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,fdidsf rfhlbjkjubf<br />
zogierti leqtini TviTon aavlens fungicidur<br />
da inseqticidur aqtivobas, sxvebi amisaTvis<br />
kooperireben fermentebTan (mag. qitinazebTan).<br />
interess warmoadgens e. w. RIPs ( ribosome-inactivating<br />
proteins)-cilovani kompleqsebi,<br />
romelTac SeswevT unari ribosomebze zemoqmedebis<br />
da maTi mwyobridan gamoyvanis.<br />
maT Soris gvxvdeba maRal toqsiurebi.<br />
leqtinebi maRalspecifiurni arian : maT ganarCeven<br />
erTmaneTisagan ara mxolod monosaqaridebs,<br />
aramed sxvadasxva oligosaqaridebsac.Lleqtinebis<br />
rolis SeswavlaSi didi<br />
wvlili miuZRvis j. aSuels – janmrTelobis<br />
erovnuli institutidan da albert ainStainis<br />
saxelobis samedicino kolejidad,romlebmac<br />
1968 w. eqsperimentSi sisxlis plazmis gansazRvrul<br />
glikoproteinebs (gp) fermentatulad<br />
moaSores sialis mJava, Semdeg es glikoproteinebi<br />
Seuyvanes sacdel baWiebs. aRmoCnda,<br />
rom sialis mJavis ar mqone glikoproteinebi<br />
maleve qrebodnen sisxlidan, gansxvavebiT intaqtur<br />
molekilebisagan, romlebis garkveuli<br />
drois ganmavlobaSi rCebodnen sisxlSi.<br />
rogorc gvaCvenes aSuelma da morelma, gpebi<br />
amTavreben TavianT arsebobas RviZlSi.sialis<br />
mJavis moSorebis Sedegad<br />
- galaqtoza, normaSi miuwvdmeli qimiuri<br />
SenaerTia, SiSvldeba da ukavSirdeba leqtins<br />
hepatocitebis zedapirze.<br />
SemdgomSi aRmoCnda, rom Tu gp-is molekulas<br />
sialis mJavasTan erTad galaqtozasac<br />
movaSorebT, maSin gp-is sisxlidan gaqrobis<br />
siCqare normas ubrundeba.<br />
am monacemebidan gamomdinare, gakeTda daskvna,<br />
rom cilebis gverdiTi naxSirwylovani<br />
jaWvebi SegviZlia gamoviyenod rogorc markerebi<br />
im molekulebis, romlebic saboloo<br />
jamSi qrebian sisxlidan da iSlebian.<br />
zedapiruli naxSirwylebis msgavsad, zedapiruli<br />
leqtinebic ganicdian cvlilebebs, ujredis<br />
fiziologiuri da paTologiuri mdgomareobis<br />
Sesabamisad. 1981 wels r. lotani da<br />
e. radi veismanis samecniero institutidan aRmoaCines<br />
– adamianisa da Tagvis simsivnuri ujredebis<br />
zedapirze – leqtinebi, romlebic<br />
normaluri ujredebis zedapirze ar iyo.<br />
SemdgomSi aRmoCnda, rom es leqtinebi metastazebis<br />
ganviTarebaSi monawileoben.<br />
manoza-SemakavSirebeli leqtinebi (mSl-i)<br />
garkveul rols asruleben mamakacebSi gulis<br />
iSemiuri daavadebis ganviTarebaSi. SratSi mSls<br />
donis momateba asocirebulia gid-is ganviTarebis<br />
riskTan mamakacebSi da ara qalebSi.<br />
rogorc cnobilia, mSl-i monawileobs<br />
komplementis aqtivaciis reaqciaSi da mniSnelovan<br />
rols asrulebs organizmis imunuri<br />
pasuxSi paTogenuri mikrobebis mimarT.<br />
doqtor t. keleri da misi kolegebi, amsterdamis<br />
samedicinoakademiur centridan, Caatares<br />
prospeqtuli kvleva<br />
«SemTxveva-kontroli» SearebiT janmrTel<br />
@__) otkb<br />
39<br />
mamakacebsa da qalebs – prospeqtuli populaciuri<br />
kvlevis monawileebs Soris EPIC-Norfolk.<br />
mSl-is sawyisi (Tavdapirveli) done 946 infarkt<br />
gadatanil pacientebis an 6 wlis ganmavlobaSi<br />
garacvlil macientebze dakvirvebiT<br />
miRebuli monacemebi Seadares mSl-is dones<br />
1799 pacientSi, romelTac ar ganuviTardaT gid.<br />
mamakacebSi mSl-is done Seadgina 1.63 ng/mggid<br />
mqone pirebSi da 1.2 ng/mg- pirebSi sakontrolo<br />
jgufidan. qalelebSi es sxvaoba iyo Zalian<br />
mcire 1.02 da 1.01 ng/mg Sesabamisad. C-reaqtiul<br />
cilaze gadaangariSebiT (gadasworebiT)<br />
mamakacebSi gid-is ganviTrebis SefardebiTi<br />
Sansi Seadgina 1.59 mSl-s maqsimaluri monacemebisaTvis<br />
(me-4 kvartili) 1 kvartilTan SedarebiT.<br />
Qalebs Soris analogiuri damokidebuleba<br />
ar dadasturda. Avtorebi aRniSnaven: ar aris<br />
gamoricxululi, rom miRebuli monacemebi garkveul<br />
wilad xsnis gid ganviTarebis riskis<br />
sxvaobas mamakacebsa da qalebs Soris.<br />
Tu gadavxedavT msoflios wamyvan bioteqnologiur<br />
firmebs, romlebic biopreparatebis<br />
sinTezs awarmoeben – SeiZleba Segvxdes leqtinebis<br />
didi CamonaTvali , maT Soris aris e.<br />
w. moniSnuli leqtinebi da a. S. leqtinebi gamoiyeneba<br />
sxvadasxva genetikuri paTologiebis<br />
diagnostikisaTvis, zogierTi mkroorganizmis<br />
identifikaciisaTvis, kvleviT saqmianobaSi.<br />
magram leqtinemi bioteqnologiaSi gamoiyeneba<br />
ufro prozaikul rolSic – specifiuri<br />
reagentis, romelic amorCeviTad ierTebs<br />
ama Tu im rTul nivTierebas : glikoproteidebs,<br />
hormonebs, sialoproteidebs da a.S. ase<br />
rom leqtinebis preparatebis meSveobiT SegviZlia<br />
miviRoT ufro mniSvnelovani, ufro<br />
Rirebuli nivTierebebi, romelic mZme daavadebebis<br />
mkurnalobaSi dagvexmareba.<br />
sakmaod prospeqtulia axali Taobis leqtinebis<br />
Seqmna – -leqtinebisa da antisxeulebis<br />
hibridebis, sxvadasxva qsovilebze zemoqmedebisaTvis,<br />
sadac leqtinebis zemoqmedeba ar<br />
aris mavne. erT-erTi msgavsi cda awarmoa doqtor<br />
andress engert-ma kiolnSi. Limfuri kvan-<br />
Zebis kibos samkurnalod man gamoiyena antisxeulebTan<br />
dakavSirebuli ricini. antisxeuli<br />
amorCeviTad miitanda ricins – simsivnesTan.<br />
Ra Tqma unda es mxolod pirveli nabijebia<br />
leqtinebis medicinaSi gamoyenebis, magram, zustad<br />
amitom is aseTi mniSvnelovania.<br />
literatura:<br />
1. www.fit-area.com<br />
2. www.medlinks.ru/article.php?sid=26720<br />
3. www.pereplet.ru/obrazovanie/stsoros/254.html<br />
4. bio-medicine.org<br />
5.www.chemnet.ru/rus/journals/membranes/22/ref0058.html<br />
6. .., .., ..<br />
. : ., 1981.<br />
7. .. //<br />
. -<br />
. ., 1984. . 1.
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