Nitrosativer Stress Berlin 2010/04: Martin L. Pall
Nitrosativer Stress Berlin 2010/04: Martin L. Pall
Nitrosativer Stress Berlin 2010/04: Martin L. Pall
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Agents Predicted to Down-Regulate the NO/ONOO- Cycle<br />
for which We Have Clinical Trial Data of Efficacy<br />
NMDA antagonists,<br />
other agents that<br />
indirectly lower<br />
NMDA activity,<br />
magnesium; FM,<br />
CFS/ME<br />
Fish oil (long chain<br />
omega-3); FM,<br />
CFS/ME<br />
Implicates excessive NMDA activity<br />
Has substantial antiinflammatory activity; may also act on<br />
neuronal tissue through roles of long chain omega-3 fatty acid in<br />
the plasma membrane and inner mitochondrial membrane<br />
Coenzyme Q10; FM;<br />
clinical observations<br />
in CFS/ME<br />
NT-factor; CFS/ME<br />
Ecklonia cava<br />
extract; FM<br />
D-ribose; CFS/ME &<br />
FM<br />
Improves mitochondrial function; may protect mitochondia<br />
from peroxynitrite mediated damage<br />
Allows regeneration of oxidized cardiolipin in<br />
mitochondrial inner membrane<br />
Polyphenolic chain breaking antioxidant; scavenges<br />
peroxynitrite and superoxide<br />
Helps restore purine nucleotides including ATP;<br />
subsequent degradation will raise uric acid levels
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