EMBO Fellows Meeting 2012
EMBO Fellows Meeting 2012
EMBO Fellows Meeting 2012
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Julia Cordero<br />
<strong>EMBO</strong> <strong>Fellows</strong> <strong>Meeting</strong> <strong>2012</strong><br />
Wnt signaling in Intestinal Homeostasis and Transformation: Lessons from the<br />
Drosophila midgut<br />
Abstract<br />
Wnt signaling is one of the main regulators of normal intestinal homeostasis in vertebrates. Critically,<br />
inactivating mutations of the Wnt signaling inhibitor APC (Adenomatous Polyposis Coli) is a hallmark of<br />
sporadic and hereditary colorectal cancer. My project involves using the adult Drosophila and mouse intestine<br />
to elucidate the cellular and molecular mechanisms involved in the regulation of normal intestinal homeostasis<br />
as well as during malignant transformation. Our results have uncovered the presence of conserved crosstalk<br />
between Wnt signalling, Myc, EGFR and JAK-Stat, which is essential to regulate the proliferation of intestinal<br />
stem cells (ISCs) in response to loss of Apc or overexpression of Wnt/Wg. We are also looking at the role of<br />
endogenous Wnt signaling and the source and regulation of the Wnt/Wg ISC niche during normal intestinal<br />
function as well as in response to injury/stress<br />
Laboratory of Owen Sansom. The Beatson Institute for Cancer Research. Glasgow, UK<br />
14-17 June <strong>2012</strong>, Heidelberg, Germany
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