Intervenciones para el carcinoma basocelular de la piel

Characteristics of included studies
Participants
Interventions
Outcomes
Notes
Allocation concealment
Study
Methods
Participants
Interventions
Outcomes
Notes
Allocation concealment
Study
Methods
Participants
Interventions
Outcomes
Notes
Allocation concealment
Study
Methods
Participants
Interventions
Norway. HP BCC. 83 patients and 245 lesions (clinical thickness less than 1mm,
diameter less than 3cm).
All lesions in both groups were treated with the same drug (topical application of 20%
ALA . three hrs later the cream was removed and light source applied. Two different
light sources used. T1: laser light (630nm). T2: broadband light.
FU: 3,6 months after treatment. Outcomes : complete, partial or no response, determined
clinically. Cosmetic outcome assessed as excellent, good and fair or poor. Pain intensity
was recorded during treatment and follow-up period.
A
Sterry 2001a
Multicentre, randomised open label, dose response. Method of randomisation not
known. ITT
USA. 93 patients, single, primary, BP superficial BCC (0.5 to 2 cm2)
T1: imiquimod thrice per week for 6 weeks with occlusion, T2: thrice per week without
occlusion for 6 weeks, T3: twice a week with occlusion for 6 weeks, T4: twice per week
without occlusion for 6 weeks.
FU: surgical excision 6 weeks after treatment
B
Sterry 2001b
Multicentre, randomised, open label, dose response study. Method of randomisation
not known.
USA. 90 patients. Single, primary, BP nodular BCC (measuring 0.25 to 1.5 cm2)
T1: imiquimod, three times per week, with occlusion for 6 weeks, T2: imiquimod, three
times per week, without occlusion, for 6 weeks, T3: imiquimod, twice a week, with
occlusion, for 6 weeks, T4: imiquimod, twice a week, without occlusion, for 6 weeks.
FU: surgical excision 6 weeks after treatment stopped.
B
Thissen 2000
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Intervenciones para el carcinoma basocelular de la piel
Single centre, Method of randomisation not known. PP
Netherlands; 103 patients. BP BCCs. Lesions superficial or nodular, less than 2cm in
diameter localised anywhere n the head and neck area.
T1: surgery. A tumour including a safety margin of 3mm from the visible margin was
removed. T2: cryosurgery ( a curette number 3 was used to debulk the tumour and a
number one was used to remove the remainder of BCC around the borders. A liquid
nitrogen spray was used to freeze the tissue. Freezing was carried out in two freezing
periods each and lasting 20 seconds. The halo thaw time between these cycles was
60 secs. All tumours were treated with the cone-spray technique, using a neoprene
cone with a wall thickness of 2mm.
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