Gene ontology & hypergeometric test
Gene ontology & hypergeometric test
Gene ontology & hypergeometric test
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Fisher exact <strong>test</strong><br />
• List of 80 significant genes from a microarray experiment of<br />
yeast (~ 6000 genes)<br />
• 10 of the 80 genes are in BP-GO term: DNA replication<br />
– Total nr of yeast genes in GO term is 100<br />
Non-sig.<br />
Signif.<br />
-GO +GO<br />
a b<br />
c d<br />
a+b<br />
c+d<br />
a+c b+d n<br />
Non-sig.<br />
Signif.<br />
Fisher exact <strong>test</strong>:<br />
p-value: 6.6 10 -07<br />
-GO +GO<br />
5830 90<br />
70 10<br />
5920<br />
80<br />
5900 100 6000
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