PeloNews_Spring 2022

PELONews

PELONews Spring 2022 Overview Extracellular Matrix (ECM) Extracellular Matrix (ECM) is the non-cellular component present within all tissues and organs and provides essential physical scaffolding for the cellular constituents and initiates crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. Vivid genetic abnormalities in ECM proteins causes many syndromes from minor to severe consequently, ECM molecules are targets for pharmacotherapy. some of the diseases caused by the abnormalities of the ECM are namely, Osteoarthritis, cancer, or genetic disorders like Marfan´s syndrome and even the acquired human diseases like coronary heart disease. Extracellular Matrices & Hydrogels products for R&D or GMP • Gelatin • Speed Coating Solution • PhenoDrive • Collagen (I, II, III, IV) • Fibronectin • Lamin • Vitronectin • ECM Mixtures • EHS Matrix • Alternatives to Matrigel and organ & cell culture derived ECMs Productlist ECMs: https://www.yumpu.com/en/document/read/62911690/ portfolio-ecm-products

New Products and Partners HydroSeev - Improving your 3D Cell culture HydroSeev, by our partner Seevix, is a formulation of a biopolymer with properties like that of spiderslik used as an additive for the betterment of mechanical properties, viability and function of 3D models. It is supplied as a stock suspension to supplement materials used for creating 3D Cellular models. Unique Structure and Properties Use SpheroSeev in drug discovery, stem cell research, cancer research and tissue engineering studies to reduce overall study costs. • Ready and easy-to-use • Minimum protocol adaption to switch from 2D or currently used 3D • high-porosity leading to bettter oxygen and nutrient access hence mimics function of vascularized tissue • Provides tissue-like environment for cells • extra strength and elasticity that provides mechanical cushioning and protection to individual cells within the spheroid. • Long shelf-life and sterile • Does not degrade over the course of the experiement. SpheroSeev Also find out about SpheroSeev ->ECM-like environment for spheroid formation in a consistent and reproducible manner. UltraGRO-PURE GI - Xeno-free human Platelet Lysate Platelets are one of the small components in blood circulation participating in primary hemostasis and thrombosis. Besides coagulation and wound healing, numerous research articles demonstrate the capability of human platelet lysate (hPL) in research, regenerative medicine and clinical applications. As a serum substitute, hPL has demonstrated higher expansion potency without compromising its differentiation characteristics and immunosuppression of T cells. AventaCell BioMedical Corp., a leading platelet lysate company, dedicating itself to developing novel human-derived products for cell culture. UltraGRO-PURE pic: AventaCell BioMedical Corp. meets your need for a consistent and reliable human protein based cell culture supplement that can support your cell production from research through to clinical trial use. UltraGRO TM – PURE GI GMP grade cell culture supplement is a gamma irradiated viral inactivated, fibrinogen depleted, xeno-free media supplement.