Issue 4 Summer 2002 - Applied Biosystems
Issue 4 Summer 2002 - Applied Biosystems
Issue 4 Summer 2002 - Applied Biosystems
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22<br />
new product review<br />
New SQL*LIMS 4.1 Software<br />
The ‘Safe Choice’ for Major Pharmaceutical Companies<br />
C<br />
ontinuing a decade long history of laboratory management<br />
system experience, in 17 of the top 20 pharmaceutical<br />
companies worldwide, <strong>Applied</strong> <strong>Biosystems</strong> announces<br />
the release of SQL*LIMS 4.1 Software. The award winning<br />
SQL*LIMS software is installed in over 1000 laboratories world<br />
wide and is available with a full range of modules for enhanced<br />
functionality to meet the specific needs of your laboratory.<br />
As a leader in the LIMS market across a variety of industries,<br />
<strong>Applied</strong> <strong>Biosystems</strong> has lead LIMS innovation with features<br />
to assist customers in complying with FDA 21 CFR Part 11<br />
ERES/ESIG and integration with MRP systems, such as SAP’s<br />
R/3 QM. SQL*LIMS software has also lead the way with its<br />
reporting tool, desktop program and instrument data exchange<br />
through its open, industry standards-based Oracle ® and<br />
MS Windows ® architecture.<br />
Furthermore, SQL*LIMS software’s flexible architectural<br />
support allows you to easily scale a system from a single<br />
workgroup to an enterprise wide global implementation. You can<br />
customise the system’s graphical user interface to meet your<br />
requirements and allow access to the system via a web browser.<br />
For more information on:<br />
SQL*LIMS 4.1 Software enter:<br />
No. 417<br />
or email InformaticsInfo@appliedbiosystems.com<br />
The new SQL*LIMS 4.1 software includes many new features<br />
for improved efficiency and performance.<br />
➜ Streamlined user account, audit and electronic<br />
record/signature configuration and monitoring<br />
Support for Oracle account profile functionality<br />
➜ Enhancements to the audit trail and electronic<br />
signature capabilities allowing you to more precisely<br />
map to your workflow<br />
➜ Expanded reporting tool integration that allows more<br />
choice options for direct application integration to<br />
external programs and 3rd-party reporting tools<br />
➜ Enhancements to optimise performance, reliability and<br />
distributed computing that allow you to scale a solution<br />
to meet your exact requirements<br />
The SQL*LIMS system provides you with immediate<br />
access to drug and raw material data, across products,<br />
suppliers and sites. You also benefit from a single<br />
comprehensive audit record that pinpoints data by lot,<br />
supplier, assay and other key criteria, all while meeting<br />
regulatory compliance. SQL*LIMS software is fully auditable<br />
and is the only comprehensive system for laboratory<br />
automation backed by the proven LIMS leader.<br />
New PrepExpress NT Software<br />
A Solution for High-throughput Purification Using the<br />
API 150EX Prep LC/MS System<br />
T<br />
he API 150EX Prep LC/MS System is a useful tool<br />
for high-throughput compound characterisation<br />
and purification. The Prep LC/MS System is easily<br />
configured for both preparative and analytical modes.<br />
Several new enhancements to this product are now<br />
available. The new PrepExpress NT software was introduced<br />
by <strong>Applied</strong> <strong>Biosystems</strong>/MDS SCIEX at Pittcon <strong>2002</strong>.<br />
It runs on top of Analyst ® software, the Windows NT ®<br />
operating software for LC/MS and LC/MS/MS instruments from<br />
<strong>Applied</strong> <strong>Biosystems</strong>/MDS SCIEX.<br />
Overview<br />
The technique of Prep LC/MS combines the separation power of<br />
large scale HPLC with the specificity of mass spectrometry.<br />
This allows for the purification of targeted compounds of known<br />
mass, obviating the need to collect all to the peaks in the<br />
LC run. Automation of the process allows the purification of<br />
hundreds of compounds weekly. Prep LC/MS is gaining<br />
widespread distinction as the tool of choice for high-throughput<br />
characterisation and purification of combinatorial libraries.<br />
Flexible Hardware Setup<br />
As seen in figure 1, the workstation can provide two<br />
separate HPLC flow paths. This accommodates both<br />
analytical and preparative configurations. The analytical flow<br />
path may be used for analytical scale sample characterisation,<br />
including purity assessment, prior to purification.<br />
Figure 1.<br />
API 150EX Prep LC/MS System schematic<br />
new product review<br />
Alternatively, the analytical flow path may be replaced by either<br />
a semi-preparative flow path, or a second preparative flow path<br />
for increased throughput.<br />
Central to the Prep LC/MS System is the API 150EX single<br />
quadrupole mass spectrometer with a TurboIonSpray source<br />
and the Gilson ® 215 liquid handler that may be used as both<br />
sample injector and fraction collector. This provides enhanced<br />
sample capacity and a wider range of collection vessels,<br />
including 48- and 24-well microtitre plates. Also, the Gilson<br />
204 fraction collector may be used. Multiple collectors of either<br />
type may be employed to further increase sample capacity.<br />
PrepExpress NT Software<br />
The new flexible PrepExpress NT Software provides one-stop<br />
control of all fraction collection parameters.<br />
Important features of the software are:<br />
➜ High-throughput unattended batch purification<br />
➜ MS (both mass-specific or non mass-specific) or UV<br />
directed fraction collection<br />
➜ Embedded, automatic purity calculations, batch creation<br />
and submission<br />
➜ Easy ‘wizard aided’ sample submission<br />
➜ Walk up sample introduction<br />
➜ Automated report generation and easy sample tracking<br />
For more information on:<br />
PrepExpress NT Software for prep LC/MS enter: No. 418<br />
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