Pharma GABA - BioGaba
Pharma GABA - BioGaba
Pharma GABA - BioGaba
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<strong>Pharma</strong> <strong>Pharma</strong> <strong>Pharma</strong> <strong>GABA</strong> <strong>GABA</strong><br />
<strong>GABA</strong>
What What’s What s <strong>GABA</strong>? <strong>GABA</strong>?<br />
a kind of amino acids widely exist<br />
in nature world, including human<br />
body.<br />
What What is is the the function function for for human?<br />
human?<br />
Exists as neurotransmitter and<br />
stimulates parasympathetic nerve<br />
system.<br />
<strong>Pharma</strong><strong>GABA</strong><br />
<strong>Pharma</strong><strong>GABA</strong><br />
Relax, anti anti-stress, anti<br />
stress,<br />
concentration, concentration, sleep sleep effect<br />
effect
NH 2<br />
COOH<br />
COOH<br />
Glutamic Glutamic acid<br />
acid<br />
■Molecular Weight: 103.12<br />
■Melting Point: 195℃<br />
■CAS No.: 56-12-2<br />
<strong>GABA</strong> <strong>GABA</strong><br />
( ( Gamma amma Amino mino mino Butyric utyric Acid cid )<br />
)<br />
→<br />
GAD<br />
( Glutamic Acid<br />
Decarboxylase )<br />
NH 2 CO 2<br />
<strong>GABA</strong> <strong>GABA</strong><br />
<strong>GABA</strong><br />
COOH<br />
■White to light yellow solid at normal temp. and atom.<br />
+
【Production Production Production Method Method Method of of of <strong>Pharma</strong><strong>GABA</strong><br />
<strong>Pharma</strong><strong>GABA</strong>】<br />
<strong>Pharma</strong><strong>GABA</strong><br />
Medium (Glutamic acid etc)<br />
| ← Lactobacillus hilgardii K-3<br />
fermentation<br />
|<br />
sterilization<br />
|<br />
filtration<br />
|<br />
spray dry<br />
|<br />
<strong>Pharma</strong><strong>GABA</strong><br />
<strong>Pharma</strong><strong>GABA</strong><br />
<strong>Pharma</strong><strong>GABA</strong><br />
Lactobacillus<br />
Lactobacillus Lactobacillus<br />
Lactobacillus hilgardii hilgardii hilgardii hilgardii K-3
Relax & Comfort effect<br />
with <strong>Pharma</strong><strong>GABA</strong>
【Measurement of Relaxation by EEG<br />
(electroencephalogram)】<br />
human brain waves<br />
δwave (less than 4Hz) : sleeping<br />
θwave (4 ~ 8Hz) : half-asleep<br />
αwave (8Hz ~ 13Hz) : calm, relax<br />
βwave (more than 13Hz) : tension
【Effect of <strong>GABA</strong> on human brain waves<br />
–αwave/βwave】<br />
αα波波//ββ波波(%)<br />
power (%) (%)<br />
α/ββ power (%)<br />
180 180<br />
160 160<br />
140<br />
120<br />
100<br />
80<br />
60<br />
High αw<br />
High βw<br />
↓<br />
Water Water Teanine <strong>GABA</strong><br />
<strong>GABA</strong><br />
水 テアニン テアニン <strong>GABA</strong><br />
<strong>GABA</strong> or teanine ; 100mg<br />
Brain waves were measured for 1 hr after <strong>GABA</strong>-intake<br />
*<br />
High αw<br />
low βw<br />
←<br />
*p
【 Loading Loading Stress Stress by by by height height 】<br />
Suspension Suspension Bridge Bridge Bridge in in Tanise Tanise Tanise Tanise (Nara Nara Pref. Pref. in in Japan Japan) Japan<br />
Mid Point
CgA<br />
CgA variability variability rate<br />
rate(%%)<br />
CgA variability rate(%)<br />
140<br />
140<br />
120<br />
120<br />
100<br />
100<br />
80<br />
60<br />
40<br />
20 20<br />
0<br />
【Result - Chromogranin A (※) 】<br />
Con<br />
<strong>GABA</strong><br />
Before Before Before Mild point After<br />
After<br />
Before Mid point After<br />
After<br />
※Chromogranin A (CgA): Mental stress marker in saliva<br />
(Toyota Central Lab. R&D Review Vol.34 No.3 (1999)
【First <strong>GABA</strong> Product from<br />
The Top Confectionary Maker】
<strong>Pharma</strong><strong>GABA</strong>’s<br />
effect on sleep
【Effect on sleep before going bed】<br />
【Subject】<br />
5 healthy males in age 20s<br />
【Measure】<br />
1.Brain wave:<br />
P3 C3 Left side<br />
(Left side of occipital) (of head-top)<br />
2. Electromyogram :chin, legs<br />
(Anterior tibial muscle)<br />
3. Electro-oculogram<br />
4. Electrocardiogram<br />
5. Rectal temperature<br />
Brain wave, electromyogram,<br />
electrooculogram<br />
Electromyogram<br />
Measuring<br />
Electrocardiogram
Falling Falling sleep<br />
sleep<br />
⇒ measured time before falling (deep) sleep<br />
Falling Falling sleep<br />
sleep ((minute minute minute)<br />
Falling sleep (min)<br />
14<br />
12 12<br />
10<br />
8<br />
6<br />
4<br />
2<br />
0<br />
【Required time to fall asleep and<br />
Length of deep sleep】<br />
Deep Deep sleep sleep sleep((min min min)<br />
Deep sleep (min)<br />
Deep Deep Deep sleep sleep in in 60 60 mints mints sleep<br />
sleep<br />
⇒ (deep, quality) sleeping time<br />
24<br />
Control Control Control <strong>GABA</strong><br />
<strong>GABA</strong><br />
Control<br />
Control Control<br />
<strong>GABA</strong><br />
<strong>GABA</strong><br />
<strong>GABA</strong><br />
29<br />
28<br />
27<br />
26<br />
25<br />
Control <strong>GABA</strong><br />
<strong>GABA</strong>
<strong>Pharma</strong><strong>GABA</strong>’s<br />
effect on mental focus
【Uchida Kraepelin (speed calculation) test】
Change rate of CgA in saliva(%)<br />
150 150<br />
150<br />
100 100<br />
100<br />
50<br />
50<br />
【Fatigue Fatigue Release Release with with <strong>GABA</strong> <strong>GABA</strong> 】<br />
**<br />
*<br />
*<br />
Change rate of corstisol in saliva(%)<br />
200<br />
200<br />
150<br />
150<br />
100<br />
100<br />
*:vs vs non non-added non added added p
Total number of the correct answers<br />
2500<br />
2000<br />
1500<br />
【Number of Correct Answers】<br />
p
“Sharp Charge” from AQUARIUS<br />
– Sharpen you in business –<br />
Launched in June, 2007
【Why Why <strong>Pharma</strong><strong>GABA</strong><br />
<strong>Pharma</strong><strong>GABA</strong>?】<br />
<strong>Pharma</strong><strong>GABA</strong>
<strong>Pharma</strong><strong>GABA</strong><br />
acquired<br />
Self-Affirmed GRAS<br />
on May 18, 2007
on August 11, 2008<br />
FDA gave <strong>Pharma</strong><strong>GABA</strong><br />
<strong>Pharma</strong><strong>GABA</strong><br />
GRAS Notice No.GRN 000257
Products on the Market
Products Marketed on the products<br />
Market
Products Marketed on the products<br />
Market
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