Issue 4 Summer 2002 - Applied Biosystems

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22 new product review New SQL*LIMS 4.1 Software The ‘Safe Choice’ for Major Pharmaceutical Companies C ontinuing a decade long history of laboratory management system experience, in 17 of the top 20 pharmaceutical companies worldwide, Applied Biosystems announces the release of SQL*LIMS 4.1 Software. The award winning SQL*LIMS software is installed in over 1000 laboratories world wide and is available with a full range of modules for enhanced functionality to meet the specific needs of your laboratory. As a leader in the LIMS market across a variety of industries, Applied Biosystems has lead LIMS innovation with features to assist customers in complying with FDA 21 CFR Part 11 ERES/ESIG and integration with MRP systems, such as SAP’s R/3 QM. SQL*LIMS software has also lead the way with its reporting tool, desktop program and instrument data exchange through its open, industry standards-based Oracle ® and MS Windows ® architecture. Furthermore, SQL*LIMS software’s flexible architectural support allows you to easily scale a system from a single workgroup to an enterprise wide global implementation. You can customise the system’s graphical user interface to meet your requirements and allow access to the system via a web browser. For more information on: SQL*LIMS 4.1 Software enter: No. 417 or email InformaticsInfo@appliedbiosystems.com The new SQL*LIMS 4.1 software includes many new features for improved efficiency and performance. ➜ Streamlined user account, audit and electronic record/signature configuration and monitoring Support for Oracle account profile functionality ➜ Enhancements to the audit trail and electronic signature capabilities allowing you to more precisely map to your workflow ➜ Expanded reporting tool integration that allows more choice options for direct application integration to external programs and 3rd-party reporting tools ➜ Enhancements to optimise performance, reliability and distributed computing that allow you to scale a solution to meet your exact requirements The SQL*LIMS system provides you with immediate access to drug and raw material data, across products, suppliers and sites. You also benefit from a single comprehensive audit record that pinpoints data by lot, supplier, assay and other key criteria, all while meeting regulatory compliance. SQL*LIMS software is fully auditable and is the only comprehensive system for laboratory automation backed by the proven LIMS leader. New PrepExpress NT Software A Solution for High-throughput Purification Using the API 150EX Prep LC/MS System T he API 150EX Prep LC/MS System is a useful tool for high-throughput compound characterisation and purification. The Prep LC/MS System is easily configured for both preparative and analytical modes. Several new enhancements to this product are now available. The new PrepExpress NT software was introduced by Applied Biosystems/MDS SCIEX at Pittcon 2002. It runs on top of Analyst ® software, the Windows NT ® operating software for LC/MS and LC/MS/MS instruments from Applied Biosystems/MDS SCIEX. Overview The technique of Prep LC/MS combines the separation power of large scale HPLC with the specificity of mass spectrometry. This allows for the purification of targeted compounds of known mass, obviating the need to collect all to the peaks in the LC run. Automation of the process allows the purification of hundreds of compounds weekly. Prep LC/MS is gaining widespread distinction as the tool of choice for high-throughput characterisation and purification of combinatorial libraries. Flexible Hardware Setup As seen in figure 1, the workstation can provide two separate HPLC flow paths. This accommodates both analytical and preparative configurations. The analytical flow path may be used for analytical scale sample characterisation, including purity assessment, prior to purification. Figure 1. API 150EX Prep LC/MS System schematic new product review Alternatively, the analytical flow path may be replaced by either a semi-preparative flow path, or a second preparative flow path for increased throughput. Central to the Prep LC/MS System is the API 150EX single quadrupole mass spectrometer with a TurboIonSpray source and the Gilson ® 215 liquid handler that may be used as both sample injector and fraction collector. This provides enhanced sample capacity and a wider range of collection vessels, including 48- and 24-well microtitre plates. Also, the Gilson 204 fraction collector may be used. Multiple collectors of either type may be employed to further increase sample capacity. PrepExpress NT Software The new flexible PrepExpress NT Software provides one-stop control of all fraction collection parameters. Important features of the software are: ➜ High-throughput unattended batch purification ➜ MS (both mass-specific or non mass-specific) or UV directed fraction collection ➜ Embedded, automatic purity calculations, batch creation and submission ➜ Easy ‘wizard aided’ sample submission ➜ Walk up sample introduction ➜ Automated report generation and easy sample tracking For more information on: PrepExpress NT Software for prep LC/MS enter: No. 418 23
24 new product review Introducing the ABI PRISM ® 3100-Avant Genetic Analyzer Growing with Your Throughput Needs! O ver a period of several years, Applied Biosystems has steadily introduced and developed a range of genetic analyzers based on capillary electrophoresis technology. This family has been built up to provide projects of all scales with a genetic analyzer of an appropriate capacity. To address the needs of low-to-medium throughput laboratories, with requirements falling between the capacity of either the ABI PRISM ® 310 Genetic Analyzer or the ABI PRISM 3100 Genetic Analyzer, we have launched the ABI PRISM 3100-Avant Genetic Analyzer. This new multi-capillary instrument is capable of processing a considerable number of samples in a fully automated 24-hour run, producing up to 48,000 bases of sequence data with the rapid sequencing protocol. A 24-hour, 5 dye fragment analysis‚ run can produce up to 5,760 genotypes with microsatellite samples or 3,840 genotypes with the multiplex SNaPshot ® kit (single nucleotide polymorphism) assay. This level of performance is achieved by coupling an array of four capillaries to the proven 3100 system optics, polymer pump system and autosampler (accepting either a 96- or a 384-well microtitre plate, which is sufficient for loading samples for a full 24-hour run). The repeated, robotic loading of samples for successive injections allows true, walk-away automation. 4-capillary array The 3100-Avant system, like all CE genetic analyzers from Applied Biosystems, will benefit from our ceaseless research and development programme that has, over a period of several years, consistently produced sequential and significant improvements in polymer performance, sequencing chemistry and downstream data analysis for existing members of the CE family. For example, the 3100-Avant system is capable of using the new 22cm and 80cm capillary lengths that were recently developed for the 3100. The short 22cm array enables higher throughput for genotyping applications with very fast runs, whereas the long 80cm array can be used for enhanced length-of-read in sequencing applications. Having a choice of four available arrays (22, 36, 50 and 80cm), one can achieve the best possible balance between throughput and resolution based upon your specific application and needs. Internal view of the ABI PRISM ® 3100-Avant Genetic Analyzer Futhermore, the 3100-Avant system can be upgraded to full 3100 system specification, so that its throughput can be extended in parallel with the demands of an expanding research programme. This option provides an effective way of spreading the capital investment for a major project through its initial (method development and establishment), and expansion (main data production), phases. With the release of the 3100-Avant system, Applied Biosystems now offers a range of genetic analyzers to suit all scales of laboratory requirements, from occasional rapid turn-around tests on individual samples, right through to the factory scale 24-hour a day operations of the major genome projects. De novo Sequencing new product review Sequence Analysis Software Comparative Sequencing BigDye ® Chemistry SNP Discovery and Validation Microsatellite Analysis Linkage Mapping Set Chemistry ABI PRISM ® 3100-Avant Genetic Analyzer SeqScape TM Software GeneScan ® Software Genotyper ® Software SNP Validation and Screening SNaPshot ® Multiplex Chemistry GeneMapper TM Software Finally, proven sequencing and fragment analysis chemistries, along with new application-specific downstream software, make the 3100-Avant system an integral part of our complete solution for all your research needs. See article on page 14 For more information on: ABI PRISM 3100-Avant Genetic Analyzer enter: No. 419 25
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Issue 4 Summer 2002 - Applied Biosystems

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