Abstract book (download .pdf file) - Redox and Inflammation ...

More documents

Recommendations

Info

Gene Targeting into the 21 st Century: Mouse Models of Human Disease from Cancer to Neuropsychiatric Disorders Mario Capecchi University of Utah School of Medicine, Salt Lake City, USA Gene targeting allows the designed modification of any gene in the mouse genome. Since genes impact all biological phenomena this methodology can be used to study any biological phenomena common to mammals in the mouse. We are using it to model human disease in the mouse. The models can be used to analyze the pathology of the disease at a level not feasible in humans and as a platform for the development of new therapeutic protocols. I will discuss modeling of a human cancer, synovial sarcoma, and a neuropsychiatric disorder, obsessive compulsive (OCD) spectrum disorder in the mouse. The former provides insight into the molecular biology of cancer. The latter provides the unexpected conclusion that microglia derived from bone marrow may be controlling behavior. 18
Activated Ras Requires Autophagy to Maintain Oxidative Metabolism and Tumorigenesis Eileen White The Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903 Autophagy is a catabolic pathway utilized by cells to support metabolism in response to starvation and to clear damaged proteins and organelles in response to stress. We report here that expression of a H-ras V12 or K-ras V12 oncogene upregulates basal autophagy, which is required for tumor cell survival in starvation and in tumorigenesis. In Ras-expressing cells, defective autophagosome formation or cargo delivery causes accumulation of abnormal mitochondria and reduced oxygen consumption. Autophagy defects also lead to tricarboxylic acid (TCA) cycle metabolite and energy depletion in starvation. As mitochondria sustain viability of Ras-expressing cells in starvation, autophagy is required to maintain the pool of functional mitochondria necessary to support growth of Ras-driven tumors. Human cancer cell lines bearing activating mutations in Ras commonly have high levels of basal autophagy, and in a subset of these, down-regulating the expression of essential autophagy proteins impaired cell growth. As cancers with Ras mutations have a poor prognosis, this “autophagy addiction” suggests that targeting autophagy and mitochondrial metabolism are valuable new approaches to treat these aggressive cancers. 19
Page 1 and 2: Luxembourg, January 26th to 28th, 2
Page 3: Luxembourg, January 26th to 28th, 2
Page 7: Preface In 1998, we organized the f
Page 11: European Research Institute for Int
Page 14 and 15: How to reach the congress center? -
Page 16 and 17: Many thanks to all exhibitors Pleas
Page 19 and 20: Wednesday January 26th, 2011 8h00 -
Page 21 and 22: Workshops 2 and Posters Session 2 1
Page 23: Oral presentations (In chronologica
Page 27 and 28: DNA-damage stress response in femal
Page 29 and 30: Towards understanding of life and d
Page 31 and 32: Systems Analysis of Endocytosis by
Page 33 and 34: Whole genome scans in drosophila to
Page 35 and 36: Search for the effects of anticance
Page 37 and 38: Redox regulation of transcription f
Page 39 and 40: A dual role of JAK1: regulation of
Page 41 and 42: Immunity and death in chronic viral
Page 43 and 44: Study of the anti-apoptotic role of
Page 45 and 46: Proteomic phenotyping of the cell s
Page 47 and 48: Traveling to the Ends of the Proteo
Page 49 and 50: Site-Specific Identification of SUM
Page 51 and 52: Mechanisms of Epigenetics in Health
Page 53 and 54: MicroRNAs and erythroid differentia
Page 55 and 56: A Systems Approach to Modeling and
Page 57 and 58: Targeting the invasive phenotype us
Page 59 and 60: Genes related to energy metabolism
Page 61 and 62: Pathological aspects of vascular ag
Page 63 and 64: Control of class III PI3 kinase in
Page 65 and 66: p75NTR regulates A! deposition by i
Page 67 and 68: Workshop presentations 61
Page 69 and 70: Agilent Technologies New enrichment
Page 71 and 72: MAPTrix TM biomimetics from amsbio:
Page 73 and 74: &:;4"N]LL" LSM"_/80?)1."#X"" LTM"K4
Page 76 and 77:
2 1 Map and bus stops 3 4 Meeting C
Page 78 and 79:
11 5 PARC DE L'EUROPE Dommeldange W
Page 80:
A heart for cancer sick children To
Page 83 and 84:
Wednesday January 26th Keynote sess
Page 85 and 86:
Session 1: Cell death Poster 1 The
Page 87 and 88:
Session 1: Cell death Poster 3 In v
Page 89 and 90:
Session 1: Cell death Poster 5 Func
Page 91 and 92:
Session 1: Cell death Poster 7 Mode
Page 93 and 94:
Session 1: Cell death Poster 9 Prot
Page 95 and 96:
Session 1: Cell death Poster 11 MAP
Page 97 and 98:
Session 1: Cell death Poster 13 Nit
Page 99 and 100:
Session 1: Cell death Poster 15 �
Page 101 and 102:
Session 1: Cell death Poster 17 Inc
Page 103 and 104:
Posters are classified by session a
Page 105 and 106:
Session 2: Cell signaling Poster 2
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Session 3: Transcriptional control
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Session 4: Immunology Poster 2 Immu
Page 129 and 130:
Session 4: Immunology Poster 4 Immu
Page 131 and 132:
Session 4: Immunology Poster 6 Iden
Page 133 and 134:
Session 4: Immunology Poster 8 Smal
Page 135 and 136:
Session 4: Immunology Poster 10 INJ
Page 137 and 138:
Session 4: Immunology Poster 12 The
Page 139 and 140:
Session 5: Proteomics Poster 1 Phos
Page 141 and 142:
Session 5: Proteomics Poster 3 Prot
Page 143 and 144:
Page 145 and 146:
Session 6: Epigenetics Poster 2 Ree
Page 147 and 148:
Session 6: Epigenetics Poster 4 Dat
Page 149 and 150:
Session 6: Epigenetics Poster 6 Fun
Page 151 and 152:
Session 6: Epigenetics 8 Switching
Page 153 and 154:
Session 6: Epigenetics Poster 10 Ep
Page 155 and 156:
Page 157 and 158:
Session 7: Cancer signaling network
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 184 and 185:
Page 187 and 188:
Session 8: Gene expression networks
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Session 9: Neurodegenerative Diseas
Page 197 and 198:
Session 9: Neurodegenerative diseas
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Notes 195
Page 215 and 216:
List of participants (In alphabetic
Page 217 and 218:
Mrs. Emilie Bana Laboratoire d'Ing
Page 219 and 220:
Dr. Alessandro Corsaro Laboratory o
Page 221 and 222:
Pr. Paul Fisher Microbial Cell Biol
Page 223 and 224:
Mr. Kasper Hoebe Cincinnati Childre
Page 225 and 226:
Mr. Hendrik Koopmans Cell Biology W
Page 227 and 228:
Mr. Romuald Menth Technical Support
Page 229 and 230:
!"# $%&'()% *%&+,&,-.+,/ 0.,),12/%&
Page 231 and 232:
!"# $%"&% '&()*+&"*,% !-.%"/+-0/1*2
Page 233 and 234:
Notes 218
Page 235 and 236:
Notes 220
Page 237:
We thank our sponsors:
show all

Abstract book (download .pdf file) - Redox and Inflammation ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?