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18 ,fdidsf rfhlbjkjubf<br />
nutriciuli problemebi da maTi<br />
koreqcia kistofibrozis dros<br />
n. badriaSvili, m. moiswrafiSvili,<br />
n. TofuriZe, n. SariqaZe,<br />
m. giorgobiani, z. SaqaraSvili<br />
kistofibrozi genetikuri daavadebaa, ganpirobebuli<br />
kistofibrozis transmembranuli<br />
maregulirebeli genis mutaciiT, mimdinareobs<br />
upiratesad sasunTqi sistemisa da kuWnawlavis<br />
traqtis dazianebiT.(1,3,5). daavadebis<br />
paTogenezSi mniSvnelovani adgili uWiravs<br />
imunuri homeostazis darRvevas. ukanaskneli<br />
wlebis farmakoTerapiuli miRwevebis<br />
safuZvelze daavadebis diagnostikis SemTxvevaSi<br />
prognozi mniSvnelovnad aris gaumjobesebuli(2,4,8).<br />
AAklinikuri suraTi vlindeba filtvis<br />
qronikuli obstruqciuli procesis, nawlauri<br />
sindromisa da fizikuri ganviTarebis SeferxebiT.<br />
asakis matebasTan erTad pankreasis<br />
garegani funqciis ukmarisobis niSnebis<br />
paralelurad izrdeba sasunTqi sistemis dazianebis<br />
simbtomebi.<br />
kistofibrozis Ayvelaze adreuli da mZime<br />
gamovlinebaa mekonialuri ileusi, romlis<br />
mizezia pankreasuli aqilia da wvrili nawlavis<br />
jirkvlebis disfunqcia.A mekonialuri<br />
ileusi literaturis mixedviT gvxvdeba<br />
avadmyofTa 10-15% da iTvleba daavadebis um-<br />
Zimes formad.<br />
malabsorbciis sindromis mkurnaloba<br />
warmatebiT xorcieldeba pankreasuli ferementebiT<br />
romelTa Soris gansakuTrebuli<br />
adgili daimkvidra fermentma kreonma. igi akmayofilebs<br />
yvela moTxovnas, romelic idealur<br />
fermentul preparats waeyeneba: fermentebis<br />
optimaluri, fiziologiur proporcia-<br />
Si Semcveloba; mJavagamZleoba; swrafi da<br />
Tanabari Sereva sakvebTan; sakvebTan erTad<br />
gadasvla pilorusSi; fermentebis swrafi da<br />
100 %-iT gamonTavisufleba TormetgojaSi,<br />
sadac aqtiurad mimdinareobs sakvebis moneleba;<br />
amasTan igi usafrTxoa, mikrosferulia,<br />
dafarulia pH mgrZnobiare kafsuliT.<br />
kreoni® 10 000 Seicavs: 150 mg pankreatins, rac<br />
Seesabameba 8 000 s.erT.amilazas, 10 000 s.erT.<br />
lipazas da 600 s.erT. proteazas; kreoni® 25<br />
000 Seicavs: 300 mg pankreatins, rac Seesabameba<br />
18 000 s.erT. amilazas, 25 000 s.erT. lipazas<br />
da 1000 s. erT. proteazas; metaboluri<br />
da cilovani cvlis koreqciisa da imunomo-<br />
dulaciis mizniT gamoiyeneba antioqsidanti<br />
apikori. igi ori biologiurad aqtiuri kompinentebiT<br />
mdidari produqtis futkris nawarmisa<br />
da yurZnis wipwis nazavia. yvavilis<br />
mtveri mdidaria organizmis Senebis, ganviTarebisa<br />
da sicocxlisaTvis aucilebeli niv-<br />
TierebebiT: cilebiT(Seicavs aminomJavebis 22<br />
saxeobas, maTgan 8 Seucvlels), najeri da<br />
ujeri cximovani mJavebiT, glikozidebiT, vitaminebiT<br />
(A,B,C,D,PP,E,K,folis mJava), fosfoterinebiT,<br />
sisxlZarRvis kedlis gamamagrebeli<br />
bioflavinoidebiT, mikro da makroelementebiT(Fe,Zn,Cu,F).<br />
amave dros yurZnis wipwa imunomodulatoria.<br />
kistofibroziT daavadebulebSi malabsorbciis<br />
mkurnaloba grZeldeba mTeli sicocxlis<br />
manZilze da iTvaliswinebs kargi<br />
nutriciuli mdgomareobis SenarCunebas, ra-<br />
Sic udidesi mniSvneloba aqvs Tanamedrove<br />
farmakologiur saSualebebs ekologiurad<br />
sufTa da balansirebul sakvebi ingredientebis<br />
fonze.<br />
Sromis mizans warmoadegenda nutriciuli<br />
statusis koreqcia kistofibroziT daavadebul<br />
bavSvebSi.<br />
masala da meTodebi: Seswavlili iyo kistofibroziT<br />
daavadebuli 1Tvidan 14 wlamde<br />
asakis 26 bavSvi, maTgan 20vaJi da 22 gogona.<br />
Mmv Sereuli forma aReniSneboda 18-s, filtvis<br />
forma 8 avadmyofs. sakontrolo jgufs<br />
Seadgenda imave asakis praqtikulad janmrTeli<br />
20 bavSvi. diagnozis dasabuTeba xdeboda<br />
anamnezuri, klinikur-instrumentuli kvlevisa<br />
da oflSi eleqtrolitebis siWarbis<br />
(>60mmol/l) gansazRvris safuZvelze. imunuri<br />
homeostazis SeswavlisaTvis isazRvreboda<br />
CD3, CD4, CD8 limfocitebi monoklonuri<br />
antisxeulebiT, B-limfocitebi komplementuri<br />
rozetkis warmoqmnis meTodiT, sisxlis<br />
SratSi IgG, IgA, IgM- manCinis radialuri imunodifuziis<br />
meTodiT.<br />
Sedegebis ganxilva: rogorc Cveni masalis<br />
analizma gviCvena kistofibrozisaTvis<br />
damaxasiaTebeli iyo pirveladi pnevmoniis<br />
gaxangrZlivebuli an morecidive mimdinareoba.<br />
miuxedavad sworad warmarTuli mkurnalobisa<br />
SemdgomSi yvela SemTxvevaSi viTardeboda<br />
qronikuli pnevmonia ormxrivi difuzuri<br />
procesiT, rac emTxveva sxva avtorTa<br />
monacemebs. Cvens SemTxvevaSi sasunTq siste-<br />
@__) otkb
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