PELONEWS Feb/March 2020 with focus on MSCs

PELONews Tags

PELONews Tags #MSCs Special MSCS Review: Therapeutic MSCs for Immunotherapy, Gene and Drug Delivery #Immunomodula tory #Immunotherapy #Antiinflammatory Agents #Drug delivery #Tumor cells #Cancer cells MORE https:// doi.org/10.1016/ j.omtm.ong>2020ong>.01.005 The researcher give an overview of the latest research in the immunological properties of MSCs, their use as immunomodulatory/ anti-inflammatory agents. They also add methods for licensing MSCs to customize their immunological profile, and their use as vehicles for transferring both therapeutic genes in genetic disease and drugs/genes designed to destroy tumor cells. [Mol Ther Methods Clin Dev] Abstract Mesenchymal stromal cells (MSC) possess several fairly unique properties that, combined, make them ideally suited for cellular-based immunotherapy and as vehicles for gene and drug delivery for a wide range of diseases/ disorders. K ey among these are: 1) their relative ease of isolation from a variety of tissues; 2) 2) the ability to be expanded in culture ong>withong>out a loss of functionality, a property that varies to some degree ong>withong> tissue source; 3) 3) they are relatively immune-inert, perhaps obviating the need for precise donor/recipient matching; 4) they possess potent immunomodulatory functions that can be tailored by so -called licensing in vitro and in vivo; 5) the efficiency ong>withong> which they can be modified ong>withong> viral-based vectors; and 6) their almost uncanny ability to selectively home to damaged tissues, tumors, and metastases following systemic administration. Also have a look at this paper: https://doi.org/10.1111/sji.12459 MSCs protect Endothelial Cells from Cytotoxic T Lymphocyte-Induced Lysis by E.F. Cahill,G. Eissner, S.Hafner... Product list MSCs, Tools and Media See what we got… Yes, it is so nice to work ong>withong> great products. Find out now… https://www.yumpu.com/en/embed/view/ iApHInxFeXgGVk2N Enjoy our comprehensive Product list of PELOBiotech‘s and our partner‘s MSCs, Tools and Media: https://www.yumpu.com/en/embed/view/iApHInxFeXgGVk2N

Introduction: What can ceMSC do in vivo? Treatments of Bone Repair & Osteogenesis imperfecta Mesenchymal cells (also known as stromal cells or non-hematopoietic cells) are a component of the bone marrow microenvironment. Although they function to support and regulate hematopoietic cell development, it is their capacity to differentiate into multiple lineages including bone, cartilage, muscle, tendon and fat, that has caused renewed interest in these cells by stem cell biologists and researchers ong>withong>in the regenerative medicine and tissue engineering fields. Emer Clarke, CSO ReachBio Research Labs, shows in her presentation an overview of these amazing cells. She explains from her point of view why MSCs are now seen as cells ong>withong> her own role, what advantages Culture expanded MScs may present for your research and more. ReachBio offers superior pre-qualified human mesenchymal cells for research & development applications Drug Screening Regenerative Medicine Research Tissue Engineering Research Cell and Gene Therapy Research Stem Cell and Developmental Biology Research Immunomodulation Studies Adipogenic Studies Click here to see this overview: Also see last page for more: 3D Islets in Co– Culture ong>withong> MSCs Features Pre-Qualified Mesenchymal Cells Each batch of ReachBio Research Lab’s Pre-Qualified Mesenchymal (Stromal) Cells are derived from normal human bone marrow and have the following characteristics Multiple replicate vials derived from single donors Minimally culture expanded Phenotypically characterized by flow cytometry Known plating efficiencies Batch-specific protocols provided MORE https:// www.reachbio.com/ mesenchymal-cells-andmedia https://www.yumpu.com/en/embed/view/wrVfiIuKLk8TCPGe Pic: ReachBio Res.Lab Example of Fat Cells Derived from MSC