Ablación por radiofrecuencia de arteria renal en la - CACI
Ablación por radiofrecuencia de arteria renal en la - CACI
Ablación por radiofrecuencia de arteria renal en la - CACI
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• Study Design<br />
SYMPLICITY HTN-3<br />
– Multi-c<strong>en</strong>ter, prospective, blin<strong>de</strong>d, randomized controlled trial<br />
• Study Objective<br />
– To <strong>de</strong>monstrate that catheter-based <strong>r<strong>en</strong>al</strong> <strong>de</strong>nervation is a safe and effective<br />
treatm<strong>en</strong>t for uncontrolled hypert<strong>en</strong>sion<br />
• Study Popu<strong>la</strong>tion<br />
– Uncontrolled hypert<strong>en</strong>sion popu<strong>la</strong>tion<br />
• SBP ≥160 mmHg <strong>de</strong>spite maximally tolerated doses of ≥3 antihypert<strong>en</strong>sive<br />
medication c<strong>la</strong>sses<br />
• Without significant <strong>r<strong>en</strong>al</strong> impairm<strong>en</strong>t (eGFR > 45mL/min)<br />
– 530 randomized subjects at 60 sites<br />
• Randomization (2:1)<br />
• All pati<strong>en</strong>ts maintained on baseline meds for 6 months<br />
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