PeloNews Spring 2024

PeloNews Spring

PELONEWS WITH A FOCUS ON MSC-EV RESEARCH PELOBiotech Newsletter Spring 2024 "The science of today is the technology of tomorrow." – Edward Teller, Hungarian-American theoretical physicist Dear Scientist, In the realm of regenerative medicine, Mesenchymal Stem / Stromal cell derived Extracellular Vesicles (MSC-EVs) have emerged as a focal point of research and therapeutic exploration. These nanoscale membranous structures, released by Mesenchymal Stem/ Stromal cells, encapsulate a diverse array of bioactive molecules, including proteins, lipids, and nucleic acids, reflecting the physiological state of their parent cells and exhibiting the capacity to modulate the behavior of recipient cells through intricate signalling mechanisms. The therapeutic potential of MSC-EVs is underscored by their ability to mimic the reparative and regenerative properties of MSCs, offering a promising avenue for targeted drug delivery systems and tissue repair strategies. Ongoing studies have delved into understanding the mechanisms of MSC-EV interactions with target cells, optimizing isolation and purification techniques, and evaluating their efficacy and safety profiles in preclinical and clinical settings. Join us in exploring the fascinating world of MSC-EVs and their transformative potential in regenerative medicine. As we delve deeper into the complexities of MSC-EVs, addressing some key aspects and critical role of defined media in enhancing EV quality. All the best to you and your research, Christiane Büchsel Head of Marketing and Communications at PELOBiotech CONTENT Overview of MSC-EVs Sneak peek of the first annual PELOBiotech Conference Advancement in Non-Animal Research and Translational Medicine" Why is defined media good for MSCs? Media and supplements for MSCs GMP-quality MSCs Upcoming PELOAcademy Webinars