I Disturbi Comportamentali e Psichici nella Demenza - Scienze della ...

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BuChE ACTIVITY INCREASES IN THE AD BRAIN,COMPARED WITH HEALTHY CONTROLSBuChE staining in the temporalcortex of a 71 year-old patient withAD. BuChE is found in plaques(), tangles ( ), dystrophicneurites ( ), and glia ()BuChE staining in an 89 year-oldnon-demented individual. BuChEstaining is limited to the glia ()Guillozet et al, Ann Neurol 1997;42:909–18
MemantinaMemantineconcentration (M) 2Receptor 1ReceptorKainate ReceptorD 2ReceptorAMPA Receptor10 -4 DA/5HT Transporter5HT 3Receptor• Antagonista noncompetitivo deirecettori NMDASigma 1Binding site10 -5Nicotinic ACh Receptor5HT 1Receptor10 -6NMDA ReceptorTherapeutic11/01/2010 concentrationJK 15Kornhuber et al (1994)
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