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endocitosis mediada por receptor

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Las partículas de LDL son trans<strong>por</strong>tadas al lisosoma endonde enzimas digestivas las degradan en aminoácidos,colesterol y ácidos grasos. Luego el colesterol es liberado alcitoplasma donde es utilizado para la síntesis de membrananueva.Cuando se acumula colesterol en la célula se apaga lasíntesis del <strong>receptor</strong> LDL dentro de la célula.Aderem, Alan, and David M. Underhill. "Mechanisms of Phagocytosis in Macrophages." Annual Review ofImmunology 17 (1999): 593–623.Alberts, Bruce, et al. Molecular Biology of the Cell, 4th ed. New York: Garland Publishing, 2000.Mukherjee, Sushmita, Richik N. Ghosh, and Frederick R. Maxfield. "Endocytosis." Physiological Reviews77 (1997): 759–803.Schmid, Sandra L. "Clathrin-Coated Vesicle Formation and Protein Sorting: An Integrated Process."Annual Review of Biochemistry 66 (1997): 511–548.

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