CURRICULUM VITAE DR. LEONARDO PANTONI - Spread

CURRICULUM VITAE 

DR. LEONARDO PANTONI 

Medico, Specialista in Neurologia 

Dottore di Ricerca in Neuroscienze 

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Pantoni - Curriculum vitae

Dr. Leonardo Pantoni 

Luogo e data di nascita: Firenze, 15 Ottobre 1964 

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Pantoni - Curriculum vitae 

Recapito professionale: SOD Stroke Unit e Neurologia 

Azienda Ospedaliero Universitaria Careggi 

Università degli Studi di Firenze 

Studi e titoli conseguiti: 

Laurea in Medicina e Chirurgia il 23 Ottobre 1989 (voto: 110 e lode/ 110) 

Diploma di Specialista in Neurologia il 15 Luglio 1993 (voto: 70 e lode/ 70) 

Research Fellowship, Department of Pathology, Division of Neuropathology, Henry Ford 

Hospital, Detroit, Michigan (USA) (Agosto 1993 - Giugno 1995) 

Titolo di Dottore di Ricerca in Neuroscienze conseguito il 1 Febbraio 1999 

Idoneità a Professore Associato conseguita presso Università degli Studi di Sassari il 3 Dicembre 

2010 

Posizione attuale: 

Dirigente Medico di I livello 

S.O.D. Stroke Unit e Neurologia, Azienda Ospedaliero Universitaria Careggi 

Principali linee di ricerca (documentate da pubblicazioni): 

� Demenza vascolare: epidemiologia, correlazioni clinico-patologiche, neuroimaging, trial 

terapeutici. 

� Patologia della sostanza bianca cerebrale età-correlata: aspetti clinici, neuroradiologici e 

patologici e loro correlazioni. 

� Neuropatologia della demenza vascolare. 

� CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and 

Leukoencephalopathy) 

� Ischemia cerebrale sperimentale (focale e globale). 

� Prevenzione secondaria e primaria delle malattie cerebrovascolari. 

� Fattori di rischio per le malattie vascolari e il deterioramento cognitivo. 

� Malattie neurologiche legate all'invecchiamento. 

� Complicanze neurologiche degli interventi cardio-chirurgici. 

� Amnesia globale transitoria. 

� Complicanze neurologiche della fibrillazione atriale. 

� Aspetti infiammatori dell'ischemia cerebrale.

INCARICHI EDITORIALI, CONGRESSUALI E VARI: 

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Curatore ed editore (con Domenico Inzitari e Anders Wallin) del libro: 

The Matter of White Matter. Clinical and pathophysiological aspects of white matter disease 

related to cognitive decline and vascular dementia. 

Utrecht, The Netherlands: Academic Pharmaceutical Productions, 2000 (438 pagine). 

Referee per riviste scientifiche: 

Lancet; JAMA; Annals of Neurology; Stroke; Neurology; Brain; Hypertension; Lancet 

Neurology; Journal of Cerebral Blood Flow and Metabolism; Nature Reviews Neurology; 

Archives of General Psychiatry; Journal of Neurology; Neurobiology of Aging; Molecular 

Psychiatry; Human Mutation; Bioessays; Journal of Neurology Neurosurgery and 

Psychiatry; American Journal of Geriatric Psychiatry; Pharmacology and Therapeutics; 

Brain Research; Neuroimage; Neuropathology and Applied Neurobiology; Cerebrovascular 

Diseases; Journal of Neuroimaging; Journal of the Neurological Sciences; 

Neuroepidemiology; European Journal of Neurology; BMC Neurology; Expert Review of 

Neurotherapeutics; Pharmacology Biochemistry and Behavior; Experimental Neurology; 

Clinical Drug Investigation; Life Sciences; International Psychogeriatrics; European 

Neurology; Journal of the International Neuropsychological Society; Psychiatric Research: 

Neuroimaging; Journal of Pharmacy and Pharmacology; CNS Drugs; Neuroradiology; 

Tohoku Journal of Experimental Medicine; Acta Neurologica Scandinavica; Neuroscience 

Letters; Clinical Neurology and Neurosurgery; Journal of Drug Assessment; Aging Clinical 

and Experimental Research; Neurology India; Neurological Sciences (formerly, Italian 

Journal of Neurological Sciences). 

Cochrane collaboration (2009)

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Revisore di richieste di finanziamento per progetti di ricerca per Austrian Science Fund 

(1998), Alzheimer’s Association (2001, 2007, 2008), Wellcome Trust (UK) (2004), Research 

Grants Council of Hong Kong (2009), UK Alzheimer’s Society (2009) 

Attività organizzative e direttive di congressi scientifici: 

Membro del Program Committee del First International Congress on Vascular Dementia, 

Ginevra (Svizzera) (3-6 Ottobre 1999). 

Membro del Scientific Advisory Board del Third Congress on Vascular Factors in 

Alzheimer's Disease, Kyoto (Giappone) (7-10 Aprile 2002) 

Membro permanente del Comitato Scientifico della European Stroke Conference 

a partire dalla 14ª edizione (Maggio 2005) 

Membro del Scientific Advisory Committee del 12° Congresso Internazionale della 

International Psychogeriatric Association, Stoccolma, Svezia (20-24 Settembre 2005) 

Co-chairman del Second Congress of the International Society for Vascular Behavioural and 

Cognitive Disorders (Firenze, 8-12 Giugno 2005). 

Membro della Commissione Scientifica 

1°, 2°, 3° Hipponion Stroke National Price (Vibo Valentia, 2006, 2008, 2010) 

Membro del Comitato Scientifico del Third Congress of the International Society for Vascular 

Behavioural and Cognitive Disorders 

San Antonio, Texas, 11-14 July, 2007 

Membro del Comitato di Coordinamento Locale del 

XXXVIII Congresso della Società Italiana di Neurologia 

Firenze, 13-17 Ottobre 2007 

Co-chairman IPA Neuroimaging in Dementia Workshop 

Florence, 11 November 2008 

Membro del Comitato Scientifico del Fourth Congress of the International Society for 

Vascular Behavioural and Cognitive Disorders 

Singapore, 14-16 Gennaio 2009 

Membro del comitato scientifico della conferenza nazionale sull’ictus Stroke a partire dal 

2010 

Letture ad invito: 

49 a livello internazionale 

74 a livello nazionale

Advisory and Editorial boards: 

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Membro dell’expert panel sulla demenza vascolare della USA National Stroke Association 

Membro dell’advisory panel del workshop "Vascular Cognitive Impairment: Harmonization 

Criteria" organizzato dal National Institutes of Neurological Disorders and Stroke a 

Washington, DC, il 24-27 Aprile 2005, e co-promosso da Canadian Stroke Network. 

Membro dell’advisory board SPREAD (Stroke Prevention And Educational Awareness 

Diffusion) sulle linee guida italiane per la prevenzione ed il trattamento dell’ictus cerebrale 

(sezione sulle complicanze psico-cognitive dell’ictus cerebrale e sezione ictus cerebrale 

giovanile) 

Membro del panel per lo sviluppo delle linea guida sull’"Impiego delle tecniche di imaging 

nelle demenze" dell’Istituto Superiore di Sanità. 

Membro dell’Executive Committee dell’International Society for Vascular Behavioural and 

Cognitive Disorders (2009-2013) 

Membro dell’editorial board di Acta Neurologica Scandinavica (dal 2006) 

Membro dell’editorial board dell’International Journal of Alzheimer’s Disease (dal 2009) 

Chairman del Publication Committee della International Psychogeriatric Association 

Editor della sezione Vascular Cognitive Impairment della rivista Stroke (dal Luglio 2010) 

Membro dell’editorial board di Cerebrovascular Diseases (dal 2011) 

AFFILIAZIONE A SOCIETA’ E ORGANIZZAZIONI SCIENTIFICHE 

Società Italiana di Neurologia 

Gruppo di Studio Malattie Cerebrovascolari (Società Italiana di Neurologia) quindi 

denominata Associazione Italiana Ictus-Italian Stroke Association - ISA 

European Task Force on Age-Related White Matter Changes 

Comitato Scientifico dell’Italian Stroke Forum Network e dal 2011 membro del Comitato 

Direttivo (revisore dei conti). 

Membro fondatore della International Society for Vascular Behavioural and Cognitive 

Disorders (VAS-COG). 

Membro del Board of Directors della International Psychogeriatric Association (IPA) (2003- 

2007, rieletto per il quadriennio 2007-2011)

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Membro dell’Executive Committee della International Society for Vascular Behavioural and 

Cognitive Disorders (VAS-COG) (eletto 2009-2013). 

Affiliazioni a società scientifiche (segue) 

Membro del Consiglio Direttivo della Società Italiana di Neurogeriatria 

(2009-2011) 

Fellow European Stroke Organization (dal 2010)

PRINCIPALI PUBBLICAZIONI: 

Articoli pubblicati su riviste internazionali: 

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1. Pantoni L, Inzitari D, Colao MG, De Mayo E, Marini P, Mazzotta F. Cytomegalovirus 

encephalitis in a non-immunocompromised patient: CSF diagnosis by in situ hybridization 

cells. Acta Neurologica Scandinavica 1991;84:56-58. 

2. Pantoni L, Inzitari D, Pracucci G, Lolli F, Giordano GP, Bracco L, Amaducci L. 

Cerebrospinal fluid proteins in patients with leucoaraiosis: possible abnormalities in 

blood-brain barrier function. Journal of the Neurological Sciences 1993;115:125-131. 

3. Pantoni L, Inzitari D. Hachinski's Ischemic Score and the diagnosis of vascular 

dementia: a review. The Italian Journal of Neurological Sciences 1993;14:539-546. 

4. Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years 

after Binswanger's report: a review. Stroke 1995;26:1293-1301. 

5. Garcia JH, Pantoni L. Stroke in childhood. Seminars in Pediatric Neurology 

1995;2:180-191. 

6. Pantoni L, Garcia JH, Brown GG. Vascular pathology in three cases of progressive 

cognitive deterioration. Journal of the Neurological Sciences 1996;135:131-139. 

7. Pantoni L, Garcia JH. Binswanger's disease: what's in a name? Cerebrovascular 

Diseases 1996;6:259-262. 

8. Pantoni L, Garcia JH, Gutierrez JA. Cerebral white matter is highly vulnerable to 

ischemia. Stroke 1996;27:1641-1647. 

9. Pantoni L, Moretti M, Inzitari D. The first Italian report of "Binswanger's disease". The 

Italian Journal of Neurological Sciences 1996;17:367-370. 

10. Pantoni L, Carosi M, Amigoni S, Mascalchi M, Inzitari D. A preliminary open trial with 

nimodipine in patients with cognitive impairment and leukoaraiosis. Clinical 

Neuropharmacology 1996;19:497-506. 

11. Inzitari D, Cadelo M, Marranci ML, Pracucci G, Pantoni L. Vascular deaths in elderly 

neurological patients with leukoaraiosis. Journal of Neurology, Neurosurgery, and 

Psychiatry 1997;62:177-181. 

12. Pantoni L, Poggesi L, Repice A, Inzitari D. Disappearance of motor tics after Wernicke's 

encephalopathy in a patient with Tourette's syndrome. Neurology 1997;48:381-383.

Articoli pubblicati su riviste internazionali (segue): 

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13. Pantoni L, Garcia JH. Pathogenesis of leukoaraiosis: a review. Stroke 1997;28:652-659. 

14. Inzitari D, Pantoni L, Lamassa M, Pallanti S, Pracucci G, Marini P. Emotional arousal 

and phobia in transient global amnesia. Archives of Neurology 1997;54:866-873. 

15. Pantoni L, Garcia JH. Cognitive impairment and cellular/vascular changes in cerebral 

white matter. Annals of New York Academy of Sciences 1997;826:92-102. 

16. Scheltens P, Erkinjuntti T, Leys D, Wahlund L-O, Inzitari D, del Ser T, Pasquier F, 

Barkhof F, Mäntylä R, Bowler J, Wallin A, Ghika J, Fazekas F, Pantoni L. White matter 

changes on CT and MRI: an overview of visual rating scales. European Neurology 

1998;39:80-89. 

17. Pantoni L, Sarti C, Inzitari D. Cytokines and cell adhesion molecules in cerebral 

ischemia: experimental bases and therapeutic perspectives. Arteriosclerosis, Thrombosis 

and Vascular Biology 1998;18:503-513. 

18. Inzitari D, Pantoni L. Subcortical vascular dementia: therapeutical aspects. Archives of 

Gerontology and Geriatrics 1998;suppl 6:263-268. 

19. Pantoni L. Experimental approaches to white matter disease. Dementia and Geriatric 

Cognitive Disorders 1998;9(suppl.1):20-24. 

20. Erkinjuntti T, Pantoni L, Scheltens P. Cooperation and networking on white matter 

disorders: the European Task Force on Age-Related White Matter Changes. Dementia 

and Geriatric Cognitive Disorders 1998;9(suppl.1):44-45. 

21. Inzitari D, Pantoni L. Cognitive impairment and cerebrovascular diseases. European 

Journal of Neurology 1998;5(suppl 5):S9-S13. 

22. Leys D, Englund E, del Ser T, Inzitari D, Fazekas F, Bornstein N, Erkinjuntti T, Bowler J, 

Pantoni L, Parnetti L, de Reuck J, Ferro J, Bogousslavsky J, on behalf of the European 

Task Force on Age-Related White Matter Changes. White matter changes in stroke 

patients. Relationship with stroke subtypes and outcome. European Neurology 

1999;42:67-75. 

23. Melani A, Pantoni L, Corsi C, Bianchi L, Monopoli A, Bertorelli R, Pepeu G, Pedata F. 

Striatal outflow of adenosine, excitatory amino acids, �-aminobutyric acid, and taurine in 

awake freely moving rats following middle cerebral artery occlusion. Correlations with 

neurological deficit and histopathological damage. Stroke 1999;30:2448-2455. 

24. Pantoni L, Leys D, Fazekas F, Longstreth WT Jr., Inzitari D, Wallin A, Filippi M, 

Scheltens P, Erkinjuntti T, Hachinski V. The role of white matter lesions in cognitive 

impairment of vascular origin. Alzheimer Disease and Associated Disorders 

1999;13(suppl.3):S49-S54.


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25. Inzitari D, Erkinjuntti T, Wallin A, del Ser T, Pantoni L. Is subcortical vascular dementia 

a clinical entity for clinical drug trials? Alzheimer Disease and Associated Disorders 

1999;13(suppl.3):S66-S68. 

26. Rossi R, Inzitari D, Pantoni L, del Ser T, Erkinjuntti T, Wallin A, Bianchi C, Badenas 

JM, Beneke M. Nimodipine in subcortical vascular dementia trial. Alzheimer Disease 

and Associated Disorders 1999;13(suppl.3):S159-S165. 

27. Erkinjuntti T, Bowler JV, DeCarli CS, Fazekas F, Inzitari D, O'Brien JT, Pantoni L, 

Rockwood K, Scheltens P, Wahlund L-O, Desmond DW. Imaging of static brain lesions 

in vascular dementia: implications for clinical trials. Alzheimer Disease and Associated 

Disorders 1999;13(suppl.3):S81-S90. 

28. Pantoni L, Bianchi C, Beneke M, Inzitari D, Wallin A, Erkinjuntti T. The Scandinavian 

Multi-Infarct Dementia Trial: a double-blind, placebo-controlled trial on nimodipine in 

multi-infarct dementia. Journal of the Neurological Sciences 2000;175:116-123. 

29. Pantoni L, Rossi R, Inzitari D, Bianchi C, Beneke M, Erkinjuntti T, Wallin A. Efficacy 

and safety of nimodipine in subcortical vascular dementia: a subgroup analysis of the 

Scandinavian Multi-Infarct Dementia Trial. Journal of the Neurological Sciences 

2000;175:124-134. 

30. Inzitari D, Erkinjuntti T, Wallin A, del Ser T, Romanelli M, Pantoni L. Subcortical 

vascular dementia as a specific target for clinical trials. Annals of the New York Academy 

of Sciences 2000;903:510-521. 

31. Erkinjuntti T, Inzitari D, Pantoni L, Wallin A, Scheltens P, Rockwood K, Desmond DW. 

Limitations of clinical criteria for the diagnosis of vascular dementia in clinical trials: is 

subcortical vascular dementia a solution? Annals of the New York Academy of Sciences 

2000;903:262-272. 

32. Erkinjuntti T, Inzitari D, Pantoni L, Wallin A, Scheltens P, Rockwood K, Roman GC, 

Chui H, Desmond DW. Research criteria for subcortical vascular dementia in clinical 

trials. Journal of Neural Transmission Supplement 2000;59:23-30. 

33. Inzitari D, Carlucci G, Pantoni L. White matter changes: the clinical consequences in the 

aging population. Journal of Neural Transmission Supplement 2000;59:1-8. 

34. Pantoni L, Lamassa M, Inzitari D. Transient global amnesia: a review emphasizing 

pathogenic aspects. Acta Neurologica Scandinavica 2000;102:275-283. 

35. Pantoni L, Sarti C, Pracucci G, Di Carlo A, Vanni P, Inzitari D, for the Italian 

Longitudinal Study on Aging. Lipoprotein(a) serum levels and vascular diseases in an 

older Caucasian population cohort. Journal of the American Geriatrics Society 

2001;49:117-125.


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36. Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjögren M, Wallin A, Ader 

H, Leys D, Pantoni L, Pasquier F, Erkinjuntti T, Scheltens P. A new rating scale for agerelated 

white matter changes applicable to MRI and CT. Stroke 2001;32:1318-1322. 

37. Sarti S, Pantoni L, Pracucci G, Di Carlo A, Vanni P, Inzitari D, for the Italian 

Longitudinal Study on Aging. Lipoprotein(a) and cognitive performances in an elderly 

white population: cross-sectional and follow-up data. Stroke 2001;32:1678-1683. 

38. Di Carlo A, Perna AM, Pantoni L, Basile AM, Bonacchi M, Pracucci G, Trefoloni G, 

Bracco L, Sangiovanni V, Piccini C, Palmarini MF, Carbonetto F, Biondi E, Sani G, 

Inzitari D. Clinically relevant cognitive impairment after cardiac surgery: a 6-month 

follow-up study. Journal of the Neurological Sciences 2001;188:85-93. 

39. Pantoni L, Basile AM, Romanelli M, Piccini C, Sarti C, Nencini P, Inzitari D. Abulia 

and cognitive impairment in two patients with capsular genu infarct. Acta Neurologica 

Scandinavia 2001;104:185-190. 

40. Fazekas F, Barkhof F, Wahlund LO, Pantoni L, Erkinjuntti T, Scheltens P, Schmidt R. 

CT and MRI rating of white matter lesions. Cerebrovascalur Diseases 2002;13 (Suppl. 

2):31-36. 

41. Pantoni L. Pathophysiology of age-related cerebral white matter changes. 

Cerebrovascular Diseases 2002;13 (Suppl. 2):7-10. 

42. Sarti C, Pantoni L, Bartolini L, Inzitari D. Persistent impairment of gait performances 

and working memory after bilateral common carotid artery occlusion in the adult Wistar 

rat. Behavioural Brain Research 2002;136:13-20. 

43. Mascalchi M, Moretti M, Della Nave R, Lolli F, Tessa C, Carlucci G, Bartolini L, 

Pracucci G, Pantoni L, Filippi M, Inzitari D. Longitudinal evaluation of leukoaraiosis 

with whole brain ADC histograms. Neurology 2002;59:939-940. 

44. Román GC, Erkinjuntti T, Wallin A, Pantoni L, Chui HC. Subcortical ischaemic vascular 

dementia. Lancet Neurology 2002;1:426-436. 

45. Pantoni L, Simoni M, Pracucci G, Schmidt R, Barkhof F, Inzitari D. Visual rating scales 

for age-related white matter changes (leukoaraiosis): can the heterogeneity be reduced? 

Stroke 2002;33:2827-2833. 

46. Pantoni L, Palumbo V, Sarti C. Pathological lesions in vascular dementia. Annals of the 

New York Academy of Sciences 2002;977:279-291.


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47. Melani A, Pantoni L, Bordoni F, Gianfriddo M, Bianchi L, Vannucchi MG, Bertorelli R, 

Monopoli A, Pedata F. The selective A2A receptor antagonist SCH 58261 reduces striatal 

transmitter outflow, turning behavior and ischemic brain damage induced by permanent 

focal ischemia in the rat. Brain Research 2003;959:243-250. 

48. O’Brien JT, Erkinjuntti T, Reisberg B, Roman R, Sawada T, Pantoni L, Bowler JV, 

Ballard C, DeCarli C, Gorelick PB, Rockwood K, Burns A, Gauthier S, DeKosky ST. 

Vascular cognitive impairment. Lancet Neurology 2003;2:89-98. 

49. Pantoni L. Not-so-silent infarcts. Lancet Neurology 2003;2:335. 

50. Wallin A, Milos V, Sjögren M, Pantoni L, Erkinjuntti T. Classification and subtypes of 

vascular dementia. International Psychogeriatrics 2003;15(suppl.1):27-37. 

51. Pantoni L, Simoni M. Pathophysiology of cerebral small vessels in vascular cognitive 

impairment. International Psychogeriatrics 2003;15(suppl.1):59-65. 

52. Schmidt R, Scheltens P, Erkinjuntti T, Pantoni L, Markus HS, Wallin A, Barkhof F, 

Fazekas F, for the European Task Force on Age-Related White Matter Changes. White 

matter lesion progression. A surrogate endpoint for trials in cerebral small vessel disease. 

Neurology 2004;63:139-144. 

53. Inzitari D, Lamassa M, Pantoni L, Basile AM. Therapy of vascular dementias. Archives 

of Gerontology and Geriatriacs 2004;38(Suppl):229-234. 

54. Pantoni L, Sarti C, Pescini F, Bianchi S, Bartolini L, Nencini P, Basile AM, Lamassa M, 

Kalaria RN, Dotti MT, Federico A, Inzitari D. Thrombophilic risk factors and unusual 

clinical features in three Italian CADASIL patients. European Journal of Neurology 

2004;11:782-787. 

55. Pantoni L. Treatment of vascular dementia: evidence from trials with non-cholinergic 

drugs. Journal of the Neurological Sciences 2004;226:67-70. 

56. Pantoni L, Basile AM, Pracucci G, Asplund K, Bogousslavsky J, Chabriat H, Erkinjuntti 

T, Fazekas F, Ferro JM, Hennerici M, O'Brien J, Scheltens P, Visser MC, Wahlund L-O, 

Waldemar G, Wallin A, Inzitari D, on behalf of the LADIS Study Group. Impact of agerelated 

cerebral white matter changes on the transition to disability. The LADIS 

(Leukoaraiosis And DISability in the elderly) Study: rationale, design and methodology. 

Neuroepidemiology 2005;24:51-62. 

57. Pantoni L, Bertini E, Lamassa M, Pracucci G, Inzitari D. Clinical features, risk factors, and 

prognosis in transient global amnesia: a follow-up study. European Journal of Neurology 

2005;12:350-356.


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58. Dotti MT, Federico A, Mazzei R, Bianchi S, Scali O, Conforti FL, Sprovieri T, Guidetti 

D, Aguglia U, Consoli D, Pantoni L, Sarti C, Inzitari D, Quattrone A. The spectrum of 

NOTCH3 mutations in 28 Italian CADASIL families. Journal of Neurology, 

Neurosurgery and Psychiatry 2005;76:736-738. 

59. Pantoni L, Del Ser T, Soglian AG, Amigoni S, Spadari G, Binelli D, Inzitari D. Efficacy 

and safety of nimodipine in subcortical vascular dementia: a randomized placebocontrolled 

trial. Stroke 2005;36:619-624. 

60. van der Flier WM, van Straaten ECW, Barkhof F, Ferro JM, Pantoni L, Basile AM, 

Inzitari D, Erkinjuntti T, Wahlund LO, Rostrup E, Schmidt R, Fazekas F, Scheltens P, on 

behalf of the LADIS study group. Medial temporal lobe atrophy and white matter 

hyperintensities are associated with mild cognitive deficits in non-disabled elderly: the 

LADIS study. Journal of Neurology, Neurosurgery and Psychiatry 2005;76:1497-1500. 

61. Firback MJ, O’Brien JT, Pakrasi S, Pantoni L, Simoni M, Erkinjuntti T, Wallin A, 

Wahlund L-O, van Strateen I, Inzitari D, on behalf of the LADIS group. White matter 

hyperinyensities and depression. Preliminary results from the LADIS study. International 

Journal of Geriatric Psychiatry 2005;20:674-679. 

62. van der Flier WM, van Straaten ECW, Barkhof F, Verdello A, Madureira S, Pantoni L, 

Inzitari D, Erkinjuntti T, Crisby M, Waldemar G, Schmidt R, Fazekas F, Scheltens P, on 

behalf of the LADIS study group. Small vessel disease and general cognitive function in 

non-disabled elderly: the LADIS study. Stroke 2005;36:2116-2120. 

63. Pescini F, Sarti C, Pantoni L, Mangiafico S, Bianchi S, Dotti MT, Federico A, Inzitari 

D.Cerebellar arteriovenous malformation and vertebral artery aneurysm in a CADASIL 

patient. Acta Neurologica Scandinavica 2006;113:62-63. 

64. Basile AM, Pantoni L, Pracucci G, Asplund K, Chabriat H, Erkinjuntti T, Fazekas F, 

Ferro JM, Hennerici M, O'Brien J, Scheltens P, Visser MC, Wahlund L-O, Waldemar G, 

Wallin A, Inzitari D, on behalf of the LADIS Study Group. Age, hypertension, and 

lacunar stroke are the major determinants of the severity of age-related white matter 

changes. The LADIS (Leukoaraiosis And DISability in the elderly) Study. 

Cerebrovascular Diseases 2006;21:315-322. 

65. van Straaten ECW, Fazekas F, Rostrup E, Scheltens P, Schmidt R, Pantoni L, Inzitari D, 

Waldemar G, Erkinjuntti T, Mantyla R, Wahlund L-O, Barkhof F, on behalf of the LADIS 

study group. Impact of white matter hyperintensities scoring method on correlations with 

clinical data: the LADIS study. Stroke 2006;37:836-840.. 

66. Pantoni L, Sarti C, Alafuzoff I, Jellinger K, Munoz DG, Ogata J, Palumbo V. 

Postmortem examination of vascular lesions in cognitive impairment. A survey among 

neuropathological services. Stroke 2006;37:1005-1009.


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67. Pantoni L. New evidence in the field of white matter changes [Article in Japanese]. No 

To Shinkei 2006;58:298-302. 

68. Prati P, Casaroli M, Bignamini A, Scotti S, Canciani L, Ruscio M, Balestrieri M, 

Bornstein N, Zanetti O, Tosetto A, Castellani S, Pantoni L, Touboul PJ, Inzitari D. 

Cognitive Impairment and Carotid Atherosclerosis in a General Italian Midlife and Old 

Population. Neuroepidemiology 2006;27:33-38. 

69. Pantoni L, Poggesi A, Basile AM, Pracucci G, Barkhof F, Chabriat H, Erkinjuntti T, 

Ferro JM, Hennerici M, O'Brien JT, Schmidt R, Visser MC, Wahlund L-O, Waldemar G, 

Wallin A, Inzitari D on behalf of the LADIS Study Group. Leukoaraiosis predicts hidden 

global functioning impairment in nondisabled elderly. The LADIS (Leukoaraiosis and 

Disability in the Elderly) Study. Journal of the American Geriatrics Society 

2006;54:1095-1101. 

70. Guo X, Pantoni L, Simoni M, Gustafson D, Bengtsson C, Palmertz B, Skoog I. Midlife 

respiratory function related to white matter lesions and lacunar infarcts in late life: The 

Prospective Population Study of Women in Gothenburg, Sweden. Stroke 2006;37:1658- 

1662. 

71. Pantoni L. White matter ischemia: time to begin integrating experimental and clinical 

data. European Neurology 2006;56:71-73. 

72. Madureira S, Verdelho A, Ferro J, Basile AM, Chabriat H, Erkinjuntti T, Fazekas F, 

Hennerici M, O’Brien J, Pantoni L, Salvadori E, Scheltens P, Visser MC, Wahlund L-O, 

Waldemar G, Wallin A, Inzitari D on behalf of the LADIS Study. Development of a 

neuropsychological battery for a multinational study: the LADIS (Leukoaraiosis And 

DISability): experience and baseline data. Neuroepidemiology 2006;27:101-116. 

73. Krishnan MS, O’Brien JT, Firbank MJ, Pantoni L, Carlucci G, Erkinjuntti T, Wallin A, 

Wahlund L-O, Scheltens P, van Straaten ECW, Inzitari D,on behalf of the LADIS group. 

Relationship between periventricular and deep white matter lesions and depressive 

symptoms in older people. The LADIS Study. International Journal of Geriatric 

Psychiatry 2006;21:983-989. 

74. O’Brien JT, Firbank MJ, Krishnan MS, van Straaten ECW, van de Flier W, Petrovic K, 

Pantoni L, Simoni M, Erkinjuntti T, Wallin A, Wahlund L-O, Inzitari D on behalf of the 

LADIS group.White matter hyperintensities rather than lacunar infacts are associated with 

depressive symptoms in older people. The LADIS study. American Journal of Geriatric 

Psychiatry 2006;14:834-841. 

75. Gouw AA, van der Flier WM, van Straaten ECW, Barkhof F, Ferro JM, Baezner H. 

Pantoni L, Inzitari D, Erkinjuntti T, Wahlund L-O, Waldemar G, Schmidt R, Fazekas F, 

Scheltens P on behalf of the LADIS study group. Simple versus complex assessment of 

white matter hyperintensities in relation to gait and cognition in non-disabled elderly, 

experience within the LADIS study. Journal of Neurology 2006; 253:1189-1196.


14 


76. Ryberg C, Rostrup E, Stegmann MB, Barkhof F, Scheltens P, van Straaten ECW, 

Fazekas F, Schmidt R, Ferro JM, Baezner H, Erkinjuntti T, Jokinen H, Wahlund L-O, 

O’Brien J, Basile AM, Pantoni L, Inzitari D, Waldemar G, on behalf of the LADIS 

study group. Clinical significance of corpus callosum atrophy in a mixed elderly 

population. Neurobiology of Aging 2007;28:955-963.. 

77. Jokinen H, Ryberg C, Kalska H, Ylikoski R, Rostrup E, Stegmann MB, Waldemar G, 

Madureira S, Ferro JM, van Straaten EC, Scheltens P, Barkhof F, Fazekas F, Schmidt R, 

Carlucci G, Pantoni L, Inzitari D, Erkinjuntti T. Corpus callosum atrophy is associated 

with mental slowing and executive deficits in subjects with age-related white matter 

hyperintensities. The LADIS study. Journal of Neurology, Neurosurgery and Psychiatry 

2007;78:491-496. 

78. Inzitari D, Simoni M, Pracucci G, Poggesi A, Basile AM, Chabriat H, Erkinjuntti T, 

Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien J, Barkhof F, Visser MC, 

Wahlund LO, Waldemar G, Wallin A, Pantoni L; LADIS Study Group. Risk of rapid 

global functional decline in elderly patients with severe cerebral age-related white matter 

changes: the LADIS study. Archives of Internal Medicine 2007;167:81-88. 

79. Korf ES, van Straaten EC, de Leeuw FE, van der Flier WM, Barkhof F, Pantoni L, 

Basile AM, Inzitari D, Erkinjuntti T, Wahlund LO, Rostrup E, Schmidt R, Fazekas F, 

Scheltens P; LADIS Study Group. Diabetes mellitus, hypertension and medial temporal 

lobe atrophy: the LADIS study. Diabetic Medicine 2007;24:166-171. 

80. Ylikoski R, Jokinen H, Andersen P, Salonen O, Madureira S, Ferro J, Barkhof F, van der 

Flier W, Schmidt R, Fazekas F, Scheltens P, Waldemar G, Salvadori E, Pantoni L, 

Inzitari D, Erkinjuntti T. Comparison of the Alzheimer's Disease Assessment Scale 

Cognitive Subscale and the Vascular Dementia Assessment Scale in Differentiating 

Elderly Individuals with Different Degrees of White Matter Changes. The LADIS Study. 

Dementia and Geriatric Cognitive Disorders 2007;24:73-81. 

81. Pantoni L, Poggesi A, Inzitari D. The relation between white matter lesions and 

cognition. Current Opinion in Neurology 2007;20:390-397. 

82. Pescini F, Bianchi S, Dotti MT, Federico A, Inzitari D, Pantoni L. First report of a 

Romanian CADASIL patient following immigration to Italy. European Journal of 

Neurology, 2007;14:e7-8. 

83. Teodorczuk A, O'brien JT, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T, Wallin A, 

Wahlund LO, Gouw A, Waldemar G, Schmidt R, Ferro JM, Chabriat H, Bazner H, 

Inzitari D; the LADIS Group. White matter changes and late-life depressive symptoms: 

longitudinal study. British Journal of Psychiatry 2007;191:212-217.


15 


84. Verdelho A, Madureira S, Ferro JM, Basile AM, Chabriat HC, Erkinjuntti T, Fazekas F, 

Hennerici MM, O'brien J, Pantoni L, Salvadori E, Scheltens P, Visser MC, Wahlund 

LO, Gunhild Waldemar G, Wallin A, Inzitari D. Differential impact of cerebral white 

matter changes, diabetes, hypertension and stroke on cognitive performance among non 

disabled elderly. The LADIS study. Journal of Neurology Neurosurgery and Psychiatry 

2007;78:1325-1330. 

85. Frisoni GB, Galluzzi S, Pantoni L, Filippi M. The effect on cognition of white matter 

lesions in the elderly: small but detectable. Nature Clinical Practice Neurology 

2007;3:620-627. 

86. Sjöstrand K, Rostrup E, Ryberg C, Larsen R, Studholme C, Baezner H, Ferro J, Fazekas 

F, Pantoni L, Inzitari D, Waldemar G; LADIS Study Group. Sparse decomposition and 

modeling of anatomical shape variation. IEEE Transaction Medical Imaging 

2007;26:1625-1635. 

87. Gouw AA, van der Flier WM, van Straaten EC, Pantoni L, Bastos-Leite AJ, Inzitari D, 

Erkinjuntti T, Wahlund LO, Ryberg C, Schmidt R, Fazekas F, Scheltens P, Barkhof F. 

Reliability and sensitivity of visual scales versus volumetry for evaluating white matter 

hyperintensity progression. Cerebrovascular Diseases 2008;25:247-253. 

88. Pescini F, Bianchi S, Salvadori E, Poggesi A, Dotti MT, Federico A, Inzitari D, Pantoni 

L. A pathogenic mutation on exon 21 of the NOTCH3 gene causing CADASIL in an 

octogenarian paucisymptomatic patient. Journal of the Neurological Sciences 

2008;267:170-173. 

89. Baezner H, Blahak C, Poggesi A, Pantoni L, Inzitari D, Chabriat H, Erkinjuntti T, 

Fazekas F, Ferro JM, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund L-O, 

Waldemar G, Wallin A, Hennerici MG, on behalf of the LADIS Study Group. 

Association of gait and balance disorders with age-related white matter changes -the 

LADIS study. Neurology 2008;70:935-942. 

90. Pantoni L. Leukoaraiosis: from an ancient term to an actual marker of poor 

prognosis (invited editorial). Stroke 2008;39:1401-1403. 

91. Guo X, Skoog I, Idrizbegovic E, Pantoni L, Simoni M, Rosenhall U. Hearing loss and 

cortical atrophy in a population-based study on non-demented women. Age Ageing 

2008;37:333-336. 

92. Dyrby TB, Rostrup E, Baaré WF, van Straaten EC, Barkhof F, Vrenken H, Ropele S, 

Schmidt R, Erkinjuntti T, Wahlund LO, Pantoni L, Inzitari D, Paulson OB, Hansen LK, 

Waldemar G; on behalf of the LADIS study group. Segmentation of age-related white 

matter changes in a clinical multi-center study. Neuroimage 2008;41:335-345.


16 


93. Gouw AA, van der Flier WM, Fazekas F, van Straaten EC, Pantoni L, Poggesi A, 

Inzitari D, Erkinjuntti T, Wahlund LO, Waldemar G, Schmidt R, Scheltens P, Barkhof F; 

on behalf of the LADIS Study Group. Progression of white matter hyperintensities and 

incidence of new lacunes over a 3-year period. The Leukoaraiosis and Disability Study. 

Stroke 2008;39:1414-1420. 

94. Miranda B, Madureira S, Verdelho A, Ferro JM, Pantoni L, Salvadori E, Chabriat H, 

Erkinjuntti T, Fazekas F, Hennerici M, O'Brien J, Scheltens P, Visser MC, Wahlund LO, 

Waldemar G, Wallin A, Inzitari D. Self-perceived memory impairment and cognitive 

performance in an elderly independent population with age-related white matter changes. 

Journal of Neurology Neurosurgery and Psychiatry 2008;79:869-873. 

95. Poggesi A, Pracucci G, Chabriat H, Erkinjuntti T, Fazekas F, Verdelho A, Hennerici M, 

Langhorne P, O'Brien J, Scheltens P, Visser MC, Crisby M, Waldemar G, Wallin A, 

Inzitari D, Pantoni L, on behalf of the LADIS Study Group. Urinary complaints in Non- 

Disabled Elders With Age-Related White Matter Changes: the LADIS Study. Journal of 

the American Geriatrics Society 2008;56:1638-1643. 

96. Galluzzi S, Lanni C, Pantoni L, Filippi M, Frisoni GB. White matter lesions in the 

elderly: pathophysiological hypothesis on the effect on brain plasticity and reserve. 

Journal of the Neurological Sciences 2008;273:3-9. 

97. Valenti R, Poggesi A, Pescini F, Inzitari D, Pantoni L. Psychiatric disturbances in 

CADASIL: a brief review. Acta Neurologica Scandinavica 2008;118:291-295. 

98. Simoni M, Pantoni L, Pracucci G, Palmertz B, Guo X, Gustafson D, Skoog I. 

Prevalence of CT-detected cerebral abnormalities in an elderly Swedish population 

sample. Acta Neurologica Scandinavica 2008;118:260-267. 

99. Ryberg C, Rostrup E, Sjöstrand K, Paulson OB, Barkhof F, Scheltens P, van Straaten 

ECW, Fazekas F, Schmidt R, Erkinjuntti T, Wahlund L-O, Basile AM, Pantoni L, 

Inzitari D, Waldemar G, on behalf of the LADIS study group. White matter changes 

contribute to corpus callosum atrophy in the elderly: The LADIS study. AJNR American 

Journal of Neuroradiology 2008; 29:1498-1504. 

100. Gouw AA, van der Flier WM, Pantoni L, Inzitari D, Erkinjuntti T, Wahlund LO, 

Waldemar G, Schmidt R, Fazekas F, Scheltens P, Barkhof F, on behalf of the LADIS 

study group. On the etiology of incident brain lacunes: longitudinal observations 

from the LADIS study. Stroke 2008;39:3083-3085. 

101. Stromillo ML, Dotti MT, Battaglini M, Mortilla M, Bianchi S, Plewnia K, Pantoni L, 

Inzitari D, Federico A, De Stefano N. Structural and Metabolic Brain Abnormalities in 

Preclinical CADASIL. Journal of Neurology Neurosurgery and Psychiatry 2009;80:41- 

47.


17 


102. Jokinen H, Kalska H, Ylikoski R, Madureira S, Verdelho A, Gouw A, Scheltens P, 

Barkhof F, Visser MC, Fazekas F, Schmidt R, O'Brien J, Hennerici M, Baezner H, 

Waldemar G, Wallin A, Chabriat H, Pantoni L, Inzitari D, Erkinjuntti T. MRI-Defined 

Subcortical Ischemic Vascular Disease: Baseline Clinical and Neuropsychological 

Findings. The LADIS Study. Cerebrovascular Diseases 2009;27:336-344. 

103. Ropele S, Seewann A, Gouw AA, van der Flier WM, Schmidt R, Pantoni L, Inzitari D, 

Erkinjuntti T, Scheltens P, Wahlund LO, Waldemar G, Chabriat H, Ferro J, Hennerici M, 

O'Brien J, Wallin A, Langhorne P, Visser MC, Barkhof F, Fazekas F; LADIS study 

group. Quantitation of brain tissue changes associated with white matter hyperintensities 

by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis 

and Disability in the Elderly) study. Journal of Magnetic Resonance Imaging 

2009;29:268-274. 

104. Zipoli V, Hakiki B, Portaccio E, Lolli F, Siracusa G, Giannini M, Pantoni L, Pescini F, 

Sorbi S, Amato M. The contribution of cerebrospinal fluid oligoclonal bands to the early 

diagnosis of multiple sclerosis. Multiple Sclerosis 2009;15:472-478. 

105. Nannucci S, Pescini F¸ Poggesi A, Ciolli L, Patrosso MC, Marocchi A, Inzitari D, Penco 

S, Pantoni L. Familial cerebral cavernous malformation: report of a further Italian 

family. Neurological Sciences 2009;30:143-147. 

106. Jokinen H, Kalska H, Ylikoski R, Madureira S, Verdelho A, van der Flier WM, Scheltens 

P, Barkhof F, Visser MC, Fazekas F, Schmidt R, O'Brien J, Waldemar G, Wallin A, 

Chabriat H, Pantoni L, Inzitari D, Erkinjuntti T; LADIS group. Longitudinal cognitive 

decline in subcortical ischemic vascular disease--the LADIS Study. Cerebrovascular 

Diseases 2009;27:384-391. 

107. Pantoni L, Poggesi A, Inzitari D. Cognitive decline and dementia related to 

cerebrovascular diseases: some evidence and concepts. Cerebrovascular Diseases 

2009;27(Suppl. 1):191-196. 

108. Benisty S, Gouw AA, Porcher R, Madureira S, Hernandez K, Poggesi A, van der Flier 

WM, Van Straaten EC, Verdelho A, Ferro J, Pantoni L, Inzitari D, Barkhof F, Fazekas 

F, Chabriat H. Location of lacunar infarcts correlates with cognition in a sample of non 

disabled subjects with age-related white matter changes: the LADIS study. Journal of 

Neurology Neurosurgery and Psychiatry 2009;80:478-483. 

109. Blahak C, Baezner H, Pantoni L, Poggesi A, Chabriat H, Erkinjuntti T, Fazekas F, Ferro 

JM, Langhorne P, O'Brien J, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari 

D, Hennerici MG. Deep frontal and periventricular age-related white matter changes but 

not basal ganglia and infratentorial hyperintensities are associated with falls - crosssectional 

results from the LADIS study. Journal of Neurology Neurosurgery and 

Psychiatry 2009;80:608-613.


18 


110. Inzitari D, Pracucci G, Poggesi A, Carlucci G, Barkhof F, Chabriat H, Erkinjuntti T, 

Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien J, Scheltens P, Visser MC, 

Wahlund LO, Waldemar G, Wallin A, Pantoni L for the LADIS Study Group. Changes 

in white matter as determinant of global functional decline in older independent 

outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort. 

BMJ 2009 Jul 6;339:b2477. doi: 10.1136/bmj.b2477 

111. Guo X, Pantoni L, Simoni M, Bengtsson C, Björkelund C, Lissner L, Gustafson D, 

Skoog I. Blood Pressure Components and Changes in Relation to White Matter Lesions: 

A 32-year Prospective Population Study of Women. Hypertension 2009;54.57-62. 

112. Saia V, Pantoni L. Progressive stroke in pontine infarction. Acta Neurologica 

Scandinavica 2009;120:213-215. 

113. Pantoni L. Should memory clinic physicians be independent in assessing neuroimaging 

of patients with cognitive impairment? Aging Clinical and Experimental Research 

2009;21:264-265. 

114. Pantoni L, Pescini F, Nannucci S, Sarti C, Bianchi S, Dotti MT, Federico A, Inzitari D. 

Comparison of clinical, familial, and MRI features of CADASIL and NOTCH3 negative 

patients. Neurology 2010;74:57-63. 

115. Pescini F, Cesari F, Giusti B, Sarti C, Zicari E, Bianchi S, Dotti MT, Federico A, 

Balestrino M, Enrico A, Gandolfo C, Gori AM, Abbate R, Pantoni L, Inzitari D. Bone 

Marrow-Derived Progenitor Cells in Cerebral Autosomal Dominant Arteriopathy With 

Subcortical Infarcts and Leukoencephalopathy. Stroke 2010;41:218-223. 

116. Teodorczuk A, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T, Wallin A, Wahlund 

LO, Scheltens P, Waldemar G, Schrotter G, Ferro JM, Chabriat H, Bazner H, Visser M, 

Inzitari D, O'Brien JT. Relationship between baseline white-matter changes and 

development of late-life depressive symptoms: 3-year results from the LADIS study. 

Psychological Medicine 2010;40:603-610. 

117. Madureira S, Verdelho A, Moleiro C, Ferro JM, Erkinjuntti T, Jokinen H, Pantoni L, 

Fazekas F, Van der Flier W, Visser M, Waldemar G, Wallin A, Hennerici M, Inzitari D. 

Neuropsychological Predictors of Dementia in a Three-Year Follow-Up Period: Data 

from the LADIS Study. Dementia and Geriatric Cognitive Disorders 2010;29:325-334. 

[IF 3,142] 

118. Bianchi S, Rufa A, Ragno M, D'Eramo C, Pescini F, Pantoni L, Cappelli A, Perretti A, 

Zicari E, Zolo P, Inzitari D, Dotti MT, Federico A. High frequency of exon 10 mutations 

in the NOTCH3 gene in Italian CADASIL families: phenotypic peculiarities. Journal of 

Neurology 2010;257:1039-1042. [IF 2,536]


19 


119. Schmidt R, Ropele S, Ferro J, Madureira S, Verdelho A, Petrovic K, Gouw A, van der 

Flier WM, Enzinger C, Pantoni L, Inzitari D, Erkinjuntti T, Scheltens P, Wahlund LO, 

Waldemar G, Rostrup E, Wallin A, Barkhof F, Fazekas F; on behalf of the LADIS study 

group. Diffusion-Weighted Imaging and Cognition in the Leukoariosis and Disability in 

the Elderly Study. Stroke 2010;41:e402-408. [IF 6,499] 

120. Jonsson M, Zetterberg H, van Straaten E, Lind K, Syversen S, Edman Å, Blennow K, 

Rosengren L, Pantoni L, Inzitari D, Wallin A. Cerebrospinal fluid biomarkers of white 

matter lesions – cross-sectional results from the LADIS study. European Journal of 

Neurology 2010;17:377-382. [IF 2,732] 

121. Verdelho A, Madureira S, Moleiro C, Ferro JM, Santos CO, Erkinjuntti T, Pantoni L, 

Fazekas F, Visser M, Waldemar G, Wallin A, Hennerici M, Inzitari D. White matter 

changes and diabetes predict cognitive decline in the elderly: the LADIS study. 

Neurology 2010;75:160-167. [IF 7,043] 

122. Pantoni L. Cerebral small vessel diseases: a reappraisal of nosology, pathogenesis, 

neuroimaging, clinical correlates, and therapeutic issues [invited review]. Lancet 

Neurology 2010; 9:689-701. [IF 14,270] 

123. Olesen PJ, Gustafson DR, Simoni M, Pantoni L, Ostling S, Guo X, Skoog I. Temporal 

lobe atrophy and white matter lesions are related to major depression over 5 years in the 

elderly. Neuropsychopharmacology 2010; 35:2638-2645. 

124. Pantoni L, Gorelick P. Advances in vascular cognitive impairment 2010. Stroke 

2011;42:291-293. 

125. Valenti R, Pescini F, Antonini S, Castellini G, Poggesi A, Bianchi S, Inzitari D, Pallanti 

S, Pantoni L. Major depression and bipolar disorders in CADASIL: a study using the 

DSM-IV semi-structured interview. Acta Neurologica Scandinavica, in press. 

126. Valenti R, Bianchi S, Pescini F, D’Eramo C, Inzitari D, Dotti MT, Pantoni L. First 

report of a pathogenic mutation on exon 24 of the NOTCH3 gene in a CADASIL family. 

Journal of Neurology, in press. 

127. Jokinen H, Gouw AA, Madureira S, Ylikoski R, van Straaten ECW, van der Flier WM, 

Barkhof F, Scheltens P, Fazekas F, Schmidt R, Verdelho A, Ferro JM, Pantoni L, 

Inzitari D, Erkinjuntti T. Incident lacunes influence cognitive decline: the LADIS study. 

Neurology, in press.

Libri scritti: 

Pantoni L. Ipertensione e deterioramento cognitivo vascolare 

Editrice G&G srl, Roma, 2006 (75 pagine). 

20 

Pantoni - Curriculum vitae

Capitoli di libri: 

21 


1. Inzitari D, Marinoni M, Ginanneschi A, Mascalchi M, Pracucci G, Ancona AL, Piccininni 

MS, Di Carlo AS, Pantoni L. Pathophysiology of leucoaraiosis. In: Culebras A, Matías 

Guiu J, Román G (Eds). New Concepts in Vascular Dementia. Barcelona, Prous Science 

Publishers, 1993:103-113. 

2. Pantoni L, Garcia JH. Cerebral ischemia and cognitive impairment in the elderly. In : 

Bruno A, Chollet F, Vellas BJ, Albarede JL (Eds). Facts and Research in Gerontology 

1996. Stroke in the Elderly. Paris: Serdi Publisher 1996:171-182. 

3. Garcia JH, Ho K-L, Pantoni L. Pathology. In: Barnett HJM, Mohr JP, Stein BM, Yatsu 

FM (Eds). Stroke. Pathophysiology, Diagnosis, and Management (third edition). New 

York: Churchill Livingstone, 1998:139-157. 

4. Inzitari D, Pantoni L. Do stroke patients with white matter changes have an increased 

risk for dementia? In: Leys D, Pasquier F, Scheltens P (Eds). Stroke and Alzheimer's 

Disease. The Hague, The Netherlands: Holland Academic Graphics, 1998:141-155. 

5. Garcia JH, Pantoni L. Cellular inflammation in experimental ischemic stroke. In: Miller 

PL (Ed). Stroke therapy: basic, preclinical, and clinical directions. New York: John 

Wiley & Sons, Inc., 1999:271-297. 

6. Sarti C, Pantoni L. CADASIL and other hereditary forms of vascular 

leukoencephalopathy. In: Pantoni L, Inzitari D, Wallin A (Eds). The matter of white 

matter. Clinical and pathophysiological aspects of white matter disease related to 

cognitive decline and vascular dementia. Utrecht, The Netherlands: Academic 

Pharmaceutical Productions, 2000:335-345. 

7. Pantoni L. Cerebral white matter ischemia and anoxia: data from experimental models. 

In: Pantoni L, Inzitari D, Wallin A (Eds). The matter of white matter. Clinical and 

pathophysiological aspects of white matter disease related to cognitive decline and 

vascular dementia. Utrecht, The Netherlands: Academic Pharmaceutical Productions, 

2000:377-388. 

8. Erkinjuntti T, Pantoni L. Subcortical vascular dementia. In: Gauthier S, Cummings JL 

(Eds). Alzheimer’s Disease and Related Disorders Annuals. London, UK: Martin Dunitz 

Ltd, 2000:101-133. 

9. Inzitari D, Romanelli M, Pantoni L. Leukoaraiosis and cognitive impairment. In: O’Brien 

J, Ames D, Burns A (Eds). Dementia, Second edition. London: Edward Arnold 

Publishers, 2000:635-653. 

10. Pantoni L, Simoni M. The role of white matter lesions in cognitive impairment of 

vascular origin. In: Vellas B, Fitten LJ, Winblad B, Feldman H, Grundman M, Giacobini 

E (eds). Research and Practice in Alzheimer’s Disease, volume 5. Paris: Serdi Edition, 

2001:98-102.

Capitoli di libri (segue): 

22 


11. Pantoni L, Garcia JH. Ischemic injury to the cerebral white matter: neuropathology of 

human and experimental lesions. In: Choi D, Dacey RG, Hsu CY, Powers WJ (eds). 

Cerebrovascular Disease: Momentum at the End of the Second Millennium (American 

Heart Association Monograph Series). Armonk, New York: Futura Publishing Company, 

Inc., 2001:115-129. 

12. Pantoni L, Lammie A. Cerebral small vessel disease: pathological and pathophysiological 

aspects in relation to vascular cognitive impairment. In: Erkinjuntti T, Gauthier S 

(eds).Vascular cognitive impairment. London: Martin Dunitz Ltd., 2002:115-133. 

13. Wallin A, Milos V, Sjögren M, Pantoni L, Erkinjuntti T. Classification and subtypes of 

vascular dementia. In: Erkinjuntti T, Gauthier S (eds). Vascular cognitive impairment. 

London: Martin Dunitz Ltd., 2002:27-42. 

14. Pantoni L. Subtypes of vascular dementia and their pathogenesis: a critical overview. In: 

Bowler J, Hachinski V (eds). Vascular cognitive impairment: preventable dementia. 

Oxford: Oxford University Press, 2003:217-229. 

15. Inzitari D, Lamassa M, Pantoni L. Treatment of vascular dementias. In: Bowler J, 

Hachinski V (eds). Vascular cognitive impairment: preventable dementia. Oxford: Oxford 

University Press, 2003:277-292. 

16. Sarti C, Pantoni L. Experimental models of vascular dementia: a focus on white matter 

disease and incomplete infarction. In: Bowler J, Hachinski V (eds). Vascular cognitive 

impairment: preventable dementia. Oxford: Oxford University Press, 2003:76-92. 

17. Pantoni L. The role of white-matter lesions in dementia. In: Gauthier S, Scheltens P, 

Cummings JL (eds). Alzheimer’s Disease and related disorders annual 2004. London, 

UK: Martin Dunitz Ltd, 2004:47-59. 

18. Pantoni L, Inzitari D. Leukoaraiosis and cognitive impairment. In: Burns A, O’Brien J, 

Ames D (Eds). Dementia, Third edition. London: Edward Arnold Publishers, 2005:546- 

564. 

19. Ogata J, Yamanishi H, Pantoni L. Neuropathology of ischemic brain injury. In: Fisher M 

(editor). Handbook of Clinical Neurology, volume 92 (3 rd series) Stroke, Part I. 

Edinburgh, Elsevier, 2009;92:93-116. 

20. Pantoni L, Pescini F, Poggesi A. Physiopathology of large-vessel vascular dementia. In: 

Wahlund L-O, Erkinjuntti T, Gauthier S (Eds). Vascular cognitive impairment in clinical 

practice. Cambridge, Cambridge University Press, 2009:95-117. 

21. Poggesi A, Pantoni L. Investigations in Primary Care. Frontiers in Neurology and 

Neuroscience 2009;24:66-78.

Capitoli di libri in italiano: 

23 


1. Inzitari D, Pantoni L. Demenze vascolari: risonanza magnetica morfologica. In: Tedeschi 

G, Cirillo S, Caltagirone C. Le neuroimmagini delle demenze. Roma, Critical Medicine 

Publishing Editore, 2005:129-148. 

2. Pantoni L, Inzitari D. Demenza vascolare. In: Gambina G, Pasetti C. Introduzione alla 

malattia di Alzheimer e alle altre demenze. Dalla clinica alla bioetica. Verona, Edizioni 

Libreria Cortina 2008: 203-210.

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