Piante officinali, principi attivi e sistema immunitario

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2.3. FITOTERAPIA E IMMUNOMODULAZIONE. Toxicity and genotoxicity of antimalarial alkaloid rich extracts derived from Mitragyna inermis O. Kuntze and Nuclea latifolia. Traore et al. Phytother.Res. 2000;14 (8): 608 - 11. 2 <strong>Piante</strong> del MALI Utilizzate nella medicina tradizionale. Mitragyna inermis (Willd.) O. Küntze, Rubiaceae Nauclea latifolia (Sm.), Rubiaceae Studio della tossicità e della genotossicità in vivo e in vitro 2
2.3. FITOTERAPIA E IMMUNOMODULAZIONE. Toxicity and genotoxicity of antimalarial alkaloid rich extracts derived from Mitragyna inermis O. Kuntze and Nuclea latifolia. Traore et al. Phytother.Res. 2000;14 (8): 608 - 11. Modello sperimentale Mitragyna inermis (Willd.) O. Küntze Nauclea latifolia (Sm.) Inibizione della sintesi proteica nelle cellule Nessun effetto mutagenico Nessun effetto genotossico Estratto alcaloide In vitro può interagisce in vitro con il DNA batterico e cellulare Portando quindi a un blocco della divisione cellulare in G2-M In vivo può portare a una rottura del singola catena del DNA nel fegato, reni e cellule del sangue 3
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Piante officinali, principi attivi e sistema immunitario

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