Fragment based drug design
Fragment based drug design
Fragment based drug design
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Strukturní screening fragmentů<br />
R1 N R2<br />
N N<br />
R3<br />
• Higher hit rate<br />
• Detect unique structures (mM)<br />
100R1x100R2x100R3 = 1,000,000 cmpds<br />
• Precise structural data (validate/prioritise the hits)<br />
• Rapid structure <strong>based</strong> optimisation<br />
• Room to optimise<br />
• High re-use re use -protein protein family specific scaffolds
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