studiul factorilor critici in dizolvarea si eliberarea - Prezentare
studiul factorilor critici in dizolvarea si eliberarea - Prezentare
studiul factorilor critici in dizolvarea si eliberarea - Prezentare
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Activitati (cont<strong>in</strong>uare) :<br />
4.7. Efectuarea de studii de cedare <strong>in</strong> vitro d<strong>in</strong> comprimate <strong>in</strong> fluide <strong>si</strong>muland<br />
mediul <strong>in</strong>test<strong>in</strong>al preprandial<br />
4.8. Efectuarea de studii de cedare <strong>in</strong> vitro d<strong>in</strong> comprimate <strong>in</strong> fluide <strong>si</strong>muland<br />
mediul gastric postprandial<br />
4.9. Efectuarea de studii de cedare <strong>in</strong> vitro d<strong>in</strong> comprimate <strong>in</strong> fluide <strong>si</strong>muland<br />
mediul <strong>in</strong>test<strong>in</strong>al postprandial<br />
4.10. Metode factoriale <strong>in</strong> analiza <strong>factorilor</strong> <strong>critici</strong> de dizolvare<br />
4.11. Studii priv<strong>in</strong>d componenta difuzionala <strong>in</strong> cedarea d<strong>in</strong> forme farmaceutice.<br />
Solutii matematice la ecuatia difuziei <strong>in</strong> conditii <strong>in</strong>itiale <strong>si</strong> de frontiera date<br />
4.12. Analiza statistica a variabilitatii rezultatelor studiilor de cedare <strong>in</strong> vitro<br />
<br />
4.13. Studii priv<strong>in</strong>d strategii de dezvoltare <strong>si</strong> validare a metodelor de dizolvare <strong>in</strong><br />
optimizarea formularii medicamentelor solide <strong>si</strong> semisolide<br />
4.14. Standardizare metode de <strong>studiul</strong> cedarii d<strong>in</strong> forme farmaceutice semisolide<br />
4.15. Elaborarea unor metrici de comparare a curbelor de dizolvare obt<strong>in</strong>ute <strong>in</strong><br />
conditii diferite<br />
4.16. Corelari <strong>in</strong>tre metodele “fiziologice” <strong>si</strong> cele “alternative” <strong>si</strong> elaborarea unor<br />
modele predictive<br />
4.17. Estimarea gradului de predictibilitate asupra comportamentului <strong>in</strong>-vivo<br />
pentru modelele elaborate<br />
4.18. Analiza beneficiu/risc <strong>in</strong> cazul folo<strong>si</strong>rii metodelor alternative <strong>in</strong> locul celor<br />
cu reactivi fiziologici<br />
4.19. Disem<strong>in</strong>are rezultate: conectarea la retele de cercetare nationale <strong>si</strong><br />
<strong>in</strong>ternationale, updatare pag<strong>in</strong>a WEB, organizare / participare la cursuri.<br />
Identificare <strong>si</strong> atribuirea drepturilor de proprietate <strong>in</strong>telectuala
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