bavSvTa asakis mwvave
bavSvTa asakis mwvave
bavSvTa asakis mwvave
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<strong>mwvave</strong> limfoiduri leikemia momdinareobs Zvlis tvinidan, magram<br />
blasturi ujredebi sistematurad gvxvdebian sxva organoebSic: TimusSi,<br />
RviZlSi, elenTaSi, limfur kvanZebSi, saTesle parkebSi, centralur<br />
nervul sistemaSi.<br />
daavadebis prevencia: radgan ar aris dadgenili mll-is gamomwvevi<br />
mizezi, Sesabamisad ar arsebobs misi Tavidan acilebis profilaqtikuri<br />
RonisZiebebi.<br />
klinikuri simptomebi: mll-iT daavadebuli pacientebi diagnozisas<br />
avlenen im niSnebsa da simptomebs, romlebic gamowveulia Zvlis tvinis<br />
infiltraciiT da eqstramedularuli daavadebiT. Sesabamisad, pacients<br />
aReniSneba Zvlis tvinis ukmarisoba anemiiT, trombocitopeniiT da<br />
neotropeniiT. klinikur monacemebSi yovelive es vlindeba sisustiT da<br />
sifermkrTaliT, peteqiebiT, sisxldeniT da cxelebiT. leikemiis<br />
eqstramedularuli gavrcela manifestirdeba limfadenopaTiiT da<br />
hepato-splenomegaliiT, osalgiebiT, sunTqvis ukmarisobiT. centraluri<br />
nervuli sistemis dazianebis SemTxvevaSi pacients aReniSneba Tavis<br />
tkivili, Rebineba da gulisreva, meningialuri niSnebi, leTargia;<br />
kranialuri nervebis (umetesad me-7 , me-3, me-4 da me-6 nervebis) CarTva<br />
vlindeba maTi pareziT. spinaluri da intrakranialuri masis<br />
SemTxvevebSi adgili aqvs nervebze kompresiiT gamoxatul simptomatikas.<br />
testikularuli leikemia diagnozisas iSviaTia da, Tu adgili aqvs,<br />
vlindeba saTesle parkebis mtkivneulobiT da gadidebiT.<br />
diagnozi: anamnezis dadgenisa da fizikaluri gasinjvis Semdeg<br />
pacients utardeba Semdegi bazisuri laboratoriuli testebi:<br />
sisxlis sruli analizi - hemoglobinis da formiani ujredebis<br />
raodenobrivi diferencirebis mizniT SesaZloa damTvleli manqanis<br />
gamoyeneba, magram limfoblastebis identificirebis da morfologiis<br />
dasadgenad aucileblad ikvleva gimzas wesiT SeRebili nacxebi. nacxebs<br />
swavlobs hematologi an specialisti paTomorfologi.<br />
Zvlis tvinis aspiratis sruli morfologia - tardeba Zvlis tvinis<br />
aspiratidan damzadebuli nacxebis gamokvleviT. mll formebis dros<br />
gamoyofilia sami ZiriTadi morfologiuri forma:<br />
• L1: patara zomis, mwiri citoplazmiT da SeumCneveli birTvebiT.<br />
• L2: ujredebi ufro didi zomis arian, vidre L1, uCveneben zomis<br />
heterogenobas, mkafio birTvakebiT da Warbi citoplazmiT.<br />
• L3: arian didi zomis, citoplazmuri bazofiliiT, maT umetesad<br />
aqvT citoplazmuri vakuolizacia da morfologiurad identuri<br />
arian berkitis limfomis ujredebisa.<br />
blasturi ujredebis imunologia - mll leikemiis imunologiuri<br />
klasifikaciiT dadginda, rom limfoblastebi bevr maxasiaTeblebs<br />
iyofen normalur limfoiduri rigis ujredebTan. blasturi ujredebis<br />
imunoglobulinebis da T ujredovani receptoruli genebis gamovleniT,<br />
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