Breast Cancer whole genome sequences-Nature May 2016
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RESEARCH<br />
ARTICLE<br />
A. Survival (years) by Rearrangement Signature<br />
100<br />
90<br />
80<br />
70<br />
OS (%)<br />
60<br />
50<br />
p= 0.235<br />
40<br />
30<br />
20<br />
10<br />
0<br />
A :n= 60<br />
B :n= 54<br />
C :n= 60<br />
D :n= 61<br />
E :n= 89<br />
F :n= 36<br />
G :n= 66<br />
0 2 4 6 8 10<br />
Time ( Years)<br />
B. Age<br />
C. Grade<br />
D. Menopausal status<br />
80<br />
70<br />
100<br />
80<br />
1<br />
2<br />
3<br />
100<br />
80<br />
post<br />
peri<br />
pre<br />
60<br />
60<br />
60<br />
Age<br />
50<br />
%<br />
40<br />
%<br />
40<br />
40<br />
20<br />
20<br />
30<br />
A B C D E F G<br />
Rearrangement Signature cluster<br />
0<br />
A B C D E F G<br />
Rearrangement Signature cluster<br />
0<br />
A B C D E F G<br />
Rearrangement Signature cluster<br />
E. ER status<br />
F. Immune Response metagene panel<br />
G. Lymphocytic infiltration score<br />
%<br />
100<br />
80<br />
60<br />
40<br />
negative<br />
positive<br />
score<br />
5<br />
4<br />
3<br />
2<br />
1<br />
%<br />
100<br />
80<br />
60<br />
40<br />
nil<br />
mild<br />
moderate<br />
severe<br />
20<br />
0<br />
20<br />
0<br />
A B C D E F G<br />
Rearrangement Signature cluster<br />
−1<br />
A B C D E F G<br />
Rearrangement Signature cluster<br />
0<br />
A B C D E F G<br />
Rearrangement Signature cluster<br />
Extended Data Figure 6 | Rearrangement cluster groups and associated features. a, Overall survival (OS) by rearrangement cluster group. b, Age of<br />
diagnosis. c, Tumour grade. d, Menopausal status. e, ER status. f, Immune response metagene panel. g, Lymphocytic infiltration score.<br />
© <strong>2016</strong> Macmillan Publishers Limited. All rights reserved
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