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Bulbar urethral sling placement in males by the transobturator ... - BJUI

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www.bjui.org. Atlas of Surgery<br />

<strong>Bulbar</strong> <strong>urethral</strong> <strong>sl<strong>in</strong>g</strong> <strong>placement</strong> <strong>in</strong> <strong>males</strong> <strong>by</strong> <strong>the</strong> <strong>transobturator</strong><br />

approach us<strong>in</strong>g <strong>the</strong> American Medical Systems AdVance TM system<br />

Correspondence to:<br />

H.J. Zeif, R. Jones, Y.Z. Almallah<br />

Urology Department, The Queen Elizabeth Hospital,<br />

University Hospital Birm<strong>in</strong>gham NHS Foundation Trust<br />

Mr Zaki Almallah, Consultant Urological Surgeon<br />

Queen Elizabeth Hospital, University Hospital Birm<strong>in</strong>gham NHS Foundation Trust,<br />

Edgbaston, Birm<strong>in</strong>gham B15 2TH, UK<br />

Zaki.almallah@uhb.nhs.uk


www.bjui.org. Atlas of Surgery<br />

The <strong>transobturator</strong> <strong>sl<strong>in</strong>g</strong> suspension is a treatment option for <strong>males</strong> with stress<br />

ur<strong>in</strong>ary <strong>in</strong>cont<strong>in</strong>ence (SUI) due to <strong>in</strong>tr<strong>in</strong>sic ur<strong>in</strong>ary sph<strong>in</strong>cter deficiency postprostatectomy.<br />

It can be offered to men who rema<strong>in</strong> unsatisfied follow<strong>in</strong>g<br />

conservative management. The latter <strong>in</strong>cludes pelvic floor muscle exercises,<br />

biofeedback and electrical stimulation. Recently pharmaco<strong>the</strong>rapy with Duloxet<strong>in</strong>e, a<br />

dual seroton<strong>in</strong>-noradrenal<strong>in</strong>e reuptake <strong>in</strong>hibitor has been used off-licence <strong>in</strong> men with<br />

variable success rates. Surgical treatment options <strong>in</strong>clude <strong>in</strong>jection of peri<strong>urethral</strong><br />

bulk<strong>in</strong>g agents, <strong>in</strong>sertion of extra<strong>urethral</strong> (non-circumferential) retropubic adjustable<br />

compression devises (ProAct TM ) and <strong>in</strong>sertion of artificial ur<strong>in</strong>ary sph<strong>in</strong>cters (AUS) or<br />

bulbo<strong>urethral</strong> <strong>sl<strong>in</strong>g</strong>s. Whereas peri<strong>urethral</strong> bulk<strong>in</strong>g agents have low success rates,<br />

artificial ur<strong>in</strong>ary sph<strong>in</strong>cters were nom<strong>in</strong>ated <strong>the</strong> reference standard treatment for postprostatectomy<br />

<strong>in</strong>cont<strong>in</strong>ence <strong>by</strong> <strong>the</strong> third International Consultation on Incont<strong>in</strong>ence <strong>in</strong><br />

2002. They have demonstrated good efficacy <strong>in</strong> severe SUI with high social<br />

cont<strong>in</strong>ence and patient satisfaction rates. However, <strong>the</strong> disadvantages of AUS are<br />

<strong>the</strong> need for manual dexterity and mental capacity to operate <strong>the</strong> sph<strong>in</strong>cter. AUS is<br />

expensive and carries risk of cuff erosion, <strong>in</strong>fection and mechanical failure.<br />

Male <strong>sl<strong>in</strong>g</strong>s are <strong>in</strong>dicated <strong>in</strong> mild to moderate SUI. Male <strong>sl<strong>in</strong>g</strong> procedures <strong>in</strong>clude<br />

bone anchor<strong>in</strong>g and suprapubic suspension techniques. The former raises concerns<br />

about possible bone related complications, <strong>the</strong> latter risks bladder perforation or<br />

bleed<strong>in</strong>g <strong>by</strong> us<strong>in</strong>g <strong>the</strong> retropubic pathway for <strong>sl<strong>in</strong>g</strong> implantation. The AMS AdVance TM<br />

system is self-anchor<strong>in</strong>g and relatively easy to implant. It uses a <strong>transobturator</strong><br />

pathway for implantation and fixation, which is already established <strong>in</strong> women,<br />

m<strong>in</strong>imiz<strong>in</strong>g <strong>the</strong> risk of harm<strong>in</strong>g any sensitive structures <strong>in</strong> <strong>the</strong> male pelvis and omitt<strong>in</strong>g<br />

<strong>the</strong> need for bone-anchor<strong>in</strong>g screws. The <strong>the</strong>oretical pr<strong>in</strong>ciple beh<strong>in</strong>d <strong>the</strong> AdVance TM<br />

Sl<strong>in</strong>g is relocation of <strong>the</strong> bulb, ra<strong>the</strong>r than compression.<br />

The National Institute for Health and Cl<strong>in</strong>ical Excellence (NICE) issued its guidel<strong>in</strong>es<br />

on ‘Sub<strong>urethral</strong> syn<strong>the</strong>tic <strong>sl<strong>in</strong>g</strong> <strong>in</strong>sertion for stress ur<strong>in</strong>ary <strong>in</strong>cont<strong>in</strong>ence <strong>in</strong> men’ <strong>in</strong><br />

March 2008 [1]. They state that current efficacy and safety evidence appears<br />

adequate provided normal arrangements for cl<strong>in</strong>ical governance and audit are <strong>in</strong><br />

place. Efficacy rates described range from 39-96% [2-7] depend<strong>in</strong>g on <strong>the</strong> vary<strong>in</strong>g<br />

def<strong>in</strong>itions of success and follow-up periods <strong>in</strong> between studies. Rates for <strong>urethral</strong><br />

erosion requir<strong>in</strong>g <strong>sl<strong>in</strong>g</strong> removal range from 0-6% [2-6] and for <strong>in</strong>fection from 4-6%<br />

[3,5,6]. Postoperative pa<strong>in</strong> or dysuria is common, with pa<strong>in</strong> persist<strong>in</strong>g longer than 3<br />

months requir<strong>in</strong>g analgesia described <strong>in</strong> 12% of one case series [6]. Ur<strong>in</strong>ary retention<br />

rates <strong>in</strong> one study was 3% requir<strong>in</strong>g repeat surgery [3] and 12% <strong>in</strong> ano<strong>the</strong>r resolv<strong>in</strong>g<br />

with ca<strong>the</strong>terisation for up to 3 days [6]. No osseous complications were reported.<br />

The re-<strong>in</strong>tervention rate for re-adjustment of <strong>sl<strong>in</strong>g</strong> tension was 8% <strong>in</strong> one study [5].<br />

NICE recommends that patient consent should <strong>in</strong>clude <strong>the</strong> risk of treatment failure<br />

(especially <strong>in</strong> severe SUI and post-radio<strong>the</strong>rapy) and decrease of treatment benefits<br />

over time. They should only be performed at specialized post-prostatectomy<br />

<strong>in</strong>cont<strong>in</strong>ence Units which offer alternative treatment options <strong>in</strong>clud<strong>in</strong>g artificial ur<strong>in</strong>ary<br />

sph<strong>in</strong>cters. Surgeons should submit all patient data to <strong>the</strong> registry of <strong>the</strong> British<br />

Association of Urological Surgeons (BAUS). Key outcomes considered should<br />

<strong>in</strong>clude <strong>in</strong>cont<strong>in</strong>ence reduction, patient satisfaction and quality of life, effect duration<br />

and residual volume.


www.bjui.org. Atlas of Surgery<br />

Method<br />

Before surgery active <strong>in</strong>fection is excluded. Antibiotic prophylaxis aga<strong>in</strong>st gram<br />

positives, gram negatives and anaerobes is given on <strong>in</strong>duction <strong>in</strong> <strong>the</strong>atre. The patient<br />

is placed <strong>in</strong> a dorsal lithotomy position with legs bent at 90 degrees and slightly<br />

abducted. Sterile preparation of <strong>the</strong> per<strong>in</strong>eal, genital and gro<strong>in</strong> areas and drap<strong>in</strong>g of<br />

<strong>the</strong> operative field leaves <strong>the</strong> latter exposed with <strong>the</strong> anus excluded.<br />

AMS 1<br />

3


www.bjui.org. Atlas of Surgery<br />

Cystourethroscopy is used to confirm normal anatomy of <strong>the</strong> bladder and urethra. It<br />

also allows assessment of <strong>urethral</strong> bulb mobility, with <strong>the</strong> <strong>in</strong>dex f<strong>in</strong>ger gently push<strong>in</strong>g<br />

<strong>the</strong> <strong>urethral</strong> bulb forward. This simple f<strong>in</strong>ger test simulates <strong>the</strong> anterior relocation of<br />

<strong>the</strong> <strong>urethral</strong> bulb as will be achieved <strong>by</strong> implantation of <strong>the</strong> AdVance TM Sl<strong>in</strong>g.<br />

Below Open bulbar urethra as seen dur<strong>in</strong>g cystourethroscopy.<br />

Below Good coaptation dur<strong>in</strong>g <strong>the</strong> f<strong>in</strong>ger test, push<strong>in</strong>g <strong>the</strong> bulbar urethra anteriorly.<br />

4


www.bjui.org. Atlas of Surgery<br />

The bladder is emptied at <strong>the</strong> end of cystourethroscopy. A <strong>urethral</strong> Foley ca<strong>the</strong>ter is<br />

<strong>in</strong>serted. A 5-7cm lower per<strong>in</strong>eal midl<strong>in</strong>e <strong>in</strong>cision close to <strong>the</strong> anus is made.<br />

The subcutaneous tissue is divided down onto <strong>the</strong> bulbospongiosus muscle.<br />

The latter is <strong>the</strong>n divided <strong>in</strong> <strong>the</strong> midl<strong>in</strong>e and opened up like a book.<br />

AMS 6<br />

5


www.bjui.org. Atlas of Surgery<br />

This exposes <strong>the</strong> corpora cavernosa and proximal <strong>urethral</strong> bulb. With a Foley<br />

ca<strong>the</strong>ter <strong>in</strong> situ <strong>the</strong> urethra is easily identifiable.<br />

AMS 7<br />

Urethral Bulb<br />

6


www.bjui.org. Atlas of Surgery<br />

Us<strong>in</strong>g blunt dissection <strong>the</strong> bulbocavernosus muscles and <strong>urethral</strong> bulb can be easily<br />

divided from <strong>the</strong> bulbospongiosus muscle.<br />

AMS 8<br />

Bulbospongiosus Muscle<br />

Urethral Bulb<br />

7


www.bjui.org. Atlas of Surgery<br />

The first fibers of <strong>the</strong> per<strong>in</strong>eal body are extensions of <strong>the</strong> superficial anal sph<strong>in</strong>cter.<br />

They can be cut without compromis<strong>in</strong>g <strong>the</strong> anal sph<strong>in</strong>cter <strong>in</strong>tegrity as its competence<br />

depends on <strong>the</strong> <strong>in</strong>tact <strong>in</strong>ternal sph<strong>in</strong>cter.<br />

AMS 9<br />

Superficial Fibres<br />

of Per<strong>in</strong>eal Body<br />

8


www.bjui.org. Atlas of Surgery<br />

After hav<strong>in</strong>g cut <strong>the</strong> superficial fibres <strong>the</strong> central tendon of <strong>the</strong> per<strong>in</strong>eal body is cut<br />

which is a clear dense nodule easy to palpate. Do not extend <strong>the</strong> <strong>in</strong>cision past <strong>the</strong><br />

per<strong>in</strong>eal body. This might cause <strong>the</strong> <strong>sl<strong>in</strong>g</strong> to slip past <strong>the</strong> <strong>urethral</strong> bulb.<br />

AMS 10<br />

Sufficient mobility can be demonstrated us<strong>in</strong>g a f<strong>in</strong>ger to push <strong>the</strong> bulb proximally.<br />

The idea is to fully mobilize <strong>the</strong> proximal <strong>urethral</strong> bulb up to <strong>the</strong> per<strong>in</strong>eal body.<br />

AMS 11<br />

9


www.bjui.org. Atlas of Surgery<br />

The dissection is advanced laterally <strong>in</strong> between <strong>the</strong> medial bulb and lateral corpora<br />

cavernosa and up to <strong>the</strong> central tendons on both sides us<strong>in</strong>g a ma<strong>in</strong>ly blunt<br />

technique with scissors.<br />

AMS 12<br />

Urethral Bulb<br />

Corpus Cavernosum<br />

10


www.bjui.org. Atlas of Surgery<br />

This allows to put a f<strong>in</strong>ger <strong>in</strong>to <strong>the</strong> upper triangular portion created <strong>by</strong> <strong>the</strong> lateral<br />

corpus cavernous and medial corpus spongiosum. This is where <strong>the</strong> <strong>in</strong>troducer<br />

needle is later received. In <strong>the</strong> apex of <strong>the</strong> triangle <strong>the</strong> under surface of <strong>the</strong> <strong>in</strong>ferior<br />

pubic ramus can be felt (<strong>the</strong> extension of <strong>the</strong> pudendal nerve onto <strong>the</strong> dorsal nerve of<br />

<strong>the</strong> penis runs just beh<strong>in</strong>d <strong>the</strong> corpora cavernosa).<br />

AMS 13<br />

Upper triangular portion<br />

11


www.bjui.org. Atlas of Surgery<br />

The <strong>in</strong>sertion of <strong>the</strong> adductor longus tendon is identified. It is well palpable with <strong>the</strong><br />

patient <strong>in</strong> lithotomy position. The medial border of <strong>the</strong> obturator fossa lies 1cm<br />

beneath and lateral. The ideal position to perforate is at <strong>the</strong> medial border <strong>in</strong> between<br />

<strong>the</strong> upper and lower thirds of <strong>the</strong> obturator fossa.<br />

AMS 14<br />

12


www.bjui.org. Atlas of Surgery<br />

Small stab <strong>in</strong>cisions are made 1cm below and lateral to <strong>the</strong> <strong>in</strong>sertion of <strong>the</strong> adductor<br />

longus tendon at <strong>the</strong> medial border of <strong>the</strong> obturator foramen.<br />

AMS 15<br />

Stab Incisions<br />

13


www.bjui.org. Atlas of Surgery<br />

A needle is used to probe <strong>the</strong> bone and help identify <strong>the</strong> po<strong>in</strong>t of entrance <strong>in</strong> <strong>the</strong><br />

medial obturator fossa.<br />

AMS 16<br />

The needles can be left <strong>in</strong> situ as direction guides before <strong>the</strong> <strong>in</strong>troducer needles are<br />

<strong>in</strong>serted.<br />

14


www.bjui.org. Atlas of Surgery<br />

The rotation of each <strong>in</strong>troducer needle is practiced <strong>in</strong> space above <strong>the</strong> patient to<br />

visualize <strong>the</strong> path and to ma<strong>in</strong>ta<strong>in</strong> a constant axis of rotation at about 45 degrees.<br />

Then <strong>the</strong> <strong>in</strong>troducer needle is passed through <strong>the</strong> stab <strong>in</strong>cision. Resistance is felt<br />

when <strong>the</strong> needle tip reaches <strong>the</strong> external obturator muscle and obturator membrane.<br />

A pop can be felt when <strong>the</strong> needle tip passes through. Some gentle f<strong>in</strong>ger pressure<br />

on <strong>the</strong> <strong>in</strong>troducer needle is usually necessary to achieve this.<br />

AMS 19<br />

Introducer Needle<br />

15


www.bjui.org. Atlas of Surgery<br />

The needle tip can be felt under <strong>the</strong> <strong>in</strong>ferior pubic ramus with <strong>the</strong> f<strong>in</strong>ger.<br />

AMS 20<br />

16


www.bjui.org. Atlas of Surgery<br />

Us<strong>in</strong>g a rotational movement of <strong>the</strong> <strong>in</strong>troducer needle <strong>the</strong> needle tip is guided <strong>by</strong> <strong>the</strong><br />

<strong>in</strong>dex f<strong>in</strong>ger <strong>in</strong>to apex of <strong>the</strong> triangular area formed <strong>by</strong> <strong>the</strong> corpus cavernosum and<br />

corpus spongiosum. There it can be seen exit<strong>in</strong>g <strong>in</strong>to <strong>the</strong> wound.<br />

AMS 21<br />

AMS 22<br />

Tip of<br />

Introducer Needle<br />

17


www.bjui.org. Atlas of Surgery<br />

One <strong>sl<strong>in</strong>g</strong> end is clipped onto <strong>the</strong> tip of <strong>the</strong> guidance needle. The <strong>sl<strong>in</strong>g</strong> tension<strong>in</strong>g<br />

sutures and blue dots should face away from <strong>the</strong> urethra.<br />

AMS 23<br />

By back rotation, <strong>the</strong> <strong>sl<strong>in</strong>g</strong> is pulled <strong>in</strong>to position. This may sometimes take some<br />

force.<br />

AMS 24<br />

Sl<strong>in</strong>g Exit<br />

Sl<strong>in</strong>g Entry<br />

18


www.bjui.org. Atlas of Surgery<br />

The same procedure is performed on <strong>the</strong> contralateral side after hav<strong>in</strong>g identified <strong>the</strong><br />

<strong>in</strong>sertion of <strong>the</strong> adductor longus tendon.<br />

AMS 25<br />

19


www.bjui.org. Atlas of Surgery<br />

AMS 26<br />

Tip of<br />

Introducer Needle<br />

20


www.bjui.org. Atlas of Surgery<br />

AMS 27<br />

Sl<strong>in</strong>g Ends<br />

Centre portion of Sl<strong>in</strong>g<br />

21


www.bjui.org. Atlas of Surgery<br />

The center portion of <strong>the</strong> <strong>sl<strong>in</strong>g</strong> is positioned over <strong>the</strong> proximal <strong>urethral</strong> bulb.<br />

AMS 28<br />

22


www.bjui.org. Atlas of Surgery<br />

There it is sutured <strong>in</strong> place with four tack<strong>in</strong>g sutures, two sutures proximally and two<br />

distally. The idea is to spread out <strong>the</strong> centre portion of <strong>the</strong> <strong>sl<strong>in</strong>g</strong> to prevent it from<br />

roll<strong>in</strong>g up or k<strong>in</strong>k<strong>in</strong>g.<br />

AMS 29<br />

Fixation Suture<br />

23


www.bjui.org. Atlas of Surgery<br />

AMS 30<br />

Both <strong>sl<strong>in</strong>g</strong> ends are pulled simultaneously to tension <strong>the</strong> <strong>sl<strong>in</strong>g</strong>. This aims at caus<strong>in</strong>g<br />

proximal relocation of <strong>the</strong> posterior surface of <strong>the</strong> proximal <strong>urethral</strong> bulb of about 2.5-<br />

3.5cm.<br />

AMS 31<br />

Simultaneous Pull<br />

of Sl<strong>in</strong>g Ends<br />

Fixation Suture<br />

24


www.bjui.org. Atlas of Surgery<br />

AMS 32<br />

For fur<strong>the</strong>r <strong>sl<strong>in</strong>g</strong> fixation can be achieved <strong>by</strong> creat<strong>in</strong>g a subcutaneous tunnel. The<br />

<strong>sl<strong>in</strong>g</strong> ends are cut level with <strong>the</strong> sk<strong>in</strong> mak<strong>in</strong>g sure <strong>the</strong>y are properly buried under <strong>the</strong><br />

sk<strong>in</strong>.<br />

AMS 33<br />

25


www.bjui.org. Atlas of Surgery<br />

AMS 34<br />

AMS 35<br />

26


www.bjui.org. Atlas of Surgery<br />

The dead space created <strong>by</strong> proximal relocation of <strong>the</strong> <strong>urethral</strong> bulb should be<br />

obliterated as much as possible before wound closure. In order to achieve this <strong>the</strong><br />

bulbospongiosus muscle is sutured <strong>in</strong> <strong>the</strong> midl<strong>in</strong>e.<br />

The wound is closed <strong>in</strong> layers<br />

.<br />

27


www.bjui.org. Atlas of Surgery<br />

AMS 38<br />

Trial without ca<strong>the</strong>ter 24-48 hours after surgery.<br />

He should restra<strong>in</strong> from strenuous exercise for 4-6 weeks, along with squatt<strong>in</strong>g,<br />

extreme leg spreads, climb<strong>in</strong>g and sexual activity.<br />

Insertion of <strong>the</strong> AdVance TM Sl<strong>in</strong>g system does not prevent future surgery <strong>in</strong> <strong>the</strong> form<br />

of artificial ur<strong>in</strong>ary sph<strong>in</strong>cter, InVance TM Sl<strong>in</strong>g or penile pros<strong>the</strong>sis implantation.<br />

References<br />

1 The National Institute for Health and Cl<strong>in</strong>ical Excellence (NICE): Sub<strong>urethral</strong><br />

syn<strong>the</strong>tic <strong>sl<strong>in</strong>g</strong> <strong>in</strong>sertion for stress ur<strong>in</strong>ary <strong>in</strong>cont<strong>in</strong>ence <strong>in</strong> men. March 2008.<br />

http://www.nice.org.uk/nicemedia/pdf/IPG256Guidance.pdf<br />

2 Comiter CV. (2005) The male per<strong>in</strong>eal <strong>sl<strong>in</strong>g</strong>: <strong>in</strong>termediate-term results.<br />

Neurourol. Urodyn. 24: 648-653.<br />

3 Fischer MC, Huckabay C, Nitti VW. (2007) The male per<strong>in</strong>eal <strong>sl<strong>in</strong>g</strong>:<br />

assessment and prediction of outcome. J Urol 177: 1414-1418.<br />

4 Castle EP, Andrews PE, Itano N et al. (2005) The male <strong>sl<strong>in</strong>g</strong> for postprostatectomy<br />

<strong>in</strong>cont<strong>in</strong>ence: mean follow-up of 18 months. J Urol 173: 1657-1660.<br />

5 Romano SV, Metrebian SE, Vaz F et al. (2006) An adjustable male <strong>sl<strong>in</strong>g</strong> for<br />

treat<strong>in</strong>g ur<strong>in</strong>ary <strong>in</strong>cont<strong>in</strong>ence after prostatectomy: a phase III multicenter trial. BJU<br />

International 97: 533-539.<br />

6 Fassi-Fehri H, Badet L, Cherass A et al. (2007) Efficacy of <strong>the</strong> InVance male<br />

<strong>sl<strong>in</strong>g</strong> <strong>in</strong> men with stress ur<strong>in</strong>ary <strong>in</strong>cont<strong>in</strong>ence. European Urology 51: 498-503.<br />

7 Samli M, S<strong>in</strong>gla AK. (2005) Absorbable versus nonabsorbable graft: outcome<br />

of bone anchored male <strong>sl<strong>in</strong>g</strong> for post-radical prostatectomy <strong>in</strong>cont<strong>in</strong>ence. J Urol 173:<br />

499-502.<br />

8 Schaeffer AJ, Clemens JQ, Ferrari M et al. (1998) The male bulbo<strong>urethral</strong><br />

<strong>sl<strong>in</strong>g</strong> procedure for post-radical prostatectomy <strong>in</strong>cont<strong>in</strong>ence. J Urol 159: 1510-1515.<br />

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