No Slide Title - NKI / AvL
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No Slide Title - NKI / AvL
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Testen van klassieke cytostatica en PARPi in muismodel<br />
• Classical compounds<br />
voor ILC<br />
Rottenberg et al. PNAS 2007 and unpublished<br />
Donor: JJ/CB #2045<br />
Muizen ILC<br />
DOX DOC CIS Muizen BRCA1<br />
800<br />
700<br />
– In vitro: 5FU, 5’DFUR, cisplatin, docetaxel, doxorubicin,<br />
valproic-acid<br />
Tumor size %<br />
600<br />
500<br />
400<br />
300<br />
200<br />
100<br />
0<br />
– In vivo, transplanted WcrH;Cdh1F/F;p53F/F tumors :<br />
• cisplatin (6 mg/kg i.v. ; day 0, 14),<br />
• docetaxel (25 mg/kg i.v. ; day 0, 7, 14),<br />
• doxorubicin (5 mg/kg i.v. ; day 0, 7, 14)<br />
• Topotecan (4mg/kg i.p.; days 0,1,2,3,4)<br />
• PARPi (50 mg/kg i.p.; daily 0-27)<br />
• Cisplatin + PARPi (6 mg/kg i.v.; day 0,14, 50 mg/kg i.p.;<br />
daily 0-27)<br />
0 5 10 15 20 25 30<br />
control<br />
docetaxel<br />
doxorubicin<br />
topotecan<br />
PARPi<br />
cisplatin<br />
cisplatin +PARPi<br />
Days
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