Metoder til vurdering af nyrefunktion og proteinuri - Dansk Selskab ...

Analysemetoder til bestemmelse af cystatin C .............................................................................. 20
Standardisering........................................................................................................................... 21
Biologisk variation ..................................................................................................................... 21
Referenceintervaller ....................................................................................................................... 21
Estimeret glomerulær filtrations rate (eGFR) ................................................................................ 22
Fejlkilder ved anvendelse af P-cystatin C som mål for GFR ..................................................... 22
Rekommandationer ........................................................................................................................ 23
Bestemmelse af nyrefunktion baseret på karbamid ........................................................................... 24
Plasma karbamid ............................................................................................................................ 24
Målt renal clearance af karbamid ................................................................................................... 24
Estimeret glomerulær filtrations rate (eGFR) ................................................................................ 24
Rekommandationer ........................................................................................................................ 24
Afsluttende kommentarer til vurdering af nyrefunktion .................................................................... 25
Overordnede rekommandationer til vurdering af proteinuri/albuminuri ........................................... 26
Alment om proteinuri/albuminuri ...................................................................................................... 27
Fysiologi......................................................................................................................................... 27
Klinisk betydning ........................................................................................................................... 27
Proteinuri eller albuminuri ............................................................................................................. 28
Referenceområde for proteinuri/albuminuri .................................................................................. 28
Døgnurin eller spoturin .................................................................................................................. 28
Kontrol af nyresygdom .............................................................................................................. 30
Rekommandationer ........................................................................................................................ 30
Metoder til bestemmelse af proteinuri/albuminuri............................................................................. 31
Point of care test (POCT) ............................................................................................................... 31
Stix ............................................................................................................................................. 31
U-albumin .............................................................................................................................. 31
U-protein ................................................................................................................................ 31
Testudstyr ................................................................................................................................... 31
U-albumin og U-kreatinin ...................................................................................................... 31
Laboratoriemetoder ........................................................................................................................ 32
U-albumin .............................................................................................................................. 32
U-protein ................................................................................................................................ 32
Kvalitetskrav .................................................................................................................................. 32
U-albumin .............................................................................................................................. 32
Vurdering ............................................................................................................................... 32
Prøvemateriale ............................................................................................................................... 33
Holdbarhed ................................................................................................................................. 33
Fejlkilder ........................................................................................................................................ 33
Rekommandationer ........................................................................................................................ 33
Algoritme til screening for albuminuri .............................................................................................. 34
Afsluttende kommentarer til vurdering af proteinuri ......................................................................... 35
Referenceliste ..................................................................................................................................... 36
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