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<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery<br />

Volume 8 Number 1 <strong>April</strong> 2011<br />

The <strong>of</strong>ficial publication <strong>of</strong> the Association <strong>of</strong> Otorhinolaryngologists <strong>of</strong> India, <strong>Gujarat</strong> State Branch (AOI GSB)<br />

All rights owned by the Association <strong>of</strong> Otorhinolaryngologists <strong>of</strong> India, <strong>Gujarat</strong> State Branch ( AOI GSB )<br />

Editor - Dr. Vikas Sinha<br />

Address - Dean & Pr<strong>of</strong>essor E.N.T., M.P. Shah Medical College,<br />

Jamnagar-361008<br />

E - Mail - dr_sinhavikas@yahoo.co.in , Tel. Mobile - 09879579193<br />

STATEMENT OF OWNERSHIP AND OTHER PARTICULAR ABOUT GUJARAT JOURNAL OF<br />

OTORHINOLARYNGOLOGY AND HEAD AND NECK SURGERY<br />

1. Place <strong>of</strong> publication Jamnagar<br />

2. Periodicity <strong>of</strong> publication <strong>April</strong>- August-December<br />

3. Nationality <strong>of</strong> Editor / Publisher Indian<br />

4. Printer's Name & Address Jamnagar<br />

5. Editor's Name & Address Dr. Vikas Sinha<br />

Dean & Pr<strong>of</strong>essor E.N.T.,<br />

M.P. Shah Medical College,<br />

Jamnagar - 361 008.<br />

6. Publisher's Name & Address Published by Dr. Vikas Sinha , Hon. Editor on behalf <strong>of</strong><br />

Association <strong>of</strong> Otorhinolaryngologists <strong>of</strong> India,<br />

<strong>Gujarat</strong> State Branch ( AOI GSB )<br />

Hon. Sec. Dr. Heman B. Shah<br />

Yogeshwar Clinic, Pratap Road, Raopura<br />

Vadodara - 390 001 ( <strong>Gujarat</strong> )<br />

7. Name <strong>and</strong> address <strong>of</strong> Individual who own Association <strong>of</strong> Otorhinolaryngologists <strong>of</strong> India<br />

the Newspaper <strong>and</strong> Partners or Shareholders <strong>Gujarat</strong> State Branch ( AOI GSB )<br />

holding more than one percent <strong>of</strong> the total<br />

Capital<br />

I , Dr. Vikas Sinha hereby declare that the particular given above , are true to the best <strong>of</strong> my knowledge <strong>and</strong> belief.<br />

Date 01-04-2011 Dr. Vikas Sinha<br />

This journal does not guarantee directly or indirectly for the quality or efficiency <strong>of</strong> any product or services described in the<br />

advertisements in this issue which is purely commercial in nature.<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


From th desk <strong>of</strong> editor<br />

The journal is going strong with each passing issue. More <strong>and</strong> more research articles, case study <strong>and</strong> case reports are being sent to<br />

the editorial <strong>of</strong>fice. All the articles are being subjected to scrutiny by sending to the different reviewers across all over India <strong>and</strong><br />

abroad. Without reviewer approval no article is being published. By this way only journal is able to sustain good quality. This year<br />

it has been decided to publish the journal three times in a year. Although it is a big financial strain to the editorial team <strong>of</strong> journal<br />

but for the vertical <strong>and</strong> horizontal growth <strong>of</strong> the journal it became essential to increase the publication from two to three times in<br />

year, making effort to publish more frequently.<br />

Dr. Vikas Sinha<br />

Dean, Pr<strong>of</strong> E.N.T.<br />

Editor<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery<br />

Jamnagar<br />

Cell +91 9879579193, E mail dr_sinhavikas@yahoo.co.in<br />

Editorial Board <strong>of</strong> Gujart <strong>Journal</strong> <strong>of</strong><br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery<br />

Editor<br />

Dr. Vikas Sinha<br />

Treasurer<br />

Dr. Viral A. Chhaya<br />

Editorial Board Member<br />

Dr. Dilavar A. Barot<br />

Editorial Board Member<br />

Dr. Niral Modi<br />

Editorial Board Member<br />

Dr. Hiten Maniyar<br />

International Advisor<br />

Dr. Yong Ju Jang (South Korea)<br />

Dr. Wolfgang Gubisch (Germany)<br />

Dr. Prepageran (Malaysia)<br />

Dr. Khalid Mahida (Pakistan)<br />

Executive Committee <strong>of</strong> Association <strong>of</strong><br />

Otolaryngologists <strong>of</strong> India <strong>Gujarat</strong> State Branch<br />

(AOI GSB)<br />

President<br />

Dr. Atul Kansara<br />

Shalimar Complex, Paldi, Ahmedabad<br />

Cell 9825034050<br />

Vice President<br />

Dr. K. N. Pansara<br />

Pansara Hospital, Sumair Club Road,<br />

Jamnagar.<br />

Cell 07874122991<br />

Hony. Secretary<br />

Dr. Hemant Shah<br />

Yogeshwar Clinic, Pratap Road<br />

Raopura, Baroda<br />

Cell 9825335063<br />

Hony. Treasurer<br />

Dr. Jyoti Vaishnav<br />

Plot No. 4, Opp An<strong>and</strong> Park, Nr.Shabri School<br />

B/h Ishita Hospital Vasna Road, Vadodata<br />

Cell 9925033983<br />

Hony. Editor<br />

Dr. Vikas Sinha<br />

Dean, Pr<strong>of</strong>essor E.N.T.<br />

M.P.Shah medical College<br />

Jamnagar<br />

Cell 9879579193<br />

E Mail dr_sinhavikas@yahoo.co.in<br />

The views expressed in the article are entirely <strong>of</strong> individual author. The journal or editor bears no<br />

responsibility about authenticity <strong>of</strong> the article or otherwise any claim howsoever.<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery<br />

Volume 8 Number 1 <strong>April</strong> - 2011<br />

Editorial article<br />

Counseling the Parents <strong>of</strong> H<strong>and</strong>icapped Children- need <strong>of</strong> the hour<br />

Anu N. Nagarkar, Nitin M Nagarkar- Ch<strong>and</strong>igarh<br />

Main article<br />

Utility <strong>of</strong> fine needle aspiration cytology in the diagnosis <strong>and</strong> management <strong>of</strong> thyroid swellings<br />

Ajay George, Sharan kumar Shetty, Sanjay Kumar, Ranjan Kumar – Nalgonda ( A.P.)<br />

Bedside tracheostomy:experience <strong>of</strong> 100 cases<br />

Santosh U.P, Sanjay B Patil,Vinay Bhat, Sunil Pai,Deepak Janardhan– Davangere ( Karnataka)<br />

Tympanoplasty with <strong>and</strong> without cortical mastoidectomy for tubotympanic type <strong>of</strong> chronic suppurative<br />

otitis media.<br />

Shrinivas Shripatrao Chavan, Sunil Deshmukh, Vasant G. Pawar, Vaibhav G. Kirpan, Smita<br />

W .Khobragade, Kaustubh V Sarvade – Aurangabad (Maharashtra)<br />

A study <strong>of</strong> oto-acoustic emission (OAE) in 130 cases: a screening tool for hearing loss in children.<br />

Jaymin A. Contractor, Piyush M. Vaghmashi, Rahul B. Patel, Ishwar M. Chaudhari, Dilavar A.<br />

Barot, Neepa Jariwala- Surat (<strong>Gujarat</strong>)<br />

Endoscopic endonasal dacryocystorhinostomy: Outcome in 81 cases<br />

Sharan kumar Shetty, Ajay George,Sanjay Kumar ,Ranjan Kumar – Nalgonda ( A.P.)<br />

A study <strong>of</strong> the corelation <strong>of</strong> the clinical features, radiological evaluation <strong>and</strong> operative findings in chronic<br />

suppurative otitis media with cholesteatoma<br />

Santosh U.P, S.M Siddalingappa, Sheeba Mathew, Vinay Bhat, Deepak Janardhan- Davangere<br />

(Karnataka)<br />

Tumours <strong>of</strong> maxilla<br />

Darshan V Doshi, J. A. Contractor, I. K. Aditya- Ahmedabad, Surat (<strong>Gujarat</strong>)<br />

Aetiological Study <strong>of</strong> 100 Cases <strong>of</strong> Hoarseness <strong>of</strong> Voice<br />

Harvinder Kumar, Sonia Seth, Deep Kishore -Hisar (Haryana)<br />

Case report<br />

Malignant external otitis – an atypical presentation <strong>and</strong> management dilemma<br />

George A. Mathew, Kamal Kishore- Ludhiana (Punjab)<br />

Bilateral parotid abscess in a neonate<br />

Madhavi S..Raibagkar, Meeta R. Bathla, Vipul M. Patel, Vikas Arora- Ahmedabad (<strong>Gujarat</strong>)<br />

Gingival granular cell tumour <strong>of</strong> newborn<br />

Tripti R.Chopade,M.V.Jagade, Ashish R.G<strong>and</strong>he, Dhyaneshwar Ahire-Mumbai (Maharashtra)<br />

ExtranasopharyngealAngi<strong>of</strong>iroma in Female<br />

Shrinivas Shripatrao Chavan ,Sunil D.Deshmukh ,Vasant G. Pawar, Vaibhav G. Kirpan ,<br />

SmitaW.,Khobragade Kaustubh,V.Sarvade,RajanBindu-Aurangabad ( Maharashtra)<br />

Hairy polyp <strong>of</strong> nasopharynx in adult<br />

Ajit Daharwal,Hansa Banjara,B. R. Singh,Digvijay Singh,S.Sarkar - Raipur (Chattisgarh)<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011<br />

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1<br />

Editorial Article<br />

Counseling the parents <strong>of</strong> h<strong>and</strong>icapped children- need <strong>of</strong> the hour<br />

1 2<br />

Anu N. Nagarkar , Nitin M Nagarkar - Ch<strong>and</strong>igarh<br />

Abstract<br />

Parents <strong>of</strong> children with serious illness <strong>and</strong> h<strong>and</strong>icap usually come in contact with representatives <strong>of</strong> several clinical<br />

pr<strong>of</strong>essions. Many <strong>of</strong> these clinicians may never think much about the trauma the parents <strong>and</strong> family members <strong>of</strong> such a<br />

child go through. The pr<strong>of</strong>essional interest in parent counseling seems negligible. This paper has been aimed at describing<br />

the role the pr<strong>of</strong>essionals can play in helping the parents <strong>of</strong> a h<strong>and</strong>icapped child come to terms with the reality <strong>and</strong> guide<br />

them as to what best can be done for their child. Key words: Counseling,Parents,Illness,H<strong>and</strong>icap<br />

Introduction<br />

No society has been as responsive as ours to the plea “Heal the<br />

hurt child”. While much more can <strong>and</strong> should be done, we are<br />

witnessing the fruits <strong>of</strong> an unparalled marshalling <strong>of</strong> the<br />

forces <strong>of</strong> related specialties in medicine, surgery, psychology,<br />

social work, rehabilitation <strong>and</strong> education for the care <strong>of</strong> the<br />

seriously ill or h<strong>and</strong>icapped child. Advances in molecular<br />

genetics research <strong>of</strong>fer, in genetic counseling, the prospect <strong>of</strong><br />

prevention <strong>of</strong> certain genetic errors; new <strong>and</strong> innovative<br />

diagnostic <strong>and</strong> remedial techniques are now being used in the<br />

prenatal period; other increasingly sophisticated diagnostic<br />

<strong>and</strong> treatment procedures are daily adding to our capability <strong>of</strong><br />

helping the child with a major illness or h<strong>and</strong>icap, but there is,<br />

<strong>of</strong> course, another side <strong>of</strong> the coin. There are many chronic<br />

illnesses <strong>and</strong> physical h<strong>and</strong>icaps for which the word cure is<br />

inapplicable <strong>and</strong> for which the goal <strong>of</strong> relative adaptation<br />

must be substituted.<br />

Various problems like congenital hearing loss, cerebral palsy,<br />

mental retardation, autism, specific language impairment fall<br />

under the purview <strong>of</strong> the pediatrician, otolaryngologist <strong>and</strong><br />

the audiologist/ speech & language pathologist. Breaking the<br />

news <strong>of</strong> a permanent h<strong>and</strong>icap <strong>of</strong> any sort to the parents <strong>of</strong> a<br />

new born baby is extremely traumatic. A counselor whether a<br />

pr<strong>of</strong>essional from psychology, a pediatrician or an<br />

audiologist/ speech & language pathologist has an important<br />

role to play at such times. But <strong>of</strong> equal or even more important<br />

is the content <strong>of</strong> our discussion. Counseling is a process <strong>of</strong><br />

helping parents overcome their conflicting attitudes towards<br />

their child, which is <strong>of</strong>ten a difficult <strong>and</strong> time consuming<br />

procedure.Need for Counseling Parents-Parents <strong>of</strong> children<br />

with h<strong>and</strong>icaps are just like other parents: they have their<br />

unique assets <strong>and</strong> liabilities, their own self concepts, their<br />

hopes <strong>and</strong> fantasies regarding their children. They had not<br />

expected that their child would be h<strong>and</strong>icapped. Each parent<br />

will bring to the situation his own differential perceptions <strong>of</strong><br />

the child <strong>and</strong> his h<strong>and</strong>icap, his own assets <strong>and</strong> limitations for<br />

h<strong>and</strong>ling his role in the situation. Some will accept the<br />

challenge with fervor <strong>and</strong> skill <strong>of</strong> remarkable proportions;<br />

others will be overwhelmed, guilt ridden <strong>and</strong> impotent. To<br />

most parents though it is painfully difficult, threatening <strong>and</strong><br />

highly ego-involving experience to face the reality <strong>of</strong><br />

h<strong>and</strong>icap in a child. In this situation they need a sympathetic<br />

<strong>and</strong> tactful pr<strong>of</strong>essional advice from the clinician in the form<br />

<strong>of</strong> counseling. Children reflect their parents' emotional <strong>and</strong><br />

social adjustment patterns. The child's disability is likely to<br />

adversely affect the parent's personality <strong>and</strong> adaptation. So to<br />

help the parents accept the h<strong>and</strong>icap/ disability <strong>of</strong> their child,<br />

counseling <strong>of</strong> the highest quality is a must.<br />

Process <strong>of</strong> Couneling-The clinician has to make an effort to<br />

give a true picture <strong>of</strong> the child's condition to the parents <strong>and</strong><br />

try to help them to achieve the best possible solution for it.<br />

Once the diagnosis has been made, the first response that<br />

follows is that <strong>of</strong> shock <strong>and</strong> disbelief. The clinician has to be<br />

very careful <strong>and</strong> considerate about their feelings.To work with<br />

these parents <strong>and</strong> their children with sympathy <strong>and</strong> respect,<br />

the clinician must remember that the child with a h<strong>and</strong>icap is<br />

still a child with feelings, needs, wishes <strong>and</strong> desires to which<br />

the parents will have to respond.<br />

Conclusion<br />

Parents are the linchpin <strong>of</strong> the family <strong>and</strong> counseling for the<br />

young newly diagnosed child with a h<strong>and</strong>icap needs to be<br />

directed to them. A proper counseling can add an element <strong>of</strong><br />

relief <strong>and</strong> success to the otherwise grim picture. Well prepared<br />

<strong>and</strong> well conducted discussion with parents is an important<br />

part <strong>of</strong> the treatment <strong>and</strong> rehabilitative process<br />

Address for Correspondence<br />

Dr. Nitin M.Nagarkar<br />

Pr<strong>of</strong> E.N.T , Govt. Medical College, Sector 32,Ch<strong>and</strong>igarh<br />

E mail: nitinanurishabh@yahoo.com<br />

Cell-+91 9646121546<br />

1 Speech Pathologist, Department <strong>of</strong> Otolaryngology, Postgraduate Institute <strong>of</strong> Medical Education & Research, Ch<strong>and</strong>igarh,<br />

2 Pr<strong>of</strong>essors, Department <strong>of</strong> Otolaryngology- <strong>Head</strong> & <strong>Neck</strong> Surgery, Government Medical College & Hospital, Ch<strong>and</strong>igarh<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


Introduction:<br />

The era <strong>of</strong> modern diagnostic cytopathology began with the<br />

publication in early 1940s by Drs G. Papanicolaou <strong>and</strong> H.<br />

Traut <strong>of</strong> their work on the cytological diagnosis <strong>of</strong> uterine<br />

1<br />

cancer . Since then fine needle aspiration cytology (FNAC) <strong>of</strong><br />

the thyroid gl<strong>and</strong> is firmly established as a first-line<br />

diagnostic test for the evaluation <strong>of</strong> goiter <strong>and</strong> the single most<br />

effective test for the pre-operative diagnosis <strong>of</strong> a solitary<br />

thyroid nodule. There is now a large body <strong>of</strong> world literature<br />

attesting to its accuracy <strong>and</strong> advantages, although the need for<br />

caution in interpretation, meticulous attention to technique<br />

2<br />

<strong>and</strong> the limitations <strong>of</strong> diagnosis are also well documented .<br />

The prevalence <strong>of</strong> palpable thyroid swellings in the<br />

population is about 4% <strong>and</strong> fewer than 5% <strong>of</strong> these are<br />

3<br />

malignant . The accuracy <strong>of</strong> clinical, biochemical <strong>and</strong><br />

radiological investigations in distinguishing between benign<br />

<strong>and</strong> malignant thyroid swellings is rather poor. FNAC can<br />

reliably confirm benignity in about two-thirds <strong>of</strong> benign<br />

swellings. The potential benefits <strong>of</strong> reducing unnecessary<br />

surgery <strong>and</strong> reducing costs for benign lesions in this way are<br />

4<br />

obvious .<br />

In this study we propose to study the utility <strong>of</strong> FNAC in the<br />

management <strong>of</strong> patients with thyroid swellings.<br />

Aim:To verify the efficacy <strong>of</strong> fine needle aspiration cytology<br />

in the diagnosis <strong>and</strong> management <strong>of</strong> thyroid swellings.<br />

Materials <strong>and</strong> methods:<br />

The study was conducted during a 16 month period from<br />

January, 2009 to <strong>April</strong>, 2010.<br />

2<br />

Main Article<br />

Utility <strong>of</strong> fine needle aspiration cytology in the diagnosis <strong>and</strong> management <strong>of</strong> thyroid swellings<br />

1 2 3 4<br />

Ajay George ,Sharan kumar Shetty ,Sanjay Kumar ,Ranjan Kumar - Nalgonga (A.P.)<br />

Abstract<br />

Introduction: Thyroid swellings affect about 4% <strong>of</strong> the population. Fine needle aspiration cytology (FNAC) is an<br />

established diagnostic modality in the management <strong>of</strong> thyroid swellings. Aim: To verify the utility <strong>of</strong> FNAC in the<br />

diagnosis <strong>and</strong> management <strong>of</strong> thyroid swellings. Materials <strong>and</strong> Methods: All cases <strong>of</strong> thyroid swelling presenting to our<br />

OPD during a 16 month period from January, 2009 to <strong>April</strong>, 2010 were included in the study regardless <strong>of</strong> age <strong>and</strong> sex. All<br />

cases were thoroughly examined <strong>and</strong> investigated by FNAC, ultrasonography <strong>of</strong> neck <strong>and</strong> thyroid function test. Patients<br />

requiring surgery were operated <strong>and</strong> the surgical specimen was sent for histopathological examination. Observations:<br />

Thyroid swellings were very common in female <strong>and</strong> most commonly presented in the third decade <strong>of</strong> life. The commonest<br />

FNAC diagnosis was colloid goiter. Confirmed malignancy was noted in 6 cases. Aspirate was inadequate for an opinion in<br />

11 cases. Histopathological confirmation was done in the operated cases. It showed an accuracy rate <strong>of</strong> 75.89% for FNAC.<br />

Conclusion: FNAC is the gold st<strong>and</strong>ard in the diagnosis <strong>of</strong> thyroid swellings.<br />

Key words: Goiter, Fine needle aspiration cytology.<br />

Inclusion critera-All cases <strong>of</strong> thyroid swellings presenting or<br />

referred to the ENT out patient department.Patients <strong>of</strong> both<br />

sexes.Patients <strong>of</strong> all age groups. Exclusion critera-<strong>Neck</strong><br />

swellings due to any other pathology like lymphadenopathy.<br />

After taking a detailed clinical history, all cases underwent a<br />

thorough ENT <strong>and</strong> head <strong>and</strong> neck examination. The clinical<br />

findings were recorded <strong>and</strong> then the patients were referred for<br />

fine needle aspiration cytology to the department <strong>of</strong><br />

pathology. For FNAC, the patients were kept in the supine<br />

position with a pillow under the shoulder to make the thyroid<br />

swelling prominent. 25 or 27 gauge needle was used for the<br />

aspiration. Depending on the size <strong>of</strong> the lesion, 2 – 4 passes<br />

were made with the needle using different angles or points <strong>of</strong><br />

2<br />

entry . The FNAC specimens were immediately alcohol –<br />

fixed to preserve their cellular characteristics.<br />

Thyroid function tests like T3, T4 <strong>and</strong> TSH were also ordered<br />

for. Ultrasonography <strong>of</strong> the neck was done to visualize the<br />

nature <strong>and</strong> extent <strong>of</strong> thyroid swelling, the lobe involvement<br />

<strong>and</strong> effect on surrounding great vessels <strong>and</strong> other important<br />

anatomical structures.<br />

Depending on the nature <strong>of</strong> the goiter as reported in FNAC<br />

<strong>and</strong> depending on the thyroid function status decision was<br />

taken regarding need for surgery <strong>and</strong> the extent <strong>of</strong> surgery.<br />

Patients requiring thyroid surgery but having altered thyroid<br />

function status were stabilized medically before posting for<br />

surgery. The main indications <strong>of</strong> surgery included the report<br />

<strong>of</strong> neoplasia, multinodular goiter <strong>and</strong> large solitary nodules<br />

causing cosmetic deformity or compression symptoms. least<br />

1,2 3,4<br />

Associate Pr<strong>of</strong>essor, Assistant pr<strong>of</strong>essor,<br />

Kamineni Institute <strong>of</strong> Medical Sciences, Sreepuram, Narketpally, Nalgonda,A.P.<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


number <strong>of</strong> cases i.e. 2 cases in each age group.<br />

Patients with Hashimoto's thyroiditis were kept on follow up<br />

<strong>and</strong> given symptomatic treatment as per individual<br />

requirements. Some cases <strong>of</strong> Hashimoto's thyroiditis with<br />

ungainly appearance <strong>of</strong> thyroid swelling <strong>and</strong> complaining <strong>of</strong><br />

pain even after stabilization by hormone therapy were also<br />

operated on request <strong>of</strong> the patient. The surgical specimen was<br />

sent for histopathological examination. The histopathology<br />

report was compared with the FNAC report to look for<br />

discrepancies. All results were collected, tabulated <strong>and</strong><br />

analyzed.<br />

Observations <strong>and</strong> discussion:<br />

Based on the above inclusion <strong>and</strong> exclusion criteria, a total <strong>of</strong><br />

190 cases were included during the period <strong>of</strong> the study. Out <strong>of</strong><br />

these 169 cases were female <strong>and</strong> the remaining male. This<br />

overwhelming predominance <strong>of</strong> female in diseases thyroid is<br />

a well known fact <strong>and</strong> has been documented in many studies<br />

5<br />

<strong>and</strong> text books . The age distribution was as shown in Table<br />

No. 1. The commonest age group <strong>of</strong> presentation <strong>of</strong> thyroid<br />

swellings was the 21 – 30 years group accounting for a third <strong>of</strong><br />

the cases. The second <strong>and</strong> fourth decades <strong>of</strong> life also had<br />

significant number <strong>of</strong> patients with 36 (18.95%) <strong>and</strong> 44<br />

(23.16%) cases respectively. The groups <strong>of</strong> extremes <strong>of</strong> age<br />

like the first decade <strong>and</strong> the over sixty years age group had the<br />

least number <strong>of</strong> cases i.e. 2 cases in each age group.<br />

The FNAC report showed a maximum <strong>of</strong> 77 (40.52%) cases<br />

<strong>of</strong> colloid goiter. Out <strong>of</strong> these cases 51 cases were <strong>of</strong> nodular<br />

goiter whereas 26 cases had diffuse collide goiter. The next<br />

commonest diagnosis was Hashimoto's thyroiditis with 72<br />

cases (37.89%). Follicular neoplasia was diagnosed in15<br />

cases. Confirmed malignant lesions were reported in 6 cases,<br />

which included 4 cases <strong>of</strong> papillary carcinoma, <strong>and</strong> 1 case<br />

each <strong>of</strong> medullary carcinoma <strong>and</strong> anaplastic carcinoma. There<br />

were 9 cases <strong>of</strong> cysts which got reduced on aspiration. In 11<br />

cases (5.77%) the aspirated material was found to be<br />

inadequate for reporting. Published data suggests the rate <strong>of</strong><br />

6, 7<br />

inadequate samples to be in the range <strong>of</strong> 9% - 31% . Use <strong>of</strong><br />

ancillary techniques like ultra sonography guided FNAC <strong>of</strong><br />

thyroid has been shown to reduce the proportion <strong>of</strong><br />

8<br />

indeterminate samples .<br />

Thyroid function test report revealed euthyroid state in 137<br />

cases. 31 cases were hypothyroid <strong>and</strong> the remaining 22 cases<br />

were hyperthyroid. Ultrasonography <strong>of</strong> the neck revealed<br />

thyroid enlargement in all cases. There was diffuse<br />

enlargement in 106 cases. Solitary thyroid nodule was<br />

revealed in 54 cases. There was multinodular enlargement in<br />

the remaining 30 cases. There was displacement <strong>of</strong> the great<br />

vessels <strong>of</strong> neck by the thyroid swelling in 21 cases. In 3 cases<br />

there was also lymph node enlargement most likely due to<br />

metastases from malignant thyroid lesion.<br />

3<br />

Surgery was chosen as the mode <strong>of</strong> treatment in 112 cases.<br />

These included 67 cases <strong>of</strong> colloid goiter, 12 cases <strong>of</strong><br />

Hashimoto's thyroiditis who had ungainly <strong>and</strong> painful neck<br />

swelling inspite <strong>of</strong> stabilization on thyroxine<br />

supplementation. All the cases <strong>of</strong> neoplasia were also<br />

operated upon. <strong>Neck</strong> dissection was done together with the<br />

thyroidectomy in the 3 cases with lymph node involvement.<br />

Out <strong>of</strong> the 11 cases with indeterminate FNAC report 9 were<br />

operated upon. 3 cases <strong>of</strong> thyroid cyst were also operated<br />

upon as they were filling up repeatedly after aspiration.<br />

Though contemporary literature is very clear that the<br />

optimum managment <strong>of</strong> Hashimoto's thyroiditis is by<br />

thyroxine, there have been reports where thyroidectomy has<br />

9, 10<br />

been done for Hashimoto's thyroiditis . The indication for<br />

surgery in these reports was painful swelling.<br />

Histopathology report <strong>of</strong> the surgical specimen revealed<br />

colloid goiter in 71 cases, Hashimoto's thyroiditis in 12 cases,<br />

follicular adenoma in 17 cases, follicular carcinoma in 3 cases<br />

<strong>and</strong> thyroid cyst in 3 cases. The 6 cases <strong>of</strong> malignancy<br />

detected by FNAC were confirmed after histopathology. A<br />

different diagnosis from that reported by FNAC was noted in<br />

3 cases. These included 2 cases <strong>of</strong> colloid goiter <strong>and</strong> one case<br />

<strong>of</strong> Hashmoto's thyroiditis which were found to be follicular<br />

adenoma. Out <strong>of</strong> the 15 cases <strong>of</strong> follicular neoplasia reported<br />

on FNAC, 12 had follicular adenoma <strong>and</strong> the remaining three<br />

had carcinoma. Out <strong>of</strong> the 9 cases in which no diagnosis could<br />

be reached by FNAC, 6 cases turned out to be colloid goiter. 2<br />

cases had follicular adenoma <strong>and</strong> the remaining 1 case had<br />

Hashimoto's thyroiditis. Traditionally it has been<br />

contentiously believed that most <strong>of</strong> the cases which are<br />

11<br />

indeterminate by FNAC turn out to be follicular neoplasia .<br />

In our study majority <strong>of</strong> these cases i.e. two thirds <strong>of</strong> them<br />

turned out to be colloid goiters. Thus 9 cases out <strong>of</strong> the 112<br />

cases (8.05%) with histopathological confirmation turned out<br />

to be malignancy. This is somewhat more than the 3.9%<br />

12<br />

reported by Lin et al in their large series <strong>of</strong> over 21,000 cases.<br />

The smaller sample size <strong>of</strong> the present study could be the<br />

cause <strong>of</strong> this discrepancy.What is most notable here is that in<br />

the present study FNAC did not miss any case <strong>of</strong> malignancy<br />

other than follicular which anyway cannot be diagnosed by<br />

FNAC. What is even more notable is that there also were no<br />

false positives as far as malignancy was concerned. But this<br />

accuracy <strong>of</strong> 100% achieved in the present study is somewhat<br />

on the higher side. Contemporary literature on this topic<br />

13, 14<br />

report accuracy in the range <strong>of</strong> 80% .<br />

Thus in the present study FNAC could give a conclusive <strong>and</strong><br />

correct diagnosis in 85 out <strong>of</strong> the 112 cases on which full data<br />

is available. This gives an accuracy rate <strong>of</strong> 75.89%. The<br />

accuracy rate achieved in our study compares favorably with<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


15 16<br />

that achieved by Bajaj et al (74.3%) <strong>and</strong> Morgan et al.<br />

(67.2%).<br />

Conclusion<br />

Fine needle aspiration cytology is a very useful investigation<br />

in the diagnosis <strong>and</strong> management <strong>of</strong> thyroid swellings. It<br />

gives precise information for the decision making regarding<br />

surgery for goiter. The pitfalls in the use <strong>of</strong> FNAC in thyroid<br />

swellings are well known <strong>and</strong> well documented <strong>and</strong> hence can<br />

be anticipated. The use <strong>of</strong> ancillary techniques together with<br />

FNAC <strong>and</strong> clinical co-relation can further optimize the utility<br />

<strong>of</strong> FNAC in the diagnosis <strong>and</strong> management <strong>of</strong> thyroid<br />

swellings.<br />

References<br />

1. Grunze H., Spriggs AI. History <strong>of</strong> clinical cytology – a<br />

selection <strong>of</strong> documents. Darmstadt: E. Giebeler; 1980.<br />

2. Thyroid. In: Orell S.R., Sterrett G.F., Whitaker D. Fine<br />

Needle Aspiration Cytology. 4th edn. New Delhi:<br />

Elsevier; 2005; p.125.<br />

3. Gharib H., Goellener JR. Fine-needle aspiration biopsy<br />

<strong>of</strong> the thyroid: an appraisal. Ann Intern Med. 1993; 118:<br />

282 – 289.<br />

4. Melcher NL. To operate or not to operate? The value <strong>of</strong><br />

fine needle aspiration cytology in the assessment <strong>of</strong><br />

thyroid swellings. J Clin Pathol. 1997; 50: 941 – 943.<br />

5. Shaheen O.H. The thyroid gl<strong>and</strong>. In: Hibbert J. ed.<br />

Scott-Brown's Otolaryngology. 6th edn. Oxford:<br />

Butterworth-Heinemann; 1997; p. 5/18/7.<br />

6. Caraway NP, Sniege N, Samaan NA. Diagnostic<br />

pitfalls in thyroid fine needle aspiration: a review <strong>of</strong><br />

394 cases. Diag. Cytopathology.1993, 9:345-350.<br />

7. Burch HB, Burman KP, Reed HL et al. Fine needle<br />

aspiration biopsy <strong>of</strong> thyroid nodules: determinants <strong>of</strong><br />

insufficiency rate <strong>and</strong> malignancy yield at<br />

thyoiddectomy. Acta Cyto.1996, 40:1176-1183.<br />

8. Cai XJ, Valiyaparambath N, Nixon P. et al. Ultrasoundguided<br />

fine needle aspiration cytology in the diagnosis<br />

<strong>and</strong> management <strong>of</strong> thyroid nodules. Cytopathology.<br />

2006 Oct;17(5):251-6.<br />

9. Ohye H, Fukata S, Kubota S. et al. Successful<br />

treatment for recurrent painful Hashimoto's thyroiditis<br />

by total thyroidectomy. Thyroid. 2005 Apr;15(4):340-5.<br />

10. Kon YC, DeGroot LJ. Painful Hashimoto's thyroiditis<br />

as an indication for thyroidectomy: clinical<br />

characteristics <strong>and</strong> outcome in seven patients.J Clin<br />

Endocrinol Metab. 2003 Jun;88(6):2667-72.<br />

11. Pang T, Gill A, McMullen T. et al. Correlation between<br />

indeterminate aspiration cytology <strong>and</strong> final<br />

histopathology <strong>of</strong> thyroid neoplasms. Surgery. 2010 Mar<br />

15. [Epub ahead <strong>of</strong> print.<br />

12. Lin JD, Chao TC, Huang BY et al. Thyroid cancer in<br />

4<br />

the thyroid nodules evaluated by ultrasonography <strong>and</strong><br />

fine-needle aspiration cytology. Thyroid. 2005 Jul;<br />

15(7):708-17.<br />

13. B. Mundasad, I. Mcallister, J. Carson et al. Accuracy<br />

Of Fine Needle Aspiration Cytology In Diagnosis Of<br />

Thyroid Swellings. The Internet <strong>Journal</strong> <strong>of</strong><br />

Endocrinology. 2006; 2(2).<br />

14. Cap J, Ryska A, Rehorkova P, Hovorkova E, et al.<br />

Sensitivity <strong>and</strong> specifity <strong>of</strong> the fine needle aspiration<br />

biopsy <strong>of</strong> the thyroid: clinical point <strong>of</strong> view. Clinical<br />

Endocrinology 1999, 51(4):509-51.<br />

15. Bajaj Y., De M., Thompson A. Fine needle aspiration<br />

cytology in diagnosis <strong>and</strong> management <strong>of</strong> thyroid<br />

diseases. J. Laryngol. Otol. 2006 Jun; 120(6): 467 – 9.<br />

16. Morgan JL, Serpell JW, Cheng MS. Fine-needle<br />

aspiration cytology <strong>of</strong> thyroid nodules: how useful it<br />

is? ANZ J. Surg. 2003 Jul; 73(7): 480-3.<br />

Address for correspondence<br />

Ajay George<br />

Department <strong>of</strong> ENT,<br />

Kamineni Institute <strong>of</strong> Medical Sciences, Sreepuram,<br />

Narketpally, Nalgonda,Andhra Pradesh – 508254.<br />

E mail – doc_ajay@yahoo.com ,Cell+918980178187<br />

35th Annual Conference <strong>of</strong><br />

Otolaryngologists <strong>of</strong> India<br />

<strong>Gujarat</strong> State Branch<br />

Rajpath Club Ahmedabad.<br />

th th th<br />

16 ,17 , 18 December 2011.<br />

Organising Chairman<br />

Dr. Atul Kansara<br />

Organising Secretary<br />

Dr. Navin Patel, Dr. Kalpesh Patel.<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


5<br />

Main Article<br />

Bedside tracheostomy:experience <strong>of</strong> 100 cases<br />

1 2 3 4 5<br />

Santosh U.P , Sanjay B Patil , Vinay Bhat , Sunil Pai , Deepak Janardhan – Davangere (Karnataka)<br />

Abstract<br />

Introduction: Tracheostomy is probably the most common surgical procedure performed on critically ill patients.<br />

Approximately 10 percent <strong>of</strong> mechanically ventilated critically ill patients undergo tracheostomy to facilitate prolonged airway<br />

<strong>and</strong> ventilatory support. Traditionally elective tracheostomies have been performed in operating room by using st<strong>and</strong>ard<br />

surgical techniques originally described by Jackson. The concept <strong>of</strong> bedside tracheostomy is attractive <strong>and</strong> surgeons have<br />

started performing open bedside tracheostomy. It is found to be safe in selected patients. The primary objective <strong>of</strong> this study was<br />

to determine safety <strong>of</strong> bedside tracheostomy in patients under prolonged mechanical ventilation.<br />

Materials <strong>and</strong> methods: It is a descriptive study conducted in two hospitals <strong>of</strong> Davangere (India) for the period <strong>of</strong> five years<br />

between <strong>April</strong> 2005 <strong>and</strong> January 2010. . Bedside open tracheostomy was performed in patients under prolonged mechanical<br />

ventilation by conventional open surgical technique under local anesthesia with patient's vitals <strong>and</strong> oxygen saturation being<br />

monitored by an intensivist. Complications <strong>of</strong> bedside tracheostomy were recorded for up to 60 days after the procedure.<br />

Results: During the study period total <strong>of</strong> 100 patients underwent bedside tracheostomy during the course <strong>of</strong> mechanical<br />

ventilation. Reasons for mechanical ventilation in above patients included poly trauma, head injury, organo-phosphorous<br />

poisoning, hanging, stroke, multi organ failure with septicemia, dengue encephalitis, ARDS <strong>and</strong> Rheumatic heart disease in<br />

respiratory failure. Overall 10 patients developed complications during the study period.<br />

Conclusion: In patients with prolonged mechanical ventilation, bedside tracheostomy seems to be safe, simple <strong>and</strong> least<br />

expensive procedure <strong>and</strong> should always be considered as an option for these patients<br />

Keywords: Bedside tracheostomy, Mechanical ventilation, complications<br />

Introduction<br />

Tracheostomy is probably the most common surgical<br />

procedure performed on critically ill patients. Approximately<br />

10 percent <strong>of</strong> mechanically ventilated critically ill patients<br />

undergo tracheostomy to facilitate prolonged airway <strong>and</strong><br />

1<br />

ventilatory support . Most critically ill patients with<br />

respiratory failure tolerate tracheal intubation for short<br />

duration with minimal complications, but longer duration (><br />

1week) <strong>of</strong> mechanical ventilation will have adverse<br />

2<br />

outcomes . Several new interventions such as low tidal<br />

volume ventilation, patient positioning, weaning <strong>and</strong><br />

sedation protocols have been adopted to reduce the morbidity<br />

<strong>and</strong> mortality in patients with prolonged mechanical<br />

3<br />

ventilation . However tracheostomy is electively performed<br />

in many critically ill patients requiring prolonged mechanical<br />

ventilation or frequent broncho-pulmonary toilet or to help<br />

with weaning from mechanical ventilation. It is better<br />

tolerated than oral or nasal tracheal intubation <strong>and</strong> is thought<br />

to reduce sedation requirements <strong>and</strong> time in the intensive care<br />

unit (ICU).<br />

Traditionally elective tracheostomies have been performed in<br />

operating room by using st<strong>and</strong>ard surgical techniques<br />

originally described by Jackson. The concept <strong>of</strong> bedside<br />

tracheostomy is attractive <strong>and</strong> surgeons have started<br />

performing open bedside tracheostomy. It is found to be safe<br />

in selected patients.The primary objective <strong>of</strong> this study was to<br />

determine safety <strong>of</strong> bedside tracheostomy in patients under<br />

prolonged mechanical ventilation.<br />

Material <strong>and</strong> Method<br />

It is a descriptive study conducted in two hospitals <strong>of</strong><br />

Davangere (India) for the period <strong>of</strong> five years between <strong>April</strong><br />

2005 <strong>and</strong> January 2010. During the study prior to bedside<br />

tracheostomy brief history <strong>of</strong> the patients were noted with<br />

special emphasis on indications for mechanical ventilation<br />

<strong>and</strong> duration <strong>of</strong> mechanical ventilation. A general physical<br />

<strong>and</strong> systemic examination was carried out <strong>and</strong> thorough local<br />

examination <strong>of</strong> the neck was done. Appropriate investigations<br />

were ordered prior to tracheostomy with special emphasis on<br />

coagulation pr<strong>of</strong>ile. Informed consent was taken for the<br />

procedure from the patient's relative. Bedside open<br />

tracheostomy was performed by conventional open surgical<br />

technique under local anesthesia with patient's vitals <strong>and</strong><br />

oxygen saturation being monitored by an intensivist. Duration<br />

<strong>of</strong> the procedure <strong>and</strong> peri-operative complications were<br />

1 2 3,4,5<br />

Pr<strong>of</strong>essor, Reader, Residents, Department Of <strong>Otorhinolaryngology</strong> ,<br />

J.J.M. Medical College Davangere,Karnataka<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


noted. Cuffed tracheostomy tubes (Portex®) were used in all<br />

patients <strong>and</strong> tube size varied from 7.0 to 9.0. Proper<br />

positioning <strong>of</strong> the tube was confirmed by demonstrating<br />

symmetrical movement <strong>of</strong> chest wall <strong>and</strong> maintenance <strong>of</strong><br />

normal airway pressures, expiratory volumes <strong>and</strong> satisfactory<br />

oxygen saturation with a pulse oxymeter. Chest radiography<br />

was obtained on the first post-operative day to confirm proper<br />

positioning <strong>of</strong> tracheostomy tube <strong>and</strong> to exclude<br />

pneumothorax. Complications <strong>of</strong> bedside tracheostomy were<br />

recorded for up to 60 days after the procedure. Complications<br />

were classified as early complications, for events directly<br />

related to the surgical procedure occurring during<br />

tracheostomy tube placement <strong>and</strong> up to 24 hours after the<br />

procedure. Late complications included those occurring<br />

during the hospital stay or at home after discharge. Each<br />

complication was classified as major or minor according to its<br />

clinical relevance <strong>and</strong> whether or not it was life threatening.<br />

Patient's relatives were educated by the intensivist <strong>and</strong> ICU<br />

nurse regarding routine tracheostomy care, changing the<br />

tracheostomy tube <strong>and</strong> possible complications that could be<br />

experienced <strong>and</strong> their management. Patients needing short<br />

term tracheostomy were decannulated before discharge.<br />

Patients who maintained oxygen saturation <strong>of</strong> more than 90<br />

percent in room air were considered to be eligible for<br />

decannulation. Other patients were followed up regularly to<br />

determine the necessity for continuation <strong>of</strong> tracheostomy.<br />

When primary pathology allowed decannulation, it was<br />

performed in hospital setting.<br />

were ordered prior to tracheostomy with special emphasis on<br />

coagulation pr<strong>of</strong>ile. Informed consent was taken for the<br />

procedure from the patient's relative. Bedside open<br />

tracheostomy was performed by conventional open surgical<br />

technique under local anesthesia with patient's vitals <strong>and</strong><br />

oxygen saturation being monitored by an intensivist.<br />

Duration <strong>of</strong> the procedure <strong>and</strong> peri-operative complications<br />

were noted. Cuffed tracheostomy tubes (Portex®) were used<br />

in all patients <strong>and</strong> tube size varied from 7.0 to 9.0. Proper<br />

positioning <strong>of</strong> the tube was confirmed by demonstrating<br />

symmetrical movement <strong>of</strong> chest wall <strong>and</strong> maintenance <strong>of</strong><br />

normal airway pressures, expiratory volumes <strong>and</strong> satisfactory<br />

oxygen saturation with a pulse oxymeter. Chest radiography<br />

was obtained on the first post-operative day to confirm proper<br />

positioning <strong>of</strong> tracheostomy tube <strong>and</strong> to exclude<br />

pneumothorax. Complications <strong>of</strong> bedside tracheostomy were<br />

recorded for up to 60 days after the procedure. Complications<br />

were classified as early complications, for events directly<br />

related to the surgical procedure occurring during<br />

tracheostomy tube placement <strong>and</strong> up to 24 hours after the<br />

procedure. Late complications included those occurring<br />

6<br />

during the hospital stay or at home after discharge. Each<br />

complication was classified as major or minor according to its<br />

clinical relevance <strong>and</strong> whether or not it was life threatening.<br />

Patient's relatives were educated by the intensivist <strong>and</strong> ICU<br />

nurse regarding routine tracheostomy care, changing the<br />

tracheostomy tube <strong>and</strong> possible complications that could be<br />

experienced <strong>and</strong> their management. Patients needing short<br />

term tracheostomy were decannulated before discharge.<br />

Patients who maintained oxygen saturation <strong>of</strong> more than 90<br />

percent in room air were considered to be eligible for<br />

decannulation. Other patients were followed up regularly to<br />

determine the necessity for continuation <strong>of</strong> tracheostomy.<br />

When primary pathology allowed decannulation, it was<br />

performed in hospital setting.<br />

Results<br />

During the study period total <strong>of</strong> hundred patients underwent<br />

bedside tracheostomy during the course <strong>of</strong> mechanical<br />

ventilation. Reasons for mechanical ventilation in above<br />

patients included poly trauma, head injury, organophosphorous<br />

poisoning, hanging, <strong>and</strong> stroke, multi organ<br />

failure with septicemia, dengue encephalitis, ARDS <strong>and</strong><br />

Rheumatic heart disease in respiratory failure<br />

In the study group seventyeight patients were male <strong>and</strong><br />

twentytwo were female with male to female ratio <strong>of</strong> 3.5:1,<br />

Youngest being eighteen years <strong>and</strong> oldest eightyfive years.<br />

Median incubation period before tracheostomy was seven<br />

days with range being 5-28 days. Overall 10 patients<br />

developed complications. Three patients developed early<br />

complications <strong>and</strong> all were major complications. One patient<br />

developed cardiac arrest during the procedure <strong>and</strong> patient was<br />

revived successfully then procedure was completed. One<br />

patient developed surgical emphysema involving face, neck<br />

<strong>and</strong> upper chest during first post operative day. It was<br />

managed conservatively <strong>and</strong> it subsided after three days.<br />

Difficulty in placement <strong>of</strong> tracheostomy tube was<br />

encountered in one patient for whom small sized tube was<br />

placed successfully. Seven patients developed late<br />

complications <strong>of</strong> which four were major <strong>and</strong> three were<br />

minor. Major complications included pneumothorax <strong>and</strong><br />

tracheo-oesophageal fistula, where as minor complications<br />

included bleeding from tracheostomy site <strong>and</strong> tracheocutaneous<br />

fistula. Pneumothorax was managed by placement<br />

<strong>of</strong> intercostal drainage tube. Patients with tracheooesophageal<br />

fistula were referred to thoracic surgeon for<br />

further management. Bleeding from tracheostomy site was<br />

managed by ligation <strong>of</strong> bleeding vessels. Trachea-cutaneous<br />

fistula was repaired by excision <strong>of</strong> fistulous tract <strong>and</strong><br />

secondary suturing. During the time <strong>of</strong> this presentation<br />

seventu two patients were alive <strong>and</strong> successfully<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


decannulated. Thirteen patients are still alive with<br />

tracheostomy tube. Total <strong>of</strong> fifteen patients succumbed to<br />

their underlying primary disease.<br />

Discussion<br />

Tracheostomy is performed primarily in critically ill patients<br />

who require prolonged mechanical ventilation <strong>and</strong>/or in<br />

whom multiple attempts in weaning from mechanical<br />

4<br />

ventilation have been unsuccessful for 14-21 days .<br />

Tracheostomy facilitates weaning by decreasing the work <strong>of</strong><br />

5<br />

breathing in patients with limited respiratory reserve .<br />

Tracheostomy reduces sedation requirements <strong>and</strong> allows for<br />

early patient mobilization <strong>and</strong> feeding. Prolonged tracheal<br />

intubation has been associated with hazards such as ventilator<br />

associated pneumonia, subglottic stenosis <strong>and</strong> adverse effects<br />

6<br />

<strong>of</strong> persistent sedation. In a study conducted by Pena et al 86<br />

percent <strong>of</strong> all patients presenting with subglottic stenosis had<br />

prior history <strong>of</strong> prolonged tracheal intubation with a mean<br />

duration <strong>of</strong> 17 days. The optimal timing for tracheostomy in<br />

patients under mechanical ventilation is still controversial <strong>and</strong><br />

the current trend seems to be early tracheostomy usually<br />

carried out within 7 days <strong>of</strong> tracheal intubation. Previously<br />

tracheostomy was traditionally performed by open technique<br />

in operating room. Performing surgical tracheostomy on<br />

bedside in ICU setup eliminates the need for transporting<br />

critically ill patients to the operating room. In this way<br />

hazards like emergency intubations <strong>and</strong> detachments <strong>of</strong> the<br />

vascular line can be avoided <strong>and</strong> the patient is not subjected to<br />

inconvenience <strong>of</strong> transportation.<br />

Various studies have been undertaken to compare the benefits<br />

<strong>and</strong> complications <strong>of</strong> tracheostomy <strong>and</strong> prolonged tracheal<br />

7<br />

intubation in mechanically ventilated patients. Stauffer et al<br />

conducted a study comparing complications <strong>of</strong> early<br />

tracheostomy with complications <strong>of</strong> prolonged tracheal<br />

intubation <strong>and</strong> concluded that complication rate <strong>of</strong><br />

tracheostomy was more <strong>and</strong> severe. They recommended not<br />

to undertake tracheostomy for initial 3 weeks <strong>of</strong> mechanical<br />

8<br />

ventilatory support.Hefner et al advocated tracheostomy in<br />

patients who were expected to require more than one week <strong>of</strong><br />

9<br />

mechanical ventelation. Brooks et al found that the duration<br />

<strong>of</strong> mechanical ventilation <strong>and</strong> total cost <strong>of</strong> hospitalization<br />

were significanty lower in early tracheostomy group. In our<br />

series overall complication rate was 10 % <strong>of</strong> which 6 % were<br />

major <strong>and</strong> 4 % were minor. None <strong>of</strong> our patients succumbed to<br />

complications directly related to the procedure. In our study ,<br />

the difficulties encountered during bedside procedure, were<br />

practically nil due to the cumulative experience <strong>and</strong><br />

teamwork <strong>of</strong> nursing staff <strong>and</strong> the respiratory therapist, along<br />

with the improved monitoring facilities. Though additional<br />

resources have been utilized in terms <strong>of</strong> staff <strong>and</strong> materials,<br />

the costs <strong>and</strong> risks associated with transport <strong>of</strong> critically ill<br />

patients were avoided. Moreover, improved utilization <strong>of</strong> OT<br />

time <strong>and</strong> avoidance <strong>of</strong> delays in treatment was achieved with<br />

flexibility <strong>of</strong> being available to perform bedside tracheostomy<br />

.However absence <strong>of</strong> control group limits the power <strong>of</strong> our<br />

conclusions <strong>and</strong> absence <strong>of</strong> some information such as<br />

APACHE II scores, ventilatory parameters, coagulation<br />

disorders <strong>and</strong> intra-operative bleeding quantification<br />

weakens our conclusions. A study which considers the above<br />

parameters would allow statistical analysis <strong>and</strong> would be <strong>of</strong><br />

great interest.<br />

7<br />

Conclusion<br />

Bedside tracheostomy, though old fashioned, it is the<br />

simplest, safest <strong>and</strong> least expensive procedure, equivalent to<br />

that being undertaken in operation theatres, provided sound<br />

<strong>and</strong> consistent technique is adopted, especially in patients<br />

with prolonged mechanical ventilation.<br />

References<br />

1. Frutos-Vivar F, Esteban A, Apezteguía C, Anzueto A,<br />

Nightingale P, González M, Soto L, Rodrigo C, Raad J,<br />

David CM, Matamis D, D' Empaire G, International<br />

Mechanical Ventilation Study Group: Outcome <strong>of</strong><br />

mechanically ventilated patients who require a<br />

tracheostomy. Crit Care Med 2005, 33:290-298.<br />

2. Hubmayr RD, Burchardi H, Elliot M, et al, American<br />

Thoracic Society Assembly on Critical Care, European<br />

Respiratory Society, European Society <strong>of</strong> Intensive Care<br />

Medicine, Societe de Reanimation de Langue Francaise.<br />

Statement <strong>of</strong> the 4th International Consensus Conference<br />

in Critical Care on ICU-Acquired Pneumonia—Chicago,<br />

Illinois, May 2002. Intensive Care Med. 2002;28:1521-<br />

1536<br />

3. Acute Respiratory Distress Syndrome Network.<br />

Ventilation with lower tidal volumes as compared with<br />

traditional tidal volumes for acute lung injury <strong>and</strong> the<br />

acute respiratory distress syndrome. N Engl J Med.<br />

2000;342:1301-1308.<br />

4. Heffner JE. The role <strong>of</strong> tracheotomy in weaning. Chest.<br />

2001;120(6,suppl):477S-481S.<br />

5. Davis K Jr, Campbell RS, Johannigman JA, Valente JF,<br />

Branson RD. Changes in respiratory mechanics after<br />

tracheostomy. Arch Surg. 1999;134: 59-62.<br />

6. Pena J, Cicero R, Marin J, Ramirez M, Cruz S, Navarro F.<br />

Laryngotracheal reconstruction in subglottic stenosis: an<br />

ancient problem still present. Otolaryngol <strong>Head</strong> <strong>Neck</strong><br />

Surg. 2001;125:397-400.<br />

7. Stauffer JL, Olson DE, Petty TL. Complications <strong>and</strong><br />

consequences <strong>of</strong> endotracheal intubation <strong>and</strong><br />

tracheotomy: a prospective study <strong>of</strong> 150 critically ill adult<br />

patients. Am J Med. 1981;70:65 76.<br />

8. Heffner JE. Timin tracheotomy : calender watching or<br />

individualization <strong>of</strong> care ? [editorial] Chest 1998 : 114:<br />

361-363<br />

9. Brook AD, Sherman G, Malen J. Kollef. Early versus late<br />

tracheostomy in patients who require prolonged<br />

mechanical vntilation. Am J Crit Care. 2009:9:352-359.<br />

Address for correspondence<br />

Dr. Santosh U.P<br />

'SAAVAN' No 4123<br />

th<br />

14 cross, Anjaneya layout<br />

DAVANGERE -577004<br />

PH-0091-8192-222422,<br />

CELL-0091-9845155223<br />

Email – drsantoshup@gmail.com<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


8<br />

Main Article<br />

Tympanoplasty with <strong>and</strong> without cortical mastoidectomy for tubotympanic type <strong>of</strong> chronic<br />

suppurative otitis media.<br />

1 2 3 4<br />

Shrinivas Shripatrao Chavan , Sunil D .Deshmukh , Vasant G. Pawar , Vaibhav G. Kirpan , Smita W<br />

5 6<br />

.Khobragade , Kaustubh V Sarvade – Aurangabad (Maharashtra)<br />

Abstract: There are various theories for surgical management for; Chronic suppurative otitis media(C.S.O.M.). One theory<br />

suggest cortical mastoidectomy combined with tympanoplasty is helpful for both dry <strong>and</strong> wet ear, the second theory suggest<br />

cortical mastoidectomy with tympanoplasty is helpful for discharging ear but not for dry ear <strong>and</strong> the third theory suggests<br />

cortical mastoidectomy is not helpful either for dry ear <strong>and</strong> discharging ear. The purpose <strong>of</strong> this study is to compare the surgical<br />

outcome <strong>of</strong> tympanoplasty verses cortical mastoidectomy with tympanoplasty done for tubotymapnic type <strong>of</strong> C.S.O.M.<br />

Study design : Retrospective design.<br />

Setting: Tertiary referral hospital .<br />

Patient <strong>and</strong> Method: 150 cases <strong>of</strong> C.S.O.M. underwent surgery tympanoplasty with cortical mastoidectomy [75 cases ] Group A<br />

<strong>and</strong> tympanoplasty without cortical mastoidectomy [75 cases ] Group B . The results were analyzed at 2 weeks, 1 months <strong>and</strong> 4<br />

th<br />

months post operative follow up. The success rate <strong>of</strong> surgical outcome was judged by graft uptake at 4 month follow up by<br />

doing otoscopic examination <strong>and</strong> EUM on every postoperative visit.<br />

Results: 150 cases <strong>of</strong> Tubotympanic type <strong>of</strong> C.S.O.M. were operated. The mean age was 28 years. There was male<br />

preponderance. The X ray mastoid Schuller's view showed sclerotic mastoid in 140 (93.33%) cases. 75 cases were operated by<br />

doing Tympanoplasty without cortical mastoidectomy <strong>and</strong> another 75 cases were operated by tympanoplasty with cortical<br />

nd<br />

mastoidectomy. The success rate was 100% in both the study group at 2 week <strong>of</strong> postoperative follow up. At 1 month <strong>of</strong><br />

postoperative follow up the success rate was 100 % in tympanoplasty with cortical mastoidectomy <strong>and</strong> 97.33 % in<br />

tympanoplasty without cortical mastoidectomy. At 4th month the success rate was 97.33 % in tympanoplasty with cortical<br />

mastoidectomy <strong>and</strong> 93.33 % in tympanoplasty without cortical mastoidectomy.<br />

Keywords: Tubotympanic type; Chronic Suppurative Otitis Media ; Tympanoplasty ; with <strong>and</strong> without cortical mastoidectomy.<br />

Introduction:<br />

C.S.O.M. defined as chronic infection confined to middle ear<br />

mucosal cleft which is composed <strong>of</strong> eustachain tube,<br />

hypotympanum , mesotympanum , epitympanum, aditus <strong>and</strong><br />

mastoid air cells. Clinically three varieties <strong>of</strong> C.S.O.M has<br />

described 1] Tubotympanic type 2] Atticoantral type 3]<br />

[1]<br />

Tuberculous type. Perforation is a breach in integrity <strong>of</strong><br />

tympanic membrane <strong>and</strong> is nature mechanism to achieve<br />

.[2]<br />

ventilation in face <strong>of</strong> middle ear inflammation The surgical<br />

application <strong>of</strong> the operating microscope, first by Nylen in<br />

1921 as a monocular instrument, <strong>and</strong> then by Holmgren, who<br />

introduced the binocular operating microscope in 1922,was<br />

an important advance destined to play an increasing role in the<br />

.[3]<br />

perfection <strong>of</strong> technique <strong>of</strong> tympanoplasty The surgical<br />

methods <strong>and</strong> indication <strong>of</strong> tympanoplasty have come a long<br />

way since the days <strong>of</strong> Wullestein who in year 1953 coined <strong>and</strong><br />

described tympanoplasty as repair <strong>of</strong> the tympanic<br />

[4,5]<br />

membrane using spilt thickness graft. In the following year<br />

much modification took place in surgical steps <strong>of</strong><br />

tympanoplasty <strong>and</strong> so is the use high end operating<br />

microscope <strong>and</strong> microsurgical instrument so tympanoplasty<br />

had redefined by American Academy <strong>of</strong> Otolaryngology <strong>and</strong><br />

Ophthalmology subcommittee on conservation <strong>of</strong> hearing as a<br />

procedure to eradicate disease in middle ear <strong>and</strong> to reconstruct<br />

[6]<br />

hearing mechanism. The two opposing dem<strong>and</strong>s <strong>of</strong><br />

tympanoplasty namely eradicate the disease <strong>and</strong> at the same<br />

phase trying to maintain as much as normal tissue as possible<br />

to facilitate reconstruction <strong>of</strong> hearing mechanism is a<br />

dem<strong>and</strong>ing task. As long as the infection is lurking in <strong>and</strong><br />

around the middle ear cleft <strong>and</strong> mastoid antrum any attempt at<br />

[2]<br />

reconstruction may seem futile. In this context cortical<br />

mastoidectomy seem to be an integral part <strong>of</strong> every<br />

tympanoplasty. Schwartz was the first who described cortical<br />

[7]<br />

mastoidectomy. The aim <strong>of</strong> our study is to share our<br />

experience by comparing results <strong>of</strong> tympanoplasty with<br />

cortical mastoidectomy verses tympanoplasty without<br />

1 2 3 4,5,6<br />

Assistant Pr<strong>of</strong>. Pr<strong>of</strong> & <strong>Head</strong>, Sr. Resident, Resident, Govt. Medical college, Aurangabad (M.S.)<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


cortical mastoidectomy done for tubotympanic type <strong>of</strong><br />

CSOM.<br />

Materials <strong>and</strong> Methods:<br />

A retrospective study was conducted by <strong>Otorhinolaryngology</strong><br />

department <strong>of</strong> Government Medical College <strong>and</strong> hospital<br />

Aurangabad from a period <strong>of</strong> Sep 2008 to Sep 2010. The<br />

inclusion criteria <strong>of</strong> our study patient were tubotympanic type<br />

<strong>of</strong> C.S.O.M., central <strong>and</strong> subtotal type <strong>of</strong> perforation, mild<br />

<strong>and</strong> moderate hearing loss <strong>and</strong> sclerotic mastoid depicted by<br />

X ray mastoid. While exclusion criteria were atticoantral type<br />

<strong>of</strong> C.S.O.M., total <strong>and</strong> marginal perforation, severe <strong>and</strong><br />

pr<strong>of</strong>ound hearing loss, revision tympanoplasty. A<br />

preoperative preparation <strong>of</strong> all the cases were done by giving<br />

them antibiotics, antihistaminics , topical antibiotics <strong>and</strong><br />

instructed them to keep the ear dry by frequently changing the<br />

sterile cotton plug in the diseased ear in an aim to achieve dry<br />

ear preoperatively. A series <strong>of</strong> 150 patient were included in<br />

our study among which 80(53.33%) were males <strong>and</strong><br />

70(46.66%) were females between the age group <strong>of</strong> 18 to 70<br />

years. The pools <strong>of</strong> patients were r<strong>and</strong>omized into two groups.<br />

A group A [n = 75] consisting <strong>of</strong> tympanoplasty with cortical<br />

mastoidectomy <strong>and</strong> group B[n = 75] consisting <strong>of</strong><br />

tympanoplasty without cortical mastoidectomy. All patients<br />

were operated under general anaesthesia. The preoperative<br />

preparation <strong>of</strong> disease ear was done by shaving the mastoid<br />

area. The area was prepared <strong>and</strong> draped. The local infiltration<br />

in a form <strong>of</strong> 2% lignocaine with adrenaline was given. The<br />

Retroauricular (Wildes) incision was taken using scalpel<br />

blade No 20. The temporalis fascia graft was harvested. The<br />

meatotomy was done using scalpel blade No 15. Now further<br />

surgical steps were done under high end microscope. The<br />

perforation margin was refreshened by using sickle knife <strong>and</strong><br />

Bulluchi scissors. The TM flap elevated by circular knife. The<br />

annulus was lifted from posterior superior side by sickle<br />

knife. The chorda tympani nerve was delineated. The incudostapeadial<br />

joint mobility was tested. In Group B the<br />

temporalis fascia graft was placed by under lay technique.<br />

The air insufflation in the middle ear was done by elevating<br />

the TM flap with temporalis fascia graft <strong>and</strong> reposting. In the<br />

Group A, 25 patients showed mucus otitis media [glue ear]<br />

intra operatively on elevating the TM flap. The cortical<br />

mastoidectomy was done in the entire group A patient. The<br />

temporalis fascia was placed by under lay technique. In both<br />

the group while placing the temporalis fascia graft the<br />

anaesthetist were told to shut <strong>of</strong>f the nitrous oxide gas supply<br />

to patient so as to avoid diffusion <strong>of</strong> gas in middle ear <strong>and</strong> to<br />

avoid graft displacement. The medicated gelfoam was placed<br />

in the external auditory canal. The suturing was done <strong>and</strong><br />

mastoid dressing was given.<br />

9<br />

Postoperative care <strong>and</strong> followup : Patient was kept on<br />

intravenous antibiotics <strong>and</strong> oral antihitaminics <strong>and</strong> analgesic<br />

for two days in the ward. The mastoid dressing was changed<br />

nd<br />

after 48 hours. The patient was discharged on 2 day with oral<br />

antibiotics, analgesic <strong>and</strong> antihistamines. The patient were<br />

instructed to drape the operative ear while taking bath, Avoid<br />

forceful blowing on the nose,abstinence from travelling high<br />

<strong>and</strong> low altitude,not to carry heavy weight,avoid swimming<br />

<strong>and</strong> water sport activity.All patient were ask to follow up on<br />

th th<br />

7th <strong>and</strong> 15 day <strong>and</strong> at 1st <strong>and</strong> 4th month. On 7 day the<br />

sutured were removed <strong>and</strong> topical instillation <strong>of</strong> medicated<br />

ear drop was advised. On every follow up visit otoscopic<br />

th<br />

examination was done. The PTA was done on 6 week <strong>of</strong><br />

postoperatively.<br />

Results <strong>and</strong> analysis:<br />

Following the study interval all the data required was<br />

compiled. The objective assessment was done by means <strong>of</strong><br />

otoscopic examination <strong>and</strong> EUM. The operation was<br />

considered to be successful after uptake <strong>of</strong> graft on 4th month<br />

follow up by doing otoscopic examination <strong>and</strong> EUM. Of 150<br />

patients, 70 (46.66%) were females <strong>and</strong> 80 (53.33%) were<br />

males. The mean age <strong>of</strong> presentation was 28 years. All the<br />

patients had otorrhoea as their chief complaints followed by<br />

hearing loss. Out <strong>of</strong> 150 cases, 72(48%) had right ear<br />

involvement <strong>and</strong> 78(52%) had left ear involvement. During<br />

the intraoperative <strong>and</strong> immediate postoperative period <strong>and</strong> on<br />

each follow up visit, we have checked for any surgical<br />

th th<br />

complication. All patients were followed up on 7 <strong>and</strong> 15<br />

st th<br />

postoperative day <strong>and</strong> 1 <strong>and</strong> 4 month with otoscopic<br />

th<br />

examination <strong>and</strong> EUM. On 7 day follow up only soaked gel<br />

th<br />

foam was seen in external ear canal, no graft was seen. On 15<br />

postoperative day, all the patients had graft in place along with<br />

soaked gel foam on EUM with 100% graft uptake. At 1st<br />

month follow up success rate <strong>of</strong> patient who had undergone<br />

tympanoplasty with mastoidectomy was 100%, whereas that<br />

<strong>of</strong> patient who had undergone tympanoplasty without cortical<br />

mastoidectomy was 97.33%. At 4 month follow up success<br />

rate <strong>of</strong> Tympanoplasty with Cortical Mastoidectomy was<br />

97.33% <strong>and</strong> that <strong>of</strong> tympanoplasty without cortical<br />

mastoidectomy was 93.33%.the total failure rate was found to<br />

be 9.33%.<br />

Discussion:<br />

Chronic suppurative otitis media is the result <strong>of</strong> acute<br />

suppurative otitis media which has left permanent perforation<br />

.None <strong>of</strong> the literature shows that, doing cortical<br />

mastoidectomy in tubotympanic type <strong>of</strong> chronic suppurative<br />

otitis media has better outcome than tympanoplasty without<br />

cortical mastoidectomy. Tubotympanic disease is common in<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


oth children <strong>and</strong> in adults .There is no any sex preponderance<br />

<strong>and</strong> no any side preponderance seen. Out <strong>of</strong> 150 patients, we<br />

had 80(53.33%) male patients <strong>and</strong> 70(46.66%) female<br />

patients .Our mean age <strong>of</strong> presentation was 28 years, <strong>and</strong><br />

nd rd<br />

common in 2 <strong>and</strong> 3 decade.We did tympanoplasty with<br />

mastoidectomy in 75 patients (Group A) <strong>and</strong> tympanoplasty<br />

without mastoidectomy in remaining 75 patients (Group B).<br />

th th<br />

All the patients were followed up at 7 day, 15 day, 1st month<br />

<strong>and</strong> 4th month postoperative day. Otoscopic examination<br />

th<br />

was carried out to see the status <strong>of</strong> graft. At 7 day follow up,<br />

th<br />

only soaked gel foam was seen. At 15 postoperative day<br />

follow up, all the patients showed 100% graft uptake along<br />

with soaked gel foam. As the days progressed, success rate <strong>of</strong><br />

tympanoplasty without cortical mastoidectomy has fallen<br />

down which was 97.33% at one month follow up <strong>and</strong> 93.33%<br />

th<br />

at 4th month follow up. In group A success rate at 15 day <strong>and</strong><br />

1 month follow up was 100%<strong>and</strong> at four month follow up was<br />

97.33%. Graft uptake was 100% in 25(33.33%) patients<br />

having glue ear intraoperatively, in whom cortical<br />

mastoidectomy was carried out.<br />

At the end <strong>of</strong> the study the total graft failure rate was 9.33%<br />

only which was really insignificant <strong>and</strong> that was because <strong>of</strong><br />

repeated upper respiratory tract infection .Graft failure was<br />

the complication seen in patients with tympanoplatsy with<br />

cortical mastoidectomy as well as in patients with<br />

tympanoplatsy without mastoidectomy. Out <strong>of</strong> 75 patients in<br />

whom tympanoplasty with cortical mastoidectomy was<br />

carried out, 8(10.66%) patients complaining <strong>of</strong> giddiness<br />

postoperatively were managed with labyrinthine sedatives.<br />

Out <strong>of</strong> eight patients who received injection stemetil only one<br />

had extrapyramidal symptoms (neck rigidity) <strong>and</strong>, relieved<br />

with withdrawal <strong>of</strong> medication. One(1.33%) patient had<br />

Grade II facial palsy due to excessive heat produced by burr<br />

while drilling the densely sclerosed mastoid which recovered<br />

nd<br />

on 2 postoperative day, as patient was kept on steroids for<br />

seven days. 14(18.66%) patients were had loss <strong>of</strong> taste<br />

sensation due to secondary damage to chorda tympani nerve<br />

.Our 25(33.33%) patients in whom tympanoplasty without<br />

cortical mastoidectomy was carried out, showed good<br />

improvement in hearing from severe to moderate conductive<br />

hearing loss to mild to moderate hearing loss .No significant<br />

hearing improvement was noticed in patients in whom<br />

tympanoplasty with cortical mastoidectomy was done.<br />

Conclusion:<br />

There was no significant difference in graft uptake with<br />

tympanoplasty with cortical mastoidectomy as compared to<br />

tympanoplasty without mastoidectomy.Cortical<br />

Mastoidectomy does not <strong>of</strong>fer significant hearing<br />

improvement .In the Group B 25(33.33%) cases who had<br />

10<br />

moderate to severe hearing loss preoperatively have mild to<br />

moderate hearing loss postoperatively.Postoperative<br />

complications in tubotympanic type <strong>of</strong> CSOM are more with<br />

tymanoplasty with cortical mastoidectomy as compared with<br />

tympanoplasty without cortical mastoidectomy.<br />

Postoperative care should be taken to avoid upper respiratory<br />

infection which is one <strong>of</strong> the most common cause <strong>of</strong> graft<br />

rejection.For glue ear cortical mastoidectomy is preferred to<br />

avoid lurking in middle ear cleft as there was 100% graft<br />

uptake in 25(33.33%) patients with glue ear. Aerating the<br />

sclerosed mastoid does not have significant importance in<br />

uptake <strong>of</strong> graft as the results were almost same in both type <strong>of</strong><br />

study group.<br />

References:<br />

1. I. Simso Hall.BernardH.Colman.Disease <strong>of</strong> nose, throat,<br />

ear.<br />

2. AnitaKrishnan, E.K.Reddy, C.Ch<strong>and</strong>rakiran,<br />

K.M.Nalinesha <strong>and</strong> P.M.Jagganath.Indian <strong>Journal</strong> <strong>of</strong><br />

Otolaryngology <strong>and</strong> <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery 2002<br />

Volume 54,Number 3,195-198.<br />

3. NylenCO.microscope in aural surgery,its first use <strong>and</strong><br />

development, ACTAOtolaryng,a suppet.1954;116:226-<br />

240.<br />

4. Wullstein H.(Technic <strong>and</strong> early results <strong>of</strong><br />

tympanoplasty)MonatsschrOhrenheilkdLarynorhinol<br />

1953;87(4):308-311.<br />

5. Wullstein H.Funktionelle operation in mittelohrmithilfe<br />

des freionspaltlappen-transplantates.ArchOhren-Nasen-<br />

U Kehlkophf 1952; 161:422.<br />

6. Committee on Conservation <strong>of</strong> Hearing, American<br />

A c a d e m y o f O p h t h a l m o l o g y a n d<br />

Otolaryngology.St<strong>and</strong>ard classification for surgery<br />

chronic ear disease.ArchOtol 1965; 81:204.<br />

7. Zollner F. (Surgical technics for the improvement <strong>of</strong><br />

sound conductin after radical operation ).Arch Ital<br />

Otol.Rhinol Laringol 1953;64(4):455-468.<br />

Address for correspondence<br />

Dr. Shrinivas Shripatrao Chavan<br />

Assistant Pr<strong>of</strong>esso E.N.T. <strong>and</strong> <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery<br />

Govt. Medical College<br />

Aurangabad ( M.S.)<br />

E Mail : shrinivasc77@hotmail.com<br />

Cell +91 9403151515<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


11<br />

Main Article<br />

A study <strong>of</strong> oto-acoustic emissions (OAE) in 130 cases: a screening tool for hearing loss in children.<br />

1 2 3 4<br />

Jaymin A. Contractor ,Piyush M. Vaghmashi ,Rahul B. Patel ,Ishwar M. Chaudhari , Dilavar<br />

5 6<br />

A. Barot ,Neepa Jariwala - Surat (<strong>Gujarat</strong>)<br />

Abstract<br />

Hearing loss is the most common birth anomaly, affecting approximately 3 per 1000 live births <strong>and</strong> <strong>of</strong> these 20% have a<br />

pr<strong>of</strong>ound loss. Aims <strong>of</strong> the study were to screen all newborn <strong>and</strong> children with age 5 years or less, for hearingloss & to find<br />

congenital incidence <strong>of</strong> hearingloss <strong>of</strong> newborns & children in tertiary referral hospital. 39.23% (51) c<strong>and</strong>idates presented with<br />

st st<br />

'REFER' on 1 test out <strong>of</strong> which 14.61% were unilateral & 24.61 % were bilateral. On doing 1 retest at 1 month on these 51<br />

nd<br />

c<strong>and</strong>idates it was found that 9.23% (12) remain 'REFER' out <strong>of</strong> which 1.53% was unilateral & 7.69 % bilateral. On doing 2<br />

nd<br />

retest at 2 month on these 12 c<strong>and</strong>idates it was found that 3.84% (5) remained 'REFER' which was bilateral. Out <strong>of</strong> these 5<br />

c<strong>and</strong>idates only 1 came for BERA, which was suggestive <strong>of</strong> bilateral SNHL (0.76%)<br />

Key Words: OAE, hearing loss<br />

Introduction<br />

Hearing loss is the most common birth anomaly, affecting<br />

approximately 3 per 1000 live births <strong>and</strong> <strong>of</strong> these 20% have a<br />

pr<strong>of</strong>ound loss. These children are unable to hear speech<br />

sounds. Although hearing loss is one <strong>of</strong> the most common<br />

birth anomalies, the concept <strong>of</strong> universal new born screening<br />

has not been implemented in India. It's m<strong>and</strong>atory to get the<br />

newborn screened at birth in most <strong>of</strong> the developed countries<br />

<strong>and</strong> it's become st<strong>and</strong>ard <strong>of</strong> care. We still have high risk<br />

newborn screening, which misses up to 50% <strong>of</strong> newborns till<br />

school going age. This would mean they remain undiagnosed<br />

up to 4-5 years <strong>of</strong> age. This period being critical as the central<br />

auditory pathway gets developed by 5 years.<br />

If the hearing loss is not diagnosed until the child is 2 to 3<br />

years old, the emotional <strong>and</strong> social damage can be<br />

longst<strong>and</strong>ing. It can also impair language development. The<br />

most critical stage <strong>of</strong> language development occurs before 6<br />

months <strong>of</strong> age. This is sometimes referred to as a “critical<br />

period” for speech <strong>and</strong> language development. How can we<br />

go about having Universal Hearing Screening programme<br />

implemented? We are such a big nation with so many<br />

languages.We have a good National Immunization<br />

Programme in place, so the health worker responsible for it<br />

can be trained to look for hearing by performing a simple test<br />

like the ball pen click test. It is done by introducing a sound <strong>of</strong><br />

a ball pen click an inch from the ears. When compare to<br />

audiometry as the gold st<strong>and</strong>ard, the test has a good average<br />

<strong>and</strong> an accuracy <strong>of</strong> 98.9% for 1,000 ears.Those kids who fail<br />

this test can be sent for a detailed hearing evaluation with an<br />

1 3 4 6<br />

advised appropriate intervention in the form <strong>of</strong> hearing<br />

aids.So, let's make a difference in the child hearing<br />

impairment <strong>and</strong> prevent deafmutism.<br />

Aims & Objectives:<br />

1. To Screen all newborn <strong>and</strong> children with age 5 years or<br />

less, for hearing loss.<br />

2. To find incidence <strong>of</strong> congenital hearing loss <strong>of</strong> newborns<br />

& children in tertiary referral Hospital.<br />

Methods:<br />

This is a prospective study <strong>of</strong> 130 patients carried out at<br />

Department <strong>of</strong> ENT-HNS, Government Medical College,<br />

New Civil Hospital, Surat. Total 130 newborns <strong>and</strong> children<br />

aged 5 years or less seen in OPD or admitted in wards <strong>of</strong> New<br />

Civil Hospital, Surat have been included in the study. Only<br />

those c<strong>and</strong>idates having intact tympanic membrane were<br />

included in this study.<br />

Our college has Human Research Ethics Committee which<br />

approved our study. We clearly mentioned the following<br />

ethical issues in the application for approval <strong>of</strong> this study by<br />

the committee: After OAE children suspected <strong>of</strong> having<br />

hearing loss will have to be further investigated (By BERA,<br />

CT Scan etc.) for exact etiology, amount <strong>and</strong> management <strong>of</strong><br />

hearing loss. This may cause anxiety & stress in some parents<br />

& guardians even though prior to OAE they have been<br />

counseled regarding benefit <strong>of</strong> early detection <strong>of</strong> hearing loss.<br />

Parents <strong>of</strong> all the c<strong>and</strong>idates included in the study were<br />

explained about the purpose & use <strong>of</strong> OAE, detail <strong>of</strong><br />

procedure & after their consent, they were included the study.<br />

A detailed history was elicited from parents. This was<br />

Pr<strong>of</strong>essor & <strong>Head</strong>, Asst. Pr<strong>of</strong>. Audiologist:, Ex sr. Resident Dept <strong>of</strong> ENT-HNS Government Medical College, Surat.<br />

2 5<br />

Asst. pr<strong>of</strong> E.N.T. Govt. Medical; College Bhavnagar . Asst Pr<strong>of</strong> in ENT, M.P. Shah Med College, Jamnagar.<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


tympanic membrane(TM) was seen clearly, c<strong>and</strong>idates were<br />

sent for OAE.<br />

OAE was done in sound-treated room by full-time audiologist<br />

<strong>of</strong> our department by Welch Allyn Audio Path Screener. If the<br />

results were 'PASS' then no follow up OAE done. If results<br />

were ''REFER'' then c<strong>and</strong>idates were called after 1 month for<br />

nd rd<br />

2 OAE. If result still remain ''REFER'' then 3 OAE was<br />

done after another 1 month. If result still remains same then<br />

c<strong>and</strong>idate were sent for BERA (Brainstem evoked<br />

st<br />

response audiometry). Further in the study, the 1 OAE tests<br />

st nd st rd<br />

will be referred as 1 test, 2 OAE as 1 retest <strong>and</strong> 3 OAE as<br />

nd<br />

2 retest.<br />

Results & discussion:<br />

1. In our study, maximum no <strong>of</strong> patients i.e. 64.61 %were in<br />

the age group <strong>of</strong> 0-6 months. This is desirable but the goal<br />

should be to screen 100% children by this age for possible<br />

further investigations <strong>and</strong> interventions in selected cases.<br />

2. In our study, 56.15 % were male child & 43.84 % were<br />

female child which suggest male preponderance <strong>of</strong> 1.3:1.<br />

Amongst them 'REFER' result was found in 43.83% &<br />

33.33% respectively in male & female.<br />

3.96.92 % <strong>of</strong> c<strong>and</strong>idate's mothers took routine ANC visits.<br />

This is quite an encouraging result as this suggests that<br />

mothers from even low <strong>and</strong> middle socio-economic strata are<br />

now aware <strong>of</strong> the importance <strong>and</strong> benefit <strong>of</strong> regular ANC<br />

resulting in better chance <strong>of</strong> having a healthy mother & child.<br />

4.76.75 % was Term delivery & 23.84 % were Pre-term<br />

delivery.<br />

5. In our study 52.30 % births were FTND, while 24.61%<br />

were FT with LSCS. 64.70% pre-term <strong>and</strong> 39.70% FTND had<br />

st<br />

'REFER' results in 1 OAE. While amongst LSCS delivered<br />

children, 23.08% pre-term & 45.16% full term babies showed<br />

'REFER'.<br />

6.83.84 % c<strong>and</strong>idates cried immediately while 5 c<strong>and</strong>idates'<br />

history was not known to parents. 40.74 % <strong>of</strong> c<strong>and</strong>idates who<br />

cried immediately show 'REFER' while only 18.75 %<br />

amongst those who did not cried after birth show 'REFER'.<br />

This is paradoxical finding as a baby who cries immediately<br />

after birth is likely to be healthier. The very small sample size<br />

<strong>of</strong> our study may be responsible for this anomaly.<br />

7.In our study, 80 % c<strong>and</strong>idates had normal post-partum<br />

period without any complications. Out <strong>of</strong> rest 20%, 12.30 %<br />

c<strong>and</strong>idates were having history <strong>of</strong> Jaundice in immediate<br />

postpartum period, 3.84 % had LBW <strong>and</strong> 3.84 % had both<br />

LBW <strong>and</strong> Jaundice.<br />

In c<strong>and</strong>idates with normal post-partum period, 38.46% had<br />

'REFER' result.<br />

'REFER' result had a peak incidence <strong>of</strong> 80% c<strong>and</strong>idates<br />

amongst those having h/o LBW & jaundice both, while<br />

12<br />

amongst those having h/o LBW & jaundice singly; 'REFER'<br />

result was found in 40% <strong>and</strong> 31.25% respectively.<br />

8.We found that 6.92% c<strong>and</strong>idates had history <strong>of</strong> intravenous<br />

Amikacin. Out <strong>of</strong> them 33.33% had OAE result 'REFER',<br />

while amongst those having no such history (93.07%),<br />

39.66% had OAE result 'REFER'. This is again a paradoxical<br />

finding which may be due to small sample size <strong>of</strong> our study &<br />

due to conditions <strong>of</strong> middle ear.<br />

9. In our study 86.92% had no accompanied disease. 10<br />

%having CNS disease & 3.07 % having other diseases.<br />

Amongst c<strong>and</strong>idates having CNS disease, 58.33% had OAE<br />

result 'REFER', while those not having any accompanying<br />

disease only 38.05% were 'REFER'.<br />

10.63.46 % <strong>of</strong> TM was Normal & 36.15 % were retracted.<br />

C<strong>and</strong>idates with normal TM showed 30.12% 'REFER', while<br />

those with retracted drum had 55.31% 'REFER'. This is easy<br />

to explain as middle ear conditions (eg. OME) give 'REFER'<br />

st<br />

result.The 39.23% c<strong>and</strong>idates presented with 'REFER' on 1<br />

test<br />

Out <strong>of</strong> which 14.61% were unilateral & 24.61 % were<br />

st<br />

bilateral.On doing 1 retest at 1 month on these 51 c<strong>and</strong>idates,<br />

it was found that in 9.23% results still remained 'REFER' (out<br />

<strong>of</strong> which 1.53% was unilateral & 7.69 % bilateral).On doing<br />

nd nd<br />

2 retest at 2 month on these 12 c<strong>and</strong>idates, it was found that<br />

3.84% remained 'REFER' which was bilateral. Out <strong>of</strong> these 5<br />

c<strong>and</strong>idates only in 1 BERA could be done which was<br />

suggestive <strong>of</strong> bilateral SNHL (0.76%).<br />

Comparison <strong>of</strong> our study with 2 other studies conducted at<br />

Trieste <strong>and</strong> Ferrara WB (Well baby) nurseries, under<br />

Universal Neonatal Hearing Screening (UNHS) programme,<br />

Italy31<br />

At 1st test in our study 39.23 % <strong>of</strong> the patients show 'REFER',<br />

while studies <strong>of</strong> Trieste <strong>and</strong> Ferrara show 9 % <strong>and</strong> 24.9 %<br />

st<br />

respectively. The percentages <strong>of</strong> 'REFER' results at 1 retest in<br />

our study, Trieste <strong>and</strong> Ferrara were 9.23 %, 0.06 %, 2.02 %<br />

respectively.<br />

Both <strong>of</strong> these results are higher in our study.<br />

In our study the percentage <strong>of</strong> c<strong>and</strong>idates having 'REFER' in<br />

nd<br />

2 retest reduced to 3.84 % which was not performed in two<br />

other studies, instead BERA was performed.<br />

After doing BERA the results in our study, Trieste <strong>and</strong> Ferrara<br />

turned out to be SNHL in 0.76 %, 0 % <strong>and</strong> 0.70 % respectively.<br />

Conclusion:<br />

A screening programme can only be as strong as the weakest<br />

link in the follow up chain. It should be remembered that the<br />

incidence <strong>of</strong> persistent significant hearing loss increases with<br />

age.<br />

The Joint Committee on Infant Hearing (JCIH) millennium<br />

position statement (2000) defines Universal Newborn<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


Hearing Screening (UNHS) as a programme which use<br />

physiological measures to screen for hearing loss, all infants<br />

in Well Baby Nursery (WBN) <strong>and</strong> Neonatal Intensive Care<br />

Unit (NICU) before discharge <strong>and</strong> infants from alternate<br />

birthing before 1 month <strong>of</strong> age with objective <strong>of</strong> atleast 30 db<br />

hearingloss in infants.UNHS promotes early identification <strong>of</strong><br />

hearing loss.Early detection <strong>of</strong> hearing impairment due to<br />

implementation <strong>of</strong> the screening results in early intervention<br />

<strong>and</strong> implantation <strong>of</strong> deaf children which has a major positive<br />

impact on both auditory receptive skills <strong>and</strong> speech<br />

intelligibility.<br />

National Programme for Prevention & Control <strong>of</strong> Deafness<br />

(NPPCD) - In India, the Central Government has started<br />

National Programme for Prevention & Control <strong>of</strong> Deafness<br />

(NPPCD). It was launched on a pilot basis in 25 districts<br />

during 2006-2008. The programme is now integrated with<br />

NRHM (National Rural Health Mission). It is now being<br />

gradually exp<strong>and</strong>ed to other districts. It aims to cover over<br />

200 districts by 2012.Currently in <strong>Gujarat</strong> State, 1 State Nodal<br />

Officer <strong>and</strong> 26 District Nodal Officers are appointed in 26<br />

districts for implementation <strong>of</strong> NPPCD. The Overall<br />

objective <strong>of</strong> the National Programme: To prevent hearing loss<br />

due to disease or injury, do early diagnosis, treatment, medical<br />

rehabilitation, strengthening linkages, creation <strong>of</strong> database<br />

<strong>and</strong> facilitation <strong>of</strong> need based research. The ultimate aim is to<br />

ensure that no person remains needlessly deaf or suffers the<br />

consequences there<strong>of</strong>. Though we did not meet the first<br />

benchmark <strong>of</strong> JCIH 2000, our study with 130 children (93<br />

infants) suggests that even in a Government teaching hospital<br />

having immense clinical & academic workload, when<br />

Obstetricians <strong>and</strong> Pediatricians are sensitized <strong>and</strong> more paramedical<br />

personnel are available in ENT department,<br />

implementation <strong>of</strong> Universal Newborn Hearing Screening is<br />

feasible. This is the first step which should be followed by<br />

identifying the hearing impaired children <strong>and</strong> then treating<br />

them.Ultimately, the ear should hear.<br />

References:<br />

1.Scott Brown: Diseases <strong>of</strong> ear, nose <strong>and</strong> throat 4th ed, edited<br />

by John Ballantyne, John Groves: 55-65<br />

2.Chaturvedi V. N: Hearing impairment <strong>and</strong> deafness:<br />

'Magnitude <strong>of</strong> problem <strong>and</strong> strategy for prevention.' Indian<br />

<strong>Journal</strong>s <strong>of</strong> Otolaryngology <strong>and</strong> <strong>Head</strong> <strong>Neck</strong> Surgery (1999)<br />

51(2):3-6 http: //www.mass.gov/dph/fch/unhsp/index.htm<br />

3.Kemp, D.T., Ryan's., & Bray. et al(1990). 'A guide to the<br />

effective use <strong>of</strong> otoacoustic emissions'. Ear <strong>and</strong><br />

Hearing,11,93-105<br />

4.Kok M.R., VanZanten G.A, Brocaar M.P et al (1993).<br />

Aspect <strong>of</strong> spontaneous otoacoustic emissions in Healthy<br />

newborns.' Hearing Research, 69,115-123.<br />

13<br />

5.Gaskill S.A., Brown A.M. (1990): 'The behavior <strong>of</strong> acoustic<br />

distortion product, 2f1-f2, from the human ear <strong>and</strong> its<br />

relation to auditory sensitivity.' <strong>Journal</strong> <strong>of</strong> the Acoustic<br />

society <strong>of</strong> America, 88,821-839<br />

6.Keilson S.E., Khanna S.M., Ulfendahl M.N., Teich M.C. et<br />

al (1993): 'Spontaneous cellular vibrations in guinea pig<br />

cochlea.' Acta Oto-Laryngolocia, 113,591-597.<br />

7.Hurley R.M. & Musiek F.E. (1994): 'Effectiveness <strong>of</strong><br />

transient-evoked otoacoustic emissions (TEOAE) in<br />

predicting hearing level.' Ear <strong>and</strong> Hearing , 5,195-203<br />

8. Scott Brown Otolaryngology, <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery, 7th<br />

edition, edited by Michael Gleeson. (3): 3108-3119<br />

9. Scott Brown Otolaryngology. 6th ed, edited by Alae G<br />

Kerr: 1/2/1-1/2/31<br />

10.Timothy C, Hain M.D : 'OAE Testing' HTML Page<br />

modified June 13,2003<br />

Address for Correspondence:<br />

Jaymin A. Contractor<br />

52, Sugam society, Adajan Patia, R<strong>and</strong>er road, SURAT -<br />

395009.<br />

E Mail: dr_jcontractor@yahoo.co.in,<br />

Cell +91 9824190210<br />

35th Annual Conference <strong>of</strong><br />

Otolaryngologists <strong>of</strong> India<br />

<strong>Gujarat</strong> State Branch<br />

Rajpath Club Ahmedabad.<br />

th th th<br />

16 ,17 , 18 December 2011.<br />

Organising Chairman<br />

Dr. Atul Kansara<br />

Organising Secretary<br />

Dr. Navin Patel, Dr. Kalpesh Patel.<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


Introduction:<br />

Dacryocystorhinostomy (DCR) has been traditionally<br />

performed for nasolacrimal duct obstruction via an external<br />

approach, although the procedure is actually uniquely suited<br />

for an endoscopic approach. The first dacryocystectomy,<br />

dating back to 50 A.D. was performed by Celsus. Anel (1713)<br />

introduced the concept <strong>of</strong> probing <strong>and</strong> syringing. Over a<br />

period <strong>of</strong> time various techniques evolved <strong>and</strong> in 1904, Toti,<br />

w a s t h e f i r s t p e r s o n t o p e r f o r m e x t e r n a l<br />

dacryocystorhinostomy for obstruction <strong>of</strong> the nasolacrimal<br />

duct. He made an incision through the skin <strong>and</strong> created a new<br />

ostium between the nasolacrimal sac <strong>and</strong> the nose. By<br />

removing this bone, drainage to the nose was allowed through<br />

bypassing any obstruction distally. Kuhnt (1914) <strong>and</strong> Ohn<br />

(1920) introduced the concept <strong>of</strong> suturing the flap <strong>of</strong> nasal<br />

mucosa to periostium or to the sac. Summerskill (1952)<br />

exposed the sac <strong>and</strong> a polythene tube was inserted<br />

permanently in the nasolacrimal duct to maintain patency.<br />

The introduction <strong>of</strong> nasal endoscopes <strong>and</strong> improvement <strong>of</strong><br />

optics brought about thereby improved the surgery <strong>and</strong> results<br />

<strong>of</strong> endonasal endoscopic DCR In 1990 it was Rice who<br />

reported his experience using endoscopic instruments to<br />

create this neo-ostium <strong>and</strong> since then there has been quite a lot<br />

1<br />

<strong>of</strong> literature on the subject .Many modifications like LASER<br />

assisted endoscopic DCR, use <strong>of</strong> silicon tube for stenting,<br />

mitomycin C application etc. have been described, yet most <strong>of</strong><br />

the surgeons still follow the st<strong>and</strong>ard endoscopic DCR<br />

procedure. Here we share our experience <strong>of</strong> this st<strong>and</strong>ard<br />

endoscopic DCR done without mucosal flap preservation.<br />

Objectives:<br />

To study by prospective, non-r<strong>and</strong>omized method with<br />

14<br />

Main Article<br />

Endoscopic endonasal dacryocystorhinostomy: Outcome in 81 cases<br />

1 2 3 4<br />

Sharan kumar Shetty , Ajay George ,Sanjay Kumar ,Ranjan Kumar - Nalgonga (A.P.)<br />

Abstract:<br />

Endonasal dacryocystorhinostomy is an evolving procedure for the management <strong>of</strong> nasolacrimal duct obstruction. This is a case<br />

series <strong>of</strong> 81 cases done to study the outcome <strong>of</strong> endonasal dacryocystorhinostomy in relation to aetiology <strong>and</strong> symptomatology,<br />

<strong>and</strong> to study the efficacy <strong>of</strong> endonasal DCR without mucosal flap preservation. All cases were subjected to endoscopic<br />

endonasal DCR without mucosal flap preservation. Success was defined by resolution <strong>of</strong> symptoms <strong>of</strong> epiphora <strong>and</strong> patency <strong>of</strong><br />

the canalicular system on lacrimal irrigation at 1 week <strong>and</strong> on follow up. Of the 81 cases, 73 cases had nasolacrimal duct<br />

obstruction <strong>of</strong> inflammatory origin <strong>and</strong> 8 cases had traumatic aetiology. Amongst these cases, 5 required revision surgery, 6 had<br />

to undergo external dacryocystorhinostomy for persistence <strong>of</strong> symptoms <strong>and</strong> the remaining 70 cases were free <strong>of</strong> epiphora.<br />

Thus endonasal DCR is a viable surgical technique for those presenting with epiphora due to nasolacrimal duct obstruction.<br />

Keywords: Endonasal dacryocystorhinostomy, chronic dacryocystitis, epiphora<br />

relatively short postoperative follow up, the outcome <strong>of</strong><br />

endoscopic endonasal dacryocystorhinostomy in the<br />

management <strong>of</strong> nasolacrimal duct obstruction in terms <strong>of</strong><br />

aetiology <strong>and</strong> symptomatology. Also to study the success rate<br />

<strong>of</strong> endoscopic endonasal dacryocystorhinostomy when done<br />

without mucosal flap preservation.<br />

Materials <strong>and</strong> methods:<br />

A total <strong>of</strong> 81 consecutive endonasal DCRs performed from<br />

January 2008 to December 2009 were included in the study.<br />

Patients included in the study had constant epiphora due to<br />

nasolacrimal duct obstruction secondary to inflammation or<br />

trauma. Patients with previous lacrimal surgery, noticeable<br />

lower lid laxity, suspicion <strong>of</strong> malignancy <strong>and</strong> previous<br />

radiation therapy <strong>and</strong> s<strong>of</strong>t stop on lacrimal probing were<br />

excluded from the study. A detailed history <strong>of</strong> the patients<br />

presenting with constant, moderate to severe epiphora to our<br />

out patient department was taken. They were subsequently<br />

subjected to detailed ENT <strong>and</strong> ophthalmologic examination.<br />

While examining the eyelid, any lower eye lid laxity was<br />

noted. The punctum was thoroughly inspected to see if there<br />

was any obstruction or inflammation. Evaluation <strong>of</strong> the<br />

lacrimal canaliculi was done by probing. The Bowman probe<br />

was passed through the puncta, <strong>and</strong> then swung horizontally<br />

to cannulate the inferior lacrimal canaliculus. The difference<br />

in feel between a hard stop versus a s<strong>of</strong>t stop was noted. A hard<br />

stop would be a stop created by bones, such as the lacrimal<br />

bone. A s<strong>of</strong>t stop felt could be because <strong>of</strong> an obstruction in the<br />

s<strong>of</strong>t tissue. The nasolacrimal duct was further evaluated by<br />

thorough irrigation <strong>of</strong> the duct with a syringe. A nasal<br />

examination was done to note any obstructive lesions on the<br />

1,2 3,4<br />

Associate Pr<strong>of</strong>essor, Assistant pr<strong>of</strong>essor, Kamineni Institute <strong>of</strong> Medical Sciences, Sreepuram<br />

Narketpally, Nalgonda,A.P.<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


nose. This is a very important part <strong>of</strong> the examination protocol<br />

to diagnose hidden etiological factors. Obstruction <strong>of</strong> the<br />

nasolacrimal system distal to the lacrimal sac was diagnosed<br />

with nasolacrimal syringing. Radiographic imaging was not<br />

part <strong>of</strong> the routine preoperative evaluation as it does not add<br />

much to the clinical examination <strong>and</strong> outcome in a majority <strong>of</strong><br />

the cases. Otorhinolaryngological preoperative assessment<br />

including full endoscopic examination <strong>of</strong> nasal cavities was<br />

done to look for evidence <strong>of</strong> mucosal disease including polyps<br />

particularly in the middle meatus, not accessible on clinical<br />

examination. Each patient with primary nasolacrimal duct<br />

obstruction was counselled as to the advantages,<br />

disadvantages <strong>and</strong> estimated success rates <strong>of</strong> the procedure.<br />

Patients were considered for surgery either under<br />

general or local anaesthesia. Nasal cavity was packed with<br />

ribbon gauze soaked in 4% lignocaine with 1:100000<br />

0<br />

adrenaline. Under 0 rigid nasal endoscopic guidance, the<br />

lateral wall <strong>of</strong> the nose anterior to middle turbinate was<br />

infiltrated with lignocaine, 2% with 1:200000 adrenaline.<br />

Using anterior portion <strong>of</strong> the middle turbinate as a l<strong>and</strong>mark, a<br />

'C' shaped mucosal flap was elevated, exposing the lacrimal<br />

fossa. The lacrimal fossa is made up <strong>of</strong> the frontal process <strong>of</strong><br />

the maxillary bone, anteriorly <strong>and</strong> by the thin lacrimal bone<br />

posteriorly. This bone was punched out using a Kerrison's<br />

bone punch, exposing the lacrimal sac. In cases where the<br />

bone was hard it was drilled out using a micromotor drill. The<br />

sac was tented using a probe <strong>and</strong> incised to create a neoostium<br />

so that tears could drain from the canaliculus directly<br />

into the nose through the middle meatus <strong>and</strong> thus bypassing<br />

any obstruction in the nasolacrimal duct. Medial wall <strong>of</strong> the<br />

sac was excised using Blakesley forceps. The 'C' shaped<br />

mucosal flap elevated earlier was excised completely. No<br />

stents were used in any <strong>of</strong> the cases. Nasal pack was done as<br />

<strong>and</strong> when required for haemostasis.<br />

Post-operatively, nose was cleared <strong>of</strong> clots <strong>and</strong><br />

crusts. Lacrimal syringing was done twice for the first two<br />

post-operative days <strong>and</strong> then the patient was discharged. A<br />

course <strong>of</strong> topical cipr<strong>of</strong>loxacin eye drops was given for 1<br />

week. Patients were followed up at 1 week, 3 weeks<br />

postoperatively <strong>and</strong> as <strong>and</strong> when required. Mean follow up<br />

period was 1 month. During follow up, nasal endoscopy was<br />

performed to remove any crusts, to confirm the patency <strong>of</strong><br />

neo-ostium <strong>and</strong> to look for complications <strong>of</strong> the procedure.<br />

The success is assessed, subjectively based on the patient's<br />

symptoms <strong>and</strong> objectively (anatomical success) based on (i)<br />

patency on syringing <strong>and</strong> (ii) presence <strong>of</strong> a functioning<br />

rhinostomy.<br />

Observations:<br />

A total <strong>of</strong> 81 cases were studied during the period <strong>of</strong><br />

15<br />

study. Maximum cases were females accounting to 57 cases<br />

(70.4%) <strong>and</strong> males being 24 (29.6%).. Out <strong>of</strong> the 81 cases,<br />

maximum cases were in the age range <strong>of</strong> 31-40 years (34.6%),<br />

<strong>and</strong> least in the range <strong>of</strong> 61-70 years (1.2%) with youngest<br />

being 12 years <strong>of</strong> old <strong>and</strong> oldest being 65 years. The mean age<br />

<strong>of</strong> patients in the series was 30.3 years. The symptom was left<br />

sided in 48 cases (59.3%) <strong>and</strong> right sided in 33 cases<br />

(40.7%),.On history, all the cases had constant epiphora, 18<br />

cases had swelling over the medial canthus <strong>of</strong> eye, 9 cases had<br />

scar due to previous abscess <strong>and</strong> 15 cases had concomitant<br />

nasal obstruction secondary to deviated nasal septum. 73<br />

cases had a history <strong>of</strong> repeated infection <strong>of</strong> nasolacrimal<br />

system, <strong>and</strong> 8 cases had previous history <strong>of</strong> trauma<br />

unattended, <strong>of</strong> which one case developed epiphora following<br />

reduction <strong>of</strong> nasal bone fracture.Out <strong>of</strong> the total <strong>of</strong> 81 cases,<br />

75 cases were operated under general anaesthesia <strong>and</strong> the<br />

remaining 6 cases were operated under local anaesthesia.<br />

Patients who appeared to be cooperative on assessment <strong>and</strong><br />

those patients who were unfit for general anaesthesia were<br />

considered under local anaesthesia. All cases underwent<br />

endonasal DCR, with 15 cases requiring additional septal<br />

surgery to provide adequate space for the instrumentation <strong>and</strong><br />

to relieve associated nasal obstruction. Of the 73 cases <strong>of</strong><br />

inflammatory aetiology who underwent surgery, 68 cases<br />

were relieved <strong>of</strong> epiphora. 5 cases developed epiphora on<br />

follow up, indicating obstruction <strong>of</strong> the neo-ostium. A<br />

majority <strong>of</strong> the cases (6 cases - 75%) <strong>of</strong> traumatic aetiology<br />

had persistent epiphora secondary to development <strong>of</strong> fibrosis<br />

<strong>and</strong> resultant restenosis. These cases were subjected either to<br />

revision DCR or external DCR. This gives an overall success<br />

rate <strong>of</strong> 86.4%. Of the 81 patients operated, the commonest<br />

complication (15 cases -18.52%) noted on follow up was<br />

synechia <strong>and</strong> granulations in the nasal cavity. 11 cases<br />

(13.58%) suffered from residual epiphora <strong>and</strong> no passage<br />

upon irrigation. Intraoperative bleeding was minor in 48<br />

cases, moderate in 26 cases, <strong>and</strong> severe in 7 cases (8.64%),<br />

requiring anterior nasal packing. Other complications like<br />

periorbital ecchymosis <strong>and</strong> transient maxillary pain were<br />

noted in 6 cases (7.41%) <strong>and</strong> 5 cases (6.17%) respectively.<br />

Discussion:<br />

Out <strong>of</strong> the total <strong>of</strong> 81 cases majority (70.4%). This female<br />

predominance has been noted in all case series like Tsirbas<br />

2 3<br />

<strong>and</strong> Wormald (65.1%) <strong>and</strong> Ressiniotis T. et al (75.9%). The<br />

patients operated in our series were in the age range <strong>of</strong> 12<br />

years to 65 years with a meaN age <strong>of</strong> 30.3 years. This is<br />

somewhat lesser as compared to the age range <strong>of</strong> 3 years to 89<br />

years, with a mean <strong>of</strong> 59 years in the study by Tsirbas <strong>and</strong><br />

2<br />

Wormald <strong>and</strong> mean age <strong>of</strong> 75 years in the study by<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


3<br />

Ressiniotis T. et al . In our series majority <strong>of</strong> the cases had left<br />

sided disease (59.3%). This finding is similar to that reported<br />

3<br />

by Ressiniotis T. et al (53.6%) . However there is no<br />

explanation for this type <strong>of</strong> side preponderance <strong>of</strong> the disease.<br />

The commonest symptom in our case series was epiphora<br />

which was found in all cases <strong>and</strong> swelling over the medial<br />

canthus <strong>of</strong> eye which was note in 18 (22.2%) cases. This<br />

symptom pr<strong>of</strong>ile is also noted by other authors like Tsirbas<br />

2 3<br />

<strong>and</strong> Wormald <strong>and</strong> Ressiniotis T. et al . 15 (18.5%) <strong>of</strong> our cases<br />

needed septoplasty to correct the deviation <strong>of</strong> nasal septum<br />

<strong>and</strong> to create enough space to introduce the instruments<br />

2<br />

required for the procedure. Tsirbas <strong>and</strong> Wormald have also<br />

reported need for nasal septal surgery as an adjunct to DCR in<br />

46% <strong>of</strong> their cases. In 15 (18.5%) <strong>of</strong> the 81 case there were<br />

granulations <strong>and</strong> synechia in the nasal cavity on follow up.<br />

Similar rate (14.9%) <strong>of</strong> post operative granulation <strong>and</strong><br />

4<br />

synechia formation was also noted by Kansua L. et al . We<br />

could achieve a success rate <strong>of</strong> 86.4%. There is almost similar<br />

success rate reported by other authors, ranging from 100% by<br />

5 7 2<br />

Rice D. , Sprekelson 96%, Tsirbas & Wormald 89% ,<br />

8 6<br />

Whidenbecher 86% to 83% by Whittet HB et al .<br />

Conclusion:<br />

In line with contemporary literature, we conclude<br />

that endoscopic endonasal DCR is a simple <strong>and</strong> minimally<br />

invasive procedure which is highly effective in the successful<br />

management <strong>of</strong> nasolacrimal duct obstruction. It has the<br />

added advantage <strong>of</strong> being able to address any intranasal<br />

pathology which could be the basic cause <strong>of</strong> the disease.<br />

Avoidance <strong>of</strong> external scar <strong>and</strong> preservation <strong>of</strong> the lacrimal<br />

pump system are significant plus points to the procedure.<br />

References<br />

1. Gupta N. History <strong>of</strong> Lacrimal Sac Surgery.In:Gupta N.<br />

Endoscopic Dacryocystorhinostomy A Revolution. New<br />

Delhi: Paragon International Publishers; 2006; p. 1-8.<br />

2. A Tsirbas, P J Wormald. Mechanical endonasal<br />

dacryocystorhinostomy with mucosal flaps, Br J<br />

Ophthalmol 2003; 87: 43-47.<br />

3. Ressiniotis T., Gerasimos MV, Vasilios TK, Sean C. <strong>and</strong><br />

Christopher N. Dacryocystorhinostomy. A report <strong>of</strong> 200<br />

cases.BMC Ophthalmology 2005, 5:2.<br />

4. Leyla Kansua, Erdinc Aydina, Suat Avcia, Ali Kalb,<br />

Sansal Gedikb. Comparison <strong>of</strong> surgical outcomes <strong>of</strong><br />

endonasal dacryocystorhinostomy with or without<br />

mucosal flaps. Auris Nasus Larynx International journal<br />

<strong>of</strong> ORL & HNS October 2009; 36(5): 555-559.<br />

5. Rice D. Endoscopic intranasal dacryocystorhinostomy<br />

results in four patients. ArchOtolaryngol <strong>Head</strong> <strong>Neck</strong> Surg<br />

1990; 116: 1061.<br />

16<br />

6. Whittet HB, Shun-Shin GA, Awdry P. Functional<br />

endoscopic transnasal dacryocystorhinostomy. Eye 1993;<br />

7: 545-549.<br />

7. Sprekelsen MB, Barberan MT: Endoscopic<br />

dacryocystorhinostomy: surgical technique <strong>and</strong> results.<br />

Laryngoscope 1996; 106:187-189.<br />

8. Weidenbecher M, Hosemann W, Buhr W: Endoscopic<br />

endonasal dacryocystorhinostomy: results in 56 patients.<br />

Annals <strong>of</strong> Otology Rhinology Laryngology 1994;<br />

103:363-367<br />

Address for correspondence<br />

Sharan kumar Shetty<br />

Department <strong>of</strong> ENT,<br />

Kamineni Institute <strong>of</strong> Medical Sciences, Sreepuram,<br />

Narketpally, Nalgonda,Andhra Pradesh – 508254.<br />

E mail : drsharanshetty@in.com<br />

Cell+91 9287522325<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


17<br />

Main Article<br />

A study <strong>of</strong> the corelation <strong>of</strong> the clinical features, radiological evaluation <strong>and</strong> operative findings in<br />

chronic suppurative otitis media with cholesteatoma<br />

1 2, 3 4 5<br />

Santosh U.P , Dr. S.M Siddalingappa Sheeba Mathew , Vinay Bhat , Deepak Janardhan - Davangere<br />

( Karnataka)<br />

Introduction<br />

The middle ear cholesteatoma, most <strong>of</strong>ten acquired than<br />

congenital, is the main complication <strong>of</strong> COM, from the<br />

ingrowth <strong>of</strong> keratinising squamous epithelium from external<br />

auditory canal skin to middle ear, through the tympanic<br />

membrane. It is a very common disease in India <strong>and</strong> also other<br />

developing countries where conditions like poverty, over<br />

crowding, illiteracy <strong>and</strong> poor hygiene are very common. With<br />

the availability <strong>of</strong> antibiotics, operative microscope <strong>and</strong> the<br />

microsurgical operating instruments it has become easier to<br />

s u c c e s s f u l l y t r e a t m i d d l e e a r i n f e c t i o n a n d<br />

cholesteatoma.Otoscopic examination with the use <strong>of</strong><br />

binocular microscope is imperative. The characteristic <strong>of</strong><br />

cholesteatoma is the lumen <strong>of</strong> the perforation containing<br />

varying amount <strong>of</strong> epithelial debris. To minimize the<br />

interpretative errors <strong>of</strong> the mild bone erosions, particularly the<br />

tegmen, the lateral semicircular canal <strong>and</strong> horizontal potion <strong>of</strong><br />

the facial nerve canal, familiarity with the radiographic<br />

variations <strong>and</strong> comparisons with the normal side are<br />

1<br />

valuable . Prior to the availability <strong>of</strong> high resolution C.T., the<br />

mainstay <strong>of</strong> roentgenographic diagnosis <strong>of</strong> cholesteatoma<br />

was conventional filming <strong>and</strong> complex motion tomography.<br />

The radiographic appearances do not generally affect the<br />

surgical approach or the course <strong>of</strong> the operation which must<br />

be exploratory. Tomographic investigation is needed when<br />

the diagnosis is in doubt, as when the ear drum is obscured or<br />

when complications develop, but should not cause delay in<br />

instituting necessary surgery. A C.T scan may be valuable in<br />

early diagnosis <strong>of</strong> cholesteatoma, when the disease is<br />

confined to<br />

attic or posterior tympanum, beyond otoscopic view. On<br />

occasion, a decision to operate may hinge on the detection <strong>of</strong><br />

cholesteatoma presence by C.T scan alone. This article is for<br />

the budding ENT surgeons to appreciate the importance <strong>of</strong><br />

correlating the clinico radiological findings to anticipate,<br />

associate <strong>and</strong> finally to go about during surgery.<br />

Materials <strong>and</strong> methods<br />

This study group includes 30 patients who underwent<br />

surgical exploration <strong>of</strong> middle ear <strong>and</strong> or mastoid, for the<br />

removal <strong>of</strong> cholesteatoma. All patients had preoperative<br />

evaluation by otoscopy or EUM (examination under<br />

microscopy) <strong>and</strong> by plain X ray mastoid / CT scanning. These<br />

cases included only those suspected <strong>of</strong> chronic suppurative<br />

otitis media with cholesteatoma; <strong>and</strong> those cases that have no<br />

findings suggestive <strong>of</strong> cholesteatoma in the middle ear on<br />

examination <strong>and</strong> those diagnosed with congenital<br />

cholesteatoma were excluded from the study. The cases were<br />

taken from the otorhinolaryngology department <strong>of</strong> Bapuji<br />

Hospital <strong>and</strong> Chigateri Hospital, Teaching Hospitals attached<br />

to J.J.M.Medical College, Davangere, in a period <strong>of</strong> two years<br />

from December 2007 to October 2009.A detailed clinical<br />

history, with otoscopic examination was performed for all<br />

these cases. Some <strong>of</strong> the cases required EUM, to know the<br />

extent <strong>of</strong> the cholesteatoma or the bony erosion. Radiological<br />

investigation consisted <strong>of</strong> both conventional plain<br />

radiography <strong>and</strong> computerized tomography. Conventional<br />

plain radiography was in the form <strong>of</strong> a lateral oblique view<br />

(Law's) <strong>of</strong> both ears. In computerized tomography, high<br />

resolution serial 3 mm thick sections were obtained in both<br />

axial <strong>and</strong> coronal planes. Taking into consideration the cost <strong>of</strong><br />

both the radiological methods <strong>of</strong> evaluation, X-ray was more<br />

affordable <strong>and</strong> convenient for the patients. Most <strong>of</strong> these 30<br />

patients came from a low socio economic status. Following<br />

mastoid exploration, for about 18 patients CWU procedure<br />

was performed, while the rest <strong>of</strong> the cases required CWD<br />

procedure. Out <strong>of</strong> the 12 cases <strong>of</strong> CWD techniques, 4 required<br />

radical mastoidectomy <strong>and</strong> two cases underwent facial nerve<br />

decompression.<br />

Results<br />

Cholesteatoma with granulation was the commonest feature<br />

seen in the patients, followed by 6 (20%) patients who showed<br />

only cholesteatoma flakes. 6 (20%) patients presented with<br />

polypoidal mass in the external auditory canal obscuring the<br />

view <strong>of</strong> the tympanic membrane, <strong>of</strong> which 4 were with foul<br />

smelling cholesteatoma flakes. 2 (6.6%) patients had<br />

posterior canal wall sagging with cholesteatoma. In our study,<br />

in 13 patients ossicular involvement <strong>of</strong> the disease could be<br />

visualized, mostly through microscopic examination, out <strong>of</strong><br />

which 9 patients showed absence <strong>of</strong> incus <strong>and</strong> 8 cases showed<br />

malleus erosion. However, stapes involvement could not be<br />

1,2 3,4,5<br />

Pr<strong>of</strong>essor, Resident Dept <strong>of</strong> Otolaryngology,JJM Medical College Davangere (Karnataka)<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


assessed. All the X-rays <strong>of</strong> involved ears showed sclerotic<br />

mastoid. 26 (86.6%) <strong>of</strong> these patients showed cavity lesions in<br />

the X-rays, among which attic, aditus <strong>and</strong> antrum were<br />

involved in 13 (43.3%) cases. In 9 (30%) out <strong>of</strong> the 26<br />

patients, mastoid was also involved. Computed tomography<br />

was done in 10 patients. Preoperative computed tomography<br />

diagnosis <strong>of</strong> cholesteatoma was made in all these cases. The<br />

hall mark <strong>of</strong> cholesteatoma was non-dependent s<strong>of</strong>t tissue<br />

mass alone <strong>and</strong>/or bony erosion or smooth bony expansion<br />

was present in all these cases. On HRCT, epitympanum <strong>and</strong><br />

antrum were the commonest sites <strong>of</strong> cholesteatoma, 90%<br />

each. 6 (60%) <strong>of</strong> the cases showed involvement <strong>of</strong><br />

mesotympanum. Perilabyrinthine cells were involved in only<br />

one case. Destruction <strong>of</strong> malleus could be identified in 8<br />

(80%) cases. Incus was eroded in 9 (90%) cases. However,<br />

stapes involvement could be seen in only one the cases.<br />

Preoperative HRCT diagnosed dehiscence <strong>of</strong> horizontal<br />

segment <strong>of</strong> facial canal in 2 (20%) cases. Lateral semicircular<br />

canal erosion, sinus plate dehiscence, mastoid cortex<br />

dehiscence was seen in 3 patients each. Postauricular abscess<br />

<strong>and</strong> brain abscess was seen in (20%) each.In our study<br />

27(90%) patients showed cholesteatoma on surgical<br />

exploration <strong>and</strong> the remaining 3(10%) patients showed<br />

pathologies like granulation tissue <strong>and</strong> mucosal hypertrophy.<br />

Among these 27 patients only 20(66.6%) patients correlated<br />

well with the otoscopic findings <strong>of</strong> cholesteatoma with or<br />

without granulation tissue or polyp. All 3(10%) patients in<br />

whom only polypoidal mass was seen on otoscopic<br />

examination, there was associated cholesteatoma sac or<br />

debris seen on surgical exploration. Mucosal hypertrophy<br />

observed in surgical exploration was missed out in one case in<br />

which otoscopic findings showed foul smelling discharge<br />

with granulation tissue. Ossicular erosion could be<br />

appreciated by otoscopy or EUM in only 13 cases <strong>and</strong> all these<br />

cases showed malleolar or incus erosion which were in<br />

agreement with the corresponding surgical findings. There<br />

was correlation <strong>of</strong> 26 cases between the conventional mastoid<br />

X-ray findings <strong>and</strong> surgical findings for the diagnosis <strong>of</strong><br />

cholesteatoma. Comparing the extent <strong>of</strong> cholesteatoma there<br />

was an agreement <strong>of</strong> 13 (43.3%) cases seen between<br />

preoperative radiological <strong>and</strong> surgical findings in the attic,<br />

aditus <strong>and</strong> antrum. The 10 patients, in whom computed<br />

tomography was done, HRCT found to be very sensitive in<br />

diagnosing cholesteatoma accurately,(ie), the true positive<br />

were seen in 90% <strong>of</strong> the cases. However HRCT could not<br />

differentiate cholesteatoma from granulations in one case. In<br />

case <strong>of</strong> conventional radiography, there was an agreement <strong>of</strong><br />

26(86.6%) cases with the surgical findings but the one <strong>of</strong> the<br />

cases could not be diagnosed with the plain X-ray. There were<br />

18<br />

Discussion<br />

Cholesteatoma as defined by Schuknecht, is the accumulation<br />

<strong>of</strong> exfoliated keratin in the middle ear or any pneumatised area<br />

<strong>of</strong> the temporal bone, rising from the keratinized squamous<br />

epithelium. Histologically, it comprises <strong>of</strong> perimatrix <strong>of</strong><br />

subepithelial connective tissue with collagen fibres, elastic<br />

fibres, fibroblasts <strong>and</strong> inflammatory cells, together with<br />

matrix <strong>and</strong> cystic content.<br />

Otoscopic examination- Based on the observations <strong>of</strong><br />

Bluestone et al, the diagnosis <strong>of</strong> cholesteatoma is most<br />

effectively made with an otoscopic or, more accurately, with<br />

2<br />

the otomicroscope . In this study there were 20 (66.6%) cases<br />

which showed characteristic cholesteatoma flakes on<br />

examination, with or without granulation tissue or polyp. All<br />

these were in agreement with the surgical findings. 5(16.6%)<br />

cases showed granulation tissue on examination, but 4 cases<br />

among this also showed scant cholesteatoma flakes confined<br />

to the attic or both attic <strong>and</strong> antrum on surgical exploration.<br />

3<br />

This was in accordance to the results <strong>of</strong> Proctor Bruce which<br />

suggested the association <strong>of</strong> granulation tissue in 93-95% <strong>of</strong><br />

the cases <strong>of</strong> cholesteatoma. Polyp was seen in 2(6.6%) <strong>and</strong><br />

4(13.3%) patients presented with polyp in association with<br />

cholesteatoma on otoscopic examination. In very inflamed<br />

20(66.6%) <strong>of</strong> true positive cases whereas 7 false negative<br />

cases, that is, those cases in which there was no evidence <strong>of</strong><br />

cholesteatoma on otoscopic examination. ears, a<br />

cholesteatoma may not be visible at the first presentation.<br />

Sometimes there is an aural polyp obscuring the attic or<br />

posterior pars tensa; such a case should be assumed to be a<br />

4<br />

cholesteatoma until proved otherwise . In this study all these 6<br />

cases correlated well with surgical findings <strong>and</strong> showed<br />

cholesteatoma on surgical exploration.<br />

Radiological examination- A conventional plain X ray or a<br />

CT scan provides information about congenital anatomic<br />

variations that may be encountered during surgery, as well as<br />

5<br />

the complications <strong>of</strong> cholesteatoma. HRCT provides a more<br />

precise definition <strong>of</strong> the anatomic extent <strong>of</strong> the disease <strong>of</strong> the<br />

middle ear <strong>and</strong> the relationship <strong>of</strong> these cholesteatoma masses<br />

to the contiguous structures. The hallmarks <strong>of</strong> cholesteatoma<br />

are the presence <strong>of</strong> s<strong>of</strong>t tissue density in the middle ear cavity,<br />

ossicular erosions, smooth erosions <strong>of</strong> the middle ear borders<br />

<strong>and</strong> adjacent structures.In this study <strong>of</strong> the 30 patients<br />

reviewed, 26 (86.6%) patients were accurately diagnosed<br />

with cholesteatoma <strong>and</strong> correlated well with the surgical<br />

findings. Earlier series have given rates <strong>of</strong> detection <strong>of</strong><br />

surgically confirmed cholesteatomas <strong>of</strong> about 45% - 75%.<br />

7<br />

Mac Millian detected cholesteatomas in 45% <strong>of</strong> cases with<br />

8,9<br />

law projection <strong>and</strong> Brunner et al. detected cholesteatoma in<br />

58% <strong>of</strong> cases with multiple plain films. The plain films<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


demonstrated the extent <strong>of</strong> the disease in all these cases. The<br />

bony erosion could be appreciated including attic, antrum <strong>and</strong><br />

mastoid, but however, the ossicular erosions were not well<br />

visualized. Out <strong>of</strong> the 26 patients majority <strong>of</strong> the cavity lesion,<br />

13(43.3%), was seen in the atticoantral region, with widening<br />

<strong>of</strong> the aditus. Preoperative CT scan could diagnose s<strong>of</strong>t tissue<br />

density mass in all the 10 patients, with one false positive<br />

5 10<br />

interpretation. Mafee had similar results, whereas Jackler<br />

11<br />

<strong>and</strong> Garber found it to be less sensitive <strong>and</strong> specific.<br />

However, CT scan is less sensitive in differentiating<br />

cholesteatoma from granulations. Most authors are in<br />

10<br />

agreement with this finding. In this study, homogenous <strong>and</strong><br />

s<strong>of</strong>t tissue densities were present in the mastoid antrum <strong>and</strong><br />

middle ear cavity. About 30% <strong>of</strong> the cases had both<br />

granulation tissue <strong>and</strong> cholesteatoma which could not be<br />

radiographically distinguished. Cholesteatoma sac,<br />

associated with granulation tissue, mucosal oedema <strong>and</strong><br />

10<br />

effusion may be indistinguishable on CT scanning.<br />

Although cholesteatoma is said to show a lower attenuation<br />

than granulation tissue the difference is subtle<strong>and</strong> only<br />

5<br />

magnetic resonance imaging can differentiate the two.<br />

Bony erosion, an additional sign for the presence <strong>of</strong><br />

cholesteatoma was identified in 9 <strong>of</strong> the 10 cases. This is<br />

10<br />

comparable to the reports by Jackler et a1 who found<br />

cholesteatoma to be present in 80% <strong>of</strong> the cases with bony<br />

erosion who were explored.In this study, CT was found to be<br />

most accurate in identifying ossicular destruction, which is in<br />

5 10<br />

consonance with studies by Mafee et al , <strong>and</strong> Jackler et al . CT<br />

detected ossicular destruction in 9 <strong>of</strong> 10 the patients who had<br />

5<br />

such lesion on surgery. Mafee et a1 were able to define the<br />

state <strong>of</strong> the ossicular chain in 89% <strong>of</strong> cases scanned <strong>and</strong><br />

10<br />

Jackler et a1 were able to predict the state <strong>of</strong> the ossicular<br />

chain in 83.3% <strong>of</strong> their cases. In this study incus was most<br />

commonly involved <strong>and</strong> CT could identify involvement <strong>of</strong> the<br />

incus in 9 <strong>of</strong> the 10 cases, with destruction found during<br />

surgery. Dehiscence <strong>of</strong> the horizontal part <strong>of</strong> the facial canal<br />

was accurately diagnosed in 2 cases. In the studies performed<br />

10<br />

by Jackler<br />

Conclusion<br />

The diagnosis <strong>of</strong> cholesteatoma can be made with both<br />

otoscopic examination <strong>and</strong> radiological evaluation. In this<br />

study, 66.6% patients, on otoscopic examination revealed<br />

cholesteatoma, <strong>and</strong> were in agreement with the surgical<br />

findings, while 86.6% patients, showed true positive cases on<br />

radiological examination. Thus there was good correlation<br />

between the radiological evaluation <strong>and</strong> the surgical<br />

diagnosis <strong>of</strong> cholesteatoma compared to the otoscopic<br />

diagnosis. CT scan is valuable in cases suspected <strong>of</strong><br />

intracranial complications <strong>and</strong> in those cases in which<br />

19<br />

diagnosis is not obvious. Cholesteatoma in hidden areas <strong>and</strong><br />

ossicular destruction can be revealed with CT scan, which<br />

cannot be assessed on otoscopic examination. CT scan was<br />

found to be specific in the diagnosis <strong>of</strong> cholesteatoma <strong>and</strong> also<br />

in cases <strong>of</strong> lateral semicircular erosion, facial nerve canal<br />

dehiscence, sinus plate <strong>and</strong> mastoid cortex destruction.<br />

References<br />

1. Jackler RK, Witham P. Dillon, Schindler RA. Computed<br />

tomography in suppurative ear disease: a correlation <strong>of</strong><br />

surgical <strong>and</strong> radiographic findings. Laryngoscope 1984;<br />

94: p. 746-752.<br />

2. Bluestone Charles D, Klein JO. Intracranial complications<br />

<strong>and</strong> sequelae <strong>of</strong> Otitis media. In : Bluestone CD eds.<br />

Paediatric Otolaryngology. WB Saunders, Philadelphia,<br />

nd<br />

1990.2 ed: Vol 1. p. 738-740.<br />

3. Proctor B. Chronic otitis media <strong>and</strong> mastoiditis. In:<br />

Paparella MM, Shumrick DA eds Otolaryngology (Otology<br />

rd<br />

<strong>and</strong> Neurotology). WB Saunders, Philadelphia 1991. 3 ed;<br />

Vol2: p. 1366.<br />

4. Scott-Brown's. Chronic otitis media. In :<br />

<strong>Otorhinolaryngology</strong>, <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> surgery. Gleeson M,<br />

Browning GG, Burton MJ, Clarke R, Hibbert J, Jones NS,<br />

th<br />

et al, edts. Chapter 237, 7 edn. Vol. 3. Edward Arnold<br />

(Publishers) Ltd, Great Britain; 2008. P. 3395-3397.<br />

5. Mafee MF, Levin BL, Applebaum EL, Campos CF.<br />

Cholesteatoma <strong>of</strong> the middle ear <strong>and</strong> mastoid. Otolaryngol<br />

Clin North Am. 1988; 21:p. 265-268.<br />

6. Lin DPC, Bergeron RT. Contemporary radiological<br />

imaging in the evaluation <strong>of</strong> the middle ear – attic – antral<br />

complex cholesteatoma. Otolaryngol Clin North Am 1989;<br />

22: p. 897-909.<br />

7. Mac Millian AS: radiologic diagnosis <strong>of</strong> Neuro-otologic<br />

problems by conventional radiology. Arch Otolaryngol<br />

1969; 89: p. 78-82.<br />

8. Brunner S, Peterson O, S<strong>and</strong>berg LE. Tomography in<br />

cholesteatoma <strong>of</strong> the temporal bone. Correlation between<br />

the st<strong>and</strong>ard roentgenographic examinations <strong>and</strong><br />

tomography. AJR 1966; 97: p. 588-596.<br />

9. Coel MN, Godwin D. Simplified plain film screening<br />

examination for erosive otitis media. AJR 1979; 133.<br />

10. Jackler RK, Witham P. Dillon, Schindler RA. Computed<br />

tomography in suppurative ear disease: a correlation <strong>of</strong><br />

surgical <strong>and</strong> radiographic findings. Laryngoscope 1984;<br />

94:p.746-752.<br />

Address for correspondence<br />

Santosh U.P.<br />

Pr<strong>of</strong>. Dept <strong>of</strong> Otolaryngology,<br />

JJM Medical College, Davangere (Karnataka)<br />

E Mail: drsantoshup@gmail.com Cell +91 9845155223<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


20<br />

Main Article<br />

Tumours <strong>of</strong> maxilla<br />

1 2 3<br />

Darshan V Doshi , J. A. Contractor , I. K. Aditya - Ahmedabad, Surat ( <strong>Gujarat</strong>)<br />

Abstract: Background. The aim <strong>of</strong> the study was to calculate the incidence <strong>of</strong> maxillary tomour, to study the clinical<br />

presentation, to evaluate the investigation measures <strong>and</strong> their usefulness, to apply <strong>and</strong> study the various mode <strong>of</strong> treatment <strong>and</strong><br />

their outcomes <strong>and</strong> to determine the prognosis <strong>and</strong> factors affecting the prognosis <strong>of</strong> maxillary tumors.<br />

Methods. This prospective <strong>and</strong> retrospective study had included 35 patients <strong>of</strong> tumours <strong>of</strong> maxilla who presented to New Civil<br />

Hospital, Surat from Jan. 2001 to Dec. 2004 . They were regularly followed up till Dec. 2006.<br />

Results. There is an average 6 months <strong>of</strong> delay in presentation with the range <strong>of</strong> 2-18 months. Two year survival rate was<br />

80%. Five year survival rate was 70 %.<strong>Neck</strong> metastasis was an ominous sign with 3 year survival rate was 50%. Postoperative<br />

RT improves survival.<br />

Conclusion. Unsatisfactory results could be duo to rarity <strong>of</strong> tumour, delay in diagnosis, complex anatomy <strong>of</strong> the region with<br />

proximity to vital structures which makes the surgeons <strong>and</strong> radiotherapist reluctant to treat the tumour aggressively, histology <strong>of</strong><br />

tumour <strong>and</strong> preference <strong>and</strong> compliance <strong>of</strong> patient. The prognosis <strong>of</strong> cancer <strong>of</strong> maxilla has been improved over the last thirty<br />

years, due to improved investigative measures, surgical techniques <strong>and</strong> newer radiotherapy techniques.<br />

Keywords: clinical study, maxillary tumour, reviews <strong>of</strong> literature, outcomes, <strong>and</strong> prognostic factors.c<strong>and</strong>idates only 1 came for<br />

BERA, which was suggestive <strong>of</strong> bilateral SNHL (0.76%)<br />

Key Words: OAE, hearing loss<br />

Introduction:<br />

The neoplasm <strong>of</strong> sinonasal tract are rare representing only 3%<br />

<strong>of</strong> all upper aero digestive tract <strong>and</strong> about 0.3-0.8% <strong>of</strong> all<br />

1<br />

human malignancies. Cancer <strong>of</strong> the nose <strong>and</strong> paranasal<br />

sinuses has been reported to be more frequent in workers<br />

exposed to nickel, Chromium, leather, <strong>and</strong> wood dust. Leather<br />

<strong>and</strong> wood dusts were associated more with adenocarcinoma<br />

than with squamous cell carcinoma. Both primary <strong>and</strong><br />

secondary tobacco smoke also appear to be related to an<br />

increased incidence <strong>of</strong> sinonasal cancer, particularly<br />

2<br />

squamous cell carcinoma. The benign or malignant nature <strong>of</strong><br />

the tumours can only be determined after a correct<br />

histopathological diagnosis, as the clinical presentation <strong>of</strong><br />

both are <strong>of</strong>ten similar. The neoplasm <strong>of</strong> maxillary sinus is<br />

most common sino- nasal neoplasm. By the time maxillary<br />

tumours presented to a consultant, they are in an advanced<br />

stage with 6-12 months <strong>of</strong> symptoms duo to their rarity <strong>and</strong><br />

3<br />

clinical symptoms simulating chronic sinusitis. The<br />

lymphatic drainage <strong>of</strong> posterior part goes primarily to<br />

retropharyngeal <strong>and</strong> lateral pharyngeal nodes at base skull,<br />

<strong>and</strong> then to the upper jugular lymph nodes. Cancer <strong>of</strong> the<br />

anterior part spreads to the subm<strong>and</strong>ibular <strong>and</strong> upper jugular<br />

lymph nodes. Lymphatic spread is evident on initial<br />

presentation in approximately 10% <strong>of</strong> patients; an additional<br />

15% <strong>of</strong> patients will develop lymph node metastasis at some<br />

point after treatment. For squamous cell carcinoma, the rate <strong>of</strong><br />

distal metastasis is approximately 10%, it rarely occurs in the<br />

2<br />

absence <strong>of</strong> local recurrence. Availabilities <strong>of</strong> nasal telescope,<br />

CT scan <strong>and</strong> MRI help to arrive at early diagnosis <strong>and</strong> proper<br />

assessment <strong>of</strong> tumour. The treatment protocol for benign<br />

tumour is surgery while malignant tumours are treated by<br />

surgery, radiotherapy, <strong>and</strong> chemotherapy alone or in various<br />

4<br />

combinations. The surgerical incision for maxillectomy are<br />

Lateral rhinotomy, Weber-Ferguson incision, Weber-<br />

Ferguson incision with Lynch extension, Weber-Ferguson<br />

incision with lateral subcilliary extension <strong>and</strong> Weber-<br />

Ferguson incision with subcilliary <strong>and</strong> supracilliary<br />

extension. Surgery for maxillary tumour includes medial<br />

maxillectomy, peroral partial maxillectomy, sub total<br />

maxillectomy, total maxillectomy, radical maxillectomy with<br />

5<br />

orbital exenteration. If benign tumour are completely<br />

6<br />

excised, they rarely recure. Resent advances in the diagnosis<br />

<strong>and</strong> treatment <strong>of</strong> patients with maxillary sinus cancer have had<br />

a clear impact on our ability to control the disease <strong>and</strong> improve<br />

survival. Survival rates have improved from 25% to 40% in<br />

2<br />

the 1960s, to 65% to 75% in most recently reported series.<br />

Material <strong>and</strong> Method:<br />

The Study was conducted in the Dept. <strong>of</strong> ENT-HNS, New<br />

Civil Hospital, Surat, over the duration <strong>of</strong> 6 years from Jan,<br />

1 2<br />

Consultant <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Cancer Surgeon, Ahmedabad, <strong>Gujarat</strong>., J. A. Contractor Pr<strong>of</strong>essor, <strong>and</strong> <strong>Head</strong> ,<br />

3<br />

Associate Pr<strong>of</strong>essor <strong>of</strong> Department <strong>of</strong> ENT & HNS Govt. Medical College <strong>and</strong> New Civil Hospital, Surat<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


2001 to Dec, 2006.All patients with clinical diagnosis <strong>of</strong><br />

maxillary tumor were included. Non-neoplastic <strong>and</strong><br />

inflammatory conditions were excluded. All such patients<br />

were subjected to detailed history & Clinical examination<br />

which included general examination, ENT examination, oral<br />

cavity examination, local examination <strong>of</strong> cheek swelling,<br />

ophthalmic examination, neck node examination <strong>and</strong><br />

systemic examination. Routine investigations for major<br />

surgery <strong>and</strong> Contrast Enhanced CT scan paranasalsinus were<br />

done in all the patients. Material for histopathological<br />

diagnosis was obtained from cheek swelling by FNAC or<br />

biopsy from nasal mass, oral cavity or maxillary sinus via<br />

Caldwell luc approach. AJCC classification (2002) was used<br />

7<br />

to stage the malignancy. Preoperative dental impressions<br />

were taken in all patients for post operative rehabilitation.<br />

Patients were treated according to the disease stage. All the<br />

patients were regularly followed up with strict vigilance on<br />

residual or recurrence <strong>of</strong> the tumour. The follow up period<br />

ranged from 5 years to 2 years <strong>and</strong> st<strong>and</strong>er protocol for follow<br />

4<br />

up were used.<br />

Results:<br />

After a detailed study <strong>of</strong> 35 patients <strong>of</strong> tumours <strong>of</strong> maxilla, I<br />

found malignant tumours were 6 times more common than<br />

benign tumours. The incidence <strong>of</strong> maxillary malignancy was<br />

3.4% <strong>of</strong> all head <strong>and</strong> neck cancers. Benign tumours were more<br />

nd rd<br />

common in male <strong>of</strong> 2 <strong>and</strong> 3 decade. Maximum age<br />

th<br />

incidence <strong>of</strong> malignancy was in the 6 decade with median<br />

age <strong>of</strong> 51.5 years. Only 9 patients were exposed to tobacco in<br />

some other ways. In my study the most common symptom<br />

was facial (75%) in both benign <strong>and</strong> malignant tumours.<br />

Nasal symptoms coming to next i.e. 75% in benign tumors<br />

<strong>and</strong> 40% in malignant tumour <strong>and</strong> orodental symptoms<br />

occurring in 25% <strong>and</strong> 35% <strong>of</strong> cases <strong>of</strong> benign <strong>and</strong> malignant<br />

tumours respectively. The range <strong>of</strong> the duration <strong>of</strong> symptoms<br />

was 2-18 months with the median duration <strong>of</strong> 6 months. In my<br />

study, 6 out <strong>of</strong> 30 had lymphatic metastasis. All the patients<br />

with neck metastasis had squamous cell carcinoma (SCC).<br />

Benign tumours found in our study were heamangioma in 2<br />

patients, fibrous dysplasia in 2 patients <strong>and</strong> cementoosifying<br />

fibroma in 1 patients <strong>and</strong> in case <strong>of</strong> malignant tumours we<br />

found 24 patients <strong>of</strong> SCC, 3 patients <strong>of</strong> sarcomas, 2 patients <strong>of</strong><br />

salivary gl<strong>and</strong> malignancies <strong>and</strong> 1 patient <strong>of</strong> malignant<br />

melanoma. Regarding the AJCC staging 8, 12 <strong>and</strong> 10 patients<br />

were in stage 2, stage 3 <strong>and</strong> stage 4 respectively, while none <strong>of</strong><br />

the patient was in stage 1. Out<strong>of</strong> 8 patients <strong>of</strong> stage 2, 6 were<br />

treated by total maxillectomy <strong>and</strong> 2 had taken curative<br />

radiotherapy. After total maxillectomy, 2 patients had<br />

recurrence <strong>and</strong> 2 year <strong>and</strong> 5 year survival rate were 83.3% <strong>and</strong><br />

66.7% respectively. After radiotherapy, both the patient had<br />

21<br />

recurrence in one year follow. All 12 patients <strong>of</strong> stage 3 were<br />

treated by either total or extended maxillectomy <strong>and</strong> post<br />

operative radiotherapy. After maxillectomy <strong>and</strong> post<br />

operative radiotherapy, 1 patient had residual disease <strong>and</strong> 2<br />

year <strong>and</strong> 5 year survival rate were 91 % <strong>and</strong> 66% respectively.<br />

Out 10 patients <strong>of</strong> stage 4, 5 were treated by total<br />

maxillectomy with neck dissection <strong>and</strong> post operative<br />

radiotherapy <strong>and</strong> 5 had taken palliative radiotherapy. After<br />

total maxillectomy with neck dissection <strong>and</strong> post operative<br />

radiotherapy, 1 patient had residual disease <strong>and</strong> 1 had<br />

recurrence <strong>and</strong> 2 year <strong>and</strong> 5 year survival rate were 60% <strong>and</strong><br />

40% respectively. After radiotherapy, 4 patients had residual<br />

disease <strong>and</strong> one had recurrence in one year follow.<br />

All the benign tumors were treated by surgery either subtotal<br />

maxillectomy with preservation <strong>of</strong> orbital floor (4 patients) or<br />

partial medial maxillectomy (1 patient). At end <strong>of</strong> 3 years<br />

follow-up, none <strong>of</strong> the patient had residual disease or<br />

recurrence.<br />

24 patients had taken radiotherapy. Out <strong>of</strong> them 4 patients had<br />

mucositis(In Bush & Bugshav series 4 patients), 1 patient had<br />

serous otitis media(None in Bush & Bugshav series), 1 had<br />

osteoredionecrosis(In Bush & Bugshav series 2 patients), 2<br />

had neck fibrosis(None in Bush & Bugshav series) <strong>and</strong> 1 had<br />

trismus(None in Bush & Bugshav series). In Bush & Bugshav<br />

series 2 patients had blindness while in our series none <strong>of</strong> the<br />

patient had blindness after radiotherapy. After surgery 2 had<br />

ectropion, 1 had wound gapping <strong>and</strong> 1 had maggots in<br />

operated cavity.<br />

Discussion:<br />

Compared with the malignant tumour, benign tumours <strong>of</strong><br />

maxilla are rare <strong>and</strong> present in early age with male<br />

predominance. Surgery is the treatment <strong>of</strong> choice for benign<br />

tumors <strong>and</strong> if completely excised they rarely recur. In my<br />

study one case was heamangioma <strong>of</strong> maxillary sinus, which<br />

was previously operated outside civil hospital, Surat <strong>and</strong><br />

came to us with recurrence <strong>and</strong> was completely excised. In<br />

three years <strong>of</strong> follow up none <strong>of</strong> the patient with benign<br />

tumour had residual tumour or recurrence.<br />

Unlike to other study, in the present study, I found that there<br />

was no significant male predominance (M: F was 1.2:1) in<br />

1<br />

malignant maxillary tumour. There is an average 5-6 months<br />

<strong>of</strong> delay in the presentation which contributes the poor<br />

9<br />

prognosis. The symptoms <strong>of</strong> maxillary sinus malignancy<br />

depend upon extent <strong>and</strong> direction <strong>of</strong> spread <strong>and</strong> site <strong>of</strong><br />

1<br />

tumors. two patient <strong>of</strong> stage 3 who refused for surgery <strong>and</strong><br />

received radiotherapy had not obtained cure <strong>and</strong> died within 2<br />

years. Two patients <strong>of</strong> stage 3 disease, who were advised for<br />

postoperative radiotherapy but had refused for the same due<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


to fear <strong>of</strong> eye complication <strong>of</strong> radiotherapy, had developed<br />

recurrence <strong>and</strong> died within 3 years. So patient's compliance<br />

contributes the poor prognosis. All the patients who had<br />

residual disease received chemotherapy, so chemotherapy is<br />

only for palliative treatment. Two patients received curative<br />

RT but they had recurrence <strong>and</strong> when they came for follow up<br />

the tumors were too advanced to treat <strong>and</strong> died within 3 years<br />

Due to newer technique <strong>of</strong> RT, the chances <strong>of</strong> grave<br />

complications likes osteoradionecrosis <strong>and</strong> blindness were<br />

rare.<br />

Survival rate<br />

After RT , My series - 40% 1 year survival <strong>and</strong> all died before<br />

2<br />

3 years. Badib et al - 33% 4 year survival , Bush &Bugshaw -<br />

13<br />

33% 5 year survival<br />

After Surgery- My series – 83% 2 year survival, 66% 5<br />

13<br />

year survival, Bush & Budshaw - 75% 5 year survival<br />

After Surgery followed by RT, My series – 84% 2 year<br />

survival,2% 5 year survival, Bush & Budshaw - 50% 5<br />

2<br />

year survival, 65% to 75% in most recently reported series.<br />

One patient had lost for follow up <strong>and</strong> not included in<br />

survival rate. Crude 2 year <strong>and</strong> 5 year survival rates were 80%<br />

<strong>and</strong> 44% respectively.<br />

Conclusion:<br />

Delay in presentation, TNM Stage, Histology <strong>of</strong> the tumour,<br />

Patient's preference <strong>and</strong> compliance for the treatment,<br />

Combined modalities <strong>of</strong> treatment in stage II <strong>and</strong> IV, are the<br />

key factors to determine the outcome <strong>of</strong> the maxillary tumors.<br />

No significant improvement in crude 5 year survival rate <strong>and</strong><br />

it remains same as in the past. But 5 year survival rate has<br />

improved significantly after curative treatment which is<br />

comparable to the most resent reported series.<br />

References:<br />

1. J.C.Watkinson, M.N.Gage, J.N.Wilson: Stell & Maran's:<br />

th<br />

<strong>Head</strong> & <strong>Neck</strong> Surgery, 4 edition, Chap. 19, 377-96<br />

2. Ehab Y.N. Hanna, Christopher T. Westfall; Cancer <strong>of</strong> the<br />

Nasal Cavity, Paranasal Sinuses, <strong>and</strong> Orbit; In Eugene N.<br />

Myers, James Y. Sune, Jeffrey N. Myers, Enab Y.N.<br />

Hanna Editors; CANCER OF THE HEAD AND NECK;<br />

th<br />

4 edition; Chapter 9, 155-2o6.<br />

3. Badib A.O. et al: Treatment <strong>of</strong> cancer <strong>of</strong> the Para nasal<br />

sinus. Cancer, Vol.2; 533-537.<br />

4. Jatin P. Shah, Snehal G. Patet; Nasal Cavity <strong>and</strong><br />

Paranasal Sinuses; In Jatin Shah; HEAD & NECK<br />

rd<br />

SURGERY & ONCOLOGY; 3 Edition; Chapter 3;<br />

Page 57-93.<br />

5. J.C.Watkinson, M.N.Gage, J.N.Wilson: Steii & Maran's:<br />

th<br />

<strong>Head</strong> & <strong>Neck</strong> Surgery, 4 edition, Chap. 2, 22-23<br />

22<br />

6. S. K. Das, Somnath Saha, L. M. Ghosh, A.<br />

Bhowmick.haemangioma <strong>of</strong> maxillary sinus, Indian<br />

<strong>Journal</strong> <strong>of</strong> Otolaryngology <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery,<br />

Vol. 53, No. 1, 65-67.<br />

th<br />

7. AJCC cancer staging manual; 6 addition,59-67<br />

8. Guo GF, Yang AK, Xie RH et al; Prognostic analysis <strong>of</strong><br />

151 patients with maxillary sinus malignant neoplasm.<br />

Ai Zheng. 2004 Nov. 23(11 suppl.); 1456-50.<br />

9. AL-Jhani AS et al: Maxillary sinus carcinoma, Natural<br />

History <strong>and</strong> outcome. Sudi med J. 2004 Jul: 929-33.<br />

10. Kingdom TT, Kalpan MJ: Mucosal melanoma <strong>of</strong> the<br />

nasal cavity <strong>and</strong> paranasal sinuses. <strong>Head</strong> <strong>Neck</strong> 17 : 1995;<br />

184-9<br />

11. Sercarz JA, Mark RJ, Tran L, et al: Sarcoma <strong>of</strong> the nasal<br />

cavity <strong>and</strong> Para nasal sinuses. Ann Rhinol Laryngol<br />

1994 Sep; 103(9); 699-704.<br />

12. Le QT, Fu KK, Kaplan et al; Treatment <strong>of</strong> maxillary<br />

sinus carcinoma: A comparison <strong>of</strong> the 1997 <strong>and</strong> 1977<br />

American Joint Committee on Cancer staging systems.<br />

Cancer, 1999 Nov.1; 86(9): 1700-11<br />

13. Malcom A. Bagshaw. Carcinoma <strong>of</strong> Para nasal<br />

Sinuses.Cancer.Vol.50 154-158.July 1982<br />

Address for correspondence<br />

Dr. Darshan Doshi<br />

5, Madhuvan apartment. Pragna soc.<br />

B/H; Samved Hospital, Stadium 5 road<br />

Navarangpura, Ahmedabad-380009<br />

E-mail drdvdosho@yahoo.com<br />

Cell +91 9825634964<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


Introduction<br />

The symptom <strong>of</strong> hoarseness is one with many causes <strong>and</strong><br />

several treatments. Whether the patient notices vocal fatigue<br />

or says that it's harder to go with a worsening voice as the day<br />

progresses, the underlying cause <strong>of</strong> hoarseness must be found.<br />

Aims <strong>and</strong> objectives<br />

The study was aimed to study the etiology <strong>of</strong> hoarseness <strong>of</strong><br />

voice in 100 cases.<br />

Material <strong>and</strong> Method<br />

The present study was conducted on 100 patients <strong>of</strong><br />

hoarseness <strong>of</strong> voice attending ENT OPD <strong>and</strong> Indoor in ENT<br />

ward. A thorough clinical history, clinical <strong>and</strong> ENT<br />

examination were done,<br />

Observations<br />

In the present series, the peak incidence <strong>of</strong> laryngeal diseases<br />

was in the 4th decade (31%) <strong>of</strong> life though the age range was<br />

from 10 years to 86 years .66% were males <strong>and</strong> 34% were<br />

females thereby showing male preponderance in the present<br />

study. Labourers (24%) formed the predominant group<br />

followed by housewives (20%), farmers (14%) <strong>and</strong> students<br />

(8%). Out <strong>of</strong> all intralaryngeal causes (88%), vocal<br />

nodule(18%) formed the most common etiology followed by<br />

carcinoma larynx(15%), chronic hyperemic laryngitis<br />

(14%),chronic hyperplastic laryngitis(12%), acute<br />

laryngitis(10%), vocal polyp(8%), tubercular laryngitis(5%)<br />

,benign tumours (3%), radiotherapy induced (2%) <strong>and</strong><br />

external trauma in 1 % case only. While out <strong>of</strong> extralaryngeal<br />

cases (12%), neurological (10%) <strong>and</strong> functional (2%) were<br />

responsible for etiology <strong>of</strong> hoarseness.<br />

Discussion<br />

In the present study, the maximum cases were found in the<br />

fourth decade accounting for 31%. The findings are in<br />

consistence with study <strong>of</strong> Ghosh et al (2001). In the present<br />

study, the main bulk <strong>of</strong> patients who complained <strong>of</strong><br />

hoarseness consisted <strong>of</strong> labourers (24%) followed by<br />

housewives (20%), The findings <strong>of</strong> above study are in<br />

consistence with study <strong>of</strong> Baitha et al (2002) where labourers<br />

(36.36%) constituted the single largest group followed by<br />

housewives(21.81%). In the present study, majority <strong>of</strong> cases<br />

<strong>of</strong> hoarseness (88%) had pathology in larynx while only 12%<br />

had extralaryngeal pathology which included vocal cord<br />

23<br />

Main Article<br />

Aetiological study <strong>of</strong> 100 cases <strong>of</strong> hoarseness <strong>of</strong> voice<br />

1 2 3<br />

Harvinder Kumar , Sonia Seth , Deep Kishore -Hisar ( Haryana)<br />

palsy (10%) <strong>and</strong> functional dysphonia (2%). The majority <strong>of</strong><br />

the patients <strong>of</strong> hoarseness (95%) had intralaryngeal pathology<br />

<strong>and</strong> only 5% had extralaryngeal cause which included vocal<br />

cord palsy (3%) <strong>and</strong> functional dysphonia (2%).<br />

In the present study, vocal nodules (18%) formed the most<br />

common etiology. Chopra <strong>and</strong> Kapoor (1997) also reported<br />

the incidence <strong>of</strong> vocal nodules (33%) as highest in their study<br />

In the present study, the incidence <strong>of</strong> carcinoma larynx was<br />

15% cases. It was consistent with the findings <strong>of</strong> Parikh<br />

(1991) who reported incidence <strong>of</strong> carcinoma larynx to be 12%<br />

.In the present study, extralaryngeal causes formed 12% <strong>of</strong><br />

total causes <strong>of</strong> hoarseness. Baitha et al (2002) reported<br />

extralaryngeal causes to be 9.09% <strong>of</strong> total causes <strong>of</strong><br />

hoarseness. All the cases (100%) were <strong>of</strong> neurological (vocal<br />

cord palsy).<br />

Summary <strong>and</strong> Conclusion<br />

The peak incidence was in the 4th decade <strong>of</strong> life. Male<br />

preponderance was seen. Labourers formed the predominant<br />

group. Amongst intralaryngeal etiologies, vocal nodules<br />

formed the most common cause while out <strong>of</strong> extralaryngeal<br />

causes, neurological cause was predominant etiology.<br />

References<br />

1. Baitha S, Raizada RM, Singh AK et al (2002): Clinical<br />

pr<strong>of</strong>ile <strong>of</strong> hoarseness <strong>of</strong> voice. Indian <strong>Journal</strong> <strong>of</strong><br />

Otolaryngology <strong>and</strong> <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery 54: 14-18.<br />

2. Chopra <strong>and</strong> Kapoor (1997): Study <strong>of</strong> benign glottic<br />

lesions undergoing microlaryngeal surgery. Indian<br />

<strong>Journal</strong> <strong>of</strong> Otolaryngology <strong>and</strong> <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery<br />

49: 276-279.<br />

3. Ghosh SK, Chattopadhyay S, Bora H et al (2001):<br />

Microlaryngoscopic study <strong>of</strong> 100 cases <strong>of</strong> hoarseness <strong>of</strong><br />

voice. Indian <strong>Journal</strong> <strong>of</strong> Otolaryngology <strong>and</strong> <strong>Head</strong> <strong>and</strong><br />

<strong>Neck</strong> Surgery 53: 270-272.<br />

Address for correspondence<br />

Dr. Harvinder Kaur<br />

Assoc Pr<strong>of</strong> & <strong>Head</strong><br />

Maharaja Agrasen Medical College,<br />

Agroha.Hisar ( Haryana)<br />

E mail: drharvinderent@gmail.com<br />

Cell +91 9416345395<br />

1 2 3<br />

Associate Pr<strong>of</strong>essor & <strong>Head</strong>, Associate Pr<strong>of</strong>essor, Senior Resident Maharaja Agrasen Medical College,<br />

Agroha.Hisar ( Haryana)<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


Introduction-<br />

Malignant external otitis (MEO) is a severe infection <strong>of</strong> the<br />

external auditory canal, generally due to pseudomonas, most<br />

commonly affecting elderly diabetics. The condition is<br />

characterized by deep seated, excruciating, continuous ear<br />

pain, resistant to analgesics <strong>and</strong> worse at night; persistent pus<br />

discharge from the ear <strong>and</strong> granulations at the junction <strong>of</strong> the<br />

osseous <strong>and</strong> cartilaginous portions <strong>of</strong> the external auditory<br />

canal. The pathogenesis <strong>of</strong> MEO most probably depends on<br />

some underlying alterations in the immune system <strong>and</strong> the<br />

peculiar microbiological characteristics <strong>of</strong> the bacteria. Once<br />

the organism is established in the susceptible external canal, it<br />

can spread in three directions: (1) anteriorly through the<br />

fissures <strong>of</strong> Santorini to involve the infratemporal fossa,<br />

parotid gl<strong>and</strong> <strong>and</strong> facial nerve at the stylomastoid foramen;<br />

(2) posteriorly to invade the mastoid process <strong>and</strong> the vertical<br />

portion <strong>of</strong> the facial nerve; (3) medially as an osteomyelitis<br />

affecting the jugular foramen, thereby involving the cranial<br />

nerves IX, X, XI <strong>and</strong> XII <strong>and</strong> possibly causing jugular venous<br />

thrombosis, brain abscess or death. Though granulations in<br />

the external auditory canal is usually a characteristic feature<br />

<strong>of</strong> MEO, the patient can sometimes present with a normal<br />

external auditory canal, as was the case in the patient who<br />

presented to us.There is no single imaging modality to<br />

accurately evaluate the extent <strong>of</strong> the disease <strong>and</strong> the response<br />

to treatment. Computerised Tomography (CT) with the ability<br />

to delineate normal fat planes <strong>and</strong> the bony cortices has been<br />

the preferred imaging modality for evaluation <strong>of</strong> MEO. Ismail<br />

et al proposed that MRI should be used as the primary<br />

imaging modality in MEO <strong>and</strong> to monitor disease<br />

24<br />

Case report<br />

Malignant external otitis – an atypical presentation <strong>and</strong> management dilemma<br />

1 2<br />

George A. Mathew , Kamal Kishore - Ludhiana (Punjab)<br />

Abstract<br />

Malignant external otitis is a disease predominantly <strong>of</strong> elderly diabetics caused most <strong>of</strong>ten by Pseudomonas. Classical features<br />

include severe ear pain, otorrhoea <strong>and</strong> granulations in the floor <strong>of</strong> the external auditory canal. Advanced infections can cause<br />

skull base osteomyelitis, multiple cranial nerve palsies <strong>and</strong> temporom<strong>and</strong>ibular joint involvement. Though high resolution CT<br />

scan <strong>of</strong> the temporal bone has been the primary imaging modality <strong>of</strong> choice, MRI <strong>of</strong> the skullbase is emerging as a very useful<br />

tool to diagnosis <strong>and</strong> to monitor the response to treatment. Treatment consists <strong>of</strong> prolonged systemic antibiotics combined with<br />

aural toilet, removal <strong>of</strong> granulations in the external auditory canal <strong>and</strong> control <strong>of</strong> diabetes. Although systemic cipr<strong>of</strong>loxacin is<br />

the drug <strong>of</strong> choice, ceftazidime is increasingly being used due to the development <strong>of</strong> resistance to fluroquinolones. Surgical<br />

debridement is to be used judiciously <strong>and</strong> sparingly because <strong>of</strong> the risk <strong>of</strong> spreading the infection into uninvolved tissues.<br />

Key Words: Malignant external otitis (MEO), MRI skull base, Prolonged medical management<br />

progression. Both morbidity <strong>and</strong> mortality can be reduced<br />

significantly, if MEO is diagnosed early <strong>and</strong> treated<br />

aggressively, the mainstay <strong>of</strong> treatment being a suitable <strong>and</strong><br />

sufficiently protracted course <strong>of</strong> antibiotics. Treatment<br />

strategies have changed significantly over time. Surgical<br />

debridement, once the mainstay <strong>of</strong> treatment has been<br />

superseded by systemic antibiotic therapy. In particular, oral<br />

quinolones such as cipr<strong>of</strong>loxacin are highly effective against<br />

pseudomonas. This provides good bone bioavailability <strong>and</strong><br />

can be taken orally. This drug given in combination with a<br />

third or fourth generation cephalosporin may provide optimal<br />

antibiotic therapy. Topical antibiotics have no role in<br />

treatment. Gr<strong>and</strong>is et al assert that there is no role for surgical<br />

management in MEO other than diagnostic biopsies. Total<br />

surgical eradication is impractical because <strong>of</strong> deep<br />

penetration into the skull base as well as lack <strong>of</strong> demarcation<br />

lines in this diffuse pathological process; furthermore, a noninvolved<br />

middle ear or mastoid cavity may become infected<br />

after extensive surgery.<br />

Case report-<br />

A 65 year old diabetic lady was referred to ENT from the<br />

Neurology department with complaints <strong>of</strong> severe right sided<br />

headache <strong>and</strong> ear pain <strong>of</strong> two weeks duration, not controlled<br />

with analgesics, <strong>and</strong> facial palsy. On examination, she was<br />

found to have a right sided grade 3 facial weakness. The<br />

external auditory canal was normal <strong>and</strong> there was no tragal<br />

tenderness. She had a large central perforation <strong>of</strong> the<br />

tympanic membrane, but normal middle ear mucosa. The CT<br />

scan <strong>of</strong> the temporal bone was reported to be normal. A<br />

provisional diagnosis <strong>of</strong> malignant otitis externa was made<br />

1 2<br />

Assistant Pr<strong>of</strong>essor, Senior Resident, Dept <strong>of</strong> ENT, Christian Medical College, Ludhiana ( Punjab)<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


<strong>and</strong> she was started on intravenous ceftazidime 6 gm daily,<br />

<strong>and</strong> was continued for one week. The pain <strong>and</strong> facial palsy<br />

recovered completely after one week, <strong>and</strong> the patient was<br />

discharged on oral cipr<strong>of</strong>loxacin 750 mg twice daily. After<br />

one month, she presented in OPD with complaints <strong>of</strong> severe<br />

ear pain, dysphagia, <strong>and</strong> change in voice, cough <strong>and</strong><br />

aspiration. On examination, the external auditory canal was<br />

normal <strong>and</strong> the facial nerve was intact. There was a reduced<br />

gag reflex, deviation <strong>of</strong> tongue to the right <strong>and</strong> right vocal<br />

cord paralysis indicative <strong>of</strong> a right sided IX, X <strong>and</strong> XII nerve<br />

palsy. In view <strong>of</strong> the strong clinical suspicion <strong>of</strong> skull base<br />

osteomyelitis, an MRI was done (fig 1), the T2W images<br />

showed hyper intense lesion <strong>of</strong> the skull base extending to the<br />

nasopharynx, <strong>and</strong> clival erosion. She was restarted on<br />

intravenous ceftazidime 6 gm daily which was continued for<br />

six weeks. The patient showed excellent clinical recovery<br />

over six weeks with resolution <strong>of</strong> the pain, aspiration <strong>and</strong><br />

cough <strong>and</strong> her hypoglossal palsy recovered, though her vocal<br />

cord palsy persisted. She was discharged on oral<br />

cipr<strong>of</strong>loxacin 750 mg twice daily for six months, <strong>and</strong> has<br />

remained pain free <strong>and</strong> recovery <strong>of</strong> cranial nerve deficits at six<br />

months <strong>of</strong> follow up except for the right vocal cord palsy. An<br />

MRI scan 6 months later (Fig 2) showed significantly less<br />

enhancement than on the previous MRI.(Fig 1)<br />

Discussion As the number <strong>of</strong> diabetics increase, the<br />

complications <strong>of</strong> diabetes like MEO is likely to increase<br />

significantly in the coming years. Though malignant external<br />

otitis is a relatively uncommon disease, the protracted <strong>and</strong><br />

invasive nature <strong>of</strong> the disease with significant morbidity <strong>and</strong><br />

mortality in an untreated patient calls for an aggressive<br />

management strategy. Lack <strong>of</strong> a strong clinical suspicion can<br />

result in the condition being underdiagnosed, as may be the<br />

situation in our country today. Also, general practitioners<br />

need to be made aware <strong>of</strong> this clinical entity <strong>and</strong> the<br />

availability <strong>of</strong> effective treatment. In the case which is<br />

mentioned above, there were no granulations in the external<br />

auditory canal. Inadequate antibiotic treatment given<br />

elsewhere could be the reason why granulations were absent<br />

in the external auditory canal with disease persisting in the<br />

skull base. A prevalent trend <strong>of</strong> extensive surgical<br />

debridement for MEO is seen in India. Clinicians need to be<br />

made aware <strong>of</strong> the pitfalls <strong>of</strong> venturing into surgery without<br />

appropriate long term medical management. Among the five<br />

patients <strong>of</strong> MEO with skull base osteomyelitis seen in our<br />

institution from Jan 2007 to November 2009 which<br />

comprised four women <strong>and</strong> one man, all were elderly<br />

diabetics over sixty years <strong>of</strong> age, three <strong>of</strong> them having<br />

underwent surgical debridement elsewhere <strong>and</strong> continued to<br />

have severe ear pain <strong>and</strong> granulations in the external auditory<br />

25<br />

canal, all could be managed medically with high dose<br />

intravenous ceftazidime given for one to eight weeks with<br />

oral cipr<strong>of</strong>loxacin given for a further six weeks to six months,<br />

depending on the resolution <strong>of</strong> symptoms. At the end <strong>of</strong><br />

treatment, all the patients were pain free with complete<br />

resolution <strong>of</strong> granulations in the external auditory canal <strong>and</strong><br />

the MRI confirmed significant reduction in the inflammation<br />

at the skull base. The key to successful treatment is to<br />

continue the antibiotic therapy for a sufficiently long period <strong>of</strong><br />

time, sometimes even for up to one year. Recurrences can<br />

occur as long as one year later <strong>and</strong> therefore a patient should<br />

not be considered cured until at least a year after the treatment<br />

is initiated. A reasonable protocol to follow would be<br />

intravenous ceftizidime 3-6 gm per day for one week with<br />

local ear cleaning <strong>and</strong> removal <strong>of</strong> granulations in the external<br />

auditory canal. If the condition improves <strong>and</strong> the bacteria is<br />

sensitive to cipr<strong>of</strong>loxacin, the patient can be sent home on oral<br />

cipr<strong>of</strong>loxacin 750 mg twice daily for six weeks to six months.<br />

Conclusions<br />

Malignant external otitis should be suspected in a diabetic<br />

patient with deep seated ear pain <strong>and</strong> granulations in the floor<br />

<strong>of</strong> the external auditory canal with or without cranial nerve<br />

involvement. A strong clinical suspicion is required to rule out<br />

skull base osteomyelitis in the absence <strong>of</strong> granulations in the<br />

external auditory canal. MRI may be used as the primary<br />

imaging modality <strong>and</strong> to monitor disease progression.<br />

Malignant external otitis with or without skull base<br />

osteomyelitis can be cured with a long-term, high-dose,<br />

appropriate antibiotic treatment.<br />

References<br />

1. Amorosa.L, Modugno.G.C, Pirodda. A - Malignant<br />

external otitis: Review <strong>of</strong> personal experience. Acta<br />

Otolaryngologica (Stockh) 1994; 521: 1-14<br />

2. Ismail H., Hellier W.P., Batty V. ; Use <strong>of</strong> magnetic<br />

resonance imaging as the primary imaging modality in the<br />

diagnosis <strong>and</strong> follow-up <strong>of</strong> malignant external otitis: The<br />

<strong>Journal</strong> <strong>of</strong> Laryngology <strong>and</strong> Otology; 2004, 118, 7 Pg 576<br />

3. Levenson MJ, Parisier FC, Dolitsky J, Bindra G.<br />

Cipr<strong>of</strong>loxacin: drug <strong>of</strong> choice in the treatment <strong>of</strong> malignant<br />

external otitis Laryngoscope 1991; 101: 821-824<br />

4. Gr<strong>and</strong>is RJ, Branstetter BF, Yu VL. The changing face <strong>of</strong><br />

malignant (necrotizing) external otitis: clinical, radiologic<br />

& anatomical correlations. Lancet Infect Dis. 2004; 4:34-39<br />

Address for correspondence:<br />

Dr George A. Mathew,<br />

Assistant Pr<strong>of</strong>essor, Dept <strong>of</strong> ENT,<br />

Christian Medical College, Vellore, Tamilnadu- 632004<br />

E mail: georgemathew70@gmail.com<br />

Cell +91 9486860490<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


27<br />

Case report<br />

Gingival granular cell tumour <strong>of</strong> newborn<br />

1 2 3 4<br />

Trupti R.Chopade M.V.Jagade , Ashish R.G<strong>and</strong>he , Dhyaneshwar Ahire -Mumbai<br />

Abstract:<br />

Gingival granular cell tumour <strong>of</strong> newborn, or congenital epulis, is an uncommon benign s<strong>of</strong>t tissue lesion that usually arises<br />

from the alveolar mucosa <strong>of</strong> neonates. We report a case <strong>of</strong> a 10 days-old female newborn, who presented with an intraoral<br />

gingival mass .The lesion, was completely removed surgically <strong>and</strong> the patient had an uneventful postoperative course.<br />

Clinical features <strong>and</strong> treatment approach are presented <strong>and</strong> discussed, emphasizing the necessity <strong>of</strong> a multidisciplinary<br />

approach in such cases.<br />

Introduction<br />

The term gingival granular cell tumour <strong>of</strong> the newborn refers<br />

to a rare gingival tumour that most commonly occurs along<br />

the alveolar ridge <strong>of</strong> the maxilla in newborn girls, usually<br />

without associated abnormalities <strong>of</strong> the teeth or additional<br />

congenital malformations.It is also known as congenital<br />

1<br />

epulis or Neumann's tumor . Usually, it is presented as a single<br />

2<br />

lesion, however multiples cases have been reported . As<br />

spontaneous regression is rare <strong>and</strong> larger tumors may cause<br />

difficulty in feeding <strong>and</strong> respiration,surgical excision is the<br />

treatment <strong>of</strong> choice.There are no reports in the literature about<br />

2<br />

the malignant transformation <strong>of</strong> the lesion .We have reported<br />

one such case <strong>of</strong> a 10 days newborn came from the remote<br />

place .The aim <strong>of</strong> such presentation is to create the awareness<br />

among the otorhinolaryngologist regarding such congenital<br />

gingival pathologies <strong>and</strong> its benign nature as well as surgical<br />

saftey.It is a multidisciplinary approach which makes the<br />

accurate diagnosis <strong>and</strong> plans the management .<br />

Case report:<br />

10 days old female newborn from a remote place visited to<br />

ENT OPD with s<strong>of</strong>t tissue mass along the maxillary alveolar<br />

ridge.The parents gave history <strong>of</strong> this intraoral mass existing<br />

since the birth <strong>of</strong> the baby.The baby was delivered full term<br />

by vaginal delivery . The newborn was asymptomatic till the<br />

date.She had no evidence <strong>of</strong> local trauma or respiratory<br />

distress during the birth. The newborn was not having any<br />

difficulty in feeding. No history <strong>of</strong> any bleeding from the<br />

lesion.There was no significant change in the size <strong>of</strong> lesion<br />

since birth.<br />

On local examination there was a rubbery, pinkish polypoidal<br />

,non tender mass <strong>of</strong> 1.5x1x0.5 cm was present with small<br />

pedunculated stalk along the alveolar ridge.There was no<br />

other abnormality noted on physical <strong>and</strong> systemic<br />

examination.After all routine investigations were<br />

done,patient underwent the excision <strong>of</strong> lesion from its<br />

alveolar base using bipolar cautery under general<br />

anaesthesia.Histological examination revealed abundant<br />

polygonal cells with a coarse granular cytoplasm.The<br />

diagnosis was gingival granular cell tumour <strong>of</strong> the newborn.<br />

Discussion:<br />

Gingival granular cell tumour is a rare benign tumour that<br />

most <strong>of</strong>ten presents on the maxillary or m<strong>and</strong>ibular alveolar<br />

ridges.It is also known as congenital epulis which is<br />

1<br />

nonspecific term denoting the masses <strong>of</strong> gingiva . Congenital<br />

1<br />

granular cell tumor , first described by Neumann in<br />

1871,hence also known as Neumann's tumour.The lesion is<br />

more common in females than males(10 time more common<br />

3<br />

in female children) The GGCTN usually presents as single,<br />

s<strong>of</strong>t tissue mass ,smooth,firm but can occur as multiple<br />

1<br />

lesions in 5-16% <strong>of</strong> cases .It arise from maxillary alveolar<br />

ridges thrice as <strong>of</strong>ten as from the m<strong>and</strong>ibular ridges,especially<br />

2<br />

from the anterior portion . It is usually found in the region <strong>of</strong><br />

2<br />

lateral incisors or canine region .Underlying bone is usually<br />

spared. The histogenesis is uncertain, <strong>and</strong> proposed cells <strong>of</strong><br />

origin include odontogenic epithelium,undifferentiated<br />

mesenchymal cells pericytes, fibroblasts, smooth muscle<br />

5<br />

cells,nerve related cells, <strong>and</strong> histiocytes .Histologically ,the<br />

GGCTN is lined by squamous epithelium with central aspect<br />

<strong>of</strong> the tumour contains polygonal cells with course granular<br />

cytoplasm.scanty collagenous stroma surrounds these<br />

cells.The reason for the female predominance is peculiar.An<br />

10<br />

endogenous hormonal stimulus has been proposed but this<br />

theory is not proved,since detectable estrogen <strong>and</strong><br />

4<br />

progesterone receptors within the lesions are lacking . Small<br />

7<br />

lesions may regress <strong>and</strong> larger lesions must be resected, as<br />

they <strong>of</strong>ten interfere with airway patency <strong>and</strong> cause feeding<br />

difficulties.Complete surgical excision is curative,usually<br />

done under general anaesthesia but in case <strong>of</strong> difficult<br />

intubation in large size tumours it can be done under local<br />

2 1,3,4<br />

Pr<strong>of</strong> & <strong>Head</strong>, Resident Department <strong>of</strong> <strong>Otorhinolaryngology</strong> & <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery<br />

Grant Medical College <strong>and</strong> Sir J.J.group <strong>of</strong> Hospitals, Mumbai<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


6<br />

anaesthesia as well .The differential diagnosis <strong>of</strong> GGCTN<br />

includes haemangioma, fibroma, rhabdomyosarcoma,<br />

teratoma, leiomyoma, congenital dermoid cyst. In the<br />

literature, congenital epulis is reported to be an isolated<br />

finding without associated congenital abnormalities, with the<br />

exception <strong>of</strong> an occasional report <strong>of</strong> a hypoplastic or absent<br />

5<br />

underlying tooth . (A) Histopathological slide showing an<br />

overlaying parakeratinized stratified squamous epithelium.<br />

The vascularized stroma shows a benign proliferation <strong>of</strong><br />

round cells, with abundant eosinophilic granular cytoplasm<br />

<strong>and</strong> small nuclei. A connective fibrous tissue layer is<br />

separating the epithelium from the granular cells. (B) slide<br />

showing the round granular cells with eosinophilic<br />

cytoplasm, with small basophilic nuclei, occasionally placed<br />

in an eccentric position<br />

Although the congenital epulis is composed <strong>of</strong> granular cells<br />

<strong>and</strong> is similar to the true granular cell tumor (granular cell<br />

myoblastoma), the histology <strong>and</strong> epidemiology <strong>of</strong> these two<br />

lesions differ. Granular cell tumors are less vascular, <strong>of</strong>ten<br />

have a component <strong>of</strong> pseudoepitheliomatous hyperplasia,<strong>and</strong><br />

contain more conspicuous nerve bundles than do congenital<br />

epulides. Congenital epulis only occur in the gum pads <strong>of</strong><br />

infants, whereas granular cell tumors usually occur in adults<br />

7<br />

(between 20 <strong>and</strong> 60 years <strong>of</strong> age) <strong>and</strong> may involve multiple<br />

organs.Most importantly ,granule cell tumour can<br />

recur,whereas ,there have been no reports <strong>of</strong> recurrence after<br />

2<br />

excision .The GGCTN is most <strong>of</strong>tenly detected soon after the<br />

birth .Depending upon size <strong>of</strong> the lesion ,prenatal Ultra<br />

sound,usually done during the last few weeks <strong>of</strong> pregnancy<br />

8<br />

may detect its presence in utero .Also ,fetal MRI <strong>and</strong> Doppler<br />

6<br />

helps to exclude the differential diagnosis .It also has<br />

important implication in the planning the type <strong>of</strong> delivery<br />

especially in the cases with large size lesions.The GGCTN<br />

diagnosis <strong>and</strong> management is <strong>of</strong> interest for the oral <strong>and</strong><br />

maxill<strong>of</strong>acial surgeon, the radiologist, the anaesthetist, the<br />

otorhinolaryngologist, the pediatrician <strong>and</strong> the obstetrician.<br />

Although several pr<strong>of</strong>essionals are involved with prenatal<br />

<strong>and</strong> delivery care, sometimes a lesion such as the one reported<br />

may cause surprise <strong>and</strong> concern to the medical team. The<br />

interaction between pr<strong>of</strong>essionals involved with the prenatal<br />

care <strong>and</strong> those involved in the treatment <strong>of</strong> oral <strong>and</strong><br />

maxill<strong>of</strong>acial lesions <strong>and</strong> syndromes, would certainly<br />

optimize the diagnosis <strong>and</strong> treatment approaches in such<br />

cases.<br />

References<br />

1. Neumann E. Ein fall vin congenitale epulis. Arch Heilkd<br />

1871; 12:189–190<br />

2. Loyola AM, Gatti AF, Pinto DS Jr, Mesquita RA. Alveolar<br />

<strong>and</strong> extra-alveolargranular cell lesions <strong>of</strong> the newborn: report<br />

28<br />

<strong>of</strong> case <strong>and</strong> review <strong>of</strong> literature. Oral Surg Oral Med Oral<br />

Pathol Oral Radiol Endod. 1997 Dec; 84(6):668-71.<br />

3. Fuhr AH, Krogh PHJ. Congenital epulis <strong>of</strong> the newborn:<br />

centennialview <strong>of</strong> the literature. J Oral Surg 1972; 30:30–35<br />

4. Lack EE, Perez-Atayde AR, McGill TJ, Vawter GF.<br />

Gingival granular cell tumor <strong>of</strong> the newborn (congenital<br />

“epulis”): ultrastructural observations relating to<br />

histogenesis. Hum Pathol 1982; 13: 686–689<br />

5. Zarbo RJ, Lloyd RV, Beals TF, McClatchey KD.<br />

Congenital gingival granular cell tumor with smooth muscle<br />

cytodifferentiation.Oral Surg Oral Med Oral Pathol 1983;<br />

56:512–520<br />

6. Batsakis JG. Tumors <strong>of</strong> the peripheral nervous system. In:<br />

Tumors <strong>of</strong> the <strong>Head</strong> <strong>and</strong> <strong>Neck</strong>, Clinical <strong>and</strong> Pathological<br />

nd<br />

Correlations. 2 ed. Baltimore, Md: Williams & Wilkins;<br />

1979:313–333<br />

7. Jenkins HR, Hill CM. Spontaneous regression <strong>of</strong><br />

congenital epulis <strong>of</strong> the newborn. Arch Dis Child 1989;<br />

64:145–147<br />

8. Nakata M, Anno K, Matsumori LT, Sumie M, Sase M,<br />

Nakano T, et al.Prenatal diagnosis <strong>of</strong> congenital epulis: a case<br />

report. Ultrasound Obstet Gynecol.2002 Dec; 20(6):627-9.<br />

1.Photograph showing s<strong>of</strong>t tissue mass over alveolar ridge<br />

Address <strong>of</strong> correspondence:<br />

Trupti R. Chopade<br />

Department <strong>of</strong> otorhinolaryngology & head <strong>and</strong> neck<br />

surgery<br />

Grant medical college <strong>and</strong> sir j j group <strong>of</strong> hospitals,<br />

Mumbai<br />

E mail: trupti.chopade@yahoo.in<br />

Cell+91 9890300596<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


29<br />

Case report<br />

Extranasopharyngeal angi<strong>of</strong>ibroma in female<br />

1 2 3 4<br />

Shrinivas Shripatrao Chavan ,Sunil D. Deshmukh ,Vasant G. Pawar , Vaibhav G. Kirpan , Smita W.<br />

5 6 7<br />

Khobragade ,Kaustubh V. Sarvade , Rajan S. Bindu - Aurangabad ( Maharashtra).<br />

Abstract: The Nasopharyngeal angi<strong>of</strong>ibroma originating from the sphenopalatine foramen in an adolescent male is a typical<br />

entity <strong>and</strong> is considered to be the rule <strong>of</strong> thumb. Hereby we highlight a case which challenges the long held dogma with atypical<br />

patient pr<strong>of</strong>ile in terms <strong>of</strong> age, sex <strong>and</strong> origin. We illustrate an interesting case <strong>of</strong> extranasopharyngeal angi<strong>of</strong>ibroma in Female<br />

in her twenties. Despite Maxillary sinus being the most common site <strong>of</strong> origin for extra nasopharygeal angi<strong>of</strong>ibroma, this case<br />

st<strong>and</strong>s apart in showing extra nasopharyngeal angi<strong>of</strong>ibroma arising from nasal septum, the rarest site encountered in clinical<br />

scenario.<br />

Keywords: Extranasopharyngeal Angi<strong>of</strong>ibroma; Female; Nasal Septum; Endonasal approach.<br />

Introduction:<br />

The nasopharyngeal angi<strong>of</strong>ibroma [NPA] is a widely<br />

discussed <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> tumour condition which is highly<br />

vascular, noncapsulated, locally invasive, histologically<br />

benign. It's propensity to bleed torrentially is regarded as a<br />

bane for surgeon. It typically arises from the sphenopalatine<br />

foramen in an adolescent male under the influence <strong>of</strong><br />

testosterone <strong>and</strong> is also known as juvenile nasopharyngeal<br />

angi<strong>of</strong>ibroma [JNA]. The hallmark histological feature is<br />

vascular channels lined by endothelial cells devoid <strong>of</strong> muscle<br />

layer interspersed in network <strong>of</strong> collagen fibres <strong>of</strong> varying<br />

maturity. The fibrous vascular nodule <strong>of</strong> similar histological<br />

appearance when found outside the nasopharynx <strong>and</strong> or<br />

involves female sex <strong>and</strong> or involves different age group is<br />

termed as Extranasophayngeal angi<strong>of</strong>ibroma or Atypical<br />

[ 1 , 2 , 3 ]<br />

a n g i o f i r o m a . T h e r a r i t y o f<br />

Extranasopharygealangi<strong>of</strong>ibroma is evident by the study<br />

conducted by De Vincintelis <strong>and</strong> Pineeli in 1980 where they<br />

reported only 13 cases <strong>of</strong> Extranasopharygeal angi<strong>of</strong>ibrma<br />

.[4]<br />

amongst 704 cases <strong>of</strong> Angi<strong>of</strong>iroma. As per literature<br />

Maxillary sinus is the most common site for<br />

Extarnasopharyngeal angi<strong>of</strong>ibroma <strong>and</strong> Nasal septum<br />

represents the rarest site with only 7 cases reported so far<br />

[2, 5]<br />

worldwide. The Extranasopharygeal angi<strong>of</strong>ibroma has<br />

been the topic <strong>of</strong> intense debate <strong>and</strong> speculation in terms <strong>of</strong> its<br />

etiology <strong>and</strong> pathogenesis; hereby we put forward an<br />

interesting case <strong>of</strong> extranasopharyngeal angi<strong>of</strong>ibroma in a<br />

female.<br />

Case report:<br />

A 24 year old female came to <strong>Otorhinolaryngology</strong><br />

department <strong>of</strong> our institute with chief complaints <strong>of</strong> right side<br />

nasal obstruction since 1 year <strong>and</strong> history <strong>of</strong> sudden onset <strong>of</strong><br />

epistaxis since 10 days. There was no significant past medical<br />

1 2 3 4, 5, 6<br />

<strong>and</strong> surgical illness. On Nasal endoscopy the mass was<br />

pinkish red in color, smooth in appearance, s<strong>of</strong>t in consistency<br />

<strong>and</strong> sensitive to touch. The probe could easily be passed on<br />

lateral aspect but not on medial aspect. All routine<br />

investigations were within normal limits. The CT- Scan <strong>of</strong><br />

PNS predicted a well defined enhancing mass measuring 1.5 x<br />

1 cm in size occupying the right nasal cavity<br />

Procedure: 1] On nasal endoscopy there was pinkish red mass<br />

attached to the nasal septum with broad base pedicle.2] the<br />

nasal mass was removed by cauterizing the pedicle <strong>and</strong> was<br />

sent for Histopatholog.<br />

CT scan showing nasal mass Removed nasal mass<br />

Histopathology report <strong>of</strong> hematoxylene <strong>and</strong> eosin slides:<br />

shows dilated vascular channels <strong>of</strong> varying size lined by<br />

endothelial cells devoid <strong>of</strong> muscle layer surrounded by<br />

fibrotic spindle shape stroma, nuclei are plump <strong>and</strong> elongated,<br />

focal areas <strong>of</strong> haemorrhages seen. Features suggestive <strong>of</strong><br />

Angi<strong>of</strong>ibroma. Considering the rarity <strong>of</strong> such lesion to be<br />

labelled as angi<strong>of</strong>ibroma it was imperative to also rule out<br />

other vascular tumors encountered in nasal cavity.<br />

Assistant Pr<strong>of</strong>., Pr<strong>of</strong>. & <strong>Head</strong>, Sr. Resident, Resident, Dept. Of ENT & <strong>Head</strong> <strong>and</strong> <strong>Neck</strong> Surgery,<br />

7<br />

Pr<strong>of</strong> & <strong>Head</strong> Dept <strong>of</strong> Pathology, Govt. Medical College, Aurangabad (Maharashtra).<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


CD31 marking the blood vessels CD 34 marking the blood<br />

separated by fibrous stroma vessels separated by fibrous stroma<br />

The differential diagnoses which were considered were<br />

hemangiopericytoma, capillary hemangioma, solitary fibrous<br />

tumor <strong>and</strong> schwannoma.The marker study <strong>of</strong> CD 31 <strong>and</strong> CD<br />

34 ruled out hemangiopericytoma <strong>and</strong> solitary fibrous tumour<br />

from the equation.The preponderance <strong>of</strong> multiple vascular<br />

channels <strong>of</strong> varying sizes characteristic <strong>of</strong> capillary<br />

hemangioma was not observed on histology, negating the<br />

possibility <strong>of</strong> capillary hemangioma.After ruling out all the<br />

possible differentials <strong>of</strong> vascular tumours encountered in<br />

th<br />

nasal cavity we were able to report the world's 8 case <strong>of</strong><br />

Extranasopharyngeal angi<strong>of</strong>ibroma attached to nasal septum.<br />

Discussion:<br />

The term juvenile nasopharyngeal angi<strong>of</strong>ibroma is self<br />

explanatory attributed to exclusive occurrence <strong>of</strong> the lesion in<br />

nasopharyngeal area <strong>of</strong> adolescent male in their second <strong>and</strong><br />

[6, 7]<br />

early third decade. The nasopharyngeal angi<strong>of</strong>ibroma<br />

originates from sphenopalatine foramen <strong>and</strong> extends to<br />

adjacent areas namely nose, paranasal sinus, infratemporal<br />

.[7]<br />

fossa <strong>and</strong> cranium. According to Celik et al when a fibrous<br />

vascular nodule occurs outside the nasopharynx <strong>and</strong> or<br />

involves female sex <strong>and</strong> or involves other age group is termed<br />

as Extranasopharyngeal angi<strong>of</strong>ibroma or Atypical<br />

.[3]<br />

angi<strong>of</strong>ibroma. The ENA is extremely rare compared to NPA<br />

with minuscule number <strong>of</strong> cases reported in female. The ENA<br />

produces quicker symptom <strong>and</strong> inherently can be less<br />

vascular in nature.<br />

The etiopathogenesis <strong>of</strong> JNPA is till date a debatable issue as<br />

various theories has been put forward regarding its origin.<br />

According to hormonal theory it is believed that<br />

hamartomatous nidus <strong>of</strong> vascular tissue in nasopharynx gets<br />

.[7,8]<br />

activated in adolescent under influence <strong>of</strong> Testosterone. As<br />

st<br />

per vascular atavism theory 1 branchial arch artery [<br />

nd th<br />

Normally appears between 22 <strong>and</strong> 24 gestational age <strong>and</strong><br />

recedes completely by the delivery ] fails to regress<br />

completely leaving behind the persistent remnant <strong>of</strong> plexus<br />

close to the sphenopalatine foramen which forms the vascular<br />

component <strong>of</strong> angi<strong>of</strong>ibroma due to growth stimulus at the<br />

.[9]<br />

adolescent phase. Despite the plethora <strong>of</strong> theories no single<br />

theory is in a state to define the origin <strong>of</strong> JNPA, so the origin <strong>of</strong><br />

30<br />

ENPA still remains in the dark. The only possible theory<br />

which is close in explaining the origin <strong>of</strong> ENPA in our case<br />

report is the migration <strong>of</strong> Fascia Basils through the<br />

.[5,10]<br />

perpendicular plate <strong>of</strong> ethmoid to nasal septum. As per<br />

literature Maxillary sinus is the most common site for origin<br />

for ENPA but our case study st<strong>and</strong> apart showing attachment<br />

to nasal septum the rare site encountered in clinical practice<br />

.[2, 5]<br />

as have been only seven cases reported so far worldwide.<br />

As per theory, in any NPA as the age advances the fibrous<br />

tissue surpasses the angiomatous tissue to be called as<br />

Fibroangioma.<br />

References:<br />

1. Nomura K, Shimomura A, Awataguchi T, Murakami K,<br />

Kobayashi T. A case <strong>of</strong> angi<strong>of</strong>ibroma originating from the<br />

inferior nasal turbinate .AurisNasus Larynx 2005; 33:<br />

191 – 193.<br />

2. ITasca <strong>and</strong> G CeroniCompadretti .Extranasopahryngeal<br />

angi<strong>of</strong>ibroma <strong>of</strong> nasal septum .a controversial entity.<br />

ACTA Otorhinolaryngologica Italica .2008; 28: 312 –<br />

314<br />

3. Celik B, ErisenL,Saraydaroglu O, CoskunH.Atypical<br />

angi<strong>of</strong>ibromas:a report <strong>of</strong> four cases. Int J Pediatric<br />

<strong>Otorhinolaryngology</strong> 2005; 69:415-421.<br />

4. DeVincentiis G, Pinelli V. Rhinopharyngeal<br />

angi<strong>of</strong>ibroma in the pediatric age group. Clinical<br />

– s t a t i s t i c a l c o n t r i b u t i o n . I n t J P e d i a t r i c<br />

<strong>Otorhinolaryngology</strong> 1980; 2:99-122.<br />

5. H<strong>and</strong>a K.K, Kumar A, Singh M.K, Chhabra A H.<br />

Extranasopharyngeal angi<strong>of</strong>ibroma arising from the<br />

nasal septum. Int J Peadiatric <strong>Otorhinolaryngology</strong>2001;<br />

58: 163- 166.<br />

6. Akbas Y, AnadoluY .Extranasopharyngeal angi<strong>of</strong>ibroma<br />

<strong>of</strong> the head <strong>and</strong> neck in Women. Am J Otolaryngology<br />

2003; 24; 413 – 416.<br />

7. A n n a S z y m a n s k a , E l z b i e t a K o r o b o w i c z ,<br />

WieslawGolabek . A rare case <strong>of</strong> nasopharyngeal<br />

angi<strong>of</strong>ibroma in an elderly female. Eur Arch<br />

Otorhinolaryngol .2006; 263: 657 – 660.<br />

8. W i n d f u h r J P a n d R e m m e r t S .<br />

Extranasopharyngealangi<strong>of</strong>ibroma : Etiology,<br />

incidence <strong>and</strong> management. Acta Otolaryngology 2004;<br />

124: 880 – 889.<br />

9. SchickB,Plinkert P K,PrescherA.Aetiology <strong>of</strong><br />

Angi<strong>of</strong>ibroma:Reflection on their specific vascular<br />

component .Laryngorhinootology.2002;81:280-284.<br />

Address for correspondence<br />

Dr. Shrinivas Shripatrao Chavan<br />

Assistant Pr<strong>of</strong>essor, Dept <strong>of</strong> E.N.T. <strong>and</strong> <strong>Head</strong> <strong>and</strong> <strong>Neck</strong><br />

Surgery,<br />

Govt. Medical College<br />

Aurangabad (M.S.)<br />

E Mail: shrinivasc77@hotmail.com<br />

Cell +91 9403151515<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


Case report<br />

Hairy polyp <strong>of</strong> nasopharynx in adult<br />

1 2 3 4 5<br />

Ajit Daharwal ,Hansa Banjara ,B. R. Singh ,Digvijay Singh ,Sutanu Sarkar -Raipur (Chattisgarh)<br />

Abstract<br />

Hairy polyps are rare benign congenital malformations occurring in the nasopharynx or oropharynx. They arise during early<br />

embryogenesis <strong>and</strong> are invariably benign. They usually present at or soon after birth with signs <strong>of</strong> airway obstruction or feeding<br />

difficulties. Hairy polyps rarely present in older patients <strong>and</strong> only few cases have been reported in adults. We report a case <strong>of</strong><br />

Hairy polyp <strong>of</strong> nasopharynx in a 22 year old female.<br />

Key words: Hairy polyp, Nasopharynx, Adult.<br />

Introduction<br />

Hairy polyp <strong>of</strong> the nasopharynx is an unusual but well<br />

recognised entity. To date approximately 137 cases have been<br />

[1]<br />

recorded . The hairy polyps are rare developmental<br />

malformations usually presenting as pedunculated mass in the<br />

nasopharynx or oropharynx. They usually present at, or soon<br />

after birth with signs <strong>of</strong> upper aerodigestive tract obstruction.<br />

I n t r a n a s a l g l i o m a s , R h a b d o m y o s a r c o m a ,<br />

Meningoencephalocele, Rathke pouch cyst, Pharyngeal<br />

hypophysis, Craniopharyngioma are the differential<br />

diagnosis <strong>of</strong> this uncommon lesion. Very few cases <strong>of</strong> hairy<br />

polyps are reported in adults. We report a case <strong>of</strong> hairy polyp<br />

in a 22 year old female.<br />

Case Report<br />

A 22 years old female attended the Dr. B. R. A. M. Hospital<br />

with symptoms <strong>of</strong> nasal obstruction for last two months.<br />

There was no history <strong>of</strong> rhinorrhoea, rhinosinusitis, epistaxis<br />

or headache. On nasal endoscopy a solid <strong>and</strong> solitary mass<br />

was seen attached to the left lateral wall <strong>of</strong> nasopharynx. The<br />

pedunculated mass was hanging in the oropharynx [Fig. 1],<br />

grey-white in colour, firm in consistency <strong>and</strong> did not bleed to<br />

touch. Rest <strong>of</strong> the otolaryngological examination was normal.<br />

Clinically all other systemic examination showed no<br />

abnormality. Puretone <strong>and</strong> impedance audiometry was<br />

normal. X-ray paranasal sinuses showed mild haziness <strong>of</strong> left<br />

maxillary sinus. X-ray chest was found normal.<br />

Ultrasonography abdomen showed no abnormality. The<br />

routine laboratory investigations were within normal limits.<br />

Computed tomography or magnetic resonance imaging were<br />

not considered for this particular case as clinical examination<br />

did not reveal any intracranial involvement, <strong>and</strong> the mass<br />

which was well circumscribed did not involve surrounding<br />

tissue.<br />

The mass was removed trans-nasally using an endoscope<br />

under general anaesthesia. The base attachment was<br />

1,2 4 5<br />

31<br />

cauterised using bipolar diathermy. The excised mass was<br />

submitted for histopathology. There were no intraoperative or<br />

postoperative complications <strong>and</strong> one year follow-up did not<br />

reveal any recurrence. Otological examinations were found<br />

normal on follow up.<br />

On gross examination the excised mass was 4cm. x 1.5 cm. x<br />

1.5 cm, cylindrical, with grey-white appearance. The cut<br />

surface was also greyish white.<br />

On histopathological examination, the mass was covered with<br />

mature stratified squamous epithelium with presence <strong>of</strong><br />

appendages like sebaceous <strong>and</strong> sweat gl<strong>and</strong>s below the<br />

epithelium [Fig. 2]. The central portion consisted <strong>of</strong> mature<br />

fat cells <strong>and</strong> muscle [Fig. 3]. Based on these features a<br />

diagnosis <strong>of</strong> hairy polyp <strong>of</strong> nasopharynx was made.<br />

Discussion<br />

Hairy polyps <strong>of</strong> nasopharynx are rare lesions with an<br />

incidence <strong>of</strong> less than 1: 40,000 live births <strong>and</strong> till date only<br />

[1]<br />

137 cases are reported. In 1918, Brown Kelly was credited<br />

[2]<br />

for the first report <strong>of</strong> hairy polyp. Although hairy polyps are<br />

the most common type <strong>of</strong> head <strong>and</strong> neck teratoma, they are<br />

nevertheless rare; about 60% originate in the nasopharynx,<br />

with most <strong>of</strong> the remainder occurring in the oropharynx. The<br />

hairy polyps have been labelled in the earlier literature as<br />

[2]<br />

dermoid, teratoid, complex hamartoma <strong>and</strong> even teratoma.<br />

Unlike the more differentiated types <strong>of</strong> teratoma which<br />

contains all three germinal layers, hairy polyps derived from<br />

only two germinal layers namely, the ectoderm <strong>and</strong><br />

mesoderm while, dermoid is due to implantation <strong>of</strong> epidermal<br />

[3]<br />

elements or incomplete break <strong>of</strong> epithelium. Hairy polyps<br />

are not true neoplasm but represent a developmental<br />

[4]<br />

malformation. They arise during early embryogenesis. A<br />

hairy polyp arises from either the segregation <strong>of</strong> epithelial <strong>and</strong><br />

mesodermal elements during the fusion <strong>of</strong> the lateral palatine<br />

process or from the incomplete reabsorption <strong>of</strong> the buccal<br />

[5]<br />

nasopharyngeal membrane. They are invariably benign<br />

Associate Pr<strong>of</strong>essor, SeniorResident, Resident,Department <strong>of</strong> ENT <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery,<br />

3<br />

Pt. Jawaharlal Nehru Memorial Medical College, Raipur, Assistant Pr<strong>of</strong>essor, , Chhattisgarh<br />

Institute <strong>of</strong> Medical Sciences, Bilaspur ,Chhattisgarh<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


[6]<br />

with very little growth potential. Their size varies from 0.5<br />

[1]<br />

to 6 cm. <strong>and</strong> may present as sessile or pedunculated mass.<br />

Hairy polyps most frequently present in the neonatal period<br />

but occasionally be discovered in childhood <strong>and</strong> rarely in<br />

older age. Half <strong>of</strong> the cases are presented in the first year <strong>of</strong><br />

[5]<br />

life. Our case was a 22 year old female who presented with<br />

symptoms <strong>of</strong> nasal obstruction for the past 2 months. Hairy<br />

polyps are more common in females as compared to males in a<br />

[7]<br />

ratio <strong>of</strong> 6:1.<br />

Depending on the location, size <strong>and</strong> mobility, different<br />

symptoms <strong>and</strong> findings may present. Mild respiratory<br />

difficulty, nasal obstruction <strong>and</strong> drainage are the most<br />

common complaints whereas feeding difficulty, vomiting,<br />

coughing, earache <strong>and</strong> drainage, epistaxis <strong>and</strong> protruding<br />

[7, 8]<br />

mass in the oropharynx may also be seen. Chronic middle<br />

ear effusion <strong>and</strong> sleep apnoea are rarely attributable to<br />

[4]<br />

tumours <strong>of</strong> the nasopharynx.<br />

Differential diagnosis <strong>of</strong> nasopharyngeal mass in children<br />

includes a long list. Hamartoma, teratoma, dermoid,<br />

haemangioma, neuroblastoma, rhabdomyosarcoma, glioma,<br />

meningocele <strong>and</strong> a foregut thymic, thyroglossal or lingual<br />

[9]<br />

cyst should be considered. These must also be ruled out in<br />

adults. Radiological examination has an important role to<br />

play in ruling out these entities. Computed tomography (C.T.)<br />

<strong>and</strong> magnetic resonance imaging (MRI) can differentiate<br />

between their tissue characteristics, localise the origin <strong>of</strong> the<br />

tumour, rule out any intracranial or pharyngeal extension <strong>of</strong><br />

lesion <strong>and</strong> evaluate Eustachian tube <strong>and</strong> middle ear<br />

involvement, however in this case we did not considered for<br />

[9]<br />

CT or MRI evaluation. The mass was successfully removed<br />

by transoral surgery under endoscopic visualization. The<br />

endoscope-guided surgery may help avoid undesirable<br />

complications as well as completely excise the lesions<br />

32<br />

Fig. 1<br />

Hairy polyp hanging<br />

in oropharynx<br />

Fig. 2<br />

Fig. 3<br />

Case report<br />

[10]<br />

attached close to the eustachian tube openings. Surgical<br />

removal <strong>of</strong> this benign lesion is curative <strong>and</strong> there is no<br />

recurrence.<br />

This case was reported due to unusual presentation <strong>of</strong> hairy<br />

polyp in nasopharynx <strong>and</strong> rarity <strong>of</strong> this lesion in adult patient<br />

without any systemic involvement. Hairy polyps rarely<br />

present in older patients <strong>and</strong> only few cases have been<br />

reported in world literature.<br />

References:<br />

1. Luke Franklyn, R. Ashok,C. Daniel Nasopharyngeal<br />

hairy polyp in an infant with apnoeic spells.<br />

SheffieldChildren's Hospital, NHS Trust, Wester<br />

Bank,Sheffield, South Yorkshire, S10 2TH [online].<br />

2. Chaudhry AP, Loré JM, Fisher JE, et al. So-called<br />

Hairy Polyps or Teratoid Tumours <strong>of</strong> the Nasopharynx.<br />

Arch Otolaryngol 1978; 104(9): 517 525.<br />

3. McShane D, El Sherif, Doyle-Kelly W, et al. Dermoids<br />

('hairy polyps') <strong>of</strong> the oro nasopharynx. J. Laryngol<br />

Otol 1989; 103(6): 612-615 [abstr].<br />

4. Phansalkar M, Sulhyan K, Muley P, et al. Hairy polyp<br />

<strong>of</strong> Nasopharynx- A Case Report. Indian J Pathol<br />

Microbiol 2000; 43(3): 355-6.<br />

5. Gleeson Michael, Browning GG, Burton MJ, et al,<br />

editors. Scott-Brown's Otolaryngology, <strong>Head</strong> <strong>and</strong><br />

<strong>Neck</strong> Surgery, vol 2, 7th Ed. Great Britain: Hodder<br />

Arnold; 2008. p. 2119.<br />

6. Chakravarti A, Vishwakarma SK, Arora VK, et al.<br />

Dermoid (Hairy Polyp) <strong>of</strong> the Nasopharynx. Indian J<br />

Pediatr 1998; 65: 473-476.<br />

7. Singh Ishwar, Gathwala Geeta , Saxena Sanjay, et al.<br />

Dermoid <strong>of</strong> the Nasopharynx. Indian Pediatrics<br />

September 1994; 31: 1142-1143.<br />

8. Jarvis SJ, Bull PD. Hairy polyps <strong>of</strong> the nasopharynx.<br />

<strong>Journal</strong> <strong>of</strong> Laryngol & Otology 2002; 116: 467- 469.<br />

9. Uygur Kemal , Dursun Engin, Korkmaz Hakan, et al.<br />

Hairy Polyp <strong>of</strong> the Nasopharynx. Gazi Medical<br />

<strong>Journal</strong> 2000; 11: 43-46.<br />

10.Jong-Lyel Roh. Transoral endoscopic resection <strong>of</strong> a<br />

nasopharyngeal hairy polyp. International <strong>Journal</strong> <strong>of</strong><br />

Pediatric <strong>Otorhinolaryngology</strong> 2004;68(8):1087-1090<br />

Photomicrograph Photomicrograph Address for Correspondence:<br />

showing mature showing mature Dr. Ajit Daharwal<br />

stratified squamous fat cells <strong>and</strong> muscle Associate Pr<strong>of</strong>essor ENT<br />

epithelium with (H <strong>and</strong> E x 400) C – 127/6, Ballabh Nagar, Across Ring Road No. 1,<br />

sebaceous gl<strong>and</strong>s<br />

Raipur, Chhattisgarh.<br />

(H <strong>and</strong> E x 100)<br />

E-mail daharwal50@yahoo.co.in<br />

Mobile No. +91- 9981299959<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011


33<br />

NEWS LETTER<br />

1. Dr. Viral A.Chhaya Pr<strong>of</strong>. & <strong>Head</strong> ENT M.P.Shah Medical College Jamnagar<br />

th<br />

(a) won S.D. Parikh senior consultant award paper at 34 <strong>Gujarat</strong> state annual ENT conference<br />

Surat<br />

rd<br />

(b) was invited to deliver lecture on UPP at 63 annual conference <strong>of</strong> AOI Chennai<br />

2. Dr. Vikas Sinha Dean <strong>and</strong> Pr<strong>of</strong>. E.N.T. M.P.Shah Medical College Jamnagar<br />

rd<br />

(a) was judge at junior consultant award paper at 63 Annual Conference <strong>of</strong> A.O.I. Chennai<br />

th<br />

(b) invited as faculty for 7 SAARC ENT Congress at Kathm<strong>and</strong>u Nepal<br />

3. The following faculty had fellowship at M.P.Shah Medical College Jamnagar under Dr. Vikas<br />

Sinha <strong>and</strong> Dr. Viral A. Chhaya<br />

4.<br />

(a) Dr. Orjeta Tonuzi <strong>of</strong> Albania Europe - one month fellowship<br />

(b) Dr. Alexendrosis Fasolis <strong>of</strong> Greece Europe – one week fellowship<br />

(c) Dr. Ch<strong>and</strong>rashekhar ENT surgeon <strong>of</strong> Belgaon Karnataka - one month fellowship<br />

The ENT department M.P.Shah Medical College Jamnagar signed MOU (Memor<strong>and</strong>um <strong>of</strong><br />

underst<strong>and</strong>ing) with ENT department <strong>of</strong> Asan Medical Centre Seoul Korea , ENT department<br />

CAWT Irel<strong>and</strong> (Dr. Kaluskar) <strong>and</strong> Madras Research Centre (Dr. Mohan Kameshwaran)for<br />

exchange programme <strong>of</strong> faculty <strong>and</strong> resident for their training programme<br />

5. Dr. Rajesh Vishwakarma Pr<strong>of</strong> & <strong>Head</strong> ENT B.J.Medical College Ahmedabad delivered lecture at<br />

(a) Bihar on “Early diagnosis <strong>and</strong> Hearing Management”<br />

(b) NIOH Ahmedabad to doctors <strong>of</strong> Coal India Limited<br />

rd<br />

(c) Chaired session at Ballon sinuplasty <strong>and</strong> Cochlear Omplant at 63 annual conference AOI<br />

Chennai<br />

6. Dr. Girish Mishra Pr<strong>of</strong>. & <strong>Head</strong> ENT P.S.Medical College Karamsad<br />

rd<br />

(a) Chairman on “Current Status <strong>and</strong> Future development <strong>of</strong> Cochlear Implant” on at 63 annual<br />

conference <strong>of</strong> AOI at Chennai<br />

th<br />

(b) Hosted 4 Annual Conference <strong>of</strong> <strong>Gujarat</strong> Society <strong>of</strong> <strong>Head</strong> & <strong>Neck</strong> Oncology. Dr. Sidharth<br />

Shah was the organizing secretary. A preconference workshop was conducted wherein<br />

cadaveric dissection to demonstrate various <strong>Head</strong> & <strong>Neck</strong> surgeries.<br />

(c) Principal Investigator <strong>of</strong> WHO supported tobacco cessation centre at P.S.Medical College,<br />

Karamsad is now given the status <strong>of</strong> regional training centre.<br />

7. Dr. Mukesh Ramani Assistant Pr<strong>of</strong>essor ENT at B.J.Medical College Ahmedabad delivered<br />

lecture at Asia Oceana congress Newzeal<strong>and</strong>.<br />

8. Dr Ajay Shah, Associate Pr<strong>of</strong>essor E.N.T. N.H.L. Medical College, Ahmedabad was invited for<br />

laser workshop at Akola M.S. <strong>and</strong> organized a live surgical workshop on FESS V.S.Hospital<br />

Ahmedabad<br />

9. Dr. Atul Kansara,Pr<strong>of</strong>esssor & <strong>Head</strong> E.N.T.,L.G.Medical College, Ahmedabad became<br />

President <strong>of</strong> AOI- GSB, Dr. K. N. Pansara Vice President <strong>of</strong> AOI- GSB<br />

rd<br />

10. Dr. Farida Wadia <strong>of</strong> Surat delivered lecture on CA larynx at 63 AOI conference Chennai<br />

11. Dr Vinod Shah, E.N.T. Surgeon, Surat moderated “management <strong>of</strong> paediatric airway disorder”at<br />

rd<br />

63 AOI conference Chennai<br />

12. Dr Saumitra Shah, E.N.T. Surgeon,Surat was awarded “Dr R.A.F. Cooper”award on Cochlear<br />

rd<br />

Implant at 63 AOI conference Chennai<br />

13. Dr. Ajay George joined SBKS medical college Waghodia (Baroda) as Pr<strong>of</strong>essor ENT<br />

<strong>Otorhinolaryngology</strong> <strong>and</strong> <strong>Head</strong> & <strong>Neck</strong> Surgery, Vol. 8 No. 1, <strong>April</strong> 2011

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