Heart-type Fatty Acid-Binding Protein (H-FABP) Assay
Heart-type Fatty Acid-Binding Protein (H-FABP) Assay
Heart-type Fatty Acid-Binding Protein (H-FABP) Assay
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H-<strong>FABP</strong>: a true global ACS marker<br />
Automated assay for H-<strong>FABP</strong><br />
Randox can provide a rapid immunoturbidimetric (IT) assay for the quantitative determination of <strong>Heart</strong> - <strong>type</strong> fatty<br />
acid binding protein (H-<strong>FABP</strong>) in serum and plasma. The fully automated assay is suitable for use on a wide range of<br />
analysers, with results obtained in fourteen minutes.<br />
What is H-<strong>FABP</strong>?<br />
• A small cytoplasmic protein (15kDa – significantly smaller than TnI, TnT, CK-MB & Myo)<br />
• Transports fatty acids from cell membrane to mitochondria for oxidisation<br />
• H-<strong>FABP</strong> is 20 times more cardiac specific than Myoglobin<br />
• Released as early as 30 minutes after an ischemic episode<br />
Peak<br />
Level<br />
CK-MB<br />
cTnl<br />
cTnT<br />
Ischemia Necrosis<br />
Cardiac myocyte<br />
Time after symptom onset<br />
H-<strong>FABP</strong><br />
Myo<br />
Cardiac myocyte<br />
References<br />
1. Data on file<br />
2. Pearson IR, Hall AS, Gale CP, Sivananthan MU, Viswanathan K, Kilcullen N, Barth JH, In Acute Coronary Syndromes, <strong>Heart</strong>-<strong>type</strong> <strong>Fatty</strong> <strong>Acid</strong> <strong>Binding</strong> <strong>Protein</strong> is a<br />
More Accurate Predictor of Long Term Prognosis than Troponin. Circulation. 2010;122:A11374<br />
H-<strong>FABP</strong><br />
Troponin<br />
Ref 1
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