>and</strong> continuing <strong>to</strong> exp<strong>and</strong> its range. In some<br />
infested urban areas > 50% <strong>of</strong> the population is stung per year (de<br />
Shazo et al. 1990) <strong>and</strong> as much as 17% <strong>of</strong> the population is sensitized<br />
(Caplan et al. 2003). At least 80 deaths have been attributed<br />
<strong>to</strong> imported fire ants (Rhoades et al. 1989). Particularly vulnerable<br />
are the elderly <strong>and</strong> infirm in nursing homes or hospitals, unable <strong>to</strong><br />
defend themselves from attack because <strong>of</strong> limited mobility.<br />
Infants represent another vulnerable group <strong>to</strong> fire ant stings.<br />
Two fatalities attributed <strong>to</strong> southern fire ants, Solenopsis xyloni, were<br />
babies less than a year old (Coarsey 1952; Klotz et al. 2004). Nonfatal<br />
systemic reactions have been reported for two other native fire ant<br />
species, S. aurea <strong>and</strong> S. geminata (H<strong>of</strong>fman 1997), although the native<br />
fire ants are generally less aggressive than imported fire ants.<br />
Fire ant stings are characterized by an intense burning sensation<br />
due <strong>to</strong> alkaloid compounds (piperidines) in the venom. Each species<br />
has its own unique blend <strong>of</strong> these compounds, but imported fire<br />
ant stings are the most severe <strong>and</strong> typically cause the formation <strong>of</strong><br />
pseudopustules.<br />
Harvester ants possess the most <strong>to</strong>xic <strong>of</strong> all insect venoms; in<br />
fact, drop for drop, it is more <strong>to</strong>xic than rattlesnake venom (Schmidt<br />
Table 3. Ant species <strong>and</strong> their geographic distribution in the continental<br />
U.S. that have been reported <strong>to</strong> cause anaphylactic or anaphylactic-like<br />
reactions (Klotz et al. 2005b)<br />
Scientific Name Range<br />
Solenopsis invicta Southern US, New Mexico, California<br />
Solenopsis xyloni Southern <strong>and</strong> southwestern US<br />
Solenopsis aurea Southwestern US<br />
Solenopsis geminata Southern US<br />
Pogonomyrmex rugosus Western Texas <strong>and</strong> Oklahoma in<strong>to</strong><br />
southern California<br />
Pogonomyrmex maricopa West Texas in<strong>to</strong> southern California<br />
Pogonomyrmex barbatus Kansas south <strong>to</strong> Texas in<strong>to</strong> Arizona<br />
Pseudomyrmex ejectus Southern US<br />
Hypoponera punctatissima Florida, Northeast, Pacific Northwest<br />
Pachycondyla chinensis Georgia <strong>to</strong> Virginia<br />
1978). The sting has been described as “ripping muscles or tendons”<br />
<strong>and</strong> “turning a screw in the flesh” (Schmidt 1986). A neuro<strong>to</strong>xic component<br />
in the venom causes gooseflesh <strong>and</strong> sweating <strong>to</strong> occur at the<br />
sting site, <strong>and</strong> <strong>of</strong>ten victims develop pain <strong>and</strong> tenderness in nearby<br />
lymph nodes. Allergic reactions <strong>to</strong> the sting have been reported.<br />
For example, <strong>of</strong> eight patients treated for stings over a one-year<br />
period in Tucson, Arizona, four had large local reactions, <strong>and</strong> four<br />
were treated for anaphylaxis (Pinnas et al. 1977). The two species<br />
responsible, the Maricopa harvester ant, Pogonomyrmex maricopa,<br />
<strong>and</strong> the rough harvester ant, P. rugosus, are commonly found in urban<br />
areas <strong>of</strong> Tucson (Klotz et al. 2005a). Schmidt et al. (1984) determined<br />
that there was significant cross-sensitivity <strong>of</strong> patients <strong>to</strong> the various<br />
species <strong>of</strong> harvester ants.<br />
Isolated cases <strong>of</strong> anaphylactic <strong>and</strong> anaphylactic-like reactions<br />
have been reported in the U.S. for ants belonging <strong>to</strong> several genera.<br />
One case reported from South Carolina resulted from the sting <strong>of</strong> an<br />
unidentified species <strong>of</strong> Tetramorium (Majeski et al. 1974). Two cases<br />
in the southeast were due <strong>to</strong> stings by Pseudomyrmex ejectus (Klotz<br />
et al. 2005b), a twig-inhabiting ant that lives in small colonies with<br />
typically
This species does not have a sting; nevertheless, it caused an anaphylactic<br />
reaction through its bite (Schmid-Grendelmeier 1997). In addition<br />
<strong>to</strong> biting, ants in this genus spray formic acid that is produced<br />
in the venom gl<strong>and</strong> along with other compounds.<br />
Hemiptera. In comparison <strong>to</strong> the stinging Hymenoptera, biting<br />
insects cause far fewer allergic reactions. By far the most frequent in<br />
the U.S. are allergic reactions <strong>to</strong> bites from kissing bugs (Tria<strong>to</strong>ma <strong>and</strong><br />
Paratria<strong>to</strong>ma spp.). For example, in one small community in Santa<br />
Barbara County, California, about 7% <strong>of</strong> the population has been<br />
sensitized <strong>to</strong> bites <strong>of</strong> the western conenose bug, Tria<strong>to</strong>ma protracta<br />
(Marshall et al. 1986). Another species, T. rubida, is more common<br />
in central <strong>and</strong> southern Arizona <strong>and</strong> is particularly a problem in the<br />
foothills <strong>of</strong> Tucson, where most <strong>of</strong> the allergic reactions are reported<br />
for this species (Pinnas et al. 1986). Interestingly, there is little <strong>to</strong><br />
no antigenic cross-reactivity between these two species (Pinnas et<br />
al. 1986).<br />
There are 14 other species <strong>of</strong> Tria<strong>to</strong>ma that are found throughout<br />
the lower two-thirds <strong>of</strong> the U.S. (Vetter 2001). All are blood-suckers<br />
that normally parasitize wood rats, opossums, raccoons, <strong>and</strong> armadillos<br />
(Vetter 2001). During the spring <strong>and</strong> early summer dispersal,<br />
T. rubida <strong>and</strong> T. protracta sometimes enter homes <strong>and</strong> feed on the<br />
occupants as in the following case (Klotz et al. 2006):<br />
A 45-year old woman had four severe reactions <strong>to</strong> an insect bite.<br />
She found the insect in bed each time <strong>and</strong> from the description, it fit<br />
the picture <strong>of</strong> a kissing bug. She never felt the bite, but noticed her<br />
heart rate increasing <strong>and</strong> felt hot. One <strong>of</strong> the authors (JP) attributes<br />
the rapid heartbeat <strong>to</strong> the adrenal gl<strong>and</strong>’s response <strong>to</strong> elevated histamine<br />
levels, which sometimes can “self-treat” <strong>and</strong> thereby result in<br />
non-life-threatening reactions. In two instances, she lost consciousness<br />
<strong>and</strong> during one episode, she had a seizure. Her son captured a<br />
specimen from her bed that was identified as T. rubida.<br />
Although bedbugs are an emerging problem in the U.S., anaphylactic<br />
reactions <strong>to</strong> their bites, are rare (Parsons 1955).<br />
Diptera. Blood-sucking flies, including horse flies (Tabanus), deer<br />
flies (Chrysops) (Freye <strong>and</strong> Litwin 1996; Hemmer et al. 1998; Hrabak<br />
<strong>and</strong> Dice 2003; Wilbur <strong>and</strong> Evans 1975), black flies (Simuliidae)<br />
(H<strong>of</strong>fman 1987), tsetse flies (Glossina) (Stevens et al. 1996), louse<br />
flies (Hippoboscidae) (Vidal et al. 2007), <strong>and</strong> mosqui<strong>to</strong>es (Culicidae)<br />
(McCormack et al. 1995), have caused anaphylactic reactions.<br />
Considering the number <strong>of</strong> people bitten by mosqui<strong>to</strong>es, there are<br />
surprisingly few reports <strong>of</strong> anaphylactic reactions, but large local<br />
reactions are not uncommon (Engler 2001).<br />
Anaphylactic-like reactions <strong>to</strong> punkies (Culicoides) (H<strong>of</strong>fman<br />
1987), snipe flies (Symphoromyia) (Turner 1979), <strong>and</strong> stilet<strong>to</strong> flies<br />
(Therevidae) (Smith 1979) have been reported. The larvae <strong>of</strong> punkies<br />
are aquatic or semiaquatic <strong>and</strong> the adults do not travel far from<br />
where the larvae live (Triplehorn <strong>and</strong> Johnson 2005). Most snipe<br />
flies do not bite, but several species <strong>of</strong> Symphoromyia do bite <strong>and</strong><br />
are common in western mountain <strong>and</strong> coastal regions <strong>of</strong> the U.S.<br />
(Triplehorn <strong>and</strong> Johnson 2005). In the case <strong>of</strong> the stilet<strong>to</strong> fly, it was<br />
the larva that bit the victim. The adult flies are uncommon but the<br />
predaceous larvae can be found in s<strong>and</strong> or decaying wood (Triplehorn<br />
<strong>and</strong> Johnson 2005).<br />
Lepidoptera. There are several families <strong>of</strong> Lepidoptera with caterpillars<br />
possessing stinging hairs, some with venoms that can cause<br />
anaphylactic reactions in susceptible individuals. These include the<br />
pine processionary caterpillar, Thaume<strong>to</strong>poea pityocampa, so called<br />
because <strong>of</strong> the long lines they form, sometimes with hundreds <strong>of</strong> individuals<br />
following a lead caterpillar <strong>to</strong> <strong>and</strong> from the nest (Sbordoni<br />
<strong>and</strong> Forestiero 1985). Their hairs, which can be airborne, penetrate<br />
the skin <strong>and</strong> release a <strong>to</strong>xic substance (Vega et al. 1999, 2000), or may<br />
be inhaled or ingested. The most common reaction is a cutaneous<br />
lesion; however, in northwestern Spain, as many as 40% <strong>of</strong> patients<br />
diagnosed with occupational urticaria suffered anaphylactic reactions<br />
(Vega et al. 2004). There are also reports <strong>of</strong> systemic reactions<br />
in children (Shkalim et al. 2008).<br />
Anthelid larvae <strong>and</strong> frequently their cocoons are protected by<br />
stinging hairs. There are about 100 species native <strong>to</strong> Australia <strong>and</strong><br />
New Guinea, <strong>and</strong> the larger members belong <strong>to</strong> the genus Chelepteryx<br />
(Sbordoni <strong>and</strong> Forestiero 1985). The caterpillar <strong>of</strong> the whitestemmed<br />
gum moth (Chelepteryx collesi) incorporates urticating<br />
hairs in<strong>to</strong> its cocoon. The hairs, which point out, readily penetrate<br />
human skin <strong>and</strong> have caused anaphylactic-like reactions (Mulvaney<br />
et al. 1998).<br />
In Texas from 1955 <strong>to</strong> 1959, there were 54 reported cases <strong>of</strong><br />
stings by caterpillars: 47 were localized reactions, <strong>and</strong> the others<br />
anaphylactic-like reactions (Micks 1960). The caterpillar was identified<br />
in 43 <strong>of</strong> these cases <strong>and</strong> determined <strong>to</strong> be Megalopyge opercularis.<br />
Commonly known as puss caterpillars, they are covered with s<strong>of</strong>t<br />
brown hairs with poison spines beneath that can penetrate the skin,<br />
causing severe reactions (Borror et al. 1976).<br />
Arachnids<br />
Acari. There are several reports <strong>of</strong> anaphylactic reactions <strong>to</strong> bites<br />
from hard ticks (Ixodidae), most notably the Australian paralysis tick,<br />
Ixodes holocyclus (Gauci et al. 1989). Ticks caused approximately<br />
0.7% <strong>of</strong> the reported allergic reactions <strong>to</strong> arthropod stings <strong>and</strong> bites<br />
in Queensl<strong>and</strong>, Australia (Solley 1990). In other parts <strong>of</strong> the world,<br />
there are fewer reports: a 73-year old man who suffered recurrent<br />
anaphylaxis due <strong>to</strong> bites from Ixodes pacificus (Van Wye et al. 1991a,<br />
b), a widely distributed species in western North <strong>America</strong>; <strong>and</strong> cases<br />
in western Europe involving Ixodes ricinus (Moneret-Vautrin et al.<br />
1998) <strong>and</strong> Rhiphicephalus spp. (Acero et al. 2003; Valls et al. 2007).<br />
The pigeon tick, Argus reflexus, is a much more common cause<br />
<strong>of</strong> anaphylactic reactions in Europe (Hilger et al. 2005; Rolla et al.<br />
2004). It is a s<strong>of</strong>t tick (Argasidae) that is a temporary parasite <strong>of</strong> wild<br />
<strong>and</strong> domesticated pigeons. When its normal host is absent, the ticks<br />
may migrate in<strong>to</strong> households <strong>and</strong> bite the human occupants, some<br />
<strong>of</strong> whom may be allergic.<br />
Scorpions. Fatalities due <strong>to</strong> scorpion stings are by some estimates<br />
as high as 50,000 deaths per year worldwide (White 1995). These<br />
are mostly due <strong>to</strong> <strong>to</strong>xic reactions. Even in certain parts <strong>of</strong> the U.S.,<br />
scorpion stings are common. For example, in Arizona (excluding the<br />
greater Phoenix area), there were 4,655 scorpion stings reported<br />
over a two-year period from 2002-2004 (Klotz et al. 2005a).<br />
Fatalities due <strong>to</strong> scorpion stings are rare in the U.S., but five deaths<br />
were recorded from 1950-1954, one <strong>of</strong> which was an anaphylactic-like<br />
reaction (Parrish 1959). In 2001 in Arizona, a woman died<br />
from an anaphylactic-like reaction <strong>to</strong> a sting by the bark scorpion, C.<br />
exilacauda (Boyer et al. 2001). It is the deadliest species in the U.S.<br />
<strong>and</strong> is mainly found in Arizona (Curry et al. 1984). IgE-mediated<br />
anaphylaxis <strong>to</strong> its sting has also been reported (Chase et al. 2002).<br />
Although anaphylactic reactions <strong>to</strong> their stings are rare, the venom<br />
<strong>of</strong> the common striped scorpion, Centruroides vittatus, is reportedly<br />
cross-reactive with imported fire ants, S. invicta (Nugent et al. 2004).<br />
The geographic distribution <strong>of</strong> striped scorpions <strong>and</strong> imported fire<br />
ants overlap, possibly placing many more people at risk for allergic<br />
reactions.<br />
<strong>America</strong>n En<strong>to</strong>mologist • Volume 55, Number 3 137
Chilopoda. Centipedes have a pair <strong>of</strong> poison claws on the first<br />
segment behind the head that can inflict painful bites. Skin prick tests<br />
with centipede venom were positive in three patients with systemic<br />
allergic reactions <strong>to</strong> their bite (Harada et al. 2005).<br />
Treatment <strong>of</strong> Anaphylaxis<br />
Physicians treating allergies can <strong>of</strong>fer their patients three options:<br />
(1) medications, (2) immunotherapy, <strong>and</strong> (3) avoidance <strong>of</strong> the<br />
allergen (Fireman 1999).<br />
(1) Medications. Given the speed <strong>of</strong> an allergic reaction <strong>to</strong> a bite<br />
or sting, immediate medical attention is critical. Epinephrine <strong>and</strong><br />
antihistamines may be life-saving when administered early during<br />
an anaphylactic reaction. A prescription from a physician for selfinjected<br />
epinephrine is advisable for sensitized individuals who are<br />
at risk <strong>of</strong> life-threatening reactions. They should carry <strong>and</strong> know how<br />
<strong>to</strong> administer a preloaded syringe containing two doses; the second<br />
dose may be needed in some severe reactions.<br />
The antihistamines act by binding <strong>to</strong> the recep<strong>to</strong>r sites on target<br />
cells, thereby blocking the effects <strong>of</strong> histamine. Epinephrine has<br />
multiple anti-inflamma<strong>to</strong>ry effects. Methylprednisolone, a corticosteroid<br />
with broad anti-inflamma<strong>to</strong>ry properties, is <strong>of</strong>ten administered<br />
<strong>and</strong> is long-acting, but it requires hours before reaching maximum<br />
effectiveness. Its short-term benefit is questionable.<br />
(2) Immunotherapy. For the more common causes <strong>of</strong> insect sting<br />
allergy (yellowjackets, honey bees, <strong>and</strong> imported fire ants), immunotherapy<br />
is available <strong>and</strong> involves repeated injections <strong>of</strong> increasing<br />
doses <strong>of</strong> the venom extract, or in the case <strong>of</strong> imported fire ants,<br />
whole body extract. Possible mechanisms for the beneficial effects<br />
<strong>of</strong> immunotherapy include activation <strong>of</strong> lymphocytes <strong>to</strong> produce IgG<br />
blocking antibodies, which have a high affinity for the allergen <strong>and</strong><br />
can prevent it from binding <strong>to</strong> mast cells, <strong>and</strong> production <strong>of</strong> suppressor<br />
T lymphocytes, which suppress IgE production <strong>of</strong> B lymphocytes.<br />
Unfortunately, for less common causes <strong>of</strong> allergic reactions <strong>to</strong> bites<br />
<strong>and</strong> stings, commercial extracts for immunotherapy are not available.<br />
Nevertheless, some allergists have developed immunotherapy for<br />
these so-called “orphan insects.” These are not generally available<br />
<strong>and</strong> involve only a small segment <strong>of</strong> the population—usually only<br />
their own patients.<br />
(3) Avoidance <strong>of</strong> allergen. Correct identification <strong>of</strong> the <strong>of</strong>fending<br />
arthropod is critical for underst<strong>and</strong>ing its biology, which may provide<br />
useful information in preventing future accidental contacts. It is <strong>of</strong>ten<br />
helpful <strong>to</strong> the healthcare provider <strong>to</strong> contact an en<strong>to</strong>mologist or pest<br />
management pr<strong>of</strong>essional for help in identification <strong>and</strong> elimination<br />
or avoidance <strong>of</strong> the <strong>of</strong>fending arthropod.<br />
Concluding Remarks<br />
With ever-increasing urban development <strong>and</strong> sprawl in<strong>to</strong> natural<br />
habitats, there is a growing problem <strong>of</strong> bites <strong>and</strong> stings by a variety<br />
<strong>of</strong> arthropods with the potential <strong>to</strong> induce allergic reactions. It is<br />
important that the causative agents be identified <strong>and</strong> reported <strong>to</strong><br />
state or local poison control centers so that a record is maintained.<br />
Physicians, en<strong>to</strong>mologists, pest management pr<strong>of</strong>essionals, <strong>and</strong> the<br />
general public need <strong>to</strong> be made aware <strong>of</strong> these potential problems<br />
<strong>to</strong> facilitate rapid treatment <strong>of</strong> this emergency condition, potentially<br />
saving lives. 7<br />
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John H. Klotz is Cooperative Extension Specialist at the University <strong>of</strong><br />
California, Riverside. Jacob L. Pinnas <strong>and</strong> Stephen A. Klotz are Pr<strong>of</strong>essors<br />
<strong>of</strong> Medicine at the University <strong>of</strong> Arizona Health Sciences Center, <strong>and</strong><br />
Justin O. Schmidt is Direc<strong>to</strong>r <strong>of</strong> the Southwestern Biological Institute,<br />
Tucson, AZ.<br />
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