The Indian Weekender 2 June 2023

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18 FEATURE Friday, 02 June, 2023 Healthy cooking every day Quinoa and corn griddle pancake Quinoa and Corn Griddle Pancake is a healthy and interesting recipe that you can make at home to show your culinary skills. This easy recipe is perfect for occasions like kitty parties, potlucks, birthdays, anniversaries or a surprise party for someone special. This pancake recipe is one such quick-fix which will relish your taste buds and satiate your soul with its refreshing quinoa and corn flavours. Ingredients • 1/2 cup quinoa • 1/2 cup vegetable broth • 1/2 cup boiled American corn kernels • 1/4 cup shredded low fat mozzarella cheese • 2 tablespoon milk • 8 dashes virgin olive oil • 1/4 cup arugula • 1/2 cup water • 1 egg • 2 scallions • 1/4 cup wheat flour • 1 teaspoon salt • 1 avocados Method • Add quinoa, water and vegetable broth in a small saucepan, place it over a and mix properly. • Fry the pancakes in the skillet medium flame and let it boil. • Heat a large non-stick skillet just like kebabs for about 5 Cover the pan with a lid and over medium flame. minutes. Flip carefully and fry simmer it for 15 minutes on • Add 1/4 cup of the quinoa the other side of the pancake low flame. mixture and flatten it with a for about 5-10 minutes • Add quinoa, egg, corn kernels, spatula to give it the shape of more. Garnish the pancake scallions, cheese, wheat flour, a pancake. Repeat the process with arugula leaves and serve milk, hot pepper sauce, and with the remaining quinoa with chopped avocado and black pepper in a medium bowl mixture. toppings of your choice. Homemade cake Ingredients • 3 cup all purpose flour • 2 beaten egg • 2 teaspoon baking soda • 2 teaspoon vanilla essence • 2 cup powdered sugar • 1 cup butter • 2 cup milk Method • If you think you can never make that perfect sponge cake, then try this simple recipe and you will surely become a master in rolling out the perfect homemade cake. • It is a simple recipe and you can begin by mixing sugar and butter together. Whisk well until light and fluffy. • Then, take a manual whisker or a fork, if you do not have one. • Even electrical blenders are good. Once done, add the beaten eggs and blend well. • Beat further so that the mixture gets a light, white appearance. • Sift together the maida and baking soda. It is done to evenly distribute the baking soda in flour. • Gradually add this to the egg mixture. If required add a little milk and mix till the batter is fluffy and soft. • Add vanilla essence and blend well. Vanilla essence is important to camouflage the smell of eggs. • Sprinkle some maida on a greased baking tin. It will prevent sticking of the cake to the base, you can also line it with a butter paper. Irish lamb stew Ingredients • 1 kilograms lamb • 8 carrot • salt as required • water as required • 10 large potato • 4 onion • black pepper as required For Garnishing • 1 stalk parsley Method • The first step is to prepare the vegetables. Chop the potatoes in quarter, the carrots in medium-sized pieces and roughly chop the onions. Also slice the lamb into small pieces. • Now, take a large pot and fill it with water, and place over high heat. • Add the meat and potato pieces in the pot and bring it to a boil. • Then add the chopped carrots and onions in the pot. • Keep the pot low flame and • Pour the prepared mixture into the tin and place it in a pressure cooker. • Do not add water in the cooker and ensure that the tin does not touch the base of cooker. You can keep the baking dish on an inverted steel plate. Increase the flame and pressure cook for two minutes. • Now remove the whistle and cook on low flame for 35-40 minutes. • If you are using an electric oven, cook at 180 degrees for 30-35 minutes. • Insert a knife or a metal skewer into the cake and if it comes out clean, then the cake is ready to devour in. • Remove from the oven/cooker and allow to cool on a wire rack. cover the pot with a lid. Let it simmer, until the vegetables and the meat are cooked, and the gravy thickens. • Garnish with chopped parsley before serving. Lighter Takes & Easy Tips Read online www.iwk.co.nz Grilled lemon and rosemary chicken Ingredients • 1 1/2 tablespoon lemon juice • 1 1/2 tablespoon dijon mustard • 2 cloves garlic • powdered black pepper as required • 1 bunch arugula • 50 ml virgin olive oil • 1 1/2 tablespoon rosemary • kosher salt as required • 700 gm chicken cutlet • 1 lemon Method • In a large bowl, whisk together lemon juice, olive oil, dijon mustard, rosemary, garlic, kosher salt and black pepper powder. • In the same bowl add chicken cutlet pieces and leave it for marination at room te mperature. • Meanwhile, heat the grill to medium high. • Grease the grill grates using olive oil with the help of a brush. • Check for the marinated chicken now. • Remove the chicken from the marinate paste and place them on the grill. • Cook for 3-4 minutes till it cooks well from all the sides. • Place the lemon halves on the grill and let them cook. • Now, on a serving plate spread arugula leaves and place the grilled chicken on top if it. Now, squeeze the lemon juice on top of it and serve. Potato chip cookies Ingredients • 1 cup crushed potato wafers • 1 cup chocolate chips • 1 cup chopped mixed dry fruits • 1 teaspoon vanilla essence • 2 cup brown sugar • 1 teaspoon soda • 2 egg • 1 cup fresh cream For The Main Dish • 2 cup flour Method • To begin with this delicious recipe, take a bowl and add sugar, cream in it. • Beat the eggs onto it and mix it well. • Next, add soda, choco chips, vanilla essence, flour, dry fruits and potato chips to the mix. Mix it very well. • When the mixture is finally ready, pour the mixture carefully, by using a spoon, in the cookie plate. • Put the cookie plate inside Chicken broccoli Ingredients • 500 gm chopped chicken • 1 cup mayonnaise • 1 teaspoon curry powder • 1 tablespoon mixed herbs • 500 gm frozen broccoli • 1/2 cup skimmed milk • salt as required Method the oven and bake it at 180 degrees for 15-20 minutes depending on your oven type. • Keep checking in between so that you do not burn your cookies. Once baked, take out the cookies from the oven and serve warm. • To prepare this recipe, boil chicken in saucepan over medium flame. • Then, place chicken, broccoli, and other ingredients into a casserole dish mixed together. • Cover it with a foil and bake in the oven at 375°F for 30 minutes. Serve hot on rice and enjoy!
Read online www.iwk.co.nz Friday, 02 June, 2023 FEATURE 19 Patterns of pre-existing brain health characteristics found in stroke patients Extensive research has helped identify risk factors for acute stroke, but there is still a lack of information on what stroke patients’ brains look like on a population level, according to a study. The results of the first large-scale assessment of radiographic brain health in stroke patients in a community were presented by University of Cincinnati researchers at European Stroke Organisation Conference (ESOC) 2023 recently in Germany. “Imaging can be an objective manifestation of the presence and severity of clinical factors such as diabetes, hypertension, high cholesterol and kidney failure,” Achala Vagal, professor of neuroradiology at UC said. Vagal was a co-principal investigator on the Assessing Population-based Radiological brain health in Stroke Epidemiology (APRISE) study that gained new information from New blood biomarker can predict Alzheimer’s disease: Study Why do some people get Alzheimer’s while others don’t? Even more perplexing, why do many people with toxic amyloid aggregates in their brains, a clear marker of Alzheimer’s brain pathology, never get Alzheimer’s-related dementias? University of Pittsburgh School of Medicine researchers have found star-shaped brain cells called astrocytes are key to swaying the pendulum in Alzheimer’s disease progression, a game-changing finding that has been published in ‘Nature Medicine’. By testing the blood of more than 1,000 cognitively-unimpaired elderly people with and without amyloid pathology, the Pitt-led research team found only those who had a combination of amyloid burden and blood markers of abnormal astrocyte activation, or reactivity, would progress to symptomatic Alzheimer’s in the future, a critical discovery for drug development aimed at halting progression. “Our study argues that testing for the presence of brain amyloid along with blood biomarkers of astrocyte reactivity is the optimal screening to identify patients who are most at risk for progressing to Alzheimer’s disease. This puts astrocytes at the centre as key regulators of disease progression, challenging the notion that amyloid is enough to trigger Alzheimer’s disease,” said senior author Tharick Pascoal, associate professor of psychiatry and neurology at Pitt. Alzheimer’s disease is a neurodegenerative condition that causes progressive memory loss and dementia, robbing patients of many productive years of life. At the tissue level, the hallmark of Alzheimer’s disease is an accumulation of amyloid plaques, protein aggregates lodged between nerve cells of the brain, and clumps of disordered protein fibers, called tau tangles, forming inside the neurons. For many decades, brain scientists believed that an accumulation of amyloid plaques and tau tangles is not only a sign of Alzheimer’s disease but also its direct culprit. This assumption also led drug manufacturers to heavily invest into molecules targeting amyloid and tau, overlooking the contribution of other brain processes, such as the neuroimmune system. Recent discoveries by groups like Pascoal’s suggest the disruption of other brain processes, such as heightened brain inflammation, might be just as important as amyloid burden itself in starting the pathological cascade of neuronal death that causes rapid cognitive decline. In his previous research, Pascoal and his group found brain tissue inflammation triggers the spread of pathologically misfolded proteins in the brain, and is a direct cause of eventual cognitive impairment in patients with Alzheimer’s disease. Now, almost two years later, researchers have revealed that the cognitive impairment can be predicted by a blood test. Scientists tested blood samples from participants in three independent studies of cognitively unimpaired elderly people for biomarkers of astrocyte reactivity, glial fibrillary acidic protein, or GFAP, along with the presence of pathological tau. The study showed that only those who were positive for both amyloid and astrocyte reactivity showed evidence of progressively developing tau pathology. Obesity affects more than 40 per cent of Americans and the trend is expected to increase. Obesity and obesityrelated disorders have few therapy or prevention options. It is a substantial healthcare and public health burden that increases the risk of illnesses like diabetes, hypertension and cancer, and is connected to the severity of Covid-19. A Boston University Chobanian & Avedisian School of Medicine research team has identified a novel druggable signalling molecule involved in obesity, a previously unknown protein (MINAR2) discovered in the laboratory of Associate Professor of Pathology and Laboratory Medicine Nader Rahimi in 2020. “This finding can help to unravel new aspects in the mechanisms of obesity and diabetes, which could lead to the development of novel therapeutics for the prevention and treatment of obesity and diabetes,” said Rahimi, a corresponding author of ‘Inactivation of Minar2 in Mice Hyperactivates mTOR Signaling and Results in Obesity’, published online in Molecular Metabolism. To study the role of MINAR2 in obesity, the research team generated global MINAR2 knockout animal models that eliminated that gene’s function. MINAR2-deficient animal models fed on a normal non-high fat diet showed an increased fat mass ratio compared to control sexand age-matched models. When MINAR2-deficient animal models were fed a high-fat diet (HFD), they gained weight faster than control models and developed obesity with impaired glucose tolerance, a hallmark of type 2 diabetes. Researchers found mammalian target of rapamycin (mTOR) signaling which regulates metabolism and other cellular processes, such as cell proliferation and autophagy, is hyperactivated in the fat cells of MINAR2-deficient animal models. MINAR2 interacts with raptor, a specific and essential component mTOR complex 1. Excessive salt intake associated with cognitive disorders: Study Dementia is described as a loss of cognitive functioning, which includes thinking, remembering, and reasoning, and it is quite common in Japan. At the moment, treatment satisfaction for dementia is among the lowest, and no medication therapy to cure the condition is available. With the world’s population increasingly ageing, the discovery of dementia prevention and treatment medications is crucial. Cognitive impairment has been linked to the consumption of excess table salt, a ubiquitous food seasoning. High salt (HS) intake can also lead to hypertension. To prevent adverse health outcomes, the World Health Organization recommends limiting salt intake to less than 5g per day. The involvement of angiotensin II (Ang II), a hormone that plays a key role in regulating blood pressure and fluid neuroimaging results of stroke patients. The research team analysed all available clinical imaging data from nearly 3,500 patients who had a stroke in the Greater Cincinnati/Northern Kentucky region in 2015, balance, and its receptor “AT1”, as well as that of the physiologically important lipid molecule prostaglandin E2. However, the involvement of these systems in HSmediated hypertension and emotional/ assessing the imaging for signs of small vessel disease in the brain in the form of previous injury, microbleeds, white matter disease or brain atrophy, among other observations. Vagal said the team identified three distinct clusters of observable imaging characteristics that were each associated with a specific set of clinical variables. “This can help us understand the biology of pre-existing brain health in stroke patients and help guide future interventions,” she said, adding, “We expected all the imaging parameters of brain health due to small vessel disease to be closely clustered, but we found a lack of clustering of microbleeds with white matter disease.” With the knowledge gained from the study, Vagal said the team is now using the brain health imaging data to build a prediction model of recurrent stroke. cognitive impairment remains elusive. A recent study published in British Journal of Pharmacology thoroughly evaluated the aspects of HS-mediated hypertension and emotional/cognitive impairment. The study was performed by a team of collaborating researchers from Japan, and has shown how hypertension, mediated by the crosstalk between Ang II- AT1 and PGE2-EP1 causes emotional and cognitive dysfunction. Author Hisayoshi Kubota from Fujita Health University’s Graduate School of Health Science comments, “Excessive salt intake is considered a risk factor for hypertension, cognitive dysfunction, and dementia. However, studies focusing on the interaction between the peripheral and central nervous system have not sufficiently investigated this association.” According to the published data, the Researchers find molecule that impacts obesity, diabetes addition of excessive phosphates to the protein “tau” is primarily responsible for this emotional and cognitive consequence. The findings are particularly noteworthy because tau is a key protein of Alzheimer’s. The team first loaded laboratory mice with an HS solution for 12 weeks and monitored their blood pressure. “The effects of HS intake on emotional/ cognitive function and tau phosphorylation were also examined in two key areas of the mouse brain, the prefrontal cortex and the hippocampus,” explains Professpr Mouri. The brains of the experimental mice had several biochemical alternations. At the molecular level, besides the addition of phosphates to tau, the researchers also observed a decrease in the phosphate groups linked to a key enzyme called “CaMKII”, a protein involved in brain signaling.
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