PeloNews_Spring 2022

PELONews

PELONews Spring 2022 Products and Partners ideal for EV research and production Co-Culture with advanced 3D Cell Culture Tools 3D CoSeedis TM is a novel scaffoldfree 3D cell co-culture system. Some of the key features of 3D CoSeedis TM Chip: • They are highly reproducible • Easy for mass production of highly uniform organoids • Wide range of disease models • HTS compatibility Media and Partner for MSCs Gain more Control with Defined Media for MSCs Cell culture is a critical component of research, development and production in the life sciences. Cell culture media in particular, has a significant impact on the efficacy and sensitivity control of the cell culture microenvironment. PELOBiotech is strenghtening its leading position in the field of MSCs & GMP: We offer a special media for MSCs to our portfolio called CellCor, a serum free chemically defined media composed of over 200 known compounds. Through 10 years of tenacious research, producer Xcell Therapeutics, South Korea, developed Cell- Cor CD MSC products, which provide superior performance with the upmost focus safety and quality, assured by strict adherence to regulated standards following good manufacturing practices. CellCor does not contain any animal nor plant derived components, they are hPL free, and Exosome free, GMP quality. available in R&D and Scan QR-Code and get the Product sheet.

NEW Products and Partners Alternatives to Matrigel denovoMATRIX develops and manufactures biomatrix coatings that enable the culture of a wide variety of primary, stem and established cell lines. In vivo, extracellular matrix (ECM) molecules surround individual cells with essential roles in regulation of adhesion, differentiation, migration, phenotype, organization and structure. myMATRIX coatings recapitulate these major functions of the natural ECM, making cell culture easy, robust, and biologically relevant. YUMPU We have more than 70 papers, flyers and brochures to read for free. https:// www.yumpu.co m/kiosk/ pelobiotech pic: TissueClick We present our new partner Tissue Click. The company provides PhenoDrive which has the multifunctional nature which unlike GelMatrix/ Matrigel it can be used as a coating, in suspension or as a bio ink. This offers a simple and effective scale-up reducing experimental optimization and its time cost. Phenodrive vs GelMatrix/Matrigel at a glance Methods Paper alert! Development of Scaffold-free vascularized pancreatic betaislets in vitro models by the anchoring of cell lines to a biologand –functionalized gelatine substrate. Valeria Perugini et al. 2022. https://doi.org/10.1007/s10856-022-06658-3 Abstract: GelMatrix/ Matrigel Coating, Encapsulation Phenodrive Coating, Encapsulation Suspension, bioink Temperature 4 °C Room Temperature Handeling (Viscosity) High Low Microscopy Opaque Transparent Cmposition Natural Synthetic Formulations 1 6 Stability in culture 5 15 The formation of bioengineered pancreatic islets through cell anchoring to a gelatine-based biomaterial, PhenoDrive-Y, is able to mimic the basement membrane of tissues . PhenoDrive-Y led human pancreatic ß Cell line and human umbilical endothelial cell lines structure which is similar to natural vascularized pancreatic islets. The study shows the potential of PhenoDrive-Y as a substrate for the development of bioengineered vascuklarized pancreatic islets making it suitable for new therapeutics.