Kvartære ammoniumforbindelser - Sundhedsstyrelsens Rådgivende ...

anthocyanidiner og andre phenoler, der kan
have de beskyttende egenskaber (7; 11; 12).
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Neurotoxicity as cause of
decreased heart rate variability
Philippe Grandjean,
Institute of Public Health, University of
Southern Denmark, and Harvard School of
Public Health.
The heart rate variability (HRV) is an important
risk indicator for cardiovascular mortality.
At the same time, this parameter is sensitive
to neurotoxicants. It is usually expressed
as the coefficient of variation of the interval
between R peaks of the electrocardiogram
(CV-RR). Experimental studies document that
HRV is affected by methylmercury exposure
and that it depends on intact brainstem function.
We previously showed that intrauterine
mercury exposure was associated with a
decreased HRV as well as delayed peak III latencies
on brainstem auditory evoked potentials
(BAEP) at age 7 years. We hypothesized
that these changes would be permanent and
that these functions might also be sensitive to
methylmercury from the adolescents’ current
exposures.
A cohort of 1,022 births was assembled in the
Faroe Islands during a 21-month period of
1986-1987. The primary indicator of intrauterine
exposure to methylmercury was the
mercury concentration in cord blood, but maternal
hair was also analyzed. The first followup
examination was carried out seven years
later and included 913 children. At age 14
years, a total of 878 of 1,010 live cohort members
were examined and had their blood analyzed
for mercury. Eighteen children examined
had neurological disorders thought to be inde-
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