PROGRAM & ABSTRACTS - Wisconsin Union - University of ...

More documents

Recommendations

Info

Aging, Metabolism, Stress, Pathogenesis, and Small RNAs in C. elegans Topic Meeting 2012 Transcriptional Network Key to Longevity Determination and Stress Regulation Siu Sylvia Lee Cornell University, Ithaca, NY, USA The highly conserved transcriptional co-regulator HCF-1 is capable of coordinating many transcription and chromatin factor complexes and participates in a wide variety of biological processes. We previously identified the C. elegans hcf-1 null mutant to be long-lived and stress resistant. Our investigations revealed that HCF-1 modulates longevity and stress response by acting with the protein deacetylase SIR-2.1/SIRT1 to regulate the activity of DAF-16/FOXO. Interestingly, HCF-1 appears to also regulate SKN-1/NRF2 to specifically affect oxidative stress response. Our data suggest HCF-1 is an integral component of the transcriptional network key to longevity determination and stress regulation. Contact: sylvia.lee@cornell.edu Lab: Lee 6 Session 2 Plenary Speaker
Contact: xguo@bio.tamu.edu Lab: Garcia Aging, Metabolism, Stress, Pathogenesis, and Small RNAs in C. elegans Topic Meeting 2012 SIR-2.1, an HDAC, is Required To Maintain The Male Mating Potency In C. elegans Xiaoyan Guo 2 , Luis rene Garcia 2,1 1 HHMI, 2 Texas A&M University, College Station, TX In a previous study (1), we carefully characterized that C. elegans male mating behavior significantly deteriorates at adult age day 3. Through direct mating behavior observations, Ca2+ imaging, and pharmacological tests, we found that the muscular components used for mating become more excitable as the males age. To further uncover the molecular mechanism, we found that sir-2.1, a histone deacetylase in C. elegans might be the link between the male mating behavior decay and the increase of the sex muscle excitability. Compared to wild type, sir-2.1(ok434) males mating potency prematurely decline: a significant drop is observed at adult age day 2, correlating with an obvious increase of sex muscle excitability. Furthermore, we observed that sir-2.1(ok434) males have a series of metabolism disorders: significantly more glycogen, fat and ATP are synthesized in sir-2.1(ok434) males. Those observations lead to the hypothesis that there is more ROS stress undergoing in sir-2.1 (ok434), which might be responsible for the increase of sex muscle excitability increase and mating potency decline. Indeed, we found that sir-2.1(ok434) males are more sensitive to the oxidative stress, paraquat. Meanwhile, for wild type males, feeding small amount of paraquat decreases the male mating potency at day 2 and increase the sex muscle excitability. 1. Guo X, Navetta A, Gualberto DG, Garcia LR. Behavioral decay in aging male C. elegans correlates with increased cell excitability. Neurobiol Aging. 2012. Session 2 7
Page 1 and 2: Aging, Metabolism, Stress, Pathogen
Page 23 and 24: Contact: ewbank@ciml.univ-mrs.fr La
Page 25 and 26: Contact: kjdumas@umich.edu Lab: Hu
Page 27: Contact: ryan.baugh@duke.edu Lab: B
Page 31 and 32: Contact: franzcj@gmail.com Lab: Wan
Page 33 and 34: Contact: keith.blackwell@joslin.har
Page 35 and 36: Contact: lapierre@burnham.org Lab:
Page 37 and 38: Contact: nils.f@bmb.sdu.dk Lab: Fæ
Page 39 and 40: Contact: kaveh.ashrafi@ucsf.edu Lab
Page 41 and 42: Contact: emilie.demoinet@mcgill.ca
Page 43 and 44: Contact: dpark@cmmt.ubc.ca Lab: Tau
Page 45 and 46: Contact: jmelo@molbio.mgh.harvard.e
Page 47 and 48: Contact: apasquinelli@ucsd.edu Lab:
Page 49 and 50: Contact: yutao.chen@duke.edu Lab: B
Page 51 and 52: Contact: asoukas@chgr.mgh.harvard.e
Page 53 and 54: Contact: felix@biologie.ens.fr Lab:
Page 55 and 56: Contact: sszumows@ucsd.edu Lab: Tro
Page 57 and 58: Contact: jsimske@metrohealth.org La
Page 59 and 60: Contact: stroustr@fas.harvard.edu L
Page 61 and 62: Contact: haynesc@mskcc.org Lab: Hay
Page 63 and 64: Contact: pathu@umich.edu Lab: Hu Ag
Page 65 and 66: Contact: sunc@morpheus.wustl.edu La
Page 67 and 68: Contact: abigail.cabunoc@oicr.on.ca
Page 69 and 70: Contact: rtaylor@salk.edu Lab: Dill
Page 71 and 72: Contact: wmadaki@gmail.com Lab: Suz
Page 75 and 76: Contact: atchen@umich.edu Lab: Hu A
Page 77 and 78: Contact: kjdumas@umich.edu Lab: Hu
Page 79 and 80:
Aging, Metabolism, Stress, Pathogen
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Contact: cbrey@marywood.edu Lab: Ha
Page 103 and 104:
Page 105 and 106:
Contact: nharriso@scripps.edu Lab:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Contact: jrice@bmcc.cuny.edu Lab: S
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Contact: cschen@mail.ncku.edu.tw La
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Contact: jmiskowski@uwlax.edu Lab:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Contact: amirsa@caltech.edu Lab: St
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Contact: jordan.ward@ucsf.edu Lab:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Contact: mmondoux@holycross.edu Lab
Page 195 and 196:
A Aebi, Markus.....................
Page 197 and 198:
Goldstein, Leonard D...............
Page 199 and 200:
Morimoto, Richard I ...............
Page 201 and 202:
Veal, Elizabeth A .................
Page 203 and 204:
Phone • N W Studio B E Studio A E
show all

PROGRAM & ABSTRACTS - Wisconsin Union - University of ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?