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PRIMER

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owing to its efficacy at inducing remission

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This paper is an overview of the factors that are

important in SLE fatigue. Although obesity, physical

activity levels, depression, anxiety and vitamin D

levels are important, the relationship to disease

activity levels is much less clear.

155. Ruiz-Irastorza, G., Gordo, S., Olivares, N.,

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1470–1476 (2014).

Using an observational cohort of 230 patients with

SLE at inception with a 5‐year follow-up and SLICC

as a measure of tissue damage, 37% of patients

had accrued damage. Doses of >7.5 mg daily of

glucocorticoids were associated with higher levels

of damage attributable to the drug.

20 | 2016 | VOLUME 2 www.nature.com/nrdp

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