DoloÄanje encimske aktivnosti v kliniÄne namene
DoloÄanje encimske aktivnosti v kliniÄne namene
DoloÄanje encimske aktivnosti v kliniÄne namene
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Encimski inhibitorji <br />
H 3 C<br />
HO<br />
O<br />
C<br />
O -<br />
OH<br />
O<br />
• Hiperholesteromija <br />
hidroksi metil-‐glutaril CoA-‐reduktaze <br />
– mevinolin <br />
– compactin <br />
– monacol K <br />
H 3 C<br />
HO<br />
C<br />
OH<br />
O<br />
O -<br />
O<br />
O<br />
C<br />
HO<br />
H<br />
C<br />
O<br />
O<br />
O<br />
O<br />
C<br />
O<br />
C<br />
CH 3<br />
CH 3<br />
R<br />
• Giht/putika <br />
ksantin-‐oksidaza <br />
HO<br />
H<br />
mevinolin compactin monacol K <br />
O<br />
C<br />
R=H R=CH 3 <br />
– allopurinol (ksantin → topen aloksantin) <br />
O<br />
O<br />
O<br />
C<br />
R<br />
H 3 C<br />
HO<br />
O<br />
SCoA<br />
H 3 C<br />
HO<br />
O<br />
SCoA<br />
hipoksantin ksantin urna kislina
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