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Medicinal Properties of Eucommia 843
potato, tomato, and tobacco. Their inhibition activity can be effective on both
chitin-containing and chitin-free fungi. The values of IC 50 range from 35 to
155 Ag/mL for EAFP1 and from 18 to 109 Ag/mL for EAFP2. Their
antifungal effects are strongly antagonized by calcium ions. Five active
principles against yeast enzyme were isolated and characterized. Among
them, quercetin was considered to contribute mostly to the activity of the
Tochu leaves (29).
H. Other Effects
a-Glucosidase inhibitory activity was found in aqueous methanol extracts of
Tochu-cha, (29) and anticomplementary activities of its constituents have
been described (30). Inhibition of adenosine 3V,5V-cyclic monophosphate phosphodiesterase
by lignan glucosides of eucommia barkhad been reported (31).
VI. SUMMARY
Although Du-Zhong and Tochu tea have been used for millennia alone, and
as part of complex formulations with other herbs, no clinical studies on their
effects have been conducted using modern scientific methods. Some of their
chemical constituents have been characterized, and a limited number of cell
and animal studies have been performed to establish their physiological
effects. These animal models suggest that crude extracts of these herbs may
increase muscle bulkand stamina and improve collagen deposition and
maturation. Antimutagenic, antioxidant, antihypertensive, antiviral, and
antifungal properties have been reported in cell and animal studies. The lack
of modern human studies makes it difficult to comment on the safety and
efficacy of these herbs when used as medicinal drugs.
REFERENCES
1. Herbal Classic of the Divine Ploughman [Shen Nong Ben Cao Chien] circa 100
B.C. Authors unknown.
2. Li SC. [Ben Cao Kong Mu] 1580.
3. Long Zhixian. Beijing University of Traditional Chinese Medicine. Formulas of
Traditional Chinese Medicine. Beijing: Academy Press, 1998.
4. Metori K, Furutsu M, Takahashi S. The preventive effect of ginseng with Du-
Zhong leaf on protein metabolism in aging. Biol Pharm Bull 1997; 20:237–242.
5. Li JS. Related Articles [Chemical analysis of duzhong (Eucommia ulmoides) bark
and leaves]. Zhong Yao Tong Bao. 1986; 11:41–42.
6. Hattori M, Che QM, Cewali MB, Yasuyuki T, Kikuchi T, Namba T. 1988
Studies on Du Zhong leaves: constituents of the leaves of Eucommia ulmoides.
Shoyakugaku Zasshi 1988; 42:76–80.