R EED O. D INGMAN S OCIETY - Department of Surgery - University ...
R EED O. D INGMAN S OCIETY - Department of Surgery - University ...
R EED O. D INGMAN S OCIETY - Department of Surgery - University ...
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The Plastic <strong>Surgery</strong> Section with support<br />
from colleagues from across the <strong>University</strong><br />
<strong>of</strong> Michigan has been awarded a second 5year<br />
funding period.<br />
The NIH Training grant in Burn,<br />
Trauma and Wound Healing Research has<br />
as PI and Program Director Cynthia L.<br />
Marcelo, PhD and William M.Kuzon, Jr,<br />
MD, Ph.D. as co-PI and co-Director.<br />
This grant supports the training <strong>of</strong><br />
potential academic medical<br />
surgeon/scientist in basic research related<br />
to trauma in muscle and bone, burn<br />
injuries, and wound healing and tissue<br />
engineering. Residents can train in health<br />
related areas <strong>of</strong> investigation and can chose<br />
more fundamental research fields<br />
(biophysics, tissue engineering, lipid<br />
biochemistry and molecular and cell<br />
biology).<br />
The Grant supports two postdoctoral<br />
fellows per year, plus supplies, course work<br />
and travel allowances. The current<br />
trainees are Deborah Yu, MD and Ian<br />
Lytle, MD. Deborah Yu, MD, from<br />
Bethesda, MD (Georgetown <strong>University</strong><br />
School <strong>of</strong> Medicine) is studying the muscle<br />
differences between cleft palate and<br />
normal palate muscle in a goat model.<br />
She is also studying the origin <strong>of</strong> Schwann<br />
cells in a peripheral nerve allograft. Dr Yu<br />
is mentored by Paul Cederna, MD. Ian<br />
Lytle, MD has just arrived from the<br />
<strong>University</strong> <strong>of</strong> Cincinnati, and is beginning<br />
his studies with Dr. David Brown in the<br />
area <strong>of</strong> muscle regeneration. Applications<br />
for the July 1, 2006 positions are being<br />
accepted.<br />
The Plastic <strong>Surgery</strong> Research<br />
laboratories’ research faculty, composed <strong>of</strong><br />
Cynthia Marcelo, PhD, Melanie<br />
Urbanchek, PhD, and Dennis Claflin,<br />
PhD, continue their studies in the areas <strong>of</strong><br />
keratinocyte biology, facial muscle<br />
reinnervation, muscle pathology<br />
N EWS FROM THE LABORATORIES:<br />
accompanying ventral hernia, contractile<br />
properties <strong>of</strong> human single muscle fibers,<br />
and effects <strong>of</strong> the absence <strong>of</strong> the protein<br />
dystrophin on skeletal muscle contractile<br />
properties.<br />
Several fellows made significant<br />
contributions to the Plastic <strong>Surgery</strong> field<br />
through their research efforts. They<br />
include: Yasushi Fujimori, MD is an<br />
instructor <strong>of</strong> Plastic and Reconstructive<br />
<strong>Surgery</strong> <strong>of</strong> Osaka Medical College and he<br />
is currently a visiting fellow in the<br />
laboratory <strong>of</strong> Dr. Marcelo. He is<br />
investigating the role <strong>of</strong> fatty acids in<br />
epidermal stem cell culture development as<br />
part <strong>of</strong> an ongoing project in the<br />
keratinocyte biology laboratories. Vikas<br />
Dhawan, MD, PhD from Chandigarh,<br />
India (Moscow State <strong>University</strong> <strong>of</strong> Medical<br />
and Stomatological Sciences, Moscow,<br />
Russian Federation) is studying skeletal,<br />
cardiac, renal and tendon tissue<br />
engineering. Dr Dhawan is mentored by<br />
David Brown, MD. Erika Henkelman,<br />
MD, is from Toronto (<strong>University</strong> <strong>of</strong><br />
Toronto). She is studying the<br />
biomechanical pathogenesis <strong>of</strong> chronic<br />
incisional hernia with special focus on<br />
single muscle fiber function in the<br />
presence <strong>of</strong> surgically induced ventral<br />
hernia; and the role <strong>of</strong> mechanical strain<br />
during laparotomy wound healing and<br />
incisional hernia repair with focus on<br />
fibroblast culture response to mechanical<br />
stretch. Dr. Henkelman is mentored by<br />
Drs Kuzon, Urbanchek, Franz and<br />
Marcelo. Daniel Schwarz, MD<br />
(<strong>University</strong> <strong>of</strong> Illinois in Chicago) is<br />
studying metrics <strong>of</strong> bone healing in<br />
Mandibular distraction ostegenesis<br />
undergoing irradiation with the help <strong>of</strong><br />
Ayman Elmeligy, MD (<strong>University</strong> <strong>of</strong><br />
Cairo). They are mentored by Steven R<br />
Buchman, MD.<br />
Three current U <strong>of</strong> M medical<br />
14 R E E D O . D I N G M A N S O C I E T Y<br />
students have found time to complete<br />
research investigations in the laboratories.<br />
Winston Choi from Denver, CO.<br />
(Stanford <strong>University</strong>, Biomechanical<br />
Engineering) completed a project studying<br />
the abdominal oblique muscular atrophy,<br />
fibrosis and decreased compliance<br />
associated with ventral incisional<br />
herniation. Daniel Krochmal who is<br />
from Farmington Hills, Michigan<br />
(Washington <strong>University</strong> in St. Louis,<br />
Biology, PNP (Philosophy, Neuroscience,<br />
Psychology) is beginning an outcomes<br />
study <strong>of</strong> recurrent ventral hernia repair<br />
techniques after completing a study on<br />
muscle force and power output following<br />
tendon repair with altered tension.<br />
Daemeon Nicolaou, from Los Angeles,<br />
CA (UCLA Neuroscience Major) is<br />
continuing a study on immunomodulation<br />
with Anti-CD40L monoclonal Antibody<br />
(MR1) and neuroregeneration in the nerve<br />
allografts.<br />
Four undergraduates are contributing<br />
to our research goals through coursework,<br />
independent studies, and summer<br />
fellowships. Daniel Calderon, from Ann<br />
Arbor, MI, Shaun Patel, from<br />
Woodhaven, MI, and Thane Wolcott from<br />
Dexter MI are LSA students majoring in<br />
Biology at the U <strong>of</strong> M. Daniel studies<br />
Collagen types I and III concentrations in<br />
rectus abdominus and external oblique<br />
muscles <strong>of</strong> a hernia model. Shaun studies<br />
the effects <strong>of</strong> hernias upon abdominal<br />
muscle properties, while Thane studies.<br />
abdominal muscle contractile and material<br />
properties following prostheses onlay.<br />
Richard Cheng, another Ann Arbor<br />
native who attends Northwestern<br />
<strong>University</strong> studied the nerve morphology<br />
related to an improved muscle recovery<br />
using FK506 in a nerve repair model.<br />
-Drs. Urbanchek and Marcelo