bavSvTa asakis mwvave

More documents

Recommendations

Info

aris premitozuri faza (G2 faza), romelic mTavrdeba mitozuri ujredis gayofiT (faza M). ujredebis gayofis sixSire gansxvavebulia sxvadasxva simsivneebSi. Uufro xSirad ki simsivnuri zrda nelia normalur qsovilTan SedarebiT. aseTi gansxvaveba normalur ujredebs saSualebas aZlevs ganaxldnen ufro swrafad, vidre simsivnuri ujredebi da swored es udevs safuZvlad qimioTerapiuli reJimebis SerCevas. antineoplaziuri agentebi ujredTa reproduqciaze moqmedebs. zogierTi maTgani specifiuria ujredul ciklebze, zigierTi ara. Uujreduli apoptozi (ujredTa programuli sikvdili) aris meore potenciuri meqanizmi antineeoplasiuri agentebis. Qqimiuri preparatebis dozireba da daxasiaTeba dawvrilebiT ixileT mkurnalobis protokolSi. mwvave limfoiduri leikemiis da misi mkurnalobis garTulebebi mwvave lizisis sindromi, Tirkmlis ukmarisoba, sefsisi, sisxldenebi, trombozi, tifliti, neiropaTia, encefalopaTia, krunCxva, meoradi simsivneebi, zrdis hormonis deficiti. 6
mwvave limfoiduri leikemiis diagnozi inicialuri diagnozi mwvave limfoiduri leikemiis diagnozi da biologiuri daxasiaTeba mwvave leikemiis pirveladi diagnozi eyrdnoba periferiuli sisxlis, Zvlis tvinisa da cerebro-spinaluri siTxis citologiur kvlevebs. Zvlis tvinis nacxebi, romelic raodenobrivad unda iyos 4 an 8, standartulad iRebeba gimzas wesiT. Mmielogramis Seswavlisas FAB klasifikaciis Tanaxmad daTvlili unda iqnas ara nakleb 500 birTviani ujredisa. citomorfologiis Semdeg tardeba standartuli citoqimiuri reaqciebi (PAS, AcP, MPO, SBB, NACE, ANAE/ANBE ± NaF). mwvave limfoiduri leikemiis diagnozi SesaZloa daisvas mxolod im SemTxvevaSi, Tu aRniSnul nacxebze aRmoCnda 25%-is toli an meti limfoblastebi. klasikuri morfologiisa da citoqimiis Semdeg saWiroa ganisazRvros mTliani kariotipis citogenetika. amis Semdeg aseve saWiroa blasturi ujredebis gamokvleva molekuluri genetikis doneze (PCR meTodiT). blasturi ujredebis biologiuri daxasiaTebis Semdgom etaps warmoadgens maTi imunofenotipireba. imunofenotipireba unda moxdes standartuli faqs-skanis meTodiT (umjobesia 4 feriani manqana). mwvave leikemiis obligatoruli diagnostikuri meTodebi aris warmodgenili Semdeg cxrilSi: 1. citomorfologia • periferiuli sisxlis saerTo analizi • Zvlis tvinis nacxebis citomorfologia • cerebrospinaluri siTxe: ujredebis raodenoba da citologia • Zvlis tvinis nacxebis citoqimiuri Seswavla 2. gamdinare citometri • Zvlis tvinis da periferiuli sisxlis blastebis imunofenotipireba 3. citogenetika • blasturi ujredebis citogenetika maTSi struqturuli da raodenobrivi aberaciebis SeswavliT 4. molekuluri genetika • Zvlis tvinis da periferiul sisxlSi: PCR meTodiT mxolod SerCeviTi translokaciebis Seswavla (BCR/ABL, MLL,AF4, TEL/MLL1) 7
Page 1 and 2: avSvTa asakis mwvave limfoiduri lei
Page 3 and 4: mwvave limfoiduri leikemia momdinar
Page 5: gansxvavebuli arian. mkurnalobis st
Page 9 and 10: • cerebrospinalur siTxeSi ujredeb
Page 11 and 12: protokolis moTxovnebi 1. Pprotokoli
Page 13 and 14: - pacientis an misi MmSobelTan gafo
Page 15 and 16: mkurnalobis klasificacia riskis jgu
Page 17 and 18: leikemiis mqone pacientebi, rameTu
Page 19 and 20: protokoli I standartuli riskis T, s
Page 21 and 22: an reducireba ganxilul unda iqnas p
Page 23 and 24: ARA - C: citozari 75mg/m 2 /dReSi i
Page 25 and 26: ALL-BFM-95-Tan SedarebiT aRniSnul p
Page 27 and 28: dRe 2 ..../.... 14.00 : isazRvreba
Page 29 and 30: karboqsipeptidazes daniSvna xdeba i
Page 31 and 32: protokolis dawyebis kriteriumebi:
Page 33 and 34: klinikurad - Rebineba, gulisreva, Z
Page 35 and 36: einduqciuli Terapia mxari II standa
Page 37 and 38: faza III/1 protokolis dawyebis krit
Page 39 and 40: Sualeduri dacviTi Terapiis miRebis
Page 41 and 42: Terapiuli elementebi induqciis Tera
Page 43 and 44: G-CSF HR blokebis Semdeg maRali ris
Page 45 and 46: loki HR-1 dizaini bloki HR-1 iwyeba
Page 47 and 48: saaTiT adre aranakleb 2 dRisa citoz
Page 49 and 50: DEXA (deqsametazoni) - 20 mg/m 2 /d
Page 51 and 52: loki HR-3 es Terapiuli elementi ari
Page 53 and 54: CaTvliT, bronxospazmi, ris gamoc pa
Page 56 and 57:
Sualeduri dacviTi Terapiis sqema: s
Page 58 and 59:
6-MP-isa da MTX-is doza regulirdeba
Page 60 and 61:
SeniSvna: pacientebi inicialuri cen
Page 62 and 63:
c.n.s-is Terapia ALL IC-BFM-2002-is
Page 64 and 65:
sxivuri Terapiis dozebi, xangrZlivo
Page 66 and 67:
qimioTerapiis dros arsebuli da mosa
Page 68 and 69:
purinuli metabolitebis xsnadobis li
Page 70 and 71:
- mas gaaCnia ufro swrafi urikulizu
Page 72 and 73:
mwvave lizisis sindromis Terapia pr
Page 74 and 75:
maCveneblebi: kaliumi, fosfati, kre
Page 76 and 77:
hemoTerapia eriTrocitebis transfuzi
Page 78 and 79:
qimioTerapiis dros mosalodneli infe
Page 80 and 81:
dabali riskis neitropeniuli epizodi
Page 82 and 83:
gancikloviris xmarebisas pacienti R
Page 84 and 85:
5HT3 receptorebis antagonistebidan
Page 86 and 87:
invaziur procedurebTan dakavSirebul
Page 88 and 89:
• totaluri parenteraluri kvebis d
Page 90:
faza 1 wona= kg simaRle= sm s/f= m
Page 93 and 94:
wona kg protokoli M centri: simaRle
Page 95 and 96:
Terapiis mxari: centri: faza 1 prot
Page 97 and 98:
wona simaRle s/f kg sm m 2 Terapiis
Page 99 and 100:
dacviTi Terapia cikli saxeli: dab/T
Page 101 and 102:
ecidivis ganviTarebis drois definic
Page 103 and 104:
loki R2 medikamenti miRebis forma d
Page 105 and 106:
105
Page 107 and 108:
107
Page 109 and 110:
109
Page 111 and 112:
111
Page 113 and 114:
113
show all

bavSvTa asakis mwvave

Create successful ePaper yourself

Delete template?

Save as template?