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R EED O. D INGMAN S OCIETY - Department of Surgery - University ...

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The Plastic <strong>Surgery</strong> Section with support<br />

from colleagues from across the <strong>University</strong><br />

<strong>of</strong> Michigan has been awarded a second 5year<br />

funding period.<br />

The NIH Training grant in Burn,<br />

Trauma and Wound Healing Research has<br />

as PI and Program Director Cynthia L.<br />

Marcelo, PhD and William M.Kuzon, Jr,<br />

MD, Ph.D. as co-PI and co-Director.<br />

This grant supports the training <strong>of</strong><br />

potential academic medical<br />

surgeon/scientist in basic research related<br />

to trauma in muscle and bone, burn<br />

injuries, and wound healing and tissue<br />

engineering. Residents can train in health<br />

related areas <strong>of</strong> investigation and can chose<br />

more fundamental research fields<br />

(biophysics, tissue engineering, lipid<br />

biochemistry and molecular and cell<br />

biology).<br />

The Grant supports two postdoctoral<br />

fellows per year, plus supplies, course work<br />

and travel allowances. The current<br />

trainees are Deborah Yu, MD and Ian<br />

Lytle, MD. Deborah Yu, MD, from<br />

Bethesda, MD (Georgetown <strong>University</strong><br />

School <strong>of</strong> Medicine) is studying the muscle<br />

differences between cleft palate and<br />

normal palate muscle in a goat model.<br />

She is also studying the origin <strong>of</strong> Schwann<br />

cells in a peripheral nerve allograft. Dr Yu<br />

is mentored by Paul Cederna, MD. Ian<br />

Lytle, MD has just arrived from the<br />

<strong>University</strong> <strong>of</strong> Cincinnati, and is beginning<br />

his studies with Dr. David Brown in the<br />

area <strong>of</strong> muscle regeneration. Applications<br />

for the July 1, 2006 positions are being<br />

accepted.<br />

The Plastic <strong>Surgery</strong> Research<br />

laboratories’ research faculty, composed <strong>of</strong><br />

Cynthia Marcelo, PhD, Melanie<br />

Urbanchek, PhD, and Dennis Claflin,<br />

PhD, continue their studies in the areas <strong>of</strong><br />

keratinocyte biology, facial muscle<br />

reinnervation, muscle pathology<br />

N EWS FROM THE LABORATORIES:<br />

accompanying ventral hernia, contractile<br />

properties <strong>of</strong> human single muscle fibers,<br />

and effects <strong>of</strong> the absence <strong>of</strong> the protein<br />

dystrophin on skeletal muscle contractile<br />

properties.<br />

Several fellows made significant<br />

contributions to the Plastic <strong>Surgery</strong> field<br />

through their research efforts. They<br />

include: Yasushi Fujimori, MD is an<br />

instructor <strong>of</strong> Plastic and Reconstructive<br />

<strong>Surgery</strong> <strong>of</strong> Osaka Medical College and he<br />

is currently a visiting fellow in the<br />

laboratory <strong>of</strong> Dr. Marcelo. He is<br />

investigating the role <strong>of</strong> fatty acids in<br />

epidermal stem cell culture development as<br />

part <strong>of</strong> an ongoing project in the<br />

keratinocyte biology laboratories. Vikas<br />

Dhawan, MD, PhD from Chandigarh,<br />

India (Moscow State <strong>University</strong> <strong>of</strong> Medical<br />

and Stomatological Sciences, Moscow,<br />

Russian Federation) is studying skeletal,<br />

cardiac, renal and tendon tissue<br />

engineering. Dr Dhawan is mentored by<br />

David Brown, MD. Erika Henkelman,<br />

MD, is from Toronto (<strong>University</strong> <strong>of</strong><br />

Toronto). She is studying the<br />

biomechanical pathogenesis <strong>of</strong> chronic<br />

incisional hernia with special focus on<br />

single muscle fiber function in the<br />

presence <strong>of</strong> surgically induced ventral<br />

hernia; and the role <strong>of</strong> mechanical strain<br />

during laparotomy wound healing and<br />

incisional hernia repair with focus on<br />

fibroblast culture response to mechanical<br />

stretch. Dr. Henkelman is mentored by<br />

Drs Kuzon, Urbanchek, Franz and<br />

Marcelo. Daniel Schwarz, MD<br />

(<strong>University</strong> <strong>of</strong> Illinois in Chicago) is<br />

studying metrics <strong>of</strong> bone healing in<br />

Mandibular distraction ostegenesis<br />

undergoing irradiation with the help <strong>of</strong><br />

Ayman Elmeligy, MD (<strong>University</strong> <strong>of</strong><br />

Cairo). They are mentored by Steven R<br />

Buchman, MD.<br />

Three current U <strong>of</strong> M medical<br />

14 R E E D O . D I N G M A N S O C I E T Y<br />

students have found time to complete<br />

research investigations in the laboratories.<br />

Winston Choi from Denver, CO.<br />

(Stanford <strong>University</strong>, Biomechanical<br />

Engineering) completed a project studying<br />

the abdominal oblique muscular atrophy,<br />

fibrosis and decreased compliance<br />

associated with ventral incisional<br />

herniation. Daniel Krochmal who is<br />

from Farmington Hills, Michigan<br />

(Washington <strong>University</strong> in St. Louis,<br />

Biology, PNP (Philosophy, Neuroscience,<br />

Psychology) is beginning an outcomes<br />

study <strong>of</strong> recurrent ventral hernia repair<br />

techniques after completing a study on<br />

muscle force and power output following<br />

tendon repair with altered tension.<br />

Daemeon Nicolaou, from Los Angeles,<br />

CA (UCLA Neuroscience Major) is<br />

continuing a study on immunomodulation<br />

with Anti-CD40L monoclonal Antibody<br />

(MR1) and neuroregeneration in the nerve<br />

allografts.<br />

Four undergraduates are contributing<br />

to our research goals through coursework,<br />

independent studies, and summer<br />

fellowships. Daniel Calderon, from Ann<br />

Arbor, MI, Shaun Patel, from<br />

Woodhaven, MI, and Thane Wolcott from<br />

Dexter MI are LSA students majoring in<br />

Biology at the U <strong>of</strong> M. Daniel studies<br />

Collagen types I and III concentrations in<br />

rectus abdominus and external oblique<br />

muscles <strong>of</strong> a hernia model. Shaun studies<br />

the effects <strong>of</strong> hernias upon abdominal<br />

muscle properties, while Thane studies.<br />

abdominal muscle contractile and material<br />

properties following prostheses onlay.<br />

Richard Cheng, another Ann Arbor<br />

native who attends Northwestern<br />

<strong>University</strong> studied the nerve morphology<br />

related to an improved muscle recovery<br />

using FK506 in a nerve repair model.<br />

-Drs. Urbanchek and Marcelo

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