2011 HMRI Annual Report - Hunter Medical Research Institute

The Best of Health
Annual Report 2011

The Best of Health
HMRI acknowledges the following
funding support in 2011:
•
•
•
•
NSW Department of Health for providing
infrastructure funding through the NSW
Research and Development Capacity
Building Infrastructure Grants Program.
NSW Office for Medical Research for
providing infrastructure funding through
the NSW Medical Research Support
Program.
Federal Department of Health and Ageing
for capital funding for the HMRI Building
through the Health and Hospitals Fund.
NSW Health and NSW Office for Science
and Medical Research for capital funding
for the HMRI Building.

C ontents
Chairman’s Message 4
Director’s Message 5
HMRI Highlights 6
Research Programs and Networks 9
Brain and Mental Health 10
Cancer 12
Cardiovascular Health 14
Information Based Medicine 16
Pregnancy and Reproduction 18
Public Health 20
Viruses, Infections/Immunity 22
Vaccines and Asthma (VIVA)
Awards, Fellowships and Grants 25
Government Fellowships and Grants 53
Fundraising Highlights 54
Supporters 56
Governance 60
Financial Statement 63
Publications 64
Acknowledgements 79

4
A Message from the Chairman
“HMRI aims to return the faith of our supporters by
researching the important health issues that face our
community, and then translating the outcomes into
new medical practices.“
In June 2011 HMRI completed a
five year planning cycle which
had set out two principle tasks:
build a state-of-the-art research
building to accommodate 450
researchers and to employ
an internationally recognised
researcher to lead HMRI towards
its goal of becoming a world
renowned research Institute.
Both of these tasks, which
were once but dreams, will be
completed in 2012.
The research building will unite
our researchers on three sites
and when the proposed research
building at Calvary Mater
Newcastle is completed, HMRI
will provide the best of facilities
across all of its programs to
attract the most talented of
researchers and clinicians to
improve outcomes and the
health of our community.
Such dreams do not become
reality without the help of many
and it is important that we
recognise the ongoing support
of the NSW Government and
the Federal Government. All of
our local Members from both
parliaments have been helpful
and supportive.
Medical research is expensive
and requires input from all
levels of government as well as
business and individuals from
the community.
HMRI aims to return the faith of
our supporters by researching
the important health issues that
face our community, and then
translating the outcomes into
new medical practices.
The Board of HMRI has been
steadfast in its commitment
to building a world class
institute, as well as supporting
wholeheartedly initiatives to
attract internationally recognised
researchers and clinicians to
bolster and develop our talented
researchers.
I should also acknowledge
the tremendous involvement
of our co-venturers, Hunter
New England Health and the
University of Newcastle, both of
whom combine to make HMRI
possible.
The HMRI Foundation which
embraces PULSE, HCRF and
the Singleton Foundation,
continues to grow
and our fundraising
efforts for research projects
reflect the great support we
receive from businesses and
individuals.
HMRI awarded a record $2.3
million to Hunter researchers in
2011.
This generosity of support
from our community initiates a
virtuous cycle. Donations fund
research into issues that impact
on our community.
The greater the community
support for HMRI, the better we
can improve health both locally
and for all Australians.
Mr Robert Kennedy
Chair, HMRI Board

A Message from the Director
2011 was a year of celebrating
our research successes and the
achievement of our strategy to
build research excellence and
healthier communities.
Record government
infrastructure funding, record
philanthropic funding and
increased research grant funding
all combined to build research
teams of significant capacity
and see our affiliated staff and
student numbers exceed 1,000.
More importantly this funding
delivered research outcomes
that led to better health for our
community, locally and globally.
In 2011, Hunter research changed
the way healthcare is delivered
in asthma, stroke, mental health
and cancer; contributed to
government policies on ageing,
obesity and alcohol pricing;
and public health interventions
in physical activity, nutrition,
smoking, and drug strategies;
and led to commercialisation
of research in infertility, and
premature birth. There were
genetic breakthroughs in
melanoma, MS and dementia.
The HMRI Cancer Program was
awarded Priority Research Centre
“...funding delivered
research outcomes that
led to better health for our
community, locally and
globally. “
(PRC) status by the University of
Newcastle and received a Cancer
Institute NSW grant to establish
the Hunter Translational Cancer
Research Unit. The HMRI PANIC
Research Network also evolved
into the new PRC in Physical
Activity and Nutrition.
In conjunction with HCRF, HMRI
launched the ABC Research
Network, bringing together
researchers working with
children and young people from
many HMRI Programs. New
research networks were also
established in Allied Health, Rural
Health, and Nursing & Midwifery.
The 2011 HMRI Researcher of the
Year, Professor Amanda Baker,
was the first PULSE Early Career
Researcher to go on to win this
prestigious HMRI honour.
The University conferred its
highest honour on Laureate
Professor Paul Foster, rewarded
the efforts of Dr Nikola Bowden
with the Young Alumni Award,
and Professor Philip Morgan
received the Leadership Award.
The Australian Academy of
Science admitted Laureate
Professor John Aitken as a
Fellow, and Professor Chris Levi
was a Eureka Awards finalist.
During 2011 we marvelled at
the speed of construction of the
HMRI Building. A “Topping Out”
ceremony marked the end of the
external construction phase and
the “Healing” Time Capsule was
sealed by our indigenous elders.
I would like to thank everyone
associated with HMRI for their
support over the past five years.
In particular, I would like to
acknowledge our volunteers and
supporters whose efforts have
ensured that our researchers
have the resources, facilities and
career pathways necessary to
make HMRI a great place to work.
I am confident HMRI is in the
best of health and has a secure
foundation for the future.
Emeritus Professor
Maree Gleeson OAM
HMRI Director
5

6
HMRI 2011 Highlights
In 2011, the HMRI Board, Foundation,
Research Council and Administration
Office continued to support health
and medical research in the Hunter by
delivering on its strategic priorities:
• To provide an environment to nurture
health and medical research
• To grow the research quality
and capacity of HMRI-affiliated
researchers
• To be recognised for world-class
research relevant to our community
• To promote HMRI researchers and
their research outcomes
• To maintain organisational
sustainability
Through strategic use of state
government infrastructure funding and
philanthropic funding HMRI continues
to support Hunter researchers in their
quest to keep the community in the best
of health, and to help build the capacity
and success of the region’s health and
medical researchers. HMRI’s efforts were
demonstrated in the following 2011
highlights:
Maintained position as the third largest
medical research institute in NSW,
measured by peer-reviewed grant
income.
Accepted as a full member of the
Association of Australian Medical
Research Institutes.
Appointed HMRI’S next Director,
internationally-renowned neuroscientist
Professor Michael Nilsson.
Continued oversight of the HMRI
Building construction, and celebrated
the transition from heavy construction
to the fit-out phase with a “Topping Out”
ceremony.
Sealed the second HMRI Building
“Healing” Time Capsule.
Completed a feasibility study for a clinical
research facility at the Mater precinct
to integrate cancer and mental health
researchers with clinical services.
Coordinated successful application for
the Hunter Translational Cancer Research
Unit with funding of $1.4 million over
three years from the Cancer Institute
NSW.
Allocated $3.9 million in infrastructure
funding to HMRI Research Programs
to build research capacity, through the
Medical Research Support Program from
the NSW Office for Medical Research.
Launched the ABC Research Network
for Adolescents, Babies and Children
researchers, and established the Nurses &
Midwives Research Network and the Rural
Research Network.
Provided significant communications and
media services to researchers including
the inaugural special lecture, featuring
leading media personalities, to assist
researchers with media and promoting
their work.
Provided leadership and career guidance
to mid-career researchers through the
INSIGHT program.
Expanded the HMRI Clinical Trials Support
Unit as a business unit for CReDITSS
(Clinical Research Design, Information
Technology and Statistical Support),
and appointed two Health Research
Economists.
Expanded the HMRI Research Register to
1,614 volunteers.

Appointed two new Board members and three
new Foundation members.
HMRI Director Professor Maree Gleeson was
named the Hunter Business Chamber’s Business
Person of the Year.
Oversaw development of a new Strategic
Marketing Plan.
Received $3.1 million from corporate and
community donations to support research.
Consequently, HMRI awarded $2.3 million
in philanthropic funding for project grants,
equipment grants, travel grants, fellowships and
scholarships.
Undertook two Direct Mail Appeals, resulting in
743 new donors.
Organised the HMRI Ball, HMRI Golf Day, the HMRI
Cup Yacht Race, three Supporters’ Cocktail parties,
and assisted with 18 other events for which HMRI
was the beneficiary.
Organised the activities of 64 Team HMRI
Volunteers.
Promoted the inaugural national “Cook for a Cure”
campaign in partnership with Research Australia,
and presented at the inaugural philanthropy
conference in medical research “Building a
Sustainable Social Investment Strategy for Health
and Medical Research.”
Participated in the Medical Research
Commercialisation Fund Advisory Board, and
presented three projects for proof of concept
funding which are under consideration.
Participated in the National Breast Cancer
Foundation Advisory Committee to establish the
Register 4, launched in 2011 to recruit 1 million
men and women to participate in breast cancer
research.
Promoted research outcomes and researchers
through the media and HMRI publications,
including quarterly newsletters, magazine articles,
television features, and through social media
platforms.
Coordinated an integrated community awareness
campaign across television, radio and newspaper
channels.
Coordinated the NBN Television research series
and accompanying newspaper campaign to
celebrate Medical Research Week. The series
focussed on Hunter research and its impacts in
the community, and demonstrated the journey
of research - from the initial idea and the people
whose generosity enables research to happen,
right through to groundbreaking discoveries
that are helping deliver better healthcare to the
community and having national impacts.
7

Life Story: Women’s Health
Amanda Grahman watches her four-year-old
son, Zander, happily stack coloured blocks
into a pattern matching the one on the table.
This is an annual ritual for the Grahman’s
who have participated in the WATCH
(Women and their Children’s Health) Study
since Amanda’s pregnancy.
The WATCH study began in 2006 when Dr
Alexis Hure, a Post-doctoral Research Fellow
in the Research Centre for Gender, Health
and Ageing, recruited Novocastrian women
like Amanda to have a series of ultrasounds
and measurements collected throughout
their pregnancy.
“We wanted to see whether nutrition during
pregnancy was important for the growth and
development of healthy kids,” Dr Hure said.
The WATCH Study not only monitored
Zander’s growth during Amanda’s pregnancy,
it also analysed her vitamin levels, maternal
weight gain, nutrition and the impact of
breastfeeding.
“Zander was my first child, so knowing that
there was a team closely watching him was
really reassuring,” Amanda said. “Having
such a talented team of people monitoring
Zander’s growth and nutrition relieved a
great deal of stress and anxiety”.
The study has also helped identify and treat a
number of prenatal conditions that may not
have been picked up in a regular pregnancy
until much later.
“We have picked up lots of little things in our
mums and kids. Anything from some of our
mums having high cholesterol that needs
monitoring or medication, to babies whose
organs weren’t growing and developing
normally during pregnancy,” Dr Hure said.
“While this was not the main aim of the study
it is nice to think that we have been able to
offer our mums a level of health monitoring
that is beyond standard care.”
Dr Hure is now focusing her research on the role
that diet and nutrition has as a predictor for child
intelligence. Zander attends an annual appointment
at the WATCH clinic where he does an IQ test.
“Participating in the study has really emphasised
the importance of nutrition and a healthy diet both
during pregnancy and for young children,” Amanda
said.
“It is very rewarding to bring Zander back and see
that he is growing and developing intellectually. The
WATCH Study has been such a fantastic resource
and it is great to see him so happy and healthy.”
When Zander is not playing with blocks and cards
as part of the study, he enjoys an active lifestyle
with his mum. He loves to swim, jump on his
trampoline and eat bananas.
While the WATCH Study is still conducting patient
follow up and testing, Zander stands as a testament
to the positive impact that good nutrition has on
developing healthy kids.

Research Programs and Networks
The HMRI Research Programs draw
together basic biomedical, clinical
and public health researchers
from Hunter New England Health,
the University of Newcastle and
Calvary Mater Newcastle, who are
conducting the best health and
medical research to improve the
wellbeing of the community.
In 2011, there were 1,081 researchers, research
students and research support staff aligned with
HMRI’s seven research programs:
• Brain and Mental Health
• Cancer
• Cardiovascular Health
• Information Based Medicine
• Pregnancy and Reproduction
• Public Health
• Viruses, Infections/Immunity, Vaccines
and Asthma (VIVA)
HMRI facilitates collaborations between researchers
translating groundbreaking scientific advances
into better clinical care, competitive commercial
products and improved health care guidelines.
In 2011, HMRI Research Programs received
infrastructure funding from the NSW Office for
Medical Research through the Medical Research
Support Program, and the NSW Department of
Health through the Capacity Building Infrastructure
Grant Program.
This funding supports essential research
infrastructure, including research salaries, research
equipment and technology services.
HMRI Research Programs also receive funding
from the community to support research projects,
equipment, scholarships, fellowships and travel
grants. HMRI’s philanthropic fundraising efforts are
led by the HMRI Foundation, which also incorporates
PULSE, the Hunter Children’s Research Foundation
(HCRF) and the HMRI Singleton Foundation.
HMRI affiliated researchers participate in formal
research networks on a national and state level,
including:
• Neuroscience Australia Pty Ltd
• ARC Centre of Excellence in Bioinformatics
• NSW Paediatric Research Network
• NSW Neuroscience Research Network
• NSW Cardiovascular Research Network
• National Paediatric Research Network
Locally, HMRI has developed cross-Program research
networks to forge collaborations in common areas of
research.
The ABC (Adolescents, Babies and Children)
Research Network brings together researchers from
many HMRI Programs to address the health needs
of young people, and has become part of a national
paediatric clinical trials network.
The PANIC Network facilitates research into Physical
Activity and Nutrition in Inflammatory Chronic
diseases. The PANIC Network in 2011 developed into
a University of Newcastle Priority Research Centre
for Physical Activity & Nutrition.
In 2011, HMRI facilitated the formation of the Nurses
and Midwives Research Network to build research
and interdisciplinary collaborations among nurses
and midwives.
HMRI has also commenced discussions and early
planning for the formation of a Rural Research
Network and an Allied Health Research Network.
Health
Hunter New England
Local Health District
9

10
Brain and Mental Health
Program Leader:
Professor Chris Levi,
Hunter New England Local Health District
Researchers: 87
Research Students: 25
Research Support Staff: 32
Researchers in the Brain and Mental Health
Program are unlocking the mysteries of
neurological and mental health disorders,
and providing novel solutions to improve the
diagnosis and treatment of those who are
affected.
The Program brings together high-quality
neuroscience researchers who are building
tight linkages across multiple levels of
enquiry and between basic neuroscience,
clinical neuroscience and mental health and
neurological health service delivery. Their
research is focused on nationally important
disease areas of:
• Schizophrenia
• Stroke
• Affective and Addictive Disorders
• Pain and Sensory Dysfunction
• Clinical Psychology
• Neuroscience
• Cognition, Development and Ageing
• Implementation and Models of Care
Research
Researchers in the HMRI Brain and Mental
Health Program are affiliated with the
University’s Priority Research Centre for Brain
and Mental Health Research. The Program also
includes the HMRI Stroke Research Group, and
incorporates the NSW Centre for Rural and
Remote Mental Health at Orange.
Program Highlights
Researchers from the Brain and Mental Health
Program were awarded significant national
competitive funding in 2011:
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•
•
•
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•
Emeritus Professor Patricia Michie received
$514,669 to develop a maternal infection
model that mimics the brain changes seen
in schizophrenia, opening up new options
for treatment.
Associate Professor Phillip Dickson received
$348,675 to investigate how the control
of dopamine synthesis may affect the
differential loss of dopaminergic neurons in
Parkinson’s disease.
Professor Robert Callister received $461,325
to examine how peripheral sensory fibres
connect with the appropriate nerve
cells in the human spinal cord during
development.
Professor Christopher Levi received
$1,130,380 to conduct a study of patients
with transient ischaemic attacks (TIA – selflimited
brief episodes of stroke symptoms)
that will inform contemporary Australian
practice systems of care and outcomes in
TIA and minor stroke.
Associate Professor Peter Schofield
received $743,450 to assess an olfactory
‘stress test’ for the early detection of
Alzheimer’s disease.
Professor Amanda Baker received $1,117,558
to evaluate the Eating As Treatment (EAT)
intervention – a trial of a dietitian-provided
health behaviour change program to
improve nutrition in head and neck cancer
patients undergoing radiotherapy.
Dr Neil Spratt received $422,275 to
investigate brief cooling of the body
hypothermia to keep brain pressure down
after stroke or other forms of brain injury.
Dr Neil Spratt was also awarded an NHMRC
Career Development Fellowship for his
research into finding new ways to prevent
excess pressure on the brain.

Associate Professor Frini Karayanidis and her team
were also awarded $387,000 from the Australian
Research Council to study how cognitive flexibility
changes from adolescence to senescence, to
identify the brain networks that mediate this
change and explore the implications for successful
adaptation in everyday life.
Dr Doug Smith was awarded a $298,375 project
grant from the Garnett Passe and Rodney Williams
Memorial Foundation to study the effects of
ageing on the peripheral vestibular system.
A global research project involving Hunter
scientists identified five new regions of the
human genome associated with schizophrenia,
confirming that complex genetic variation
contributes to an individual’s likelihood of
developing the disease. The Schizophrenia
Psychiatric Genome-Wide Association Study
Consortium used data from the Australian
Schizophrenia Research Bank (ASRB), and also
confirmed that two other previously identified
gene loci are associated with schizophrenia.
University of Newcastle researcher Dr Liz Holliday
was presented with the Young Investigators Award
by the Stroke Society of Australasia (SSA) for her
contribution to stroke genetics work conducted
by the Australian Stroke Genetics Collaborative.
Professor Chris Levi was a finalist in the Australian
Museum’s annual Eureka Prizes. Professor Levi
was nominated for the Jamie Callachor Eureka
Prize for Medical Research, which is awarded to
an individual or team conducting outstanding
medical research translation.
Professor Mark Parsons was awarded the
University of Newcastle’s Faculty of Health
Early/Mid Career Researcher of the Year Award.
Professor Parsons was also awarded the Vice-
Chancellor Award for Research Excellence in
Health 2011.
11

12
Cancer
Program Leader:
Professor Stephen Ackland,
Calvary Mater Newcastle
Researchers: 58
Research Students: 18
Research Support Staff: 172
Researchers in the HMRI Cancer Program are helping
to reduce the incidence of cancer and finding more
effective therapies by tailoring treatments to the
genetic profile of the disease, and to the needs of the
individual patients and their carers.
The Program includes biomedical, clinical and public
health researchers who are working across specialty
research groups, including cancer genetics, cellular
and molecular oncology, anti-cancer therapies,
cancer trials, psycho-oncology for cancer patients
and carers, and health behaviours to reduce the risk
of developing cancer.
HMRI’s cancer research is focused on five key
malignancies:
• Breast Cancer
• Prostate Cancer
• Gastrointestinal Cancer
• Melanoma
• Haematological Malignancies
The Cancer Program is made up of multidisciplinary
teams of scientists, clinicians and statisticians
working to improve our understanding of cancer and
how to better prevent and treat the disease.
The Program also incorporates three national clinical
trials groups based in the Hunter:
• Australian New Zealand Breast Cancer
Trials Group
• Trans-Tasman Radiation Oncology Group
• Prostate Cancer Trials Group
The Hunter was awarded a Translational Cancer
Research Unit (TCRU) grant by the Cancer Institute
NSW in 2011. The Hunter TCRU integrates the
elements of the bi-directional research pathway
from basic science to clinical care; to facilitate
rapid development and implementation of research
discoveries; and to stimulate laboratory research on
priority questions generated from the cancer clinics.
Researchers in the HMRI Cancer Program are also
affiliated with the Clinical Cancer Research Network.
The Network was established in 2007 to facilitate
efficient conduct of clinical trials, and optimises
collaboration between 14 cancer clinical trials units
throughout Hunter New England Health to increase
participation, and ensure equity of opportunity exists
for all patients in rural, regional, metropolitan and
private practices to participate in research trials.
The strength of cancer research in the Hunter was
recognised by the University of Newcastle in 2011
through the establishment of a Priority Research
Centre in Cancer. Many members of the HMRI
Cancer Program are also affiliated with the Priority
Research Centre for Bioinformatics, Biomarker
Discovery & Information-Based Medicine. Cancer
Program members collaborate with the HMRI
Information Based Medicine and Public Health
Programs.

Program Highlights
Associate Professor Xu Dong Zhang received
$341,175 from NHMRC to explore a novel
approach to overcoming the resistance of
melanoma to drug treatments.
Dr Nikki Verrills was awarded $260,000 from
Cancer Council NSW for her research into
activating a tumour suppressor for leukaemia
therapy.
Hunter cancer researchers were awarded a
Translational Cancer Research Unit (TCRU)
grant of $1.4 million over three years by the
Cancer Institute NSW.
An international breast cancer study including
Professor John Forbes, confirmed the longterm
beneficial effect of radiotherapy and
reported a benefit for use of tamoxifen in
reducing local and contralateral new breast
cancers for women with ductal carcinoma in
situ (DCIS) treated by complete local excision.
Professor Forbes and his colleagues also
found that the 12- to 18-month change in
mammographic breast density is an excellent
predictor of response to tamoxifen in the
prevention of breast cancer.
Professor Rodney Scott was part of an
international effort that proved that taking a
regular low dose of aspirin halves the longterm
risk of cancer. With all cancers related
to Lynch syndrome, including cancer of the
endometrium in the womb, almost 30 per
cent of the patients taking the placebo had
developed a cancer compared to around 15
per cent of those taking aspirin.
A 10-year study discovered a new treatment
approach that doubles the survival chances of
men with locally advanced prostate cancer.
The University of Newcastle and Calvary
Mater Newcastle research led by Professor
Jim Denham showed that combining
radiotherapy with six months of hormone
therapy significantly reduced the death rate of
prostate cancer patients.
A group of leading international breast cancer
experts including Professor John Forbes
met to develop a consensus statement on
breast cancer prevention, with a focus on
medical and therapeutic interventions. To
keep the devastating impact of breast cancer
to a minimum, especially in the developed
countries where prevalence is presently
the highest, preventive therapy needs to
be integrated into wider strategies of risk
reduction, including avoidance of obesity and
an increase in physical activity.
The HMRI Cancer Program hosted the 4th
Annual HMRI Cancer Research Program
Symposium. Ninety delegates attended the
symposium, showcasing the region’s top
cancer researchers in both the pre-clinical
and clinical research arena.
13

14
Cardiovascular Health
Program Leader:
Associate Professor Dirk van Helden,
The University of Newcastle
Researchers: 33
Research Students: 18
Research Support Staff: 13
The HMRI Cardiovascular Health Program brings
together researchers who are exploring human heart
disease across prevention, revascularisation and
quality of life for cardiovascular and cardiopulmonary
disease patients. The researchers are working across
holistic, systemic, cellular and molecular levels,
and are focussed on cardiopulmonary control
mechanisms and the modification of physical activity
and nutrition behaviours to improve cardiovascular
health.
Research within the Cardiovascular Health Program
includes biomedical, clinical, public health and
education research, and is providing novel treatments
and interventions in the key areas of:
• Cardiophysiology (control of heart-lung
interaction and lymphatic systems)
• Clinical Cardiology (heart disease)
• Nutraceuticals and Nutrition
• Physical Activity
• Obesity and Diabetes
Many of the researchers in the program are affiliated
with the University of Newcastle Priority Research
Centre in Physical Activity and Nutrition, established
in 2011.
Program Highlights
Associate Professor Dirk van Helden was awarded
$192,450 from NHMRC to further develop a nitric
oxide-releasing chemical applied to the skin as a
novel approach to first aid treatment of venomous
snake bites.
Professor Ron Plotnikoff was awarded an NHMRC
Senior Research Fellowship for his work into Physical
Activity and Nutrition.

Dr David Lubans received $261,837 from the
Australian Research Council to design and
evaluate a school-based program to increase
physical activity and reduce sedentary behaviour
in adolescent boys from disadvantaged
backgrounds.
Associate Professor Dirk van Helden found that
applying an ointment commonly used in angina
treatment to snake bite wounds can improve
survival by up to 50 per cent. The study found
that applying ointment containing glyceryl
trinitrate slowed down the transport of the
snakebite toxin through the lymphatic system
into the bloodstream, giving snakebite victims
extra time to seek medical care.
Research led by Dr Lubans found rates of
obesity and overweight in young people can be
reduced using programs that are targeted to a
group’s particular demographic. The Hunter-based
Physical Activity Leaders (PALs) program was
specifically designed to address obesity in lowactive
adolescent boys from low socioeconomic
backgrounds, and showed that providing
convenient access to a structured program
tailored to the needs of a target group can achieve
significant weight loss results.
Results from the Hunter Illawarra Kids Challenge
Using Parent Support (HIKCUPS), led by Professor
Clare Collins, showed that changing the eating
attitudes of parents rather than children is the key
to combating childhood obesity. Researchers from
the universities of Newcastle and Wollongong
found that parents must be actively engaged in
changing the whole family’s diet to help reduce
childhood obesity.
Dr Tracy Burrows, Professor Clare Collins and
Professor Manohar Garg found an association
between the omega-3 index, weight status
and insulin resistance in children. While recent
studies in adults have suggested that the plasma
level of omega-3 fatty acids may be associated
with weight status and abdominal adiposity, this
finding in children highlights the importance of
omega-3 fatty acids in the prevention of obesityrelated
chronic diseases in later life.
Dr Melinda Neve was awarded the 2011 Emerging
Researcher by the Dietitians Association of
Australia for her groundbreaking research into
the effectiveness of an internet-based program to
help overweight and obese people lose weight.
Her research tracked the progress of participants
over 15 months, and found web-based weight loss
programs are effective in reaching a large number
of people at risk of health problems due to their
weight.
Associate Professor Derek Laver was invited
to spend a sabbatical visit with Professor Mark
Cannell at the University of Bristol, UK, to establish
a new paradigm as to how stores inside heart
cells release calcium ions, a process that is
fundamental to heart function.
Professor Philip Morgan was awarded the 2011
Leadership Award, presented by the University
of Newcastle and FordComm, recognising
the impact of his work on community health,
demonstrating that evidence-based programs can
reduce the burden of disease and improve the
quality of life for families.
15

16
Information Based Medicine
Program Leader:
Professor Rodney Scott,
The University of Newcastle
Researchers: 24
Research Students: 13
Research Support Staff: 13
The HMRI Information Based Medicine Program is
paving the way for a personalised approach to health
care, informing the development of patient-tailored
treatment to a host of diseases which are influenced
by genetic aspects. Researchers are utilising
computer technology and mathematical methods to
extract meaningful information from vast amounts of
clinical and molecular data to identify disease-related
genetic patterns.
The Program draws together the disciplines of
bioinformatics, and molecular and genetic analysis
with clinical information and population data
analysis, helping life scientists to identify patterns
in individuals that can be used to predict the risk
of disease and the likely response to different
treatments.
Researchers in the Information Based Medicine
Program are currently focused on:
• Developing mathematical models based on
Information Theory for Biomarker Discovery
• Identification of molecular markers associated
with cancers, Alzheimer’s disease, Multiple
Sclerosis, macular degeneration and stroke
• Genetics of susceptibility to infection in SIDS,
indigenous health and elite athletes
• Functional brain imaging in stroke and
schizophrenia
• Mathematical models to improve radiation
treatments for cancers
HMRI is one of only two sites in Australia where core
basic research in bioinformatics is linked directly with
clinical research practice. Many researchers are also
members of other HMRI Research Programs, creating
unique research synergies and collaborations.
The Information Based Medicine Program has many
members who are affiliated with the University’s
Priority Research Centre in Bioinformatics, Biomarker
Discovery and Information-Based Medicine, and also
incorporates:
• NBN Telethon Fellowship in Children’s Cancer
• Australian Research Council Centre for
Excellence in Bioinformatics
• HMRI Medical Physics Research Unit
• HMRI Clinical Trials Support Unit
The HMRI Clinical Trials Support Unit provides
researchers with assistance in research design, data
file management, statistical support and data linkage,
and in 2011 expanded to include the services of two
new Health Research Economists.
Program Highlights
Professor Pablo Moscato, Dr Regina Berretta and
international colleagues received $320,000 from the
Australian Research Council to find optimal solutions
for five of the most challenging problems arising
from novel biotechnologies and biomarker discovery.
Associate Professor Peter Greer was awarded
$349,794 from Cancer Council NSW to investigate
whether initial cancer treatment plans predict doses
delivered to normal tissues during prostate radiation
therapy.
Professor Chris Doran and colleagues at the
University of Sydney completed a pilot study into
the behavioural and economic costs of intellectual
disability in Australia. Their findings suggest that
behaviour problems increase costs of care of children
with intellectual disabilities. The team also secured a
$5.2 million NHMRC program grant to continue their
research into the mental health of young people with
developmental disabilities.
Professor Rodney Scott and his team published a
number of landmark reports on cancer genetics in
a number of different diseases. Most notable were

publications on bowel cancer, endometrial cancer
and breast cancer. Their research indentified for
the first time that daily low-dose aspirin reduces
the risk of cancer development in a susceptible
population, something that had been suspected as
a result of epidemiological studies but not proven.
New findings in respect to endometrial cancer risk
also indicated that there were potential areas of
confluence with prostate cancer.
Professor Scott also confirmed that gastrointestinal
polyps are a common manifestation of McCune-
Albright syndrome (MAS), a disorder caused by
somatic activating mutations in the GNAS gene,
and usually presenting with cutaneous, skeletal, and
endocrine manifestations. The study also indicated
an overlap between MAS and Peutz-Jeghers
syndrome, suggesting a putative interaction between
the genes GNAS and STK11 in the pathogenesis of
these two disorders. The findings suggest a need for
routine gastrointestinal endoscopy in patients with
MAS to establish the true incidence of polyps in
these patients.
The largest genetic study of Multiple Sclerosis (MS)
identified 57 genes that are directly linked to this
disease. Data from this study indicates that subtleties
in immune function are unequivocally associated
with MS.
Another major study identifying schizophrenia
susceptibility identified five new genes associated
with this disorder.
Dr Nikola Bowden and her team identified that
melanoma cells do not respond to the cancer
treatment drug cisplatin, a chemotherapeutic DNAdamaging
agent. Their study found reduced levels
of NER after cisplatin treatment in melanoma cell
lines, meaning the cancerous cells are resistant to
traditional chemotherapy.
A study led by Professor Pablo Moscato identified
a specific pattern of proteins in blood plasma that
distinguishes between Alzheimer’s disease and
control samples. The signatures were able to predict
Alzheimer’s disease patients that already had a
mild cognitive impairment with up to 84 per cent
sensitivity, while maintaining a strong prediction
accuracy of 90 per cent for non-demented controls
and Alzheimer’s disease. The group has now joined
forces the Alzheimer’s Disease Neurogimaging
Initiative, the largest international collaborative
program on the disease, to pursue their research into
blood biomarkers of early Alzheimer’s disease using
more powerful datasets and methodologies unique
to the IBM program.
Hunter researchers developed a new computational
strategy based on the use of supercomputers to
investigate if patterns of natural variation in human
DNA can be associated with an increased risk of
age-related macular degeneration. The results
confirm some regions of the DNA that may harbour
these variations identified also by this study. A
second study of the relationships of groups of these
variations has been completed, revealing novel
insights on the genetic risk factors of Australia’s
leading cause of blindness in the elderly.
Associate Professor Peter Greer and his colleagues
determined whether dose plans for prostate patients
can be made directly on whole-pelvic MRI scans,
compared to conventional CT scan doses with MRI
anatomy registration. They found that the differences
are small (within 2 per cent) and are largely due to
positioning differences at the MRI scanner which is
not optimised for radiation therapy positioning. This
may lead to the use of MRI-based planning which
would reduce uncertainties and cost in prostate
treatments in the future.
Associate Professor Greer pioneered the first
technique using rapid real-time cine images to
measure the accuracy of stereotactic radiosurgery as
the linear accelerator rotates about the patient. This
technique is more accurate and more efficient than
previous methods, and has generated considerable
international interest from other treatment centres to
implement the method in their clinics.
17

18
Pregnancy and Reproduction
Program Leader:
Professor Roger Smith,
The University of Newcastle
Researchers: 38
Research Students: 24
Research Support Staff: 44
The HMRI Pregnancy and Reproduction
Research Program brings together
researchers focussed on understanding
the environmental and biological
processes that control reproduction and
birth.
The Pregnancy and Reproduction
Program conducts research focused on
two themes:
• Infertility and reproduction
• Pregnancy and premature birth
The researchers are targeting the future
health of all Australians by improving the
health of pregnant women and providing
key information on the determinants of a
healthy start to life. The Program conducts
research around seven key areas:
• Understanding the mechanisms that
influence or lead to premature birth
• Trialling novel therapies to prevent
preterm birth
• Predicting adverse outcomes of
human birth
• Determining the paternal role in
miscarriage and birth defects
• Improving the diagnosis and
treatment of male and female
infertility
• Developing novel methods of fertility
regulation
• Understanding the mechanisms of
decline in female fertility with age
• Understanding the processes of egg
growth and maturation
Pregnancy and Reproduction Program
members are affiliated with the
University’s Priority Research Centre for
Reproductive Science, and incorporates
the Mothers and Babies Research
Centre, and the Australian Research
Council Centre of Biotechnology and
Development.
Program Highlights
Researchers in the Pregnancy and
Reproduction program received significant
national competitive funding in 2011:
•
•
•
•
•
Professor Roger Smith was awarded
$1,694,709 from NHMRC to better
understand the origins of diabetes and
kidney disease in Aboriginal children
and their mothers.
Dr Mark Baker was awarded an
NHMRC Career Development
Fellowship for his research into
understanding sperm motility.
The Australian Research Council
awarded Professor Keith Jones
$330,000 over three years to study
how the chromosomes in the egg are
separated so as to produce a mature
egg capable of being fertilised by a
sperm.
Professor Eileen McLaughlin and her
team received $280,000 over three
years from the ARC to investigate
new avenues for generation of
contraceptives in male animals
and to regulate stem cells for
production of specialised cell types in
biotechnological applications.
Dr Janet Holt received an ARC
Discovery Early Career Researcher
Award, and will examine how the
Fizzy-related gene (FZR1) functions
at the earliest stages of egg
development.

Laureate Professor John Aitken received the
Simmet Prize from the International Congress of
Animal Reproduction for his significant advances
in animal reproduction. The award recognises
an active research scientist for outstanding basic
and applied research in the area of assisted
reproduction of animals and is considered the
world’s most prestigious prize in this field.
Professor Roger Smith and international
colleagues found that cervical length and the ratio
of the hormones estriol to estradiol represent
good predictive indicators of the response to the
induction of labour in post-term pregnancies.
Dr Olivia Wynne Lee and her team determined
whether neonatal infection permanently alters
immune and glucocorticoid receptor signaling
pathways in the adult hippocampus. This study
shows that neonatal infection differentially alters
the gene expression profiles of both female and
male mice along immune and neuroendocrine
pathways.
Dr Phoebe Jennings and researchers in the
Egg-to-Embryo group used a novel model of
inhalational cigarette smoking to show that
chronic smoking has a detrimental effect on
oocyte (or egg cell) quality, and this can be
observed even though oocytes are removed from
the ovary and cultured in vitro. While the precise
effects of cigarette smoking on female fertility
have not yet been clearly defined, the researchers
used a model that mimics human smoking and
is able to control for variables that may confound
clinical studies to assess the impact of chronic
smoking on the quality of oocytes.
The Through our mothers’ eyes – Participant
perspectives from the Gomeroi gaaynggal
program, led by Kym Rae, was awarded the
National Award for Excellence in Arts and
Health Program for Aboriginal Health at the 3rd
International Arts and Health Conference at the
National Gallery of Australia.
19

20
Public Health
Program Leaders:
Professor Julie Byles and
Laureate Professor Rob Sanson-Fisher,
The University of Newcastle
Researchers: 89
Research Students: 34
Research Support Staff: 209
The research activities of the HMRI Public Health
Program are coordinated through the Maddison
Collaboration for Public Health, encompassing
all public health research taking place in research
groups at the University of Newcastle and
throughout Hunter New England Local Health
District.
The researchers conduct population health research,
uniting public health and health services planning,
and reducing preventable death or disability by
changing the community’s health behaviours.
The Public Health Program enhances capacity
for health services and public health research
by collaborating with health practitioners, care
providers, policy providers, government and nongovernment
organisations.
The researchers are focused on projects that are
clinically and socially relevant, providing a natural
mechanism for the translation of the research
outcomes into improvements in policy, care, and
better health for the NSW population.
The Public Health Program Capacity Building Group
is a key component of the Public Health Program,
and is funded through the NSW Health Capacity
Building Infrastructure Grants Program. The group
provides research training for, and mentoring of,
Research Fellows, PhD students and health service
clinicians; conducts collaborative research with
health service clinicians; and provides a forum for
communicating and disseminating research findings.
The Public Health Program Capacity Building Group
focuses on four key themes:
•
•
•
•
Monitoring health service use and its impacts
Health service development and evaluation
Reducing social and behavioural health risks
Bio-preparedness and reducing communicable
disease risks
Researchers within the Public Health Program are
also affiliated with the University of Newcastle
Priority Research Centre for Gender, Health and
Ageing; and the Priority Research Centre for Health
Behaviour.
Program Highlights
HMRI Public Health researchers were awarded
significant funding from the National Health and
Medical Research Council in 2011:
•
Professor Robert Sanson-Fisher received $233,710
to help increase organ donation registration by
comparing the effectiveness of two strategies
designed to encourage students attending TAFE
to register their organ donation intentions with
the Australian Organ Donation Registry.

•
•
Associate Professor Kyp Kypri received $353,035
to determine whether a computer-based brief
alcohol intervention reduces hazardous drinking
among hospital outpatients. If effective, the
intervention could be implemented nationally as
part of routine service delivery.
Associate Professor Jennifer Bowman received
$1,442,270 to undertake a rigorous test of the
efficacy of a smoking cessation intervention for
smokers with mental illness; where intervention
commences in the hospital inpatient setting and
extended support continues post-discharge.
Jamie Bryant and her team received an Australian
Research Council Linkage Project Grant of $249,408
to assess the effectiveness of a model for improving
cancer treatment systems, which emphasises
meaningful engagement of cancer consumers in
identifying, implementing and evaluating strategies
of change.
Dr Billie Bonevski was awarded a Cancer Institute
NSW Career Development Fellowship of $590,399
for her research into reducing tobacco-related
inequalities using community-based behavioural
research.
Dr Bonevski also identified the need for clear
guidelines on sun exposure limits for patients with
vitamin D deficiency, with 85 per cent of general
practitioners advising above the recommended safe
levels of UV exposure. The study found that there is a
lack of clear information for GPs regarding vitamin D,
sun exposure, sun protection and skin cancer risk.
Dr Flora Tzelepis showed that much greater
investment is needed in actively recruiting smokers
to telephone counselling quitlines if smoking rates
are to decline significantly. Her study demonstrated
that active recruitment via phone calls connects a
far greater proportion of smokers to quitlines than
passive recruitment methods including quit smoking
posters and television advertisements.
The Women, Health and Ageing report highlighted
the wide range of health care needs affecting older
women, and warned that individuals, communities,
and health care systems need to be prepared
for major health and social changes associated
with ageing. The findings, from the Australian
Longitudinal Study on Women’s Health, also
highlights the increasing levels of serious health
risks, illness and disability among future generations,
and confirms from a long-term perspective that
lifetime maintenance of low risk behaviours is the
best prospect for reducing the impact of chronic
conditions and associated health care costs.
Professor Lin Perry completed an audit of diabetes
services in rural and metropolitan parts of Hunter
New England Health and a metropolitan service in
Sydney. The researchers conducted a feasibility study
and developed a new model of coordinated care for
young adults with type 1 diabetes.
The Housing and Independent Living project
examined the environmental and built factors
important for maintaining independence in
older age. Researchers visited the homes and
neighbourhoods of over 200 people aged 75-
79 years, gathering significant information to
guide decisions about how to help people remain
independent in older ages.
In collaboration with the World Health Organisation,
Professor David Durrheim and his team undertook
a formative evaluation of the capacity of the Pacific
syndromic surveillance system to investigate and
respond to outbreaks, and whether it was meeting
its objective of acting as an early warning system.
Approximately one year after its inception, 19
countries are regularly reporting to the system,
and the evaluation found improvement in the
identification and communication about outbreaks
as a result of the syndromic surveillance system.
21

22
Viruses, Infections / Immunity,
Vaccines and Asthma (V IVA)
Program Leader:
Laureate Professor Paul Foster,
The University of Newcastle
Researchers: 44
Research Students: 28
Research Support Staff: 56
The HMRI Viruses, Infections/Immunity,
Vaccines and Asthma (VIVA) Program
brings together clinical, applied,
epidemiological and basic science
research to investigate clinical health
problems in asthma and other airway
conditions, infectious diseases, and
development of vaccines for the
prevention and treatment of disease.
The program is focused on four key areas:
• Viral infections and viral oncolysis
• Infections and immunity
• Vaccine development
• Asthma and airway diseases
Researchers within the VIVA Program
collaborate closely with other HMRI
research programs. Working with the
Pregnancy and Reproduction Program,
researchers are looking into asthma in
pregnancy and the effects of infections
during pregnancy. Researchers from
VIVA and the Information Based
Medicine Program are investigating
genetic influences in infectious diseases
and SIDS. VIVA also interacts with
Information Based Medicine for molecular
characterisation of genetic programs.
They also work closely with two
biotechnology companies based in
the Hunter, Virolytics and Hunter
Immunology.
Researchers working in respiratory
diseases are affiliated with the University
of Newcastle Priority Research Centre for
Asthma and Respiratory Diseases, and the
national Cooperative Research Centre for
Asthma and Airways.
Program Highlights
Researchers in the VIVA Program received
significant funding from the NHMRC:
•
•
•
•
•
Professor Paul Foster was awarded
$505,950 to better understand the
mechanisms that regulate steroidresistant
components of asthma,
which control inflammation and
narrowing of the airway.
Professor Foster was also awarded
$581,010 to focus on the ability of
specific microRNAs to inhibit allergic
inflammation in the airways, and
to evaluate this approach as a new
treatment for asthma.
Associate Professor Philip Hansbro
was awarded $599,685 to investigate
the role of particular proteins and
small genes that control inflammation
in chronic obstructive pulmonary
disease (COPD) and Crohn’s disease.
Dr Simon Keely was awarded $307,500
to understand the mechanisms of
how the adhesion protein β1 integrin
is involved in wound healing, and
may allow the design of therapies to
aid or accelerate wound healing in
inflammatory disease.
Dr Gerard Kaiko was awarded an
NHMRC Early Career Fellowship to
investigate the role of susceptibility
genes and microbiota in inflammatory
diseases.

Professor Paul Foster and colleagues from the
University of Newcastle and HMRI received
an ARC Linkage Infrastructure, Equipment
and Facilities Grant to purchase a FACSAria III
Fluorescence activated cell sorter. The system will
form a core facility for sorting cells in HMRI, and
will give researchers a better cellular and genetic
understanding of cancer, respiratory diseases,
reproduction and birth.
Paul Foster was awarded the University of
Newcastle’s most prestigious title of Laureate
Professor. He is just the seventh Laureate Professor
to be named by the University. The Australian
National University also awarded Professor Foster
a Doctorate of Science.
Dr Katherine Baines identified the existence of
three phenotypes of asthma that have important
differences in clinical asthma status, inflammatory
cells present, gene expression and the underlying
inflammatory pathways. The findings provide a
framework to explore pathological mechanisms
of phenotypes of asthma, important for the
development of more effective treatments. Dr
Baines was also awarded a prestigious Fellowship
to continue her studies with the PRC for Asthma
and Respiratory Disease.
Professor Peter Gibson designed an asthma
management program with the potential to
halve asthma attacks in pregnant women.
The researchers developed an algorithm that
adjusts inhaled therapies to better match airway
inflammation. The study found that using the
algorithm and symptoms led to a 50 per cent
reduction in asthma exacerbations, and was
accompanied by important changes in asthma
management including more frequent use of
inhaled steroids, but at a lower total daily dose,
and earlier introduction of long-acting treatments.
Professor Gibson also found that respiratory
diseases could soon be diagnosed through a
simple blood test. The study identified four novel
blood-based biomarkers that can tell whether a
person is suffering asthma, COPD or if they have a
healthy lung function. Identifying the biomarkers
involved in the development of airway diseases
may allow clinicians to diagnose the diseases in
their earlier, more treatable stages.
Professor Adam McCluskey developed a technique
to stop viruses and bacteria multiplying in the
human body. The international team developed
compounds that inhibit the function of clathrin –
the protein responsible for the human body taking
in ‘signalling molecules’, which stimulate cell
growth and division, and spread infections. This
opens up new approaches to treat conditions that
rely on infectious cells dividing and multiplying
through the body, such as cancer and viruses
including hepatitis C, Ebola and HIV.
Professor Philip Hansbro was awarded the
Faculty of Health Researcher of the Year Award
and published a series of papers demonstrating
the importance of bacterial infection in altering
asthma-like inflammatory responses.
Dr Adam Collison, PhD student Max Plank
and Professors Joerg Mattes and Paul Foster
demonstrated that inhibition of house dust mite
induced allergic airways disease by antagonism
of MicroRNA-145 is comparable to glucocorticoid
treatment. This demonstrates a potential new
anti-inflammatory role for inhibiting miRNA
function in asthma.
Dr Gerard Kaiko and his colleagues demonstrated
an important role for Natural Killer (NK) cells - a
cell of the innate immune system - in promoting
asthma in response to viral infections.
23

Life Story: Type 1 Diabetes
Emma Burns is a bright and bubbly 11-yearold
girl like any other, who enjoys sleepovers
with her friends and is excited about going to
high school in 2013.
Delve deeper though, and you discover that
Emma was diagnosed with type 1 diabetes
when she was just two.
While she lives a happy and independent life
today, it was not always so simple for the
Newcastle youngster. Before participating in
HMRI’s diabetes diet study, Emma and her
mother Kim had to follow a strict series of
tables and measurements to calculate her
food and insulin levels.
“Before the study we used to calculate exactly
everything that Emma ate,” Kim said. “Our
family had to devote a large amount of the
day to Emma’s diet and it was a constant
stress when we wanted to go out for a meal.”
Any childhood disease can
become extremely taxing for
families as they fit clinic visits,
medications and intensive
therapies into an already hectic
lifestyle. HMRI researcher Carmel
Smart, a Senior Paediatric Diabetes
and Endocrine Dietician at the
John Hunter Children’s Hospital,
has focused her research on
counteracting just this.
Carmel’s research demonstrated
that carbohydrate counting down
to the last gram did not improve
the accuracy of insulin treatment
in children with type 1 diabetes.
Instead, Carmel proved that
estimating carbohydrate portions
worked just as effectively.
The outcomes of this study mean life-changing
results for children like Emma. “No studies have
looked at this very practical issue that has the
potential to make a difference in the daily lives of
children with diabetes,” Carmel said.
“I’ve made it my goal to give families the right
information and the flexibility to help them manage
diabetes more effectively.”
As research progresses, the role of food is being
successfully changed from a major hurdle to
something that diabetic children can enjoy.
“This method of carbohydrate counting has allowed
us to relax and Emma now has the freedom to go
out with her friends without having to worry about
food or her diabetes,” Kim said.
Adds Emma: “I feel like everybody else now … I feel
normal and I have a normal life, I just need to do a
few extra things than my friends.”

Awards, Fellowships and Grants
HMRI raises funds to support the
Hunter’s highest quality researchers
and research projects. Funding is
distributed through the HMRI and
HCRF annual Grants Round, and
throughout the year as special grant
nominations, and comprises:
Awards
The HMRI Award for Research Excellence and the
HMRI Award for Early Career Research recognise the
outstanding contributions of individual researchers
to their field.
Travel Grants
PULSE and HMRI fund grants to help early career
researchers attend national and international
research conferences.
Exchange Visits
HMRI funds short term exchange visits to assist
early career researchers to gain new knowledge in
overseas facilities and foster international research
collaborations.
Post-doctoral Fellowships
Fellowships provide career pathways for graduates
recently awarded their PhD. They allow the
Hunter’s most promising researchers to stay in the
region and build capacity with the HMRI Research
Programs, and give Post-doctoral researchers
important experience to be competitive in NHMRC
and ARC Fellowship schemes.
PhD Scholarship top-up and Support Grants
PhD top-up scholarships and support grants
provide education opportunities for promising local
graduates, and help to retain high quality graduates
in the region.
Equipment Grants
HMRI helps Hunter researchers to purchase the
latest equipment, ensuring projects are conducted
efficiently and at the highest quality.
Project Grants
HMRI awards funding for research projects through
three processes:
• HMRI Project Grants, awarded at the annual
Awards Night through the HMRI Grants Round
peer-reviewed grants process
• Donor funded and specified grants, awarded
at the annual Awards Night through the HMRI
Grants Round, and throughout the year as
special grant nominations
• Foundation funding awarded to HMRI
In 2011, HMRI, PULSE and HCRF awarded more than
$2.3 million in philanthropic funding to health and
medical researchers at the University of Newcastle,
Hunter New England Health and Calvary Mater
Newcastle, including:
• 34 project grants totalling $936,917
• 4 new PhD scholarships and RHD Support
Grants totalling $81,561
• 2 awards for research excellence totalling
$40,000
• 9 travel grants and 2 exchange visit prizes to
early career researchers totalling $56,250
• 2 PhD conference prizes totalling $5,000
• 1 equipment grant of $75,000
Additionally, HMRI supported one new and four
continuing Post-doctoral Fellowships in 2011.
25

26
HMRI Award for Research Excellence
Sponsored by the Sparke Helmore / NBN Television Triathlon Festival
Professor Amanda Baker
Professor Amanda Baker is a senior clinical
psychologist who has practiced in the United
Kingdom and Australia and is currently in the
Centre for Mental Health at Calvary Mater
Newcastle. Amanda is an NHMRC Senior Research
Fellow at the University of Newcastle and Deputy
Director of the University’s Priority Research Centre
for Brain and Mental Health Research.
Professor Baker received a Bachelor of Arts
(Psychology) with Honours from the University of
New South Wales (UNSW), a Masters in Psychology
from the University of Sydney, and a PhD from the
UNSW. She joined the University of Newcastle in
1995 and was promoted to Professor in 2009.
Her research and clinical practice is extremely
challenging – the study of co-morbidity or the
existence of two sets of serious problems – one
being substance misuse and the other being
mental illness. These co-existing disorders
have received very little research attention as
few clinicians are experienced in both areas
and treatment services for these problems are
separated.
Professor Baker has made innovative and
scientifically rigorous contributions to the
treatment of people using tobacco, alcohol and
other drugs, who also have mental illness. Her
pioneering research has received wide recognition,
professional awards and prizes.
Professor Baker has led the largest trials of
treatments for substance use in major depression.
The studies won her team the coveted national
prize for Excellence in Research, National Drug
and Alcohol Award in 2009; with Professor Baker
receiving the 2010 Senior Scientist Award from
the Australian Professional Society for Alcohol and
Other Drugs.
In collaboration with Dr Frances Kay-Lambkin, she
has developed a DVD-based intervention known
as SHADE (Self-Help for Depression and Alcohol
and Other Drugs). This program received the NSW
Mental Health Matters Research Evaluation Award,
and has also attracted national and international
commercialisation agreements.
The ‘Healthy Lifestyles’ project aimed at improving
cardiovascular health among people with severe
mental illness has been described as “visionary”. It
has already demonstrated reductions in cigarette
smoking and alcohol consumption, as well as
improvements in diet and physical activity.
Professor Baker has attracted over $9.3 million
in research funding, and has an impressive
publication record, with 100 published
manuscripts, 2 books, 27 book chapters, 7
treatment manuals and 5 clinician guidelines.
Her prominent national and international
standing is evidenced by many invitations to
present at conferences. She has been invited to
provide professional advice on alcohol and drug
interventions and the treatment of mental illness
to the Commonwealth Department of Health &
Ageing; the World Health Organisation; and the US
National Institute of Drug Abuse.
Professor Baker’s work is of direct relevance and
benefit to improving community health and
building capacity of our health services to respond
to the breadth of mental health patients’ needs. By
marrying her clinical practice skills and experience
with her academic research and training of both
academic researchers and clinical psychologists,
Professor Baker contributes greatly to evidencebased
co-morbidity treatments.

28
HMRI Award for Early Career Research
Sponsored by PULSE
Dr Mark Baker
Dr Mark Baker is a University of Newcastle
Research Fellow in the Priority Research Centre in
Reproductive Science. He was recently awarded a
coveted National Health & Medical Research Council
Career Development Fellowship.
Dr Baker is investigating the basis of male infertility,
a condition that affects 1 in 20 Australian males.
His research aims to understand the mechanism
of creation of life - how the epididymis modifies
spermatozoa, allowing them to recognise and
fertilise the egg.
His research has important implications for both
male fertility and infertility and for development of
new contraceptives aimed at preventing fertilisation.
Dr Baker is a major contributor to developing the
first-ever combined spermicide/microbicide capable
of providing simultaneous protection against fertility
and sexually transmitted diseases.
Dr Baker has transformed the field of sperm cell
biology by harnessing the power of proteomics
technology to dissect out the protein structure of
sperm cells and establish the mechanisms by which
they regulate their function.
He has established a state-of-the art proteomics
facility at the University of Newcastle, and recently
introduced new comparative peptide analysis
technologies, making his facility the only one in
Australia with non-labelled technologies.
The world-class mass spectrometry unit is used
by Hunter scientists from many disciplines, and Dr
Baker frequently collaborates with researchers across
many HMRI Research Programs. He is recognised
internationally as a leader in mass spectrometry,
evidenced by his publications in high impact
journals and many invitations to speak world-wide.
Dr Baker was the first person in the world to
publish the entire human sperm proteome and the
first to apply new advances in metabolomics to
this cell type. He is highly respected as a talented
young biochemist who has made very significant
contributions to our understanding of sperm
biology. His technical approach to comparative
proteomics is novel and innovative, and has won
many plaudits from the research community
Dr Baker is a future leader in Australian medical
research, and brings unique skills encompassing
both innovation in technology and breadth of
knowledge in biological mechanisms. He is already
having a major impact on unravelling the causes of
male infertility and developing strategies to manage
this condition by treating the patient, not just his
spermatozoa.

Life Story: Prostate Cancer
Having spent his working life dispensing
medicines and good advice, pharmacist Vic
Carroll had a healthy respect for his own
wellbeing when he reached retirement.
Just as well …
In 2005 his regular-as-clockwork PSA checks
began showing a steady increase and when
the reading reached 6.6, Vic’s GP referred him
to a urologist. A biopsy confirmed that further
treatment was warranted.
“The ‘ray’ treatment went for seven weeks,
five days a week, but I’d drive to Waratah, have
my treatment and be home in an hour,” the
Merewether resident said.
In addition to radiotherapy Vic received
an androgen deprivation (AD) drug called
Lucrin in a clinical trial known as RADAR
(Randomised Androgen Deprivation and
Radiotherapy). By inhibiting testosterone
levels it shrinks the prostate and thus also
shrinks the prostate cancer tissue.
Five years later, and now aged 73, Vic has annual
appointments with Professor Jim Denham, a
radiation oncologist at Calvary Mater Newcastle
and a Conjoint Professor with the University of
Newcastle, who directs the RADAR trial. Vic gets
regular DREs (Digital Rectal Examinations) and his
PSA reading is currently 1.0. It’s a good result.
As Professor Denham explains, “After radiation, some
of the normal healthy cells in the prostate survive
and produce some PSA. The level will never be zero”.
Close to 3,300 men succumb to prostate cancer
each year but through research and treatment they
have a fighting chance. In The Lancet Oncology
published March 2011, Professor Denham reported
that the use of six months of AD had reduced
prostate cancer death rates 10 years after treatment
from 22 per cent to 11.4 per cent in the RADAR trial’s
predecessor (TROG 96.01).
As part of the RADAR trial, Vic also took a drug
called Zometa that is commonly used for preventing
osteoporosis but he stopped the medication after it
flared up his gout.
“Zometa reverses the loss in bone
density that Lucrin and similar drugs
can cause, but this isn’t the whole
reason for it being in the RADAR trial
design,” Professor Denham says.
“Our major hope is that it will prevent
the appearance of metastases
(secondary cancerous spread) into the
bones. We won’t know this until the
main efficacy endpoints are analysed in
early 2014.”
Today, Vic plays tennis three times a
week, walks and gardens. Meanwhile,
patient follow up in the RADAR trial is
ongoing.

30
P ULSE Education Prize
Dr Natalie Beveridge
Dr Natalie Beveridge is a Post-doctoral
Research Fellow in the HMRI Brain and Mental
Health Program. Her research focuses on
neuronal differentiation in normal human brain
development and schizophrenia.
Natalie’s research on microRNA-181b in the postmortem
brain in schizophrenia was published in
Human Molecular Genetics, and she was awarded
the University of Newcastle Vice-Chancellor’s
Award for Research Excellence for this work.
Natalie spent four months as a visiting scientist at
the Clinical Brain Disorders Branch of the National
Institutes of Health, USA, which has established an
ongoing collaboration that continues to facilitate
internationally competitive research.
The PULSE Education Prize will help Natalie attend
the 3rd Biennial Schizophrenia International
Research Conference (SIRS) in Florence, Italy,
in 2012. This will provide an opportunity to
network with other internationally recognised
schizophrenia researchers and reconnect with her
research colleagues from the National Institutes
of Health.
Dr Alexis Hure
Dr Alexis Hure is a Post-doctoral Research Fellow
in the University of Newcastle Priority Research
Centre for Gender, Health and Ageing, and is
member of the HMRI Public Health Program. As an
Accredited Practicing Dietician, Alexis is focused
on foetal growth, child nutrition and maternal-fetal
health, and nutrition during pregnancy.
Alexis is currently working on characterising what
constitutes a ‘normal’ reproductive history for
Australian women, using data collected as part
of the Australian Longitudinal Study on Women’s
Health. This is the first project she will complete
as part of her new fellowship with the Research
Centre for Gender, Health and Ageing.
Alexis is recognised by the Dietitians Association
of Australia as a Professional Mentor for Provisional
Accredited Practising Dietitians, and also received
an Advanced Accredited Practising Dietitians award
in 2010.
The PULSE Education Prize will allow Alexis
to attend the 2012 International Federation of
Gynecology and Obstetrics World Congress of
Gynecology & Obstetrics in Rome, Italy, where she
will present the results of her research.

Dr Daniel Johnstone
Dr Daniel Johnstone works in the University of
Newcastle and HMRI Centre for Information Based
Medicine, with a research focus on degenerative
diseases of the central nervous system (CNS),
specifically the brain and retina.
Daniel’s research draws on both molecular
biomedicine and computational mathematics, and
investigates the mechanisms by which different
factors, such as toxic metals or cigarette smoke,
cause CNS degeneration. His research identifies
biomarkers of early-stage CNS diseases for
potential use as diagnostic tools.
He is one of only a few researchers combining
both biomedical and bioinformatics approaches,
and has actively developed the skills to position
himself effectively between the two disciplines.
The PULSE Education Prize will allow Daniel to
attend the Perspectives in Proteomics Conference
2012 in Cambridge, UK, where he will present his
latest work on blood biomarkers of pre-clinical
Alzheimer’s disease. He will also attend the
Genomic Disorders 2012 conference, and will
meet with leading researchers at the Wellcome
Trust Sanger Institute (Cambridge) and the MRC
Functional Genomics Unit (University of Oxford).
Dr Nicole Ryan
Dr Nicole Ryan is a Post-doctoral research scientist
from the University of Newcastle, working with the
HMRI VIVA Program’s Respiratory Research Group
at John Hunter Hospital. Her research is focused
on the causes of chronic cough mechanisms and
treatments.
Nicole is currently conducting novel research into
the treatment of refractory chronic cough (cough
that doesn’t respond to usual medical treatment).
She is investigating the use of an under-researched
medication with the addition of speech pathology
in a hospital setting. Nicole is also measuring the
burden of illness and treatment of chronic cough
within the primary care setting. Both of these areas
have not been investigated before.
Nicole recently presented her cough research,
focused on a novel medication for the treatment
of chronic cough, at the 3rd American Cough
Conference in 2011.
The PULSE Education Prize will enhance Dr Ryan’s
career development and international recognition
by enabling her to attend the 2012 International
Cough Conference in London, where she will
present the results of her work.
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32
Malcolm Starkey
Malcolm Starkey is a PhD candidate at the
University of Newcastle, working in the HMRI
VIVA Program. He is investigating the link
between chlamydial respiratory infections and the
development of chronic severe asthma.
His research has shown that chlamydial infections
in early-life, but not adulthood, result in permanent
alterations in immune responses and lung
structure, resulting in reduced lung function and
more severe asthma in later life.
Malcolm has also shown in animal models that
subjects that are protected against respiratory
chlamydial infection have reduced airways
inflammation, and do not develop worsened lung
function and asthma in later life.
The PULSE Education Prize supported Malcolm’s
attendance at the Australasian Society of
Immunology meeting in Adelaide in December
2011, and the American Association of
Immunologists annual scientific meeting in Boston,
USA in 2012. These are the leading national and
international immunology conferences in infection
and immunology research, and will give Malcolm
invaluable access to cutting edge research and
provide the opportunity to present his research.

HMRI Education Prize
Dr Liz Holliday
Dr Elizabeth Holliday is an NHMRC Post-doctoral
Fellow and Biostatistics Lecturer at the University
of Newcastle and a member of the HMRI Public
Health Program.
Elizabeth’s research focuses on genetic risk factors
and other influences in stroke. She has found a
novel genetic risk factor for ischaemic stroke, the
genetic causes of which are poorly understood.
Her research supports analysing clinical subtypes
of the disease to more clearly identify genetic risk
factors for stroke.
The finding represents the culmination of nearly
a decade’s work by the Australian Stroke Genetics
Collaborative (ASGC), a consortium of neurologists
and scientists located across four Australian states,
with strong collaborations with groups in the UK
and Germany.
The HMRI Education Prize will enable Elizabeth
to attend and present on behalf of the ASGC
at the 2012 International Stroke Conference in
New Orleans, USA. The conference is one of the
key international stroke meetings, attended by
major players in the field, and provides a unique
opportunity to establish herself as a researcher of
international standing.
Dr Judith Weidenhofer
Dr Judith Weidenhofer completed her PhD at the
University of Newcastle in 2006, investigating the
molecular and cellular biology of schizophrenia.
In a change of direction, she then took a Postdoctoral
position investigating the function of a
protein (TPD52) in breast and other cancers at the
Children’s Hospital at Westmead.
In 2008 Dr Weidenhofer returned to Newcastle and
established a program of research investigating
the regulation and mechanisms of action of
tetraspanins (a group of proteins) in prostate
cancers, and she is currently establishing a similar
research program in breast cancer.
Dr Weidenhofer is forging a strong independent
research career, having initiated a number of
collaborations with both national and international
researchers.
The HMRI Education Prize will enable Dr
Weidenhofer to present her findings at the 22nd
European Association of Cancer Research meeting
in Spain, in 2012. The conference is an excellent
opportunity for Judith to forge networks and
develop her career in translational prostate cancer
research.
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34
HMRI Exchange Visit Prize
Sponsored by HMRI Life Governor, Mrs Jennie Thomas AM
Dr Andrew Gardner
Dr Andrew Gardner is a PhD candidate in the HMRI
Brain and Mental Health Program. He is examining
the prevalence, onset and progression of chronic
traumatic encephalopathy (CTE) amongst
current and retired collision sports athletes. CTE
is a neurodegenerative disease believed to be a
consequence of sports-related concussive and
sub-concussive blows.
Research into CTE has primarily relied upon
retrospective data collection following autopsy
confirmed cases. There are currently no published
prospective, longitudinal or cross-sectional studies
examining CTE in current or retired professional
athletes. Andrew aims to establish himself as a
world-leader in sports-related concussion research,
combining neurological, neuropsychiatric,
neuropsychological and behavioural methods in
one of the first studies of its kind.
The Exchange Visit Prize will allow Andrew to
participate in an exchange between the University
of Newcastle and Brigham and Women’s Hospital,
Harvard Medical School, Boston, USA. Andrew
will meet world leaders from both Brigham and
Women’s Hospital Centre for Clinical Spectroscopy
and Boston University’s Centre for the Study of
Traumatic Encephalopathy, who are currently
conducting collaborative studies into CTE.
The Centre for Clinical Spectroscopy at Brigham
and Women’s Hospital is leading the way in
innovative neuroimaging techniques, which have
particular clinical application to the examination of
individuals suspected of having CTE. Accessing the
expertise at the Centre for Clinical Spectroscopy
will enable Andrew to discuss methods for
adopting sound techniques to achieve his study
aims, and will assist in further collaborative
research efforts.
Jamie Flynn
Jamie Flynn is a PhD candidate in the HMRI Brain
and Mental Health Program investigating repair
following spinal cord injury. Jamie’s research
focuses on a group of nerve cells in the spinal cord
called long propriospinal neurons (LPNs), which
have been shown to form new connections with
nerve cells below an incomplete spinal cord lesion
after an injury. Due to their unique location and
projection patterns within the spinal cord, LPNs
can form a ‘detour circuit’ around the injury site to
allow brain signals to reach their previous targets.
Jamie is currently investigating the
electrophysiological properties of these important
neurons using targeted, whole-cell patch clamp
electrophysiology. This provides important insights
into their function, which might then be used to
improve the ability of LPNs to reconnect the spinal
cord after injury, using targeted therapeutics.
The Exchange Visit Prize will allow Jamie to spend
six months with Professor Martyn Goulding in
his Molecular Neurobiology Laboratory at the
Salk Institute, California. The lab is recognised
internationally for its neuroscience research,
having pioneered and refined many of the
techniques at the cutting edge of spinal cord
genetics. The exchange will give Jamie access to
resources and expertise to perform his experiments
from the ground up, in a world class lab that is well
established in genetic characterisation of spinal
cord circuits.

Life Story: Stroke
Watching Cyril Edwards busily shuck oysters at
The Oyster Hut on the banks of the Myall River,
he appears in perfect health. It was not long
ago, however, that Cyril suffered a severe and
debilitating stroke.
Instead of years of rigorous rehabilitation and
significant lifestyle changes, the 74-year-old
Tea Gardens resident miraculously returned
to work just four days after experiencing the
stroke.
This incredible recovery was due to remarkable
research by Professor Chris Levi and his team.
“By the time I arrived at John Hunter Hospital I
had no feeling at all down the right side of my
body and was quickly losing sensation in the
left. I was also losing my ability to speak,” Cyril
said.
“Chris Levi and his team were waiting for me
in the Emergency department, they explained
the details of the stroke research and the clotbusting
therapy. My wife Jeanette and I agreed
to proceed with it immediately.”
The therapy was so successful
it began reducing Cyril’s stroke
symptoms within just an hour and by
the next morning he began to gain the
feeling back in his arms and legs. The
most astonishing improvement was
yet to come; by the next day Cyril was
walking unassisted.
“It wasn’t until I got up and began
walking around the stroke ward that
I realised how big a deal it all was.
Other men who had similar strokes to
mine were physically immobile, and
that was when it really hit home,” Cyril
said.
“Until I saw the impact that a stroke
usually has, I didn’t understand how
lucky I was to be treated by Professor
Levi. Without that drug I may be still
lying on a bed.”
“Clot-busting therapy for acute stroke is one of
our few effective treatments and by far the most
powerful. But it can only be delivered in expert
centres and is restricted to the first few hours after
the onset of the stroke,” Professor Levi said.
“One of the most important health research
projects the HMRI Stroke Research Group is
running is the rural Pre-hospital Acute Stroke
Triage (rural PAST) project, which meant that Cyril’s
treatment effectively began when the ambulance
arrived at his home.
“Rural PAST is evaluating a new system of care
to provide access for rural stroke patients to clotbusting
drug treatment. Cyril is part of the rural
PAST study and we are delighted with his outcome
and his great progress.”
Cyril has now returned to his energetic life running
The Oyster Hut with his family.
“We live in very exciting times,” Cyril said. “Medically
and technologically the world is becoming a
wonderful place because of people like Chris Levi.”

36
HMRI Project Grants
HMRI Foundation Chairman’s Grant
Dr Lisa Wood and Prof Peter Gibson
Fatty acids, Carbohydrates and Bronchodilator
Responses in Asthma
Western-style food has been shown to be a factor
in increased asthma risk. This project aims to
investigate the mechanisms by which a nutrient
surplus heightens inflammatory responses and
interferes with pharmacological management of
the disease.
Previous work by these researchers demonstrates
that eating a high-energy mixed meal activates
innate immune responses in the airways, with
increased expression of immune regulatory
markers and airway neutrophilia. An unexpected
finding was that lung function recovery, post
normal bronchodilator treatment, was reduced in
subjects who consumed the high energy mixed
meal. The specific nutrient responsible for this
effect is uncertain and this project will assess
the affects of dietary fat versus carbohydrate on
airway inflammation and bronchodilator
response.
A/Prof Mark Parsons and Dr Peter Stanwell
Beyond Perfusion: MRS to characterise metabolic
changes in the ischaemic brain
Strokes are predominantly caused by a blood
vessel blockage in the brain, leading to an area
of brain tissue rapidly dying. Surrounding this
region is a larger area of brain tissue (ischaemic
penumbra) that is also at risk if blood flow is not
promptly restored. The size of the ischaemic
penumbra is currently measured using two
different MRI techniques called diffusion-weighted
imaging and perfusion-weighted imaging.
Magnetic resonance spectroscopy (MRS) is now
being explored as a more reliable means of
assessing tissue viability, and this research group
has pioneered new MRS sequencing that allows
new measures of brain metabolism not previously
able to be determined in a clinical setting. The
aim of this study is to use MRS imaging techniques
on hyperacute stroke patients already undergoing
MRI.
A/Prof Xu Dong Zhang and Dr Chen Chen Jiang
The Role of Phosphatidylinositol 4, 5-Bisphosphate
5-Phosphatase A (PIB5PA) in regulation of PI3K/Akt
signalling in melanoma
A major driver of uncontrolled growth and
resistance to treatment of melanoma cells is
caused by activation of the PI3K/Akt pro-survival
pathway. This project aims to clarify the role of a
protein called PIB5PA in regulating this activation,
and to establish whether down-regulation of
PIB5PA is a biomarker of a subset of melanomas.
Identification of PIB5PA as a biomarker for
progression and poor prognosis in a subset of
melanomas will provide useful information for
molecular sub-classification and personalised
treatment approaches for melanoma patients.

A/Prof Dirk Van Helden and
A/Prof Geoff Isbister
First Aid for Cytotoxic Snakebite
Traditional first aid for snake bite involves
pressure bandaging and immobilisation to
impede lymphatic transport and thus delay
toxins reaching the circulation. It is not always
possible to immobilise a snakebite victim,
nor are conventional procedures necessarily
appropriate for bites from the many snakes
with venoms that cause tissue death
(necrosis). This study intends to develop
a topical treatment that slows toxin entry
into the bloodstream and inhibits necrosis,
while allowing mobilisation. The elegance
of the discovery resides in its simplicity
and effectiveness. Reducing the need for
immobilisation and inhibiting necrosis could
markedly reduce the levels of disability
inflicted by snakebite.
Dr Billie Bonevski, A/Prof Christine Paul,
Prof Cate D’Este, A Smith and
Prof Chris Doran
Which anti-smoking media campaign best
predicts perceived effectiveness among
socioeconomically disadvantaged smokers?
An experimental study
Disadvantaged groups have the highest
smoking rates and shoulder the greatest
burden of disease from tobacco use. Mass
media campaigns have successfully reduced
general population smoking rates, but
appear to have had little impact on smoking
rates amongst disadvantaged groups. This
study will test the perceived effectiveness
of three different types of anti-smoking
media messages with socioeconomically
disadvantaged smokers. It will be the first
study of its type, providing valuable data to
guide the development and testing of future
anti-smoking media campaigns in Australia.
Dr Kirsty Pringle and Prof Eugenie Lumbers
The role of the intrarenal renin angiotensin
system in preeclampsia and
gestational hypertension
Preeclampsia can have long-term adverse
effects on maternal cardiovascular health. The
renin-angiotensin system is a key regulator of
blood pressure, however its role in the cause
of preeclampsia is not clear. It is proposed
that women who develop hypertension and
proteinuria (excessive protein in the urine) in
late gestation do so because they have a high
ratio of oxidized:reduced angiotensinogen
(AGT) in the maternal blood plasma. This
study aims to find out if the overactivity of
the intrarenal (kidney) renin-angiotensin
system induced by high levels of oxidized
AGT is specific to proteinuria, or also occurs
in gestational hypertension. The study will
also show if the abnormal AGT persists in the
period following pregnancy, and therefore
has the potential to influence the onset of
hypertension in later life.
Dr Judith Weidenhofer, Prof Leonie Ashman
and Prof Hubert Hondermarc
Does Ubiquitination control the altered
expression of tetraspanin proteins in
Breast Cancer?
Once advanced, breast cancer is largely
incurable although some patients have been
shown to benefit from more aggressive and
targeted treatment strategies. The expression
of certain tetraspanin proteins are altered
in breast cancer and are promising targets
for determining prognosis and therapy. This
study will identify the mechanisms involved
in this process and how it affects cancer cell
behaviour. This knowledge will advance the
development of prognostic biomarkers and
allow better patient selection for treatment,
improving outcomes and quality of life.
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38
Donor-Supported Project Grants
Anthony Sweetman Memorial Fund
Oesophagus Cancer Project Grant
Dr Scott Nightingale, Adam Collison,
Prof Nicholas Talley and Prof Joerg Mattes
Novel molecular markers in children with
Eosinophilic oesophagitis – association with
symptoms, oesophageal function and treatment
response and role in disease pathogenesis
Currently, both diagnosis and monitoring for
Eosinophilic oesophagitis (EoE) involves an invasive
procedure (endoscopic oesophageal biopsy),
which for children require a general anaesthetic.
This study will examine the relationship between
two particular molecules (TRAIL and Mid1) in
oesophageal mucosal biopsies, with clinical
features, oesophageal dysfunction, and response
to therapy in children with EoE. The study will
help to define a role for TRAIL and Mid1 in the
development of EoE, and may offer a non-invasive
biomarker for diagnosis and monitoring of the
condition.
Dalara Foundation Stroke Project Grant
Dr Damian McLeod, Dr Neil Spratt,
A/Prof Mark Parsons and Prof Chris Levi
Experimental brain imaging to investigate novel
protective mechanisms of short duration body
cooling after stroke
Cooling the body (hypothermia) for 12-24 hours
saves lives after some types of brain injury and
stroke, but can lead to potentially fatal intracranial
pressure (ICP) elevation brought on by rewarming.
This study will determine the mechanisms of
ICP elevation and its prevention by hypothermia
using advanced imaging techniques pioneered
by the research group. This has the potential to
revolutionise and extend the clinical application
of hypothermia treatment for stroke and other
diseases.
Ann and Eric Bone Project Grant
Prof David Durrheim and Beverley Paterson
What causes unexplained encephalitis? A pilot adult
encephalitis hospital-based surveillance system
Human encephalitis (swelling/inflammation
of the brain) causes substantial mortality and
morbidity, with subsequent severe neurological
conditions and long term cognitive impairment.
The cause of almost 70 per cent of hospitalised
cases of encephalitis is still unknown, yet there
are no standardised approaches to history taking
or diagnostic testing which would likely improve
diagnosis. This study will pilot the use of a
standardised case history form and a diagnostic
testing algorithm in cases with unexplained
encephalitis presenting at John Hunter Hospital.
HMRI Mothers and Babies Project Grant
Dr Alexis Hure, Dr David Mossman,
Prof Roger Smith and Prof Clare Collins
DNA methylation in a cohort study of nutrition
during pregnancy and childhood
The size of a baby at birth and growth during
infancy are important predictors of adult health.
The biological mechanism which helps to explain
how this happens is called epigenetics. This
study aims to investigate dietary intake, including
vitamin and mineral tables, during pregnancy
and childhood, at the same time as looking at
epigenetic markers in children. This project aims
to show that changes occur in response to what
pregnant women and children eat, and may help
explain why some children are more likely to
become overweight or perform better at school.

Rotary Club of Newcastle Enterprise
Youth Research Project Grant
Dr Tracy Burrows and Prof Clare Collins
Feasibility of targeting parents with heart disease to
improve the heart health of their children
This study focuses on Hunter parents who have
experienced a heart disease event requiring
hospitalisation in the past year. Patients are usually
highly motivated to lessen their risk of further
heart disease and to ensure family members also
have reduced risk. While it can be a challenge to
motivate children to adopt healthy eating patterns,
improving what their parents eat is the first step.
Families will be given feedback on their dietary
intake and assistance to adopt heart healthy eating
habits, and if proven to be effective, it can be rolled
out more widely.
Tomago Aluminium Juvenile Diabetes
Research Project Grant
Supported by Tomago Aluminium and HCRF
Dr Donald Anderson, Dr Bruce King,
A/Prof Patricia Crock, Michelle Neylan,
Carmel Smart and Helen Phelan
A double blind cross-over trial in young insulin
pump users comparing their glucose control when
their insulin pump settings have been set from
continuous glucose sensing data interpreted by
a new computer program (PumpTune), to when
a doctor reviews the same data and uses clinical
judgment.
Insulin replacement remains the only therapy for
Type 1 diabetes and continuous subcutaneous
insulin infusion pumps are increasingly being used
as an alternative to intermittent insulin injections
because they improve blood glucose control and
quality of life. This research group has developed
a computer program called PumpTune, which
interprets sensor information and recommends
changes to a person’s insulin pump. This study
aims to compare a doctor using PumpTune to one
using the same sensor information and graphical
software. If successful, PumpTune could be run
over the internet, with the potential to improve
glucose control for people with Type 1 diabetes.
HMRI Singleton Foundation Asthma Grant
Dr Vanessa McDonald, Dr Katie Baines and
Prof Peter Gibson
Phenotype based management of severe persistent
asthma
This study aims to test a new model of
management for people with severe asthma and to
investigate whether previously identified markers
of gene activity can predict response to treatment
in this population. Treatment will be targeted based
on biomarkers that measure airway and systemic
inflammation, co-morbidity and risk factors. This
study aims to improve patient outcomes and
inform treatment guidelines for severe asthma.
Lions District 201N3 Diabetes Foundation
Diabetes Project Grant
Prof Robin Callister, Prof Philip Morgan,
Prof Clare Collins and Prof Ron Plotnikoff
Feasibility and efficacy of a diet and exercise
prevention program for men at high risk of type 2
diabetes
Type 2 diabetes is the fastest growing chronic
disease in Australia. There is an urgent need for a
diabetes prevention program specifically designed
for men, who are generally reluctant to engage
in preventative health programs as most fail to
engage them or fit into their busy lifestyles. The
aims of this project are to determine the feasibility
and effectiveness of a diet-and-exercise resource
package including a home-based exercise program
to form a comprehensive but potentially low-cost
type 2 diabetes prevention intervention.
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40
Sparke Helmore / NBN Television Triathlon
Mental Health Project Grant
Dr Paul Tooney, A/Prof Ute Vollmer-Conna,
Paul Rasser, Tim Ehlkes, Prof Pat Michie,
A/Prof Ulrich Schall and Dr Carmel Loughland
Testing for N-methyl-D-aspartate (NMDA)
receptor antibodies in a large Australian cohort of
schizophrenia patients
Recent studies have showed that antibodies
directed against the N-methyl-D-aspartate
receptor (NMDAR) cause a form of encephalitis
that progresses from schizophrenia-like psychosis,
memory deficits, seizures, and language
disintegration into a state of unresponsiveness.
In milder or incomplete forms of NMDAR
encephalitis, patients develop predominantly
psychiatric symptoms clinically indistinguishable
from schizophrenia. As such, it is highly likely that a
largely unknown proportion of patients diagnosed
with an affective and non-affective psychosis may
suffer from anti-NMDAR encephalitis that carries a
relatively good prognosis with adequate therapy.
This project aims to assess anti-NMDAR levels
in blood serums collected from over 1,000 wellcharacterised
schizophrenia patients registered
with the Australian Schizophrenia Research Bank
(ASRB). Anti-NMDAR positive individuals will then
be further characterised based on the cognitive,
genetic and structural MRI data available from the
ASRB. The results will lead to the identification
of NMDAR positive individuals in psychiatric
populations and may improve health outcomes
through the use of more appropriate treatments.
Radford Bequest Cardiovascular Research
Project Grant
Prof Philip Hansbro and Dr Andrew Jarnicki
COPD-induced systemic inflammation activates
mast cell specific tryptases which lead to
cardiovascular disease
This project proposes that cigarette smoking
activates important immune cells, including mast
cells, which contribute to cardiovascular disease by
inducing inflammation in heart disease. Mast cell
numbers increase in cardiovascular disease, and
release inflammatory mediators (tryptases) that
potently induce inflammation and the activation
and recruitment of other immune cells. The
researchers have developed a unique model of
cigarette smoke-induced COPD and associated
cardiovascular disease. This has enabled, for
the first time, the elucidation of the the roles of
tryptases in smoking-induced, mast cell-related
processes that drive the pathological features of
cardiovascular disease. The results of this study will
have important implications for understanding the
mechanisms that lead to disease pathogenesis and
the development of new therapies for the disease.
Mark Smith Multiple Sclerosis Project Grant
Supported by A/Prof Stephen Graves
Dr Karen Ribbons and
Dr Jeannette Lechner-Scott
The cytokine gene expression profile in Multiple
Sclerosis patients with chronic fatigue
Chronic fatigue is a common but poorly defined
symptom in a variety of autoimmune diseases
including Multiple Sclerosis (MS). It is also one
of the most disabling diseases, with up to 70 per
cent of patients describing fatigue as their main
complaint. This study will examine the cytokine
gene expression in relapsing and remitting MS
patients with chronic fatigue. It will focus on
inflammation as one possible cause of fatigue
in MS, and will seek to establish a relationship
between the level of chronic fatigue as assessed by
the Modified Fatigue Impact Scale and the genetic
expression of inflammatory markers.

Stroud Rodeo Lymphoma Project Grant
Dr Flora Tzelepis, Dr Mariko Carey,
A/Prof Christine Paul, Dr Tara Clinton-McHarg
and Alison Zucca
Improving cancer care for lymphoma:
patients’ perceptions of optimal care
Cancer patients’ perceptions of care are associated
with psychological adjustment, adherence to
medical advice and prompt seeking of future
care. The Institute of Medicine, USA, has provided
an important benchmark for the definition and
measurement of optimal care; however no tool
adequately addresses this benchmark in the
Australian context. This study will use a newlydeveloped
measure to investigate lymphoma
patients’ perceptions of optimal care and test
the psychometric properties of the measure. The
research team’s strong links with the Leukaemia
Foundation will ensure findings are used to
highlight which areas of care are important to
patients and to advocate for patients’ desired
improvements to care.
Thomson Family Healthy Lifestyle Research
Project Grant
Prof Philip Morgan, Prof Robin Callister,
Prof Clare Collins, Prof Ron Plotnikoff, Prof
Christopher Doran and Myles Young
Engaging men to maintain weight loss using
innovative and cost-effective interventions: The
SHED-IT weight loss maintenance pilot study
Despite men being more susceptible than women
to many of the serious consequences of obesity
such as cardiovascular disease, men rarely engage
in weight loss programs, and when they do lose
weight they rarely maintain this weight loss. This
research group has developed and successfully
trialled a weight loss program for men. SHED-IT
differs from previous programs as it is tailored
specifically for men, has a strong theoretical base
and uses contemporary delivery methods. This
study will develop and evaluate the feasibility and
efficacy of a weight loss maintenance program
specifically for men.
Paediatric Oncology Grant
Supported by Hunter District Hunting Club
and the Lawrie Bequest
Prof Stephen Ackland, Dr Jennette Sakoff, Madhu
Garg and Dr Lyndall Tacon
Mitotane pharmacodynamics in Adrenocortical
Cancer in children and adults
Mitotane is currently the only recognised
effective systemic therapy to treat the disease
adrenocortical carcinoma, but it has substantial
toxicity including neurological effects in a
proportion of patients, recognised as related to
high plasma levels of the drug. This study will
determine the relationship between mitotane and
metabolite levels and toxicity, and confirm the
relationship with response. It will identify variable
factors that account for variability in mitotane
kinetics, including age, gender and body mass
index, providing a precise mitotane therapeutic
drug monitoring process to improve therapeutic
treatments for the disease.
HMRI Breast Cancer Research Grant
Supported by various donors
Dr Jennette Sakoff, Dr Jayne Gilbert and
Prof Adam McCluskey
Identification of a novel target for the treatment of
hormone positive breast cancer
These researchers have identified a group of small
molecules that selectively kill certain breast cancer
cells, while having little to no effect on normal
breast cells or other tumour types. This selectivity
is unprecedented and mechanism controlling
this phenomenon is not yet known. The aims of
this project are to determine the effectiveness of
our compounds to reduce tumour burden in an
animal breast cancer model and to characterise
the pathways and targets controlling the selectivity
of the lead compounds. This will provide crucial
information for the development of targeted
therapies for the treatment of breast cancer and
translation of the discovery into clinical practice.
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42
Fairfax Bequest Chronic Fatigue Project Grant
Prof Robert Clancy and Prof Maree Gleeson
Stress Related Relapsing Chronic Fatigue Syndrome
– relationship to EBV reactivation, impaired
generation of IFNγ, and response to probiotic
therapy
This project aims to identify and investigate a
particular subgroup of stressed young adults
suffering chronic persistent fatigue using a model
established for a similar study of poorly-performing
fatigued athletes. In the elite athletes suffering
recurrent respiratory infections and persistent
fatigue, the researchers have identified defective
T cell function that was reversible with a probiotic.
The aims of this pilot study are to demonstrate
defective T cell immunity in chronic relapsing
fatigue in young adults suffering stress related
chronic fatigue; to correlate this with the shedding
of EBV virus; to reverse the defect and viral
shedding with a quality probiotic; and to correlate
the changes with improved symptoms of fatigue
and sleep disturbance. This will provide evidence
for a practical and safe therapy which currently
does not exist.
Gallerie Fine Jewellery General Cancer Research
Project Grant
Prof John Forbes and A/Prof David Sibbritt
Longitudinal changes in mammographic density as
a biomarker for future breast cancer events
Breast density has been identified as one of the
strongest risk factors for breast cancer, but it is not
yet known why increased breast density leads to
a higher incidence of breast cancer. This research
will analyse changes in the mammographic
density of women who are participating in the
BreastScreen program to examine if the rate
in change of density is a useful biomarker for
subsequent risk of breast cancer. Inclusion of
breast density as a screening factor for breast
cancer could greatly alter the way in which
women are screened and treated, and may help
to increase the pool of women who should be
screened more regularly and identify those who
could reduce their screening frequency.
Lions Club of Adamstown Project Grant
A/Prof Lynne Parkinson, Prof Julie Byles,
Dr Fiona Blyth and A/Prof Hannah Pollard
The profile of pain in older women with arthritis
Population-based studies focusing on pain in
arthritis are scarce, and often assume a peripheral
rather than centralised pain mechanism. This study
aims to evaluate and describe pain (both peripheral
and centralised) associated with arthritis for a
large cohort of women aged in their 60s. It will
relate pain profiles to changes in physical function
over time. Identifying the factors associated with
these different profiles, and the role of arthritis as a
potential effect modifier of these associations, will
provide a basis for the development of effective
therapies for pain.
Lawrie Bequest Paediatric Oncology Research
Project Grant
Dr Nikola Bowden, Dr Cliff Meldrum and
Prof Rodney Scott
Development of a diagnostic genetic test for
childhood skin cancer disorders
Children with the recessive genetic disorder
Xeroderma Pigmentosum (XP) have extreme
sensitivity to UV-light, a 1000 fold increase in skin
cancers from age 2 and rarely live beyond 30 years
of age. There are eight genetic subgroups of XP
and two related disorders – Cockayne’s Syndrome
(CS) and Trichothiodystrophy (TTD), which are
related to genes in the nucleotide excision repair
(NER) pathway. This study will utilise nextgeneration
sequencing to screen all 10 NER genes
in parallel to diagnose the subgroup/disorder
present in children with XP, CS and TTD.
As a result of this study, children with these
disorders will, for the first time, be rapidly screened
to identify the genetic mutation causing their
disease. This will allow families with affected
children to make informed decisions when having
further children, and will rapidly translate into the
only diagnostic test offered worldwide for this fatal
childhood skin cancer disorder.

Fellowships
New Fellowship
Newcastle Jets Post-doctoral Fellow
The Newcastle Jets has supported a two-year
Fellowship for Dr Deb Dewar from the University
of Newcastle. The SCORES (Supporting Children’s
Outcomes using Rewards, Exercise and Skills)
project is an innovative school-based physical
activity and movement skills study that aims to
evaluate and address a notable decline in physical
activity and fundamental movement skills among
primary school children. Dr Dewar will design and
trial a primary school program to develop sports
skills and improve key aspects of physical fitness
including stamina, leg strength and balance as well
as encouraging healthy eating in 8-10 year olds.
Funding from the Newcastle Jets also supports a
PhD student for the project. The 2011 Gastronomic
Lunch provided matched funding to support the
project operating costs.
Continuing Fellowships
Greater Building Society Fellowship in
Stroke Research
The Greater Building Society has committed to a
new three-year Post-doctoral Fellowship for
Dr Neil Spratt from Hunter New England Health.
This Fellowship is to determine a patient’s
suitability for stroke treatment by assessing the
state of their brain tissue after a stroke, rather than
relying on the time delay. This research could
benefit hundreds of thousands of stroke patients
worldwide by overcoming the current three hour
treatment time barrier.
Xstrata Coal Research Fellow in Depression
Xstrata Coal supports a three-year Post-doctoral
Fellowship for Dr Kerry Inder from the University of
Newcastle, in a partnership to address depression
and suicide in rural communities. The Fellowship
has received matched funding from beyondblue:
the national depression initiative for the project
costs. The xTEND project will examine ways to
identify and minimise the risk factors for male
suicide in rural communities, focusing on the role
of social networks, relationship breakdown and
depression as potential risk factors for suicide and
develop mitigation strategies.
Mrs Joyce and Dr George Bogner Cancer
Research Fellow
Dr Katie Ashton from the University of Newcastle
was awarded the Bogner Post-doctoral
Fellowship to investigate the relationship between
the DNA repair pathway, nucleotide excision
repair (NER) and melanoma. The study is shedding
light on the biological pathways involved in the
development of melanoma, why melanomas
develop as a result of UV-light exposure, and
why melanomas are unresponsive to traditional
chemotherapeutic treatment.
Xstrata Coal Asthma Research Fellow
Xstrata Coal has supported a three-year
Postdoctoral Fellowship to investigate a newly
recognised type of asthma which accounts for 50
per cent of asthma cases. Dr Katie Baines from the
University of Newcastle is examining blood and
sputum samples from people with noneosinophilic
asthma, to identify the role that genes play in the
43

Life Story: Healthy Lifestyle Choices
Whether it is outback apple
crumble or bush kangaroo stir
fry, the back to basics cooking
club and healthy lifestyle
program is teaching kids more
than just the skills to prepare
and cook authentic and healthy
Australian meals.
The program is a direct example
of how changing nutritional
behaviours is also helping
children live healthier lives.
What began as a study in
nutrition by the University of
Newcastle’s Professor Clare
Collins at Biraban Public
School has now evolved into a
successful club that has a long
list of children and parents who
are excited and waiting to join
the program for years to come.
The school’s Indigenous Liaison Officer and
father of two, Desmond Barton, has noticed
the positive impact that the cooking club is
having on his children, who have attended the
club for over 18 months.
“Before the club Charlotte would not touch a
vegetable, the class has not only taught her
the skills to be able to make her own food but it
has given her an education in nutrition,” Desmond
said.
“With a high population of Aboriginal children
attending the school, the club provides a great
opportunity for not just the kids to get an
education in nutrition and healthy eating but
it is also giving the parents and the Aboriginal
community an opportunity to get involved and
learn about healthy lifestyles.
“You can see the kids start to realise the healthier
that the things are that they put in their stomachs,
the better their lives will be.”
The presence of the cooking club has meant that
the kids are not just engaging with their food
choices but they are actively developing healthier
food habits and lifestyle choices for the rest of
their lives.

P hD Scholarships, Support Grants and Prizes
MM Sawyer Estate PhD Scholarship in Cancer
Brianna Morten
Supervisors: Prof Rodney Scott and
Dr Kelly Avery-Kiejda
Estrogen and p53 (a gene known to stop cancer
development) are essential in normal breast
growth. p53 can control estrogen responses,
and loss of this control is associated with poorer
outcomes in breast cancer. Loss of p53 function
by a genetic fault occurs in far less breast cancers
than expected, given its essential role in stopping
cancer growth. This suggests that its function
becomes disrupted in other ways to promote
breast cancer. Additionally, smaller forms of p53
have been discovered that can inhibit its function.
This study will investigate whether these small
forms of p53 can alter estrogen responses and p53
function and, in turn, promote development of
breast cancer. This will provide new insights into
how p53 loses its function in breast cancer, and
may identify new targets for its prevention and
treatment.
Thomson Family Research Higher Degree
Support Grant
Kristine Pezdirc
Supervisors: Prof Clare Collins and
Dr Melinda Neve
Young women are vulnerable to weight gain,
which places them at risk of weight related comorbidities,
such as depression, infertility and type
2 diabetes. Weight loss interventions that appeal to
and engage young women, as well as meet their
individualised needs, are required. The potential for
eHealth interventions to achieve significant weight
loss has been highlighted, but their ability to
engage young women is not proven. This project
will assess the needs of young women for an
eHealth weight loss intervention, as well as identify
the most effective obesity treatment strategies
for young women via a systematic review of the
literature. The study will develop and evaluate
a novel eHealth intervention. It will be targeted
to young overweight women, who are at risk of
progressing to obesity, and aims to reverse the
weight gain trajectory through modest weight loss.
Thomson Family Research Higher Degree
Support Grant
Tracy Schumacher
Supervisors: Prof Clare Collins and
Dr Tracy Burrows
Children whose parents suffer a heart attack or
stroke prematurely are at a particularly high risk,
inheriting a predisposition to heart disease as
well as their parents’ eating habits and lifestyle
behaviours.
This study aims to discover whether parents are
interested in dietary change after experiencing
a significant adverse cardiovascular disease
event, and whether improving their eating habits
improves their child’s dietary intake and blood
cholesterol levels. Targeting families with a parent
who has recently been discharged from hospital
following a cardiovascular disease or stroke event,
the study will test a novel approach to assist
parents to improve their own and their child’s
eating habits. Parents will receive advice based
on their own diets and particular cardiovascular
disease risk factors and areas for improvement.
A dietitian will develop specific dietary advice
and participants will be asked to make changes
to the whole family’s food supply. The study
aims to produce evidence to support a novel
cardiovascular disease prevention program for
children whose parent has already experienced
cardiovascular disease.
45

46
Greaves Family PhD Scholarship in Immunology
Alexandra Brown
Supervisors: Prof Philip Hansbro, Dr Simon Keely
and Dr Jay Horvat
Bacterial pneumonia is a common, debilitating
and life-threatening lung disease. Streptococcus
pneumoniae is the most common cause, yet
deficiencies in the current prevention strategies
and the emergence of antibiotic resistance
have allowed the continued high incidence
of the disease. Furthermore, respiratory viral
infections and chronic lung conditions such as
chronic obstructive pulmonary disease (COPD)
substantially increase susceptibility to secondary
bacterial pneumonia. The causes of susceptibility,
however, are not completely understood.
This PhD program proposes that viral infections
and COPD increase the levels of factors that
suppress the ability of the immune system to
fight off a secondary bacterial infection, therefore
allowing the bacterial infection to develop
into pneumonia. The study aims to discover
whether targeting a specific molecule shown
to have a key role in susceptibility to secondary
bacterial pneumonia will potentially provide new
therapeutic strategies for the prevention and
treatment of secondary bacterial pneumonia.
Novo Nordisk Pharmaceuticals Scholarship in
Paediatric Diabetes
Dr Prudence Evans
Supervisors: Dr Bruce King and Carmel Smart
Dr Prudence Evans is a Senior Paediatric Registrar
at the John Hunter Children’s Hospital undertaking
a PhD in paediatric diabetes. The project aims
to determine the optimal parameters for insulin
delivery to maintain optimal glycemic control in
patients with type 1 diabetes.
Square wave insulin boluses have been a feature of
insulin pumps for many years, however extended
boluses are rarely used because they require a very
high level of knowledge and interpretation.
This project will establish when, how much and
the duration of time insulin should be delivered
by the pump in relation to the meal, and will
contribute to the development of a ‘closedloop’
insulin pump. By determining some simple
parameters for using extended boluses, they
may be used more frequently with resulting
improvements in Blood Glucose Level control.
Mark Hall PhD Student Conference Prize
Supported by Charlestown District Cricket Club
Amy Louise Martin
Amy Martin is a University of Newcastle PhD
candidate in the HMRI Information Based
Medicine Program. She is investigating genetic
predispositions to Hereditary Non-Polyposis
Colorectal Cancer (HNPCC) – an inherited form of
colorectal cancer.
In around 50 per cent of families with a clinical
diagnosis of the disease, a mutation in one of the
four genes known to be associated with HNPCC
cannot be detected with existing technologies.
If ‘new’ genes causing disease are identified in
individuals diagnosed with HNPCC, predictive
genetic testing could be offered to family
members and unnecessary invasive surveillance
prevented. Amy is investigating if genetic copy
number variation plays a role in the development
of colorectal cancer in HNPCC patients, and has
already identified some significant results for future
research.
This Conference Prize will give Amy the
opportunity to attend the 2012 Genomics Research
Conference and Exhibition in Boston, USA. This
will provide her with a unique opportunity to
access information relevant to her PhD program,
with five of the conference tracks strongly aligning
with her HNPCC research. It is also an opportunity
to network with fellow researchers in the field,
present work related to her research, and allow her
to bring back valuable experience and knowledge
to her fellow Hunter researchers.

HMRI PhD Student Conference Prize
Michelle Wong
Michelle Wong is a University of Newcastle PhD
candidate in the HMRI Information Based Medicine
Program focusing on genetic variation in the
development and/or progression of breast cancer.
Her studies are increasing the understanding of
familial breast cancer and how different genes
interact in the genetic mechanisms of the disease
and aid in the management of patients with breast
cancers. By providing a more specific diagnosis
of disease risk based on genetic information, the
development of personalised treatment can be
tailored to individual genetic profiles.
Michelle has recently performed state-of-the-art
next-generation sequencing on the BRCA1 and
BRCA2 genes involved in the genetic predisposition
to breast cancer, enabling much larger regions of
DNA to be investigated in a very short space of time
compared to conventional sequencing.
The mass of data obtained from Michelle’s project
will provide a wealth of information in a small
amount of time about the genetic regions being
investigated in inherited breast cancers. Her study
design is understood to be the first of its kind, and is
also the first next-generation sequencing project to
be conducted by HMRI researchers.
This HMRI PhD Student Conference Prize will
enable Michelle to attend the 2012 Cancer Therapy
& Research Center - American Association for
Cancer Research (CTRC-AACR) San Antonio Breast
Cancer Symposium (SABCS) in San Antonio, USA.
This conference will be attended by a broad
international audience of academic and private
company researchers and physicians from over 90
countries, and will provide an international stage for
Michelle to present results from research conducted
during her PhD.
47

48
External Foundation and Program Grant Funding
Emelyn and Jennie Thomas Postgraduate
Medical Research Scholarship Travel Grant
Amelia Tomkins
Testing stroke sonothrombolysis using an improved
experimental model of thromboembolic stroke
Despite major advances in the treatment of acute
stroke, the most effective stroke treatment is only
beneficial in a small percentage of patients. This
treatment, clot busting with tissue plasminogen
activator (tPA), only dissolves approximately
half of the major clot blockages it targets due to
limited potency. In collaboration with colleagues
in Giessen, Germany, Amelia will investigate the
use of standard ultrasound in conjunction with
tPA as an enhancer for traditional clot busting
treatment. Preliminary evidence suggests that both
conventional ultrasound, and very small bubbles
(microbubbles) used to boost ultrasound signal,
may significantly increase the effectiveness of tPA
and, subsequently, clot busting treatment.
Jennie Thomas “Sweet Poison” Project Grant
Prof Manohar Garg
Dietary fructose restriction improves plasma lipids,
satiety hormones and inflammation in obesity
There is a growing concern that high fructose
consumption in humans may be in part
responsible for the rising incidence of obesity
worldwide. This is because fructose, unlike other
carbohydrates, goes directly to the liver to be
processed. As the liver has a limited storage
capacity, excess fructose is converted to body
fat. High fructose diets have been associated
with many of the components of metabolic
syndrome (insulin resistance, elevated waist
circumference, dyslipidemia, and hypertension),
a precursor for the development of diabetes and
heart disease. This project will test the hypothesis
that restricting dietary intake of fructose is highly
satiating (provides feeling of fullness) and results
in improvements in components of metabolic
syndrome i.e. reduce blood lipids, reduce insulin
resistance and inflammation.
Gastronomic Lunch “Happy, Healthy Children”
Project Grant
A/Prof David Lubans
SCORES (Supporting Children’s Outcomes using
Rewards, Exercise and Skills)
The SCORES project is an innovative school-based
physical activity and movement skills study that
aims to evaluate and address a notable decline in
physical activity and fundamental movement skills
among primary school children. The researchers
will design and trial a primary school program to
develop sports skills and improve key aspects of
physical fitness including stamina, leg strength and
balance as well as encouraging healthy eating in
8-10 year olds. By improving skills, children will
find physical activity more fun; they will reduce
their risk of becoming overweight, improve bone
mass, and reduce their risk of ankle injuries.
The Newcastle Jets have co-funded SCORES,
supporting a Post-doctoral Fellowship and a PhD
student to implement the project.
The Ramaciotti Foundations
Equipment Grant
The Ramaciotti Foundations awarded HMRI a
$73,394 equipment grant to provide technology
to assist cancer researchers in the development
of new anti-cancer drugs, ensuring the best
outcomes for patients. The equipment will support
a research team led by Dr Rick Thorne aimed at
development of new cancer treatment strategies,
analysing signalling pathways in cancer cells. The
grant will allow the purchase of a High-Resolution
Isoelectric Phosphoprotien Signalling System
(a NanoPro instrument) to support the HMRI
Cancer Program’s drug discovery studies. HMRI
matched the funding received from the Ramaciotti
Equipment Grant to further assist the researchers.

Tomago Aluminium Research Grant in Dementia
A/Prof Frini Karayanidis and Dr Grant Bateman
The role of brain vasular flow and white matter
lesions in the development of Vascular Dementia
(VaD)
Cerebral white matter is especially vulnerable to
hypoxic-ischemic injury. Although white matter
lesions (WML) increase with age, are associated
with executive functions decline and underpin
Vascular Dementia (VaD), their underlying cause
is unknown. Recently, identified a new MRI
measure that quantifies intracranial pulse waves.
These pulse waves may damage white matter and
contribute to WML development. In the previous
phase of this study funded by HMRI, we examined
the relationship between vascular pulse waves,
WML and executive dysfunction in healthy elderly.
This second phase will test the concept that
individual variability in intracranial pulse waves
can provide a sensitive measure of risk for WML
development and cognitive/motor control decline
in older adults. Thus, this study is the first step
towards identifying early changes in vascular flow
as a measure of risk for Vascular Dementia (VaD).
HMRI Grant in Sports Medicine
Supported by Emeritus Professor
Maree Gleeson OAM
Diagnosing and managing respiratory illness in
athletes
This project grant supports the research of
University of Newcastle PhD candidate, Dr Lisa
Elkington, investigating immune function in
endurance athletes. Upper respiratory symptoms
account for 30-40 per cent of visits to sports
medicine clinics by elite athletes. The project
will examine ways of predicting athletes at
increased risk of upper respiratory tract infection/
inflammation; ways of monitoring immune
status of athletes; whether there are clinical and/
or nutritional factors that may play a role in an
athlete’s susceptibility; and whether antioxidant
therapy is an appropriate intervention to prevent
illness associated with airway inflammation. This
will improve methods for prevention, diagnosis,
treatment, and management of upper respiratory
tract illness in elite athletes.
Novo Nordisk Regional Diabetes Support
Scheme Project Grant
Dr Prudence Evans, Dr Bruce King and
Carmel Smart
What is the optimal amplitude of a square wave
insulin bolus in people with Type 1 diabetes on
insulin pump therapy?
This project aims to determine the optimal
parameters for insulin delivery to maintain optimal
glycemic control in patients with type 1 diabetes.
Square wave insulin boluses have been a feature of
insulin pumps for many years, however extended
boluses are rarely used because they require a very
high level of knowledge and interpretation. This
project will establish when, how much and the
duration of time insulin should be delivered by the
pump in relation to the meal, and will contribute
to the development of a ‘closed-loop’ insulin
pump. By determining some simple parameters for
using extended boluses, they may be used more
frequently with resulting improvements in Blood
Glucose Level control.
Barker Scholarship
Awarded by the University of Newcastle Foundation
In 2011 HMRI also assisted the University of
Newcastle Foundation with the selection of
the Barker Scholar, supported by a generous
donation from Don Barker and Annette Lynch to
the University Foundation, to support students
undertaking their PhD studies in health in stroke,
prostate cancer, melanoma and ageing.
The Barker Scholarship was awarded to University
of Newcastle PhD candidate Aoife McGarvey, who
is investigating physiotherapy on head and neck
cancer patients. Patients undergoing surgery for
head and neck cancer are not routinely referred to
physiotherapy, and this study aims to determine
if early supervised rehabilitation to strengthen the
shoulder blade muscles improves patients’ pain
and the ability to use their arm following surgery.
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50
HCRF Grants and Prizes
HCRF Project Grants
Prof Joerg Mattes, Prof Peter Gibson,
Prof Michael Hensley, A/Prof Bruce Whitehead and Dr
Vanessa Murphy
The Growing Into Asthma study: Wheezing prevalence and
markers of airways inflammation in preschoolers born to
mothers with asthma exacerbations in pregnancy
This study has established a birth cohort of more than
200 children born to mothers with and without asthma
to determine for the first time, the impact of asthma
exacerbations during pregnancy on respiratory health in
early life. Current data suggests that a subtype of wheeze,
termed multi-trigger wheeze, may be more frequent in
infants born to mothers who suffered from severe asthma
exacerbations during pregnancy. The project now aims to
investigate whether this type of wheeze is more persistent
and associated with an inflammation of the airways. The
results aim to show that asthma exacerbations during
pregnancy could affect a child’s lung health and that
preventing these may improve respiratory health in early
life.
Dr Rick Thorne and Dr Charles de Bock
Establishment of Fat1 cadherin as biomarker and unique
target for anti-cancer therapy in paediatric acute
lymphoblastic leukaemia
The cure rate for children suffering leukaemia is now
80 per cent but this still leaves a significant proportion
who relapse. The researchers have identified a unique
marker, Fat1, that indicates relapse in children with the
most common type of leukaemia (pre B-ALL). While
Fat1 is highly expressed in leukaemia it is not expressed
by normal blood cells. This project will explore these
findings and aim to produce two translatable outcomes
for addressing disease relapse. One is the development of
a new Fat1 molecular evaluation test that will provide a
new minimal residual disease marker for the management
of paediatric leukaemia patients. They will also conduct
pre-clinical feasibility studies of monoclonal antibodies
directed against Fat1, with the aim of employing these as a
new targeted therapy.

Dr Jay Horvat, Prof Phil Hansbro and
Prof Paul Foster
Elucidating the mechanisms of steroid-resistant
asthma
Between 10-30 per cent of asthmatics are steroidresistant
and account for up to 50 per cent of
asthma health-care costs. This research program
has developed a number of unique models of
infection-induced steroid-resistant asthma that
are highly representative of the human disease.
This study proposes to use these models to
elucidate the mechanisms that drive steroid
resistance in order to inform novel targets for the
development of improved therapeutic strategies for
the prevention and treatment of steroid-resistant
asthma.
HCRF also co-funded the Tomago Aluminium
Juvenile Diabetes Research Project Grant,
featured on page 39.
HCRF Education Prizes
Megan Jensen
Megan Jensen is a member of the HMRI
VIVA Program. Her research is focused on the
relationship between obesity and childhood
asthma through her PhD research based at HMRI,
and her clinical work as part of the John Hunter
Children’s Hospital paediatric respiratory team.
Megan is currently working on a research
project that will characterise obesity and asthma
in children and adolescents; assess the effect
of diet induced weight loss in children with
asthma; investigate the nature of sleep disruption
in asthmatic children; and assess changes in
metabolic, dietary and physical activity markers
as risk factors for the development of obesity in
childhood asthma.
The HCRF Education Prize will enable Megan to
attend the American Thoracic Society International
Conference in San Francisco, USA, in 2012. This
will provide Megan with the opportunity to both
present her research findings to a large number
of international researchers and clinicians and
advocate for Hunter respiratory research.
Rebecca Dyson
Rebecca Dyson is a member of the HMRI
Pregnancy and Reproduction Program.
Her research is focused on understanding
cardiovascular function in very preterm newborns.
She is particularly interested in the role of novel
molecules that affect blood flow, and their
regulation of microvascular behaviour in the stages
immediately around birth (perinatal period).
Her PhD is examining the role of gasotransmitters
in the control of microvascular tone in the initial
extrauterine period. As microvascular dysfunction
has been linked to illness severity in preterm
infants, describing these mechanisms may provide
insight into the clinical management of this system
and ultimately improve neonatal cardiovascular
outcomes.
The HCRF Education Prize will help Rebecca to
attend the joint meeting between the British
Microcirculation Society and the American
Microcirculation Society, to be held in the UK, as
well as the Annual Meeting of the Fetal & Neonatal
Physiological Society in the Netherlands, both to
be held in July 2012.
51

Life Story: Asthma in Pregnancy
Asthma is a disease that can often
become tricky to manage. However,
managing asthma and pregnancy is
an even more complex task.
When Fiona Feltrin fell pregnant with
twins, her asthma treatment soon
became a priority.
“Originally there was a lot of fear
about the impacts that asthma
medication had on babies,” Fiona
said, “I used to worry about which
treatments would be safe during my
pregnancy.”
Fiona soon enrolled in the Managing
Asthma in Pregnancy (MAP) Study,
conducted by Professor Peter Gibson
and Kelly Steel.
Traditionally the symptoms of Fiona’s asthma
were treated by her GP, however the MAP
Study offered a much more expansive analysis
of both her asthma and her pregnancy.
“Participating in the study was so much more
effective because every aspect of your asthma
was analysed and it was a very powerful
motivator to see where your health was
sitting,” Fiona said.
The study not only monitored my asthma
during my pregnancy with the twins it
motivated me to take better care of my asthma
rather than simply treating the symptoms.”
The MAP Study monitored a range of aspects
of asthma including Fiona’s lung function,
blood, and sputum and nitrous oxide.
“This is a very important study, firstly for
pregnant women with asthma, and secondly
for people with asthma in general,” Professor
Gibson said.
“For women with asthma who are pregnant, we now
have a way that can very significantly reduce asthma
attacks, and this appears to benefit not only the
mothers but also their babies.”
Not only did the MAP Study enable Fiona to breathe a
little easier knowing her asthma was being watched,
it also gave her the chance to update her knowledge
on asthma and review her treatment.
“It allowed me to make good habits for my health
again. I was reminded of things I should be
incorporating back into my lifestyle.”
Fiona now has two healthy twins and feels that the
MAP Study had a positive long-term impact on her
health.
“Nine months of monitoring really allowed me to
watch what was happening with my asthma and
engage in the process of trying to improve it,” she
said.
“Now I am more engaged with my health and what
needs to be done.”

Government Grants and Fellowships
NSW Government funding allows
HMRI to build the capacity of health
and medical research in the Hunter
region. It supports the continued
development of HMRI Research
Programs and Networks, enabling
important collaborations between
clinical, biomedical and public health
researchers.
Research Grants
In 2011, the Cancer Institute NSW awarded a
Translational Cancer Research Unit (TCRU) Grant of
$1.4 million over three years to Hunter researchers.
The grant will enable the Hunter TCRU to integrate
seamlessly the elements of the bi-directional research
pathway, from basic science to clinical care for the
community; to facilitate rapid development and
implementation of research discoveries; and to
stimulate laboratory research on priority questions
generated from the clinic. The Hunter TCRU also
received funding of $293,000 from NSW Health to
establish a clinical Post-doctoral Fellowship position.
In 2009, the NSW Government awarded Hunter
researchers $2.4 million for the establishment of
a Neurobehavioural Genetics Unit based in the
Hunter. This funding continued through 2011, with
collaborations between the researchers in the HMRI
Brain and Mental Health and Information Based
Medicine Programs helping to explain why some
people are more susceptible to developing a mental
illness than others. The grant has also funded five
major pieces of research equipment and six research
positions.
Infrastructure Grants
The NSW Office for Science and Medical Research
provided infrastructure funding of $3.1 million to HMRI
for 2010-2011 through the Medical Research Support
Program (MRSP). The funding continued to help build
capacity in key research fields, and supported 39
positions, of which 27 are research-related.
HMRI was also awarded an additional MRSP grant of
$3.9 million for 2011-2012. The total MRSP funding for
2006-2012 is $17.1 million.
MRSP funding also supported the 2011 appointment of
a Post-doctoral Health Research Economist position
for Dr Andrew Searles. He will work closely with
Professor Chris Doran to seek ways to use the health
sector’s resources in the most efficient way.
Equipment
In 2011 MRSP funds enabled HMRI to purchase or
contribute to the purchase of four new items of
research equipment:
• Ion Torrent Whole Genome Sequencer
• 2x Heraeus Multifuge X3R
• piCO smokerlyzer with sampling D piece
Fellowships
HMRI received a $1.7 million NSW Health Capacity
Building Infrastructure Grant to fund the recruitment
and support of four Post-doctoral Fellowships in the
Public Health Program, from 2010-2013:
• Jennifer Stewart Williams is monitoring health
services use and impact and is conducting
population analysis research into drug
regulation, hospitalisation, cardiovascular disease
management and women’s health.
• Megan Freund is reducing social and behavioural
health risks and is leading a number of
organisational change programs in clinical and
school settings.
• Christopher Oldmeadow is investigating health
service development and evaluation working on
the Port Waratah Cancer Study, an investigation
into possible cancer cluster among coal workers
using CHeReL data.
• Beverley Patterson is investigating
biopreparedness and reducing communicable
disease risks working on Emerging Infectious
Diseases, with a particular focus on pandemic
influenza and viral encephalitis.
53

54
Fundraising Highlights
The HMRI Foundation, PULSE and
the Hunter Children’s Research
Foundation (HCRF), raise funds for
health and medical research in the
Hunter, through community and
corporate donations and by holding
fundraising events. Funds are
awarded through a peer-reviewed
assessment process, supporting
the best research as project and
equipment grants, scholarships and
fellowships, and as awards or prizes
to leading individual researchers.
HMRI, including PULSE and HCRF, raised $3.1 million
in the 2010-11 Financial Year, comprising:
• $2,336,111 from community and corporate
donations
• $197,510 from HMRI events
• $233,904 from events held on behalf of HMRI by
supporters, including PULSE and HCRF
In 2011, HMRI awarded more than $2.3 million to
support the Hunter’s most promising research,
helping to keep our community in the best of health.
Donations keep us all in the best of health
By investing in pilot project grants and research
fellowships, HMRI philanthropic funding helps
researchers to build and develop their research
theories. Results from these early investigations help
researchers increase their competitiveness when
applying for larger external funding, such as the
National Health and Medical Research Council.
The ability to attract larger, nationally competitive
funding is an important measure of the effectiveness
of pilot funding for research:
• Since 1998, HMRI has awarded $15.2 million in
charitable funding to Hunter researchers
• Of this, $4.7 million in HMRI grants has attracted
$71.9 million in external grants
• This means that to date 30 per cent of HMRI
grants can be linked to national competitive
grant funding success
• The charitable donations to HMRI to date have
had an average leveraging effect of 15:1
By leveraging a small initial investment in research,
philanthropic community and corporate funding
helps researchers to attract major competitive
funding, leading to better health outcomes.
How is community funding used?
HMRI proudly maintains a fundraising ratio (the
amount spent on administrative and operating costs
of fundraising) significantly lower than the 40 per
cent required by the Office of Liquor Gaming and
Racing.
HMRI spent $698,658 on administration for HMRI
fundraising and event activities in 2010-11, or 23 per
cent of the funds raised. This means that for every
dollar donated to HMRI by the community, 77 cents
was directed to research or held in trust for future
research.
This funding directly supports research through
project and equipment grants, attracting and
retaining the best researchers to the region, and
helping establish collaborations with leading
researchers nationally and internationally.

HMRI Foundation
Chair: Mr Glenn Turner
HMRI attracts significant support from the
community support through the fundraising
efforts of the HMRI Foundation. In 2011 HMRI
organised the HMRI Ball, HMRI Golf Day and
the HMRI Cup Yacht Race in conjunction with
Newcastle Cruising Yacht Club. HMRI was also
the recipient of proceeds from events held by
supporters, including the Sparke Helmore/NBN
Television Triathlon, the Gastronomic Lunch of
the Year, Stroud Rodeo, the Keith Tulloch Wine
Dinner, and various golf days and cycling events.
Fundraising by the HMRI Singleton Foundation
supported a project grant at the 2011 HMRI
Awards Night.
HMRI also secured 743 new donors through
Direct Mail Appeals in 2011.
Supporting HMRI’s
early career researchers
Chair: Miss Rebecca Wilson
PULSE brings together young Hunter
professionals who raise funds for early career
researchers by organising affordable events.
PULSE funding helps early career researchers
to establish international networks and bring
research expertise back to the region.
In 2011, PULSE organised and hosted the Triple
J Hottest 100 Australia Day Party at Merewether
Bowling Club, the PULSE Hunter Valley
Experience, High Tea with a Splash of Fashion,
the PULSE Trivia Night, and an exclusive movie
screening of The Hangover Part 2. PULSE also
received proceeds from the sale of Entertainment
Books and other events held on its behalf.
PULSE distributed $30,000 at the 2011 HMRI
Awards Night, supporting the HMRI Award
for Early Career Research and the five PULSE
Education Prizes.
Chair: Mrs Janelle Shakespeare
The Hunter Children’s Research Foundation
(HCRF) raises funds for research into the health
of children. HCRF works in collaboration with
HMRI and is affiliated with Kaleidoscope – the
Children’s Health Network.
In 2011, HCRF was proud to announce Australian
fashion icon Jennifer Hawkins and retired
paediatrician Dr Cliff Hosking as dual patrons of
the Foundation.
Throughout the year, HCRF receives donations
from its dedicated ReaCH 200 Program
supporters, as well as proceeds from various
events held by HCRF supporters, including Bridal
Fairs, the Tourism Industry Lunch, the Australian
Ironman event, and was also a shared beneficiary
of Hunter Life Education’s Cash Housie.
HCRF distributed $92,000 in 2011, supporting four
research project grants and two HCRF Education
Prizes.
55

56
HMRI 2011 Supporters
HMRI’s donors and supporters help Hunter
researchers continue to find better ways to
prevent and treat a range of diseases. Our 2011
supporters include those who make small regular
contributions from their pay, donate goods or
services, right through to major supporters who
Life Governor
Jennie Thomas AM
HMRI Patron
Peter Sinclair AC
Strategic Partner
Newcastle United Jets
Foundation Platinum Circle
Estate of the Late
James Scott Lawrie
Estate of the Late
Reginald Leslie Radford
Estate of the Late
Rolf Heinz Sonntag
Haggarty Foundation
nib foundation
The University of Newcastle
Foundation Gold Circle
beyondblue
Estate of the Late Joyce Bogner
Estate of the Late
Ferma Armstrong McLean
Estate of the Late
Kenneth Leslie MacFarlane
Estate of the Late
Stephen James Fairfax
Gastronomic Lunch
Michael Hensley
Hunter New England
Local Health District
Kiriwina Investment Company
Ken Moss
Port Waratah Coal Services
Rio Tinto Australia
Thyne Reid Foundation
Xstrata Coal
Foundation Silver Circle
Robert Cameron
Centennial Coal
Dalara Foundation
Stephen Graves
Greater Charitable Foundation
Greaves Family
Geoffrey Leonard
Lions District 201N3
Diabetes Foundation
MM Sawyer Estate Trust
NBN Television
Newcastle Permanent
Charitable Foundation
Novo Nordisk Pharmaceuticals
PricewaterhouseCoopers
Prime7
Ramaciotti Foundations
Sparke Helmore / NBN Triathlon
The Newcastle Herald
Tomago Aluminium
Foundation Circle
Ablosix Pty Ltd
Ashton Coal Operations
Richard & Paula Anicich
Autore South Sea Pearls
Baachus Restaurant
Rod Bathgate
Rosemarie Bennis
Eric Bone
Grace Brown
Graham Brown
Alan Budd
Cockram Construction
NSW Pty Ltd
Crosbie Warren Sinclair
Paul Dixon
fund multiple scholarships and fellowships. These
dedicated individuals and organisations both
share and enable HMRI’s commitment to creating
a strong foundation to keep the community in the
best possible health.
James Drinkwater
Droneen Pty Ltd
Kath Elliott
Peter Etheridge
Michael Faulkner
Stephen Forgacs
Gallerie Fine Jewellery
Peter L Gardiner
Alyson Gearing
GHD
Maree Gleeson
Greater Union Organisation
Andrew Griffiths
Growers Best
Rex Harries
Esma J Holt
Hunter District Hunting Club
Hunter Herb and Garden Club Inc
Hunter Lifestyle Magazine
Hunter Region Open Heart
Association Inc
Helen Johnson
Joy Mining Machinery
Keith Tulloch Wines
Robert & Terry Kennedy
Largs Village Winter Ball
Bevan Leach
Lioness Club of Toronto
Lions Club of Adamstown
Lions Club of East Maitland Inc
Lions Club of Toronto
Ron Maitland
Peter & Lisa McKinnon
Caroline McMillen
Kellie Melrose
Ian Miller
Morriset Ladies Golf Club

Paul Most
Graham Mullane
Multiskilled Resources Australia
Ian Napier
Newcastle City Council
Newcastle Innovation Limited
OneSteel
Order of the Eastern Star –
HV District Grand Chapter
Richard Owens
peoplefusion
Chris & Shirley Piggott
Queensland Rail National
Community Giving Fund
Quota International of
Gloucester Inc
Radio Newcastle
G C Ralston
Greg Ray
Rotary Club of Newcastle
Rotary Club of Newcastle
Enterprise
Rotary Club of Newcastle
Sunrise
Deidre Russell
Scratchleys on the Wharf
Stirling Sanderson
Craig Sawyer
SKM S2F Pty Ltd
Ski for Kids
Sparke Helmore Lawyers
Anthony Stokes
Southern Beaches Rugby
Union Club
Stroud Rodeo Association
Sweetman Memorial Fund
Diana Taaffe
Tainn Hunter Classic
Tamburlaine Concert
The Bloomfield Group Foundation
The Good Guys Foundation
Tinkler Foundation
Felicity Thomson
Susan Truscott
Glenn & Leda Turner
Tyrrell’s Vineyards Pty Ltd
UGM Australia
Ian Vaughan
Karen & Peter Vaughan
VBD Chartered Accountants
West Wallsend High School
Western Suburbs Leagues Club
Wilson Mining Services
Estate of the late Janet Helen Winn
Geoffrey Woolf
Top 200
Australian Hotels Association
(NSW) - Newcastle Sub Branch
Blue Star Catering
Boardman Peasley
Capability Resources Pty Ltd
Classic Framing & Memorabillia
Cutcher & Neale
Diamond Technology Group
DM Faulkner Pty Ltd
Experienced Office Furniture
Farrow Wyatt
Chartered Accountants
Forsythes Recruitment
GB Electrical Contractors Pty Ltd
Glenwood Rural Buildings
Hunter Irrigation & Water Solutions
Hunter Land
Hunter Motor Group
Hunter Ready Mixed Concrete
HW Frost Equipment
J & J Lidbury Pty Ltd
Lawler Partners
Leonard Investment Group
Macquarie Generation
Maitland City Council
Markey Group
McDonald Jones Homes
Men of League Foundation
nabhealth
Newcastle Radiology
Newcastle Wedding
Industry Professionals
Octobrick Pty Ltd
Ranjenko Pty Ltd
R Hall & Son Pty Ltd
Ritchies Stores Pty Ltd
Robert Crawford Real Estate
Robinson Property
RPS Australia East Pty Ltd
Sheather & Merrigan
Simons Carpet Choice
Stronach Group Pty Ltd
The Junction Hotel Group
The Mutual Building Society
Toll Bulk Sands
Tri Nature Lifestyle
Whiteley Corporation
Workplace Giving
Bushrangers Bar & Brasserie
Connect Personnel
Crosbie Warren Sinclair
Forsythes
Greater Building Society
Health Support Services
Hunter Medical Research Institute
Hunter New England
Local Health District
Hunter Valley Concrete Pumping
Newcastle City Council
Newcastle City Holden
Newcastle Port Corporation
nib Health Funds
NSW Department of
Education & Training
OneSteel Community
Giving Program
Pegasus Management
peoplefusion
Rio Tinto Australia
Sparke Helmore Lawyers
TAFE
The Kloster Group
The Mutual Building Society
Tranter Lawyers
University of Newcastle
Upper Hunter Shire Council
57

Life Story: Genetics in Melanoma
Good timing, good luck and good
medicine have, so far, been powerful
allies in 67-year-old Peter Lynn’s
battle to survive melanoma. His son
David, however, perished from the
disease just over two years ago.
Barely six weeks after David’s
funeral, Peter and his wife planned
a European holiday to clear their
heads. Peter underwent a vascular
ultrasound to ward of concerns
about Deep Vein Thrombosis on a
long flight.
Unexpectedly, it revealed a metastatic
melanoma that had been sitting in
his lymph nodes.
The trip was off and within a week
Peter had undergone three operations to
remove the majority of his lymphatic systems.
Two tumours lurking near his heart
were deemed inoperable.
At his three monthly check-up Peter’s
surgeon mentioned a new clinical drug trial.
By coincidence, Peter had heard about it the
day before while visiting his lymphoedema
physiotherapist at the Calvary Mater. The
drug is targeted specifically at “BRAF-positive”
melanoma … Peter had a 50 per cent chance
of being a candidate and again he was lucky.
“I’ve been on the trial almost two years. In my
case the tumours shrunk by 60 per cent in
the first five weeks and I’ve had no new ones,”
he said.
Peter predominantly worked indoors in his
accountancy days. He always wore long
trousers and shirts and hats when playing golf
or going boating. David, 38, was a musician
and a mechanic, so he too was rarely burnt.
“The take-home message is for people to get
checked,” said Dr Nikola Bowden, an NHMRC
Post-doctoral Fellow in the University of
Newcastle’s Faculty of Health.
“You cannot rely on staying out of the sun as being
protective against melanoma.”
Dr Bowden warns that the drug currently only has
one purpose. When the melanoma reboots it’s not
BRAF any more – it goes down another untreatable
pathway.
“At the moment the drug prolongs survival but
the melanoma tends to develop resistance. Nine
months has been the average survival time so Peter
is doing well,” she said.
“My goal is to develop something for the other 50
per cent who don’t have the BRAF mutation. We’re
also working on developing better prognostic
markers to give people a more accurate prediction
of lifespan.”
Peter remains in awe of the research work being
done.
“My granddaughter turned 16 last week and my
grandson is 14. They have a 70 to 75 per cent
chance of getting melanoma, simply because they
essentially have the same fair skin as previous
generations.
“To me it’s about insuring that somebody does
something to help them.”

HMRI Governance
Financial Statement
Publications
Acknowledgements
59

60
HMRI Governance
HMRI Board
The HMRI Board oversees the management and
strategic direction of HMRI, comprising three
independent Directors from each of HMRI’s
principal partners – Hunter New England Local
Health District, the University of Newcastle and
the community – while the Chair of the Board is
also a community appointment. The Chair of the
HMRI Foundation and the Director of HMRI are also
offered a position on the HMRI Board.
Community representatives
Mr Robert (Bob) Kennedy (Chair)
Director, Beyond Broke Vineyard, Hunter Valley
HMRI Board Development Committee
HMRI Building Committee
HMRI Director Recruitment Committee
Mr Hilton Grugeon AM
Director, Hunter Land Pty Ltd
HMRI Building Committee
Mr Neville Sawyer AM
Company Director
HMRI Audit and Risk Management Committee
HMRI Board Development Committee
The Hon. Patricia Forsythe
Executive Director, Sydney Business Chamber
HMRI Corporate Governance Committee
Hunter New England Local Health District
representatives
Mr Michael DiRienzo
Chief Executive, HNE Health
HMRI Board Development Committee
Dr Nigel Lyons
Acting Deputy Director-General Strategic
Development, NSW Health
HMRI Board Development Committee
Ms Tracey McCosker
Director of Clinical Operations, HNE Health
HMRI Building Committee
HMRI Corporate Governance Committee
HMRI Director Recruitment Committee
The University of Newcastle representatives
Professor Michael Calford
Deputy Vice-Chancellor (Research), UoN
HMRI Board Development Committee
HMRI Building Committee
HMRI Director Recruitment Committee
Professor Caroline McMillen (appt. Nov 2011)
Vice-Chancellor and President, UoN
HMRI Corporate Governance Committee
Professor Nicholas Saunders (res. Oct 2011)
Vice-Chancellor and President, UoN
HMRI Corporate Governance Committee
Professor Nicholas Talley
Pro-Vice Chancellor, Faculty of Health, UoN
Mr Glenn Turner
Chair, HMRI Foundation
HMRI Building Committee
Emeritus Professor Maree Gleeson OAM
(res. Dec 2011)
Director, HMRI
HMRI Building Committee
HMRI Corporate Governance Committee
HMRI Management Committee
Emeritus Professor Peter Dunkley (appt. Dec 2011)
Acting Director, HMRI
HMRI Building Committee
HMRI Corporate Governance Committee
HMRI Management Committee
Mr Bradley Webb (Company Secretary)
HMRI Chief Operating Officer

HMRI Foundation
The HMRI Foundation is a group of highly qualified
community leaders, who volunteer their time
and expertise to oversee the direction of HMRI’s
marketing, communications and fundraising
activities. The Foundation reports to the HMRI
Board, and the Chair of the Foundation is invited to
be a member of the HMRI Board.
Mr Glenn Turner (Chair)
Chair, HMRI Foundation
Mr Mark Alexander
Partner, Crosbie Warren Sinclair
Mr Richard Anicich
Partner, Sparke Helmore
Ms Kristie Atkins
National Sales and Partnerships Manager,
AHL Entertainment
Mr Steve Connell
Oceania Technical Services Manager, Shell
Mr Geoff Crews
Director, Forsythes Recruitment
Mrs Carol Duncan
Journalist/Presenter, ABC Radio
Mrs Jann Gardner (appt. Aug 2011)
Retired Partner, Sparke Helmore
Mrs Christine Gregson
Centre Manager, Marketown and Hilltop Plaza
Mr Mark Gusse
Proprietor, Gallerie Fine Jewellery
Mr Anthony Hall (appt. Aug 2011)
Managing Director, R Hall & Son Pty Ltd
Mr Peter Harvey (res. Sept 2011)
Corporate Partnerships Manager, Variety
Mr John Henderson (appt. July 2011)
Chair, Singleton Foundation
Mrs Maureen Jack
General Manager NSW/ACT, Prime Television
Mrs Lynn Mangovski
Regional Marketing Manager,
Greater Building Society
Mrs Simmone Markey
Chief Financial Officer, Markey Group Pty Ltd
Mr Stephen Mount (appt. August 2011)
Business Development and Marketing,
Multiskilled Resources Australia P/L
Ms Heidi Pollard
Director, Communications Group
WorkCover NSW
Mr Robert Scrymgour (res. Dec 2011)
General Manager,
Leadership Management Australia
Ms Sonia Walkom
Director,
Walkom Linehans First National Real Estate
Miss Rebecca Wilson
Marketing & Communication Coordinator,
Newcastle Airport Ltd
Chair, PULSE
Mrs Vicki Woods
Managing Director,
Bushrangers Bar and Brasserie
61

62
HMRI Research Council
The HMRI Research Council brings together the
Hunter’s health and medical research leaders,
ensuring the best quality research is conducted
in the region. The Council includes the Leaders
from HMRI’s seven Research Programs, as well as
representatives from the Hunter Children’s Research
Executive, Hunter New England Local Health
District (HNE Health), the University of Newcastle
(UoN) and HMRI. The Research Council advises the
HMRI Director on research matters and processes,
and reports to the HMRI Board.
Emeritus Professor Maree Gleeson OAM
(Chair, res. Nov 2011)
Director, HMRI
Laureate Professor Paul Foster
(Chair, appt. Nov 2011)
Leader, VIVA Program
Director, Priority Research Centre for Asthma and
Respiratory Diseases, UoN
Professor Steven Ackland
Leader, Cancer Program
Area Director, Clinical Cancer Research, HNE Health
Senior Staff Specialist in Medical Oncology, Calvary
Mater Newcastle
Conjoint Professor, Faculty of Health, UoN
Dr Dinesh Arya (appt. Aug 2011)
HNE Health Representative
Area Director, HNE Mental Health Services
Ms Kim Browne (res. Aug 2011)
HNE Health Representative
Director, Population Health and Planning,
HNE Health
Professor Julie Byles
Co-Leader, Public Health Program
Director, Priority Research Centre for Gender, Health
and Ageing, UoN
Professor Chris Doran (appt. Jan 2011)
HMRI Representative
HMRI Health Research Economist
Associate Professor Derek Laver (res. Mar 2011)
Leader, Cardiovascular Health Program
Faculty of Health, UoN
Professor Afaf Girgis (res. Apr 2011)
Co-Leader, Public Health Program
Director, Centre for Health Research and Psychooncology
(CHeRP)
Conjoint Professor, Faculty of Health, UoN
Professor Chris Levi
Leader, Brain and Mental Health Program
Director of Acute Stroke Services, John Hunter
Hospital, HNE Health
Director, Priority Research Centre for Brain and
Mental Health Research, UoN
Professor Joerg Mattes (appt. Apr 2011)
HCRE Representative
Chair - Paediatrics & Child Health, Faculty of Health,
UoN
Professor John Rostas
UoN Representative
Deputy Head of Faculty (Research), Faculty of Health,
UoN
Laureate Professor Rob Sanson-Fisher OA
(appt. May 2011)
Co-Leader, Public Health Program
Director, Health Behaviour Research Group
Professor Rodney Scott
Leader, Information Based Medicine Program
Head of Discipline of Medical Genetics, Faculty of
Health, UoN
Director, Priority Research Centre for Bioinformatics,
Biomarker Discovery and Information Based
Medicine, UoN
Director of Molecular Genetics, Hunter Area
Pathology Service
Professor Roger Smith
Leader, Pregnancy and Reproduction Program
Director, Priority Research Centre for Reproductive
Science, UoN
Director, Mothers and Babies Research Centre
Associate Professor Dirk Van Helden
(appt. Mar 2011)
Leader, Cardiovascular Health Program
Principal Research Fellow, Faculty of Health, UoN
Professor Graham Vimpani (res. Apr 2011)
HCRE Representative
Clinical Chair, Kaleidoscope,
John Hunter Children’s Hospital

Financial Statement
Income Statement
For the year ended 30 June 2011
REVENUE
2011 2010
$ ‘000 $ ‘000
Fundraising and philanthropic funding 2,859 2,269
Research funding 63 90
Infrastructure funding 3,409 4,225
Capital funding including Capital Campaign 36,329 1,280
Investment income 198 155
TOTAL REVENUE 42,858 8,019
EXPENDITURE
Research expenditure 6,834 5,665
Fundraising event expenditure 176 174
Fundraising administration expenditure 522 474
Depreciation and amortisation expense 91 73
Other expenditure 287 518
TOTAL EXPENDITURE 7,910 6,904
RETAINED SURPLUS 34,948 1,115
Balance Sheet
For the year ended 30 June 2011
2011 2010
$ ‘000 $ ‘000
Current assets 7,944 9,868
Held to maturity investments 46,702 26,501
Property, plant and equipment 26,384 7,483
Intangible assets 28 43
TOTAL ASSETS 81,058 43,896
Current liabilities 3,344 1,262
Provisions 268 136
TOTAL LIABILITIES 3,612 1,398
NET ASSETS 77,446 42,498
Represented by:
ACCUMULATED SURPLUS 77,446 42,498
A full copy of the audited annual financial statements are available online at
www.hmri.net.au, or can be requested by phoning HMRI on (02) 4921 4030.
63

64
Publications
Brain and Mental Health
Aumann Tim D, Egan Kate, Lim Jamie,
Boon Wah C, Bye Chris R, Chua Hui
K, Baban Natalija, Parish Clare L,
Bobrovskaya Larisa, Dickson Phillip
Wesley, Horne Malcolm K, ‘Neuronal
activity regulates expression of tyrosine
hydroxylase in adult mouse substantia
nigra pars compacta neurons’, Journal of
Neurochemistry, 116 646-658 (2011)
Averell Lee Arthur, Heathcote Andrew
John, ‘The form of the forgetting curve
and the fate of memories’, Journal of
Mathematical Psychology, 55 25-35
(2011)
Bivard Andrew, McElduff Patrick, Spratt
Neil James, Levi Christopher Royce,
Parsons Mark William, ‘Defining the
extent of irreversible brain ischemia
using perfusion computed tomography’,
Cerebrovascular Diseases, 31 238-245
(2011)
Boccardi Marina, Frisoni Giovanni
B, Hare Robert D, Cavedo Enrica,
Najt Pablo, Pievani Michela, Rasser
Paul Edward, Laakso Mikko P, Aronen
Hannu J, Repo-Tiihonen Eila, Vaurio
Olli, Thompson Paul M, Tiihonen Jari,
‘Cortex and amygdala morphology in
psychopathy’, Psychiatry Research-
Neuroimaging, 193 85-92 (2011)
Briggs Gabrielle Daisy, Gordon
Sarah Louise, Dickson Phillip Wesley,
‘Mutational analysis of catecholamine
binding in tyrosine hydroxylase’,
Biochemistry, 50 1545-1555 (2011)
Cadilhac D A, Kilkenny M F, Longworth
M, Pollack M R P, Levi Christopher
Royce, ‘Metropolitan-rural divide for
stroke outcomes: Do stroke units make a
difference?’, Internal Medicine Journal, 41
321-326 (2011)
Campbell Linda Elisabet, Stevens
Angela F, McCabe Kathryn Louise,
Cruickshank Lynne, Morris Robin G,
Murphy Declan G M, Murphy Kieran
C, ‘Is theory of mind related to social
dysfunction and emotional problems
in 22q11.2 deletion syndrome (velocardio-facial
syndrome)?’, Journal of
Neurodevelopmental Disorders, 3 152-
161 (2011)
Catts Stanley V, Frost Aaron D J,
O’Toole Brian I, Carr Vaughan J, Lewin
Terry, Neil Amanda L, Harris Meredith
G, Evans Russell W, Crissman Belinda
R, Eadie Kathy, ‘Clinical indicators for
routine use in the evaluation of early
psychosis intervention: Development,
training support and inter-rater
reliability’, Australian and New Zealand
Journal of Psychiatry, 45 63-75 (2011)
De Ville Madeleine, Baker Amanda
Louise, Lewin Terry, Bucci Sandra,
Loughland Carmel Maree,
‘Associations between substance use,
neuropsychological functioning and
treatment response in psychosis’,
Psychiatry Research, 186 190-196 (2011)
Dodds Pennie Mandy-Jae, Donkin
Christopher, Brown Scott David,
Heathcote Andrew John, ‘Increasing
capacity: Practice effects in absolute
identification’, Journal of Experimental
Psychology: Learning, Memory and
Cognition, 37 477-492 (2011)
Dodds Pennie Mandy-Jae, Donkin
Christopher, Brown Scott David,
Heathcote Andrew John, Marley
A A J, ‘Stimulus-specific learning:
Disrupting the bow effect in absolute
identification’, Attention, Perception, and
Psychophysics, 73 1977-1986 (2011)
Donkin Chris, Brown Scott David,
Heathcote Andrew John, ‘Drawing
conclusions from choice response
time models: A tutorial using the
linear ballistic accumulator’, Journal of
Mathematical Psychology, 55 140-151
(2011)
Dowell Jon, Lumsden Mary Ann, Powis
David Alan, Munro Donald, Bore Miles
Richard, Makubate Boikanyo, Kumwenda
Ben, ‘Predictive validity of the personal
qualities assessment for selection of
medical students in Scotland’, Medical
Teacher, 33 E485-E488 (2011)
Dunlop Adrian John, ‘Harms: How
much, how many, how often?’, Drug and
Alcohol Review, 30 332-333 (2011)
Filia Sacha L, Baker Amanda Louise,
Richmond Robyn, Castle David J,
Kay-Lambkin Frances Joy, Sakrouge
Rebecca Ellen, Gurvich Caroline T, De
Castella Anthony R, Taylor Rachel,
Kulkarni Jayashri, ‘Health behaviour risk
factors for coronary heart disease (CHD)
in smokers with a psychotic disorder:
Baseline results’, Mental Health and
Substance Use: Dual Diagnosis, 4 158-171
(2011)
Flynn Jamie Robin, Brichta Alan Martin,
Galea Mary P, Callister Robert John,
Graham Brett Anthony, ‘A horizontal
slice preparation for examining the
functional connectivity of dorsal column
fibres in mouse spinal cord’, Journal of
Neuroscience Methods, 200 113-120
(2011)
Flynn Jamie Robin, Graham Brett
Anthony, Galea Mary P, Callister
Robert John, ‘The role of propriospinal
interneurons in recovery from spinal
cord injury’, Neuropharmacology, 60
809-822 (2011)

Forstmann Birte U, Wagenmakers Eric-
Jan, Eichele Tom, Brown Scott David,
Serences John T, ‘Reciprocal relations
between cognitive neuroscience and
formal cognitive models: Opposites
attract?’, Trends in Cognitive Sciences, 15
272-279 (2011)
Frisoni Giovanni B, Prestia Annapaola,
Geroldi Cristina, Adorni Andrea,
Ghidoni Roberta, Amicucci Giovanni,
Bonetti Matteo, Soricelli Andrea,
Rasser Paul Edward, Thompson Paul
M, Giannakopoulos Panteleimon,
‘Alzheimer’s CSF markers in older
schizophrenia patients’, International
Journal of Geriatric Psychiatry, 26 640-648
(2011)
Fuller Jeffrey D, Perkins David, Parker
Sharon, Holdsworth Louise, Kelly Brian
Joseph, Roberts Russell, Martinez Lee,
Fragar Lyn, ‘Effectiveness of service
linkages in primary mental health care:
A narrative review part 1’, BMC Health
Services Research, 11 1-11 (2011)
Geiser Moritz, Walla Peter Helmuth,
‘Objective measures of emotion during
virtual walks through urban environments’,
Applied Sciences, 1 1-11 (2011)
Graham Brett Anthony, Tadros Melissa
Anne, Schofield P R, Callister Robert John,
‘Probing glycine receptor stoichiometry in
superficial dorsal horn neurones using the
spasmodic mouse’, Journal of Physiology,
589 2459-2474 (2011)
Harwood Jake, Paolini Stefania, Joyce
Nick, Rubin Jeremy Mark, Arroyo Analisa,
‘Secondary transfer effects from imagined
contact: Group similarity affects the
generalization gradient’, British Journal of
Social Psychology, 50 180-189 (2011)
Hazelton Michael John, Morrall Peter,
‘Nursing, information technology and the
humanization of health care’, Evidence-
Based Practice in Nursing Informatics:
Concepts and Applications, Medical
Information Science Reference, Hershey,
PA, 135-149 (2011)
Hazelton Michael John, Rossiter Rachel
Cathrine, Sinclair Ellen, Morrall Peter,
‘Encounters with the ‘dark side’: New
graduate nurses’ experiences in a mental
health service’, Health Sociology Review,
20 172-186 (2011)
Heereman J, Walla Peter Helmuth, ‘Stress,
uncertainty and decision confidence’,
Applied Psychophysiology Biofeedback, 36
273-279 (2011)
Hinwood Madeleine, Tynan Ross, Day
Trevor Anthony, Walker Frederick Rohan,
‘Repeated social defeat selectively
increases DeltaFosB expression and
histone H3 acetylation in the infralimbic
medial prefrontal cortex’, Cerebral Cortex,
21 262-271 (2011)
Hunter Abigail Jade, Snodgrass Suzanne
Nicole, Quain Debbie, Parsons Mark
William, Levi Christopher Royce, ‘HOBOE
(head-of-bed optimization of elevation)
study: Association of higher angle with
reduced cerebral blood flow velocity in
acute ischemic stroke’, Physical Therapy,
91 1503-1512 (2011)
Inder Kerry Jill, Berry Helen Louise, Kelly
Brian Joseph, ‘Using cohort studies to
investigate rural and remote mental
health’, Australian Journal of Rural Health,
19 171-178 (2011)
James Morgan Hurley, Charnley Janine
Louise, Levi Emily Margaret, Jones
Emma, Yeoh Jiann Wei, Smith Douglas
William, Dayas Christopher Vincent,
‘Orexin-1 receptor signalling within
the ventral tegmental area, but not the
paraventricular thalamus, is critical to
regulating cue-induced reinstatement of
cocaine-seeking’, International Journal of
Neuropsychopharmacology, 14 684-690
(2011)
Jobling Phillip, ‘Autonomic control
of the urogenital tract’, Autonomic
Neuroscience: Basic and Clinical, 165 113-
126 (2011)
Karayanidis Frini, Provost Alexander
Lawson, Brown Scott David, Paton Bryan
Kerry, Heathcote Andrew John, ‘Switchspecific
and general preparation map
onto different ERP components in a taskswitching
paradigm’, Psychophysiology, 48
559-568 (2011)
Kay-Lambkin Frances, Baker Amanda
Louise, Lewin Terry, Carr Vaughan,
‘Acceptability of a clinician-assisted
computerized psychological intervention
for comorbid mental health and substance
use problems: Treatment adherence
data from a randomized controlled trial’,
Journal of Medical Internet Research, 13
254-264 (2011)
Kay-Lambkin Frances Joy, Baker Amanda
Louise, Kelly Brian Joseph, Lewin
Terry, ‘Clinician-assisted computerised
versus therapist-delivered treatment
for depressive and addictive disorders:
A randomised controlled trial’, Medical
Journal of Australia, 195 S44-S50 (2011)
Kay-Lambkin Frances Joy, Baker Amanda
Louise, Lee Nicole M, Jenner Linda, Lewin
Terry, ‘The influence of depression on
treatment for methamphetamine use’,
Medical Journal of Australia, 195 S38-S43
(2011)
Kelly Brian Joseph, Lewin Terry, Stain
Helen Joy, Coleman Clare Elizabeth,
Fitzgerald Michael Noel, Perkins David,
Carr Vaughan J, Fragar Lyn, Fuller
Jeffrey, Lyle David, Beard John R,
‘Determinants of mental health and
well-being within rural and remote
communities’, Social Psychiatry and
Psychiatric Epidemiology, 46 1331-1342
(2011)
Lee Nicole, Jenner Linda, Baker Amanda
Louise, Ritter Alison, Hides Leanne,
Norman Josephine, Kay-Lambkin Frances
Joy, Hall Kate, Dann Fiona, Cameron
Jacqui, ‘Screening and intervention for
mental health problems in alcohol and
other drug settings: Can training change
practitioner behaviour?’, Drugs: Education,
Prevention and Policy, 18 157-160 (2011)
Levin Tomer T, Kelly Brian Joseph, Cohen
Martin, Vamos Marina Jill, Landa Yulia,
Bylund Carma L, ‘Using a psychiatry
e-list to develop a model for discussing
a schizophrenia diagnosis’, Psychiatric
Services, 62 244-246 (2011)
Lim Rebecca, Kindig Angela E, Donne
Scott Wilfred, Callister Robert John, Brichta
Alan Martin, ‘Potassium accumulation
between type I hair cells and calyx
terminals in mouse crista’, Experimental
Brain Research, 210 607-621 (2011)
Maguire Jane Margaret, Thakkinstian
Ammarin, Levi Christopher Royce, Lincz
Lisa, Bisset Linda, Sturm Jonathan, Scott
Rodney, Whyte Scott, Attia John Richard,
‘Impact of COX-2 rs5275 and rs20417 and
GPIIIa rs5918 polymorphisms on 90-day
ischemic stroke functional outcome:
A novel finding’, Journal of Stroke and
Cerebrovascular Diseases, 20 134-144
(2011)
Mansfield Elise Lauren, Karayanidis Frini,
Jamadar Sharna, Heathcote Andrew
John, Forstmann Birte U, ‘Adjustments of
response threshold during task switching:
A model-based functional magnetic
resonance imaging study’, Journal of
Neuroscience, 31 14688-14692 (2011)
Miller Peter, Dunlop Adrian John,
‘Rhetoric, reality and research: What they
mean for achieving the best possible
treatment system for addiction-related
problems’, International Journal of Drug
Policy, 22 196-197 (2011)
Morrall Peter, Hazelton Michael John,
Shackleton William, ‘Homicide and its
effect on secondary victims’, Mental
Health Practice, 15 14-19 (2011)
Nagakane Yoshinari, Christensen Soren,
Brekenfeld Caspar, Ma Henry, Churilov
Leonid, Parsons Mark William, Levi
Christopher Royce, Butcher Kenneth
S, Peeters Andre, Barber Alan, Bladin
Christopher F, De Silva Deidre A,
Fink John, Kimber Thomas E, Schultz
David W, Muir Keith W, Tress Brian M,
Desmond Patricia M, Davis Stephen M,
Donnan Geoffrey A, Epithet Investigators,
‘EPITHET positive result after reanalysis
using baseline diffusion-weighted
imaging/perfusion-weighted imaging coregistration’,
Stroke, 42 59-64 (2011)
Nakamura Tamo, Michie Patricia Therese,
Fulham William Ross, Todd Juanita, Budd
Timothy William, Schall Ulrich Andreas,
Hunter Michael, Hodgson Deborah
Maree, ‘Epidural auditory event-related
potentials in the rat to frequency and
duration deviants: evidence of mismatch
negativity?’, Frontiers in Psychology, 2 367
(2011)
Nakamura Tamo, Walker Adam Keith,
Sominsky L, Allen T, Rosengren Sally
Marie, Hodgson Deborah Maree, ‘Maternal
separation in early life impairs tumor
immunity in adulthood in the F344 rat’,
Stress, 14 335-343 (2011)
Novello Denika Jade, Stain Helen Joy, Lyle
David, Kelly Brian Joseph, ‘Psychological
distress of rural parents: Family influence
and the role of isolation’, Australian
Journal of Rural Health, 19 27-31 (2011)
65

66
Ong Lin Kooi, Bobrovskaya Larisa, Walker
Frederick Rohan, Day Trevor Anthony,
Dickson Phillip Wesley, Dunkley Peter Robert,
‘The effect of social defeat on tyrosine
hydroxylase phosphorylation in the rat brain
and adrenal gland’, Neurochemical Research,
36 27-33 (2011)
Perkes Iain Edward, Schofield Peter
William, Butler Tony, Hollis Stephanie J,
‘Traumatic brain injury rates and sequelae:
A comparison of prisoners with a matched
community sample in Australia’, Brain Injury,
25 131-141 (2011)
Pievani Michela, Galluzzi Samantha,
Thompson Paul M, Rasser Paul Edward,
Bonetti Matteo, Frisoni Giovanni B, ‘APOE4
is associated with greater atrophy of the
hippocampal formation in Alzheimer’s
disease’, NeuroImage, 55 909-919 (2011)
Robinson Tracy Elizabeth, Hills Danny
James, Kelly Brian Joseph, ‘The evaluation
of an online orientation to rural mental
health practice in Australia’, Journal of
Psychiatric and Mental Health Nursing, 18
629-636 (2011)
Rubin Jeremy Mark, ‘Social Affiliation Cues
Prime Help-Seeking Intentions’, Canadian
Journal of Behavioural Science, 43 138-141
(2011)
Rubin Jeremy Mark, Paolini Stefania, Crisp
Richard J, ‘The relationship between the
need for closure and deviant bias: An
investigation of generality and process’,
International Journal of Psychology, 46 206-
213 (2011)
Santarelli Danielle Maree Faith, Beveridge
Natalie Jane, Tooney Paul Anthony, Cairns
Murray John, ‘Upregulation of dicer and
MicroRNA expression in the dorsolateral
prefrontal cortex Brodmann area 46 in
schizophrenia’, Biological Psychiatry, 69 180-
187 (2011)
Schofield Peter William, Butler Tony, Hollis
Stephanie, D’Este Catherine Anne, ‘Are
prisoners reliable survey respondents? A
validation of self-reported traumatic brain
injury (TBI) against hospital medical records’,
Brain Injury, 25 74-82 (2011)
Skelding Kathryn Anne, Rostas John Andrew,
Verrills Nicole Margaret, ‘Controlling the
cell cycle: The role of calcium/calmodulinstimulated
protein kinases I and II’, Cell
Cycle, 10 631-639 (2011)
Sol Daniel, Griffin Andrea Sigride, Bartomeus
Ignasi, Boyce Hayley Maree, ‘Exploring or
avoiding novel food resources?: The novelty
conflict in an invasive bird’, PLoS ONE, 6 1-7
(2011)
Spratt Neil James, Donnan Geoffrey A,
McLeod Damian Donald, Howells David
W, ‘’Salvaged’ stroke ischaemic penumbra
shows significant injury: Studies with the
hypoxia tracer FMISO’, Journal of Cerebral
Blood Flow and Metabolism, 31 934-943
(2011)
Stain Helen Joy, Dean John, Kelly Brian
Joseph, Blinkhorn Susan, Carnie Tracey,
‘Climate adversity: Yet another stressor for
rural adolescents’, International Public Health
Journal, 2 513-519 (2011)
Stain Helen Joy, Kelly Brian Joseph, Carr
Vaughan J, Lewin Terry, Fitzgerald Michael
Noel, Fragar Lyn, ‘The psychological
impact of chronic environmental adversity:
Responding to prolonged drought’, Social
Science and Medicine, 73 1593-1599 (2011)
Stain Helen Joy, Payne Kristy Terese,
Thienel Renate Anneliese, Michie Patricia
Therese, Carr Vaughan, Kelly Brian Joseph,
‘The feasibility of videoconferencing for
neuropsychological assessments of rural
youth experiencing early psychosis’, Journal
of Telemedicine and Telecare, 17 328-331
(2011)
Stevenson Richard J, Hodgson Deborah
Maree, Oaten Megan J, Barouei Javad,
Case Trevor I, ‘The effect of disgust on oral
immune function’, Psychophysiology, 48
900-907 (2011)
Stone Teresa Elizabeth, McMillan Margaret
Anna, Hazelton Michael John, Clayton
Edward H, ‘Wounding words: Swearing and
verbal aggression in an inpatient setting’,
Perspectives in Psychiatric Care, 47 194-203
(2011)
Thomas Lucy, Rivett Darren Anthony, Attia
John Richard, Parsons Mark William, Levi
Christopher Royce, ‘Risk factors and clinical
features of craniocervical arterial dissection’,
Manual Therapy, 16 351-356 (2011)
Thornton Louise Kylie, Baker Amanda
Louise, Johnson Martin Paul, Kay-Lambkin
Frances Joy, ‘Perceptions of anti-smoking
public health campaigns among people
with psychotic disorders’, Mental Health and
Substance Use: Dual Diagnosis, 4 110-115
(2011)
Todd Juanita, Finch Brayden, Smith Ellen,
Budd Timothy William, Schall Ulrich Andreas,
‘Temporal processing ability is related to
ear-asymmetry for detecting time cues in
sound: A mismatch negativity (MMN) study’,
Neuropsychologia, 49 69-82 (2011)
Todd Juanita, Provost Alexander
Lawson, Cooper Gavin John, ‘Lasting
first impressions: A conservative bias
in automatic filters of the acoustic
environment’, Neuropsychologia, 49 3399-
3405 (2011)
Van Maanen Leendert, Brown Scott David,
Eichele Tom, Wagenmakers Eric-Jan,
Ho Tiffany, Serences John, Forstmann
Birte U, ‘Neural correlates of trial-to-trial
fluctuations in response caution’, Journal of
Neuroscience, 31 17488-17495 (2011)
Van Ravenzwaaij Don, Brown Scott David,
Wagenmakers Eric-Jan, ‘An integrated
perspective on the relation between
response speed and intelligence’, Cognition,
119 381-393 (2011)
Walla Peter Helmuth, Brenner Gerhard,
Koller Monika, ‘Objective measures of
emotion related to brand attitude: A new
way to quantify emotion-related aspects
relevant to marketing’, PLoS ONE, 6 e26782
(2011)
Walla Peter Helmuth, Duregger Cornelia,
Deecke Luder, Dal-Bianco Peter,
‘Dysfunctional incidental olfaction in
mild cognitive impairment (MCI): An
electroencephalography (EEG) study’, Brain
Sciences, 1 3-15 (2011)
Cancer
Alkhatatbeh Mohammad Jamil, Mhaidat
N M, Enjeti Anoop, Lincz Lisa, Thorne
Rick Francis, ‘The putative diabetic plasma
marker, soluble CD36, is non-cleaved,
non-soluble and entirely associated with
microparticles’, Journal of Thrombosis and
Haemostasis, 9 844-851 (2011)
Andreyev H Jervoise N, Wotherspoon
Andrew, Denham James, Hauer-Jensen
Martin, ‘’Pelvic radiation disease’: New
understanding and new solutions for a new
disease in the era of cancer survivorship’,
Scandinavian Journal of Gastroenterology,
46 389-397 (2011)
Ashman Leonie Kay, ‘Cell line models
identify different sensitivity of mutant forms
of c-KIT to kinase inhibitory drugs and
predict the response of patients to therapy’,
Molecular Cancer Therapeutics, 10 2032-
2033 (2011)
Campbell Bronwyn E, Hofmann Andreas,
McCluskey Adam, Gasser Robin B,
‘Serine/threonine phosphatases in
socioeconomically important parasitic
nematodes - Prospects as novel drug
targets?’, Biotechnology Advances, 29 28-39
(2011)
Campbell Bronwyn E, Tarleton Mark John,
Gordon Christopher Peter, Sakoff Jennette
A, Gilbert Jayne, McCluskey Adam, Gasser
Robin B, ‘Norcantharidin analogues with
nematocidal activity in Haemonchus
contortus’, Bioorganic and Medicinal
Chemistry Letters, 21 3277-3281 (2011)
Carter Gregory Leigh, Lewin Terry, Gianacas
Louisa, Clover Kerrie, Adams Catherine
Anne, ‘Caregiver satisfaction with outpatient
oncology services: utility of the
FAMCARE instrument and development of
the FAMCARE-6’, Supportive Care in Cancer,
19 565-572 (2011)
Chang Heng-Yu, Jennings Phoebe Coral,
Stewart Jessica Lee, Verrills Nicole Margaret,
Jones Keith Thomas, ‘Essential role of
protein phosphatase 2A in metaphase II
arrest and activation of mouse eggs shown
by okadaic acid, dominant negative protein
phosphatase 2A, and FTY720’, Journal of
Biological Chemistry, 286 14705-14712 (2011)
Cuzick Jack, Sestak Ivana, Baum Michael,
Buzdar Aman, Howell Anthony, Dowsett
Mitch, Forbes John Frederick, ‘10-year
analysis of the ATAC trial: Wrong conclusion?
- Authors’ reply’, The Lancet Oncology, 12
217 (2011)
Cuzick Jack, Sestak Ivanna, Pinder Sarah E,
Ellis Ian O, Forsyth Sharon, Bundred Nigel
J, Forbes John Frederick, Bishop Hugh,
Fentiman Ian S, George William D, ‘Effect
of tamoxifen and radiotherapy in women
with locally excised ductal carcinoma in situ:
Long-term results from the UK/ANZ DCIS
trial’, The Lancet Oncology, 12 21-29 (2011)
Cuzick Jack, Warwick Jane, Pinney
Elizabeth, Duffy Stephen W, Cawthorn
Simon, Howell Anthony, Forbes John
Frederick, Warren Ruth M L, ‘Tamoxifeninduced
reduction in mammographic
density and breast cancer risk reduction: A
nested case-control study’, Journal of the
National Cancer Institute, 103 744-752 (2011)

Denham James, Steigler Allison, Lamb
David S, Joseph David, Turner Sandra,
Matthews John, Atkinson Chris, North
John, Christie David, Spry Nigel A, Tai
Keen-Hun, Wynne Chris, D’Este Catherine
Anne, ‘Short-term neoadjuvant androgen
deprivation and radiotherapy for locally
advanced prostate cancer: 10-year data
from the TROG 96.01 randomised trial’,
The Lancet Oncology, 12 451-59 (2011)
Dong L, Jiang C C, Thorne Rick
Francis, Croft A, Yang F, Liu H, De
Bock Charles Edo, Hersey P, Zhang
X D, ‘Ets-1 mediates upregulation of
Mcl-1 downstream of XBP-1 in human
melanoma cells upon ER stress’,
Oncogene, 30 3716-3726 (2011)
Dunstan Richard Hugh, Sparkes Diane
Lisa, MacDonald Margaret Macrae, Roberts
Timothy Kilgour, Wratten Christopher,
Kumar Mahesh, Baines Surinder Kaur,
Denham James, Gallagher Sarah A,
Rothkirch Tony Brian, ‘Altered amino
acid homeostasis and the development
of fatigue by breast cancer radiotherapy
patients: A pilot study’, Clinical
Biochemistry, 44 208-215 (2011)
Ebert Martin A, Lamb David S, Joseph
David J, Steigler Allison, Denham James,
‘A methodology for the analysis of PSA
response signatures’, Radiotherapy and
Oncology, 98 198-202 (2011)
Gordon Christopher Peter, Young Kelly
Ann, Hizartzidis Lacey, Deane Fiona Maria,
McCluskey Adam, ‘Investigation of the
one-pot synthesis of quinolin-2-(1H)-ones
and the discovery of a variation of the
three-component Ugi reaction’, Organic
and Biomolecular Chemistry, 9 1419-1428
(2011)
Gordon Christopher Peter, Young Kelly
Ann, Robertson Mark James, Hill Timothy
Adrian, McCluskey Adam, ‘An Ugiintramolecular
Diels-Alder route to highly
substituted tetrahydroepoxyisoindole
carboxamides’, Tetrahedron, 67 554-561
(2011)
Harwood Rachael, Douglas Charles
Duguid, Clark David, ‘Decision aids for
breast and nodal surgery in patients with
early breast cancer: Development and a
pilot study’, Asia-Pacific Journal of Clinical
Oncology, 7 114-122 (2011)
Hatton Joan, Greer Peter Brian, Tang
Colin, Wright Philip, Capp Anne, Gupta
Sanjiv, Parker Joel, Wratten Christopher,
Denham James, ‘Does the planning dosevolume
histogram represent treatment
doses in image-guided prostate radiation
therapy? Assessment with cone-beam
computerised tomography scans’,
Radiotherapy and Oncology, 98 162-168
(2011)
Kostyrka Ben Henley, Li Jiong,
Soundappan S V, Cassey John Gerard,
Alvaro Frank, Dalla Pozza L, Kumar
Rajendra, ‘Features and outcomes of
neonatal neuroblastoma’, Pediatric Surgery
International, 27 937-941 (2011)
Lamb David S, Denham James, Joseph
David, Matthews John, Atkinson Chris,
Spry Nigel A, Duchesne Gillian, Ebert
Martin, Steigler Allison, Delahunt Brett,
D’Este Catherine Anne, ‘A comparison
of the prognostic value of early PSA
test-based variables following external
beam radiotherapy, with or without
preceding androgen deprivation: Analysis
of data from the TROG 96.01 randomized
trial’, International Journal of Radiation
Oncology Biology Physics, 79 385-391
(2011)
Loi Sherene, Symmans W Fraser, Bartlett
John M S, Fumagalli Debora, Van’T Veer
Laura, Forbes John Frederick, Bedard
Philippe, Denkert Carsten, Zujewski
Joanne, Viale Giuseppe, Pusztai Lajos,
Esserman Laura J, Leyland-Jones Brian
R, ‘Proposals for uniform collection of
biospecimens from neoadjuvant breast
cancer clinical trials: Timing and specimen
types’, The Lancet Oncology, 12 1162-1168
(2011)
Luckett T, Britton Benjamin, Clover Kerrie,
Rankin N M, ‘Evidence for interventions
to improve psychological outcomes
in people with head and neck cancer:
A systematic review of the literature’,
Supportive Care in Cancer, 19 871-881
(2011)
Macgregor Kylie Anne, McCluskey
Adam, ‘Ionic liquids accelerate access
to N-substituted-1,8-naphthalimides’,
Tetrahedron Letters, 52 767-769 (2011)
McGettigan Patricia, Lincz Lisa,
Attia John Richard, McElduff Patrick,
Bissett Linda, Peel Roseanne, Stokes
Barrie James, Hancock Stephen John,
Henderson Kim Maree, Seldon Michael
Richard, Henry David Alexander, ‘The
risk of coronary thrombosis with cyclooxygenase-2
inhibitors does not vary
with polymorphisms in two regions of the
cyclo-oxygenase-2 gene’, British Journal
of Clinical Pharmacology, 72 707-714
(2011)
Roberts Kathryn Grace, McDougall Fiona
Karen, Verrills Nicole Margaret, ‘Essential
requirement for PP2A inhibition by the
oncogenic receptor c-KIT suggests PP2A
reactivation as a strategy to treat c-KIT+
cancers - Response’, Cancer Research, 71
2404-2404 (2011)
Sadeqzadeh Elham, De Bock Charles Edo,
Zhang Xu Dong, Shipman Kristy Lea, Scott
Naomi Marie, Song Chaojun, Yeadon
Trina, Oliveira Camila Salum De, Jin
Boquan, Hersey Peter, Boyd Andrew W,
Burns Gordon Frood, Thorne Rick Francis,
‘Dual processing of FAT1 cadherin protein
by human melanoma cells generates
distinct protein products’, Journal of
Biological Chemistry, 286 28181-28191
(2011)
Tang Gong, Cuzick Jack, Costantino
Joseph P, Dowsett Mitch, Forbes John
Frederick, Crager Michael, Mamounas
Eleftherios P, Shak Steven, Wolmark
Norman, ‘Risk of recurrence and
chemotherapy benefit for patients with
node-negative, estrogen receptor-positive
breast cancer: Recurrence score alone and
integrated with pathologic and clinical
factors’, Journal of Clinical Oncology, 29
4365-7372 (2011)
Tarleton Mark John, Gilbert Jayne,
Robertson Mark James, McCluskey
Adam, Sakoff Jennette A, ‘Library
synthesis and cytotoxicity of a family of
2-phenylacrylonitriles and discovery of an
estrogen dependent breast cancer lead
compound’, MedChemComm, 2 31-37
(2011)
Tarleton Mark John, McCluskey Adam, ‘A
flow chemistry route to 2-phenyl-3-(1Hpyrrol-2-yl)propan-1-amines’,
Tetrahedron
Letters, 52 1583-1586 (2011)
Upanal Nazeerahamad Nabisaheb, Enjeti
Anoop, ‘Primary lymphoma of the uterus
and cervix: Two case reports and review of
the literature’, Australian and New Zealand
Journal of Obstetrics and Gynaecology, 51
559-562 (2011)
Valero Vicente, Forbes John Frederick,
Pegram Mark D, Pienkowski Tadeusz,
Eiermann Wolfgang, Von Minckwitz
Gunter, Roche Henri, Martin Miguel,
Crown John, Mackey John R, Fumoleau
Pierre, Rolski Janusz, Mrsic-Krmpotic
Zrinka, Jagiello-Gruszfeld Agnieszka,
Riva Alessandro, Buyse Marc, Taupin
Henry, Sauter Guido, Press Michael F,
Slamon Dennis J, ‘Multicenter phase III
randomized trial comparing docetaxel
and trastuzumab with docetaxel,
carboplatin, and trastuzumab as first-line
chemotherapy for patients with HER2gene-amplified
metastatic breast cancer
(BCIRG 007 Study): Two highly active
therapeutic regimens’, Journal of Clinical
Oncology, 29 149-156 (2011)
Viale G, Regan M M, Dell’Orto P,
Mastropasqua M G, Maiorano E,
Rasmussen B B, Macgrogan G, Forbes
John Frederick, Paridaens R J, Colleoni
M, Lang I, Thurlimann B, Mouridsen
H, Mauriac L, Gelber R D, Price K N,
Goldhirsch A, Gusterson B A, Coates
A S, ‘Which patients benefit most from
adjuvant aromatase inhibitors? Results
using a composite measure of prognostic
risk in the BIG 1-98 randomized trial’,
Annals of Oncology, 22 2201-2207 (2011)
Von Kleist Lisa, Stahlschmidt Wiebke,
Bulut Haydar, Gromova Kira, Puchkov
Dmytro, Robertson Mark James,
Macgregor Kylie Anne, Tomlin Nikolay,
Pechstein Arndt, Chau Ngoc, Chircop
Megan, Sakoff Jennette Anne, Von Kries
Jens Peter, Saenger Wolfram, Krausslich
Hans-Georg, Shupliakov Oleg, Robinson
Phillip J, McCluskey Adam, Haucke Volker,
‘Role of the clathrin terminal domain in
regulating coated pit dynamics revealed
by small molecule inhibition’, Cell, 146
471-484 (2011)
67

68
Cardiovascular Health
Ball Geoff D C, Mackenzie-Rife Kelly A,
Newton Mandi S, Alloway Christina A,
Slack Julie M, Plotnikoff Ronald Cyril, Goran
Michael I, ‘One-on-one lifestyle coaching for
managing adolescent obesity: Findings from
a pilot, randomized controlled trial in a realworld,
clinical setting’, Paediatrics & Child
Health, 16 345-350 (2011)
Barnett Lisa M, Morgan Philip James, Van
Beurden Eric, Ball Kylie, Lubans David
Revalds, ‘A reverse pathway? Actual and
perceived skill proficiency and physical
activity’, Medicine and Science in Sports and
Exercise, 43 898-904 (2011)
Baumert Mathias, Lambert Elisabeth,
Vaddadi Gautam, Sari Carolina Ika,
Esler Murray, Lambert Gavin, Sanders
Prashanthan, Nalivaiko Eugene, ‘Cardiac
repolarization variability in patients
with postural tachycardia syndrome
during graded head-up tilt’, Clinical
Neurophysiology, 122 405-409 (2011)
Baumert Mathias, Schlaich Markus P,
Nalivaiko Eugene, Lambert Elisabeth, Sari
Carolina Ika, Kaye David M, Elser Murray D,
Sanders Prash, Lambert Gavin, ‘Relation
between QT interval variability and cardiac
sympathetic activity in hypertension’,
American Journal of Physiology - Heart and
Circulatory Physiology, 300 H1412-H1417
(2011)
Beig Mirza Irfan, Callister Robin, Saint David
A, Bondarenko Eugene, Walker Frederick
Rohan, Day Trevor Anthony, Nalivaiko
Eugene, ‘Voluntary exercise does not affect
stress-induced tachycardia, but improves
resistance to cardiac arrhythmias in rats’,
Clinical and Experimental Pharmacology and
Physiology, 38 19-26 (2011)
Belanger Lisa J, Plotnikoff Ronald Cyril, Clark
Alexander, Courneya Kerry S, ‘Physical
activity and health-related quality of life in
young adult cancer survivors: a Canadian
provincial survey’, Journal of Cancer
Survivorship, 5 44-53 (2011)
Burrows Tracy Lee, Collins Clare Elizabeth,
Garg Manohar Lal, ‘Omega-3 index,
obesity and insulin resistance in children’,
International Journal of Pediatric Obesity, 6
e532-e539 (2011)
Cliff Dylan P, Okely Anthony D, Morgan
Philip James, Steele Julie R, Jones Rachel
A, Colyvas Kim Jerry, Baur Louise A,
‘Movement skills and physical activity in
obese children: Randomized controlled trial’,
Medicine & Science in Sports & Exercise, 43
90-100 (2011)
Collins Clare Elizabeth, Morgan Philip
James, Warren Janet M, Lubans David
Revalds, Callister Robin, ‘Men participating
in a weight-loss intervention are able to
implement key dietary messages, but not
those relating to vegetables or alcohol: the
Self-Help, Exercise and Diet using Internet
Technology (SHED-IT) study’, Public Health
Nutrition, 14 168-175 (2011)
Collins Clare Elizabeth, Okely Anthony
D, Morgan Philip James, Jones Rachel A,
Burrows Tracy Lee, Cliff Dylan P, Colyvas
Kim Jerry, Warren Janet Margaret,
Steele Julie R, Baur Louise A, ‘Parent diet
modification, child activity, or both in obese
children: An RCT’, Pediatrics, 127 619-627
(2011)
Faulkner Guy, McCloy Cora, Plotnikoff
Ronald Cyril, Tremblay Mark S, ‘Relaunching
a national social marketing campaign:
Expectations and challenges for the ‘new’
ParticipACTION’, Health Promotion Practice,
12 569-576 (2011)
Gravina Fernanda Sbaraini, Jobling Phillip,
Kerr Karen Patricia, De Oliveira Ramatis,
Parkington H C, Van Helden Dirk Ferdinand,
‘Oxytocin depolarizes mitochondria in
isolated myometrial cells’, Experimental
Physiology, 96 949-956 (2011)
Hall Laura, Collins Clare Elizabeth, Morgan
Philip James, Burrows Tracy Lee, Lubans
David Revalds, Callister Robin, ‘Children’s
intake of fruit and selected energy-dense
nutrient-poor foods is associated with
fathers’ intake’, Journal of the American
Dietetic Association, 111 1039-1044 (2011)
Hwang Hyun Seok, Hasdemir Can, Laver
Derek Rowland, Mehra Divya Rajendra,
Turhan Kutsal, Faggioni Michela, Yin
Huiyong, Knollmann Bjorn C, ‘Inhibition
of Cardiac Ca2+ Release Channels (RyR2)
Determines Efficacy of Class I Antiarrhythmic
Drugs in Catecholaminergic Polymorphic
Ventricular Tachycardia’, Circulation:
Arrhythmia and Electrophysiology, 4 128-135
(2011)
Imayama Ikuyo, Plotnikoff Ronald Cyril,
Courneya Kerry S, Johnson Jeffrey A,
‘Determinants of quality of life in type
2 diabetes population: the inclusion of
personality’, Quality of Life Research, 20 551-
558 (2011)
James Carole Lesley, ‘Occupational analysis
and occupational rehabilitation’, Occupation
Analysis in Practice, Wiley-Blackwell,
Chichester, West Sussex, 232-245 (2011)
James Carole Lesley, Mackenzie Lynette,
Capra Mike, ‘Inter- and intra-rater reliability
of the manual handling component of the
WorkHab Functional Capacity Evaluation’,
Disability and Rehabilitation, 33 1797-1804
(2011)
Jones Rachel A, Sinn Natalie, Campbell
Karen J, Hesketh Kylie, Denney-Wilson
Elizabeth, Morgan Philip James, Lubans
David Revalds, Magarey Anthea, ‘The
importance of long-term follow-up in
child and adolescent obesity prevention
interventions’, International Journal of
Pediatric Obesity, 6 178-181 (2011)
Kabir Muammar M, Saint David A, Nalivaiko
Eugene, Abbott Derek, Baumert Mathias,
‘Time delay correction of the synchrogram
for optimized detection of cardiorespiratory
coordination’, Medical and Biological
Engineering and Computing, 49 1249-1259
(2011)
Kabir Muammar M, Saint David A, Nalivaiko
Eugene, Abbott Derek, Voss Andreas,
Baumert Mathias, ‘Quantification of
cardiorespiratory interactions based on joint
symbolic dynamics’, Annals of Biomedical
Engineering, 39 2604-2614 (2011)
Kaur Gunveen, Cameron-Smith David,
Garg Manohar Lal, Sinclair Andrew J,
‘Docosapentaenoic acid (22:5n-3): A review
of its biological effects’, Progress in Lipid
Research, 50 28-34 (2011)
Kumar Saurabh, Sutherland Fiona, Teh
Andrew W, Heck Patrick M, Lee Geoffrey,
Garg Manohar Lal, Sparks Paul B, ‘Effects
of chronic omega-3 polyunsaturated fatty
acid supplementation on human pulmonary
vein and left atrial electrophysiology in
paroxysmal atrial fibrillation’, American
Journal of Cardiology, 108 531-535 (2011)
Laver Derek Rowland, Van Helden Dirk
Ferdinand, ‘Three independent mechanisms
contribute to tetracaine inhibition of cardiac
calcium release channels’, Journal of
Molecular and Cellular Cardiology, 51 357-
369 (2011)
Lubans David Revalds, Cliff Dylan P,
‘Muscular fitness, body composition and
physical self-perception in adolescents’,
Journal of Science and Medicine in Sport, 14
216-221 (2011)
Lubans David Revalds, Morgan Philip
James, Aguiar Elroy Joseph, Callister
Robin, ‘Randomized controlled trial of the
Physical Activity Leaders (PALs) program
for adolescent boys from disadvantaged
secondary schools’, Preventive Medicine, 52
239-246 (2011)
Lubans David Revalds, Morgan Philip James,
Callister Robin, Plotnikoff Ronald Cyril,
Eather Narelle, Riley Nicholas, Smith Chris
J, ‘Test-retest reliability of a battery of fieldbased
health-related fitness measures for
adolescents’, Journal of Sports Sciences, 29
685-693 (2011)
Lubans David Revalds, Morgan Philip James,
McCormack Ann Carolyn, ‘Adolescents
and school sport: The relationship between
beliefs, social support and physical selfperception’,
Physical Education and Sport
Pedagogy, 16 237-250 (2011)
Magarey Anthea, Watson Jane Felicity,
Golley Rebecca K, Burrows Tracy Lee,
Sutherland Rachel, McNaughton Sarah
A, Denney-Wilson Elizabeth, Campbell
Karen, Collins Clare Elizabeth, ‘Assessing
dietary intake in children and adolescents:
Considerations and recommendations for
obesity research’, International Journal of
Pediatric Obesity, 6 2-11 (2011)
McIlveen Stephen Andrew, White Saxon
William, Quail Anthony Walker, McLeod
Damian Donald, Parsons G, ‘Integration
of baroreflex and autoregulation control of
bronchial blood flow in awake dogs’, Acta
Physiologica, 203 299-310 (2011)
Minaker Leia M, Storey Kate E, Raine
Kim D, Spence John C, Forbes Laura E,
Plotnikoff Ronald Cyril, McCargar Linda
J, ‘Associations between the perceived
presence of vending machines and food and
beverage logos in schools and adolescents’
diet and weight status’, Public Health
Nutrition, 14 1350-1356 (2011)
Morgan Philip James, Callister Robin,
‘Effects of a preseason intervention
on anthropometric characteristics of
semiprofessional rugby league players’,
Journal of Strength and Conditioning
Research, 25 432-440 (2011)

Morgan Philip James, Collins Clare
Elizabeth, Plotnikoff Ronald Cyril, Cook
Alyce Therese, Berthon Bronwyn, Mitchell
Simon, Callister Robin, ‘Efficacy of a
workplace-based weight loss program
for overweight male shift workers: The
Workplace POWER (Preventing Obesity
Without Eating like a Rabbit) randomized
controlled trial’, Preventive Medicine, 52
317-325 (2011)
Morgan Philip James, Lubans David
Revalds, Callister Robin, Okely A D,
Burrows Tracy Lee, Fletcher Richard,
Collins Clare Elizabeth, ‘The ‘Healthy
Dads, Healthy Kids’ randomized controlled
trial: Efficacy of a healthy lifestyle program
for overweight fathers and their children’,
International Journal of Obesity, 35 436-
447 (2011)
Morgan Philip James, Lubans David
Revalds, Collins Clare Elizabeth, Warren
Janet M, Callister Robin, ‘12-month
outcomes and process evaluation of the
SHED-IT RCT: An internet-based weight
loss program targeting men’, Obesity, 19
142-151 (2011)
Morgan Philip James, Warren Janet
M, Lubans David Revalds, Collins Clare
Elizabeth, Callister Robin, ‘Engaging men
in weight loss: Experiences of men who
participated in the male only SHED-IT
pilot study’, Obesity Research and Clinical
Practice, 5 e239-e248 (2011)
Munro Irene Adams, Bore Miles Richard,
Munro Donald, Garg Manohar Lal, ‘Using
personality as a predictor of diet induced
weight loss and weight management’,
International Journal of Behavioral
Nutrition and Physical Activity, 8 - (2011)
Nalivaiko Eugene, ‘Animal models of
psychogenic cardiovascular disorders:
What we can learn from them and what
we cannot’, Clinical and Experimental
Pharmacology and Physiology, 38 115-125
(2011)
Pakpour Amir H, Zeidi Isa Mohammadi,
Chatzisarantis Nikos, Molsted Stig,
Harrison Adrian P, Plotnikoff Ronald Cyril,
‘Effects of action planning and coping
planning within the theory of planned
behaviour: A physical activity study of
patients undergoing haemodialysis’,
Psychology of Sport and Exercise, 12 609-
614 (2011)
Phang Melinda, Lazarus Sheryl, Wood
Lisa Gai, Garg Manohar Lal, ‘Diet and
thrombosis risk: Nutrients for prevention
of thrombotic disease’, Seminars in
Thrombosis and Hemostasis, 37 199-208
(2011)
Plotnikoff Ronald Cyril, Johnson Steven
T, Loucaides Constantinos A, Bauman
Adrian E, Karunamuni Nandini D,
Pickering Michael A, ‘Population-based
estimates of physical activity for adults
with Type 2 Diabetes: A cautionary tale of
potential confounding by weight status’,
Journal of Obesity, 2011 1-5 (2011)
Plotnikoff Ronald Cyril, Karunamuni
Nandini, ‘Steps towards permanently
increasing physical activity in the
population’, Current Opinion in Psychiatry,
24 162-167 (2011)
Plotnikoff Ronald Cyril, Lippke Sonia,
Johnson Steven T, Hugo Kylie, Rodgers
Wendy, Spence John C, ‘Awareness
of Canada’s Physical Activity Guide
to Healthy Active Living in a large
community sample’, American Journal of
Health Promotion, 25 294-297 (2011)
Plotnikoff Ronald Cyril, Pickering Michael
A, Glenn Nicole, Doze Sandra L,
Reinbold-Matthews Melissa L, McLeod
Laura J, Lau David C W, Fick Gordon H,
Johnson Steven T, Flaman Laura, ‘The
effects of a supplemental, theory-based
physical activity counseling intervention
for adults with type 2 diabetes’, Journal
of Physical Activity and Health, 8 944-954
(2011)
Plotnikoff Ronald Cyril, Trinh Linda,
Courneya Kerry S, Karunamuni Nandini,
Sigal Ronald J, ‘Predictors of physical
activity in adults with type 2 diabetes’,
American Journal of Health Behavior, 35
359-370 (2011)
Saul Megan E, Thomas Paul A, Dosen
Peter John, Isbister Geoffrey Kennedy,
O’Leary Margaret A, Whyte Ian Macgregor,
McFadden Sally Anne, Van Helden Dirk
Ferdinand, ‘A pharmacological approach
to first aid treatment for snakebite’, Nature
Medicine, 17 809-811 (2011)
Taylor Lorian M, Spence John C,
Raine Kim, Sharma Arya M, Plotnikoff
Ronald Cyril, ‘Self-reported physical
activity preferences in individuals with
prediabetes’, The Physician and Sports
Medicine, 39 41-49 (2011)
Trinh Linda, Plotnikoff Ronald Cyril,
Rhodes Ryan E, North Scott, Courneya
Kerry S, ‘Associations between physical
activity and quality of life in a populationbased
sample of kidney cancer survivors’,
Cancer Epidemiology Biomarkers &
Prevention, 20 859-868 (2011)
Tudor-Locke Catrine, Craig Cora L, Beets
Michael W, Belton Sarahjane, Cardon
Greet M, Duncan Scott, Hatano Yoshiro,
Lubans David Revalds, Olds Timothy S,
Raustorp Anders, Rowe David A, Spence
John C, Tanaka Shigeho, Blair Steven
N, ‘How many steps/day are enough? for
children and adolescents’, International
Journal of Behavioral Nutrition and
Physical Activity, 8 78 (2011)
Information Based
Medicine
Bailey Helen D, Armstrong Bruce K, De
Klerk Nicholas H, Fritschi Lin, Attia John
Richard, Scott Rodney, Smibert Elizabeth,
Milne Elizabeth, ‘Exposure to professional
pest control treatments and the risk of
childhood acute lymphoblastic leukemia’,
International Journal of Cancer, 129 1678-
1688 (2011)
Dempsey Shane Edward, Warren-Forward
Helen, ‘An analysis of the professional and
academic interest of medical radiation
science students’, Radiography, 17 145-151
(2011)
Elith Craig, Dempsey Shane Edward,
Findlay Naomi Ann, Warren-Forward
Helen, ‘An introduction to the intensitymodulated
radiation therapy (IMRT)
techniques, tomotherapy, and VMAT’,
Journal of Medical Imaging and Radiation
Sciences, 42 37-43 (2011)
Findlay Naomi Ann, Warren-Forward
Helen, Dempsey Shane Edward,
‘Development and validation of reflective
inventories: assisting radiation therapists
with reflective practice’, Journal of
Radiotherapy in Practice, 10 3-12 (2011)
Gill Anthony J, Chou Angela, Vilain
Ricardo Enrique, Clifton-Bligh Roderick
J, ‘’Pediatric-type’ gastrointestinal stromal
tumors are SDHB negative (‘type 2’) GISTs’,
American Journal of Surgical Pathology,
35 1245-1247 (2011)
Gustafsson Helen, Vial Philip, Kuncic
Zdenka, Baldock Clive, Denham James,
Greer Peter Brian, ‘Direct dose to
water dosimetry for pretreatment IMRT
verification using a modified EPID’, Medical
Physics, 38 6257-6264 (2011)
Hondow Heather L, Fox Stephen B,
Mitchell Gillian, Scott Rodney, Beshay
Victoria, Wong Stephen Q, Kconfab
Investigators, Dobrovic Alexander, ‘A
high-throughput protocol for mutation
scanning of the BRCA1 and BRCA2 genes’,
BMC Cancer, 11 265 (2011)
Inostroza-Ponta Mario, Berretta Regina
Esther, Moscato Pablo Alberto, ‘QAPgrid: A
two level QAP-based approach for largescale
data analysis and visualization’, PLoS
ONE, 6 e14468 (2011)
Kiejda Kelly Anne, Bowden Nikola Ann,
Croft Amanda J, Scurr Lyndee L, Kairupan
Carla Felly, Ashton Katie Ann, Talseth-
Palmer Bente, Rizos Helen, Zhang Xu
Dong, Scott Rodney, Hersey Peter, ‘P53
in human melanoma fails to regulate
target genes associated with apoptosis
and the cell cycle and may contribute
to proliferation’, BMC Cancer, 11 203-219
(2011)
Kiejda Kelly Anne, Wong Michelle, Scott
Rodney, ‘Genetic markers in breast
cancer - How far have we come from
BRCA1?’, Asia-Pacific Journal of Molecular
Medicine, 1 1-15 (2011)
Lambert Jonathon Andrew, Greer
Peter Brian, Menk Frederick William,
Patterson Jackie, Parker Joel, Dahl
Kara, Gupta Sanjiv, Capp Anne, Wratten
Christopher, Tang Colin, Kumar Mahesh,
Dowling Jason, Hauville Sarah Louise,
Hughes Cynthia, Fisher Kristen, Lau
Peter, Denham James, Salvado Olivier,
‘MRI-guided prostate radiation therapy
planning: Investigation of dosimetric
accuracy of MRI-based dose planning’,
Radiotherapy and Oncology, 98 330-334
(2011)
Moran S, Warren-Forward Helen, ‘A
retrospective study of the performance
of radiographers in interpreting screening
mammograms’, Radiography, 17 126-131
(2011)
69

70
Rowshan Farzad Pejman, Sabet Mahsheed,
O’Connor John Daryl, Greer Peter Brian,
‘Isocenter verification for linac-based
stereotactic radiation therapy: review of
principles and techniques’, Journal of
Applied Clinical Medical Physics, 12 12 (2011)
Rowshan Farzad Pejman, Sabet Mahsheed,
O’Connor John Daryl, Greer Peter Brian,
‘Verification of the linac isocenter for
stereotactic radiosurgery using cine-EPID
imaging and arc delivery’, Medical Physics,
38 3963-3970 (2011)
Smith Casey Jo, Oscarson M, Ronnblom L,
Alimohammadi M, Perheentupa J, Husebye
E S, Gustafsson J, Nordmark G, Meloni A,
Crock Patricia Anne, Kampe O, Bensing
S, ‘TSGA10-A target for autoantibodies in
Autoimmune Polyendocrine Syndrome
Type 1 and Systemic Lupus Erythematosus’,
Scandinavian Journal of Immunology, 73
147-153 (2011)
Talseth-Palmer Bente, Brenne Ingvild S,
Ashton Katie Ann, Evans Tiffany-Jane,
McPhillips Mary, Groombridge Claire,
Suchy Janina, Kurzawski Grzegorz,
Spigelman Allan, Lubinski Jan, Scott
Rodney, ‘Colorectal cancer susceptibility
loci on chromosome 8q23.3 and 11q23.1 as
modifiers for disease expression in lynch
syndrome’, Journal of Medical Genetics, 48
279-284 (2011)
Talseth-Palmer Bente, Scott Rodney,
‘Genetic variation and its role in malignancy’,
International Journal of Biomedical Science,
7 158-171 (2011)
Vilain Ricardo Enrique, Dudding Tracy
Elizabeth, Braye Stephen Geoffrey,
Groombridge Claire, Meldrum C, Spigelman
Allan David, Ackland Stephen, Ashman
Leonie Kay, Scott Rodney, ‘Can a familial
gastrointestinal tumour syndrome be allelic
with Waardenburg syndrome?’, Clinical
Genetics, 79 554-560 (2011)
Wong Michelle, Nordfors Cecilia, Mossman
David, Pecenpetelovska Gordana, Kiejda
Kelly Anne, Talseth-Palmer Bente, Bowden
Nikola Ann, Scott Rodney J, ‘BRIP1, PALB2,
and RAD51C mutation analysis reveals their
relative importance as genetic susceptibility
factors for breast cancer’, Breast Cancer
Research and Treatment, 127 853-859 (2011)
Zacharin Margaret, Bajpai Anurag, Chow
Chung Wo, Catto-Smith Anthony, Stratakis
Constantine, Wong Michelle, Scott Rodney,
‘Gastrointestinal polyps in McCune Albright
syndrome’, Journal of Medical Genetics, 48
458-461 (2011)
Zhou Jinxia, Broe Melissa, Huang Yue,
Anderson John P, Gai Wei-Ping, Milward
Adrienne Elizabeth, Porritt Michelle,
Howells David, Hughes Andrew J, Wang
Xiaomin, Halliday Glenda M, ‘Changes in
the solubility and phosphorylation of alphasynuclein
over the course of Parkinson’s
disease’, Acta Neuropathologica, 121 695-704
(2011)
Pregnancy and
Reproduction
Ainsworth Christopher James, Nixon Brett,
Aitken Robert John, ‘The electrophoretic
separation of spermatozoa: An analysis of
genotype, surface carbohydrate composition
and potential for capacitation’, International
Journal of Andrology, 34 e422-e434 (2011)
Aitken Robert John, ‘The capacitationapoptosis
highway: Oxysterols and
mammalian sperm function’, Biology of
Reproduction, 85 9-12 (2011)
Aitken Robert John, Carey A J, Beagley K
W, ‘Dual purpose contraceptives: targeting
fertility and sexually transmitted disease’,
Journal of Reproductive Immunology, 88
228-232 (2011)
Aitken Robert John, Curry Benjamin John,
‘Redox regulation of human sperm function:
From the physiological control of sperm
capacitation to the etiology of infertility and
DNA damage in the germ line’, Antioxidants
& Redox Signaling, 14 367-381 (2011)
Aitken Robert John, Findlay Jock K, Hutt
Karla J, Kerr Jeff B, ‘Apoptosis in the germ
line’, Reproduction, 141 139-150 (2011)
Aitken Robert John, Hanson Adrienne R,
Kuczera Lesley Hicks, ‘Electrophoretic sperm
isolation: Optimization of electrophoresis
conditions and impact on oxidative stress’,
Human Reproduction, 26 1955-1964 (2011)
Aitken Robert John, Henkel Ralf R, ‘Sperm
cell biology: current perspectives and future
prospects’, Asian Journal of Andrology, 13
3-5 (2011)
Aitken Robert John, Koppers Adam J,
‘Apoptosis and DNA damage in human
spermatozoa’, Asian Journal of Andrology, 13
36-42 (2011)
Amirshahi Ashkan, Wan Charles, Beagley
Kenneth, Latter Joanna Louise, Symonds
Ian Martin, Timms Peter, ‘Modulation
of the Chlamydia trachomatis In vitro
transcriptome response by the sex
hormones estradiol and progesterone’, BMC
Microbiology, 11 150 (2011)
Baker Mark Andrew, ‘The ‘omics revolution
and our understanding of sperm cell
biology’, Asian Journal of Andrology, 13 6-10
(2011)
Frye Cheryl A, Hirst Jonathan James,
Brunton Paula J, Russell John A,
‘Neurosteroids for a successful pregnancy’,
Stress, 14 1-5 (2011)
Holt Janet Elizabeth, Tran Suzanne My-
Trinh, Stewart Jessica Lee, Minahan Kyra
Lee, Garcia-Higuera Irene, Moreno Sergio,
Jones Keith Thomas, ‘The APC/C activator
FZR1 coordinates the timing of meiotic
resumption during prophase I arrest in
mammalian oocytes’, Development, 138
905-913 (2011)
Jennings Phoebe Coral, Merriman-Jones
Julie Amanda, Beckett Emma Louise,
Hansbro Philip Michael, Jones Keith Thomas,
‘Increased zona pellucida thickness and
meiotic spindle disruption in oocytes
from cigarette smoking mice’, Human
Reproduction, 26 878-884 (2011)
Jones Lisa Jane, Craven Paul, Attia John
Richard, Thakkinstian Ammarin, Wright
Ian Michael, ‘Network meta-analysis of
indomethacin versus ibuprofen versus
placebo for PDA in preterm infants’, Archives
of Disease in Childhood-Fetal and Neonatal
Edition, 96 F45-F52 (2011)
Koppers Adam John, Mitchell Lisa Ann,
Wang Jian Ping, Lin Minjie, Aitken Robert
John, ‘Phosphoinositide 3-kinase signalling
pathway involvement in a truncated
apoptotic cascade associated with motility
loss and oxidative DNA damage in human
spermatozoa’, Biochemical Journal, 436 687-
698 (2011)
Liu J P, Lu D, Nicholson Richard Charles, Li
P Y, Wang F, ‘Toxicity of a novel anti-tumor
agent 20(S)-ginsenoside Rg3: A 26-week
intramuscular repeated administration
study in Beagle dogs’, Food and Chemical
Toxicology, 49 1718-1727 (2011)
Maiti Kaushik, Paul Jonathan Winter,
Read Mark A, Chan Eng Cheng, Riley S C,
Nahar Pravin, Smith Roger, ‘G-1-activated
membrane estrogen receptors mediate
increased contractility of the human
myometrium’, Endocrinology, 152 2448-2455
(2011)
Marques F Z, Pringle Kirsty Gay, Conquest
Alison Louisa, Hirst Jonathan James,
Markus M A, Sarris M, Zakar Tamas, Morris
B J, Lumbers Eugenie Ruth, ‘Molecular
characterization of renin-angiotensin system
components in human intrauterine tissues
and fetal membranes from vaginal delivery
and cesarean section’, Placenta, 32 214-221
(2011)
McLaughlin Eileen Anne, Aitken Robert John,
‘Is there a role for immunocontraception?’,
Molecular and Cellular Endocrinology, 335
78-88 (2011)
McLaughlin Eileen Anne, Hime Gary R,
‘Spermatids do it differently! Paip2a-the
essential regulator of spermiogenesis?’, Asian
Journal of Andrology, 13 122-124 (2011)
Nixon Brett, Mitchell Lisa Ann, Anderson
Amanda Lee, McLaughlin Eileen Anne,
O’Bryan Moira K, Aitken Robert John,
‘Proteomic and functional analysis of human
sperm detergent resistant membranes’,
Journal of Cellular Physiology, 226 2651-
2665 (2011)
Paul Jonathan Winter, Maiti Kaushik, Read
Mark A, Hure Alexis Jayne, Smith Julia Irene,
Chan Eng Cheng, Smith Roger, ‘Phasic
phosphorylation of caldesmon and ERK 1/2
during contractions in human myometrium’,
PLoS ONE, 6 1-7 (2011)
Pringle Kirsty Gay, Zakar Tamas, Yates Della,
Mitchell Carolyn Margaret, Hirst Jonathan
James, Lumbers Eugenie Ruth, ‘Molecular
evidence of a (pro)renin/(pro)renin receptor
system in human intrauterine tissues
in pregnancy and its association with
PGHS-2’, Journal of the Renin-Angiotensin-
Aldosterone System, 12 304-310 (2011)
Rakovich Tatsiana, Boland Coilin, Bernstein
Ilana Ruth, Chikwana Vimbai M, Iwata-
Reuyl Dirk, Kelly Vincent P, ‘Queuosine
deficiency in eukaryotes compromises
tyrosine production through Increased
tetrahydrobiopterin oxidation’, Journal of
Biological Chemistry, 286 19354-19363 (2011)

Rees Merridie, May Jennifer Ann, Rae Kym
Maree, ‘Is it me? Or is there something
in the water? Client decision making in
nursing’, Australian Journal of Advanced
Nursing, 28 67-73 (2011)
Sferruzzi-Perri A N, Owens J A, Pringle
Kirsty Gay, Roberts C T, ‘The neglected
role of insulin-like growth factors in the
maternal circulation regulating fetal
growth’, Journal of Physiology, 589 7-20
(2011)
Torricelli Michela, Novembri Romina,
Voltolini Chiara, Conti Nathalia, Biliotti
Giulia, Piccolini Enrico, Cevenini
Gabriel, Smith Roger, Petraglia Felice,
‘Biochemical and biophysical predictors
of the response to the induction of labor
in nulliparous postterm pregnancy’,
American Journal of Obstetrics and
Gynecology, 204 e1-6 (2011)
Walker Adam Keith, Hiles Sarah Ashlee,
Sominsky Bar Luba, McLaughlin Eileen
Anne, Hodgson Deborah Maree, ‘Neonatal
lipopolysaccharide exposure impairs
sexual development and reproductive
success in the Wistar rat’, Brain, Behavior,
and Immunity, 25 674-684 (2011)
Winskill Rhonda Ann, Keatinge Diana
Rosemary, Hancock Stephen John,
‘Influences on parents’ decisions when
determining whether their child is sick
and what they do about it: A pilot study’,
International Journal of Nursing Practice,
17 126-132 (2011)
Yawno Tamara, Yan Edwin B, Hirst
Jonathan James, Walker David W,
‘Neuroactive steroids induce changes in
fetal sheep behavior during normoxic and
asphyxic states’, Stress, 14 13-22 (2011)
Zakar Tamas, Mesiano Sam, ‘How
does progesterone relax the uterus in
pregnancy?’, New England Journal of
Medicine, 364 972-973 (2011)
Public Health
Adams Jon, Lui Chi-Wai, Sibbritt David
William, Broom Alex, Wardle Jon, Homer
Caroline, ‘Attitudes and referral practices
of maternity care professionals with
regard to complementary and alternative
medicine: An integrative review’, Journal
of Advanced Nursing, 67 472-483 (2011)
Adams Jon, Sibbritt David William,
Lui Chi-Wai, ‘The urban-rural divide
in complementary and alternative
medicine use: a longitudinal study of
10,638 women’, BMC Complementary and
Alternative Medicine, 11 1-7 (2011)
Anothaisintawee Thunyarat, Attia John
Richard, Nickel J Curtis, Thammakraisorn
Sangsuree, Numthavaj Pawin, McEvoy
Mark Anthony, Thakkinstian Ammarin,
‘Management of chronic prostatitis/
Chronic pelvic pain syndrome: A
systematic review and network metaanalysis’,
JAMA: The Journal of the
American Medical Association, 305 78-86
(2011)
Anstey Kaarin J, Bielak Allison A M,
Birrell Carole L, Browning Colette J,
Burns Richard A, Byles Julie Ellen, Kiely
Kim M, Nepal Binod, Ross Lesley A, Steel
David, Windsor Timothy D, Dynopta
Team, ‘Understanding ageing in older
Australians: The contribution of the
Dynamic Analyses to Optimise Ageing
(DYNOPTA) project to the evidence base
and policy’, Australasian Journal on
Ageing, 30 24-31 (2011)
Anstey Kaarin J, Kiely Kim M, Booth
Heather, Birrell Carole L, Butterworth
Peter, Byles Julie Ellen, Luszcz Mary A,
Gibson Richard Edward, ‘Indigenous
Australians are under-represented in
longitudinal ageing studies’, Australian and
New Zealand Journal of Public Health, 35
331-336 (2011)
Arthur Carol, Kable Ashley Kathryn,
Levett-Jones Tracy Lynn, ‘Human patient
simulation manikins and information
communication technology use in
Australian schools of nursing: A crosssectional
survey’, Clinical Simulation in
Nursing, 7 e219-e227 (2011)
Astbury Jill, Bruck Dorothy, Loxton
Deborah Joanne, ‘Forced sex: A critical
factor in the sleep difficulties of young
Australian women’, Violence and Victims,
26 53-72 (2011)
Bailey Helen D, Milne Elizabeth, De
Klerk Nicholas H, Fritschi Lin, Attia John
Richard, Cole Catherine, Armstrong
Bruce K, ‘Exposure to house painting and
the use of floor treatments and the risk of
childhood acute lymphoblastic leukemia’,
International Journal of Cancer, 128 2405-
2414 (2011)
Bailey Kylie Anne, ‘Book Review: Drugs of
Abuse, Volume I, The International Scene’,
Drug and Alcohol Review, 30 229 (2011)
Bailey Kylie Anne, ‘Book Review: Drugs
of Abuse, Volume III, Prevention and
Treatment’, Drug and Alcohol Review, 30
231 (2011)
Bailey Kylie Anne, ‘Review: Dog Ear Cafe:
How the Mt Theo Program Beat the
Curse of Petrol Sniffing’, Drug and Alcohol
Review, 30 449-450 (2011)
Bartsch Lauren J, Butterworth Peter,
Byles Julie Ellen, Mitchell Paul, Shaw
Jonathan, Anstey Kaarin J, ‘Examining
the SF-36 in an older population: Analysis
of data and presentation of Australian
adult reference scores from the Dynamic
Analyses to Optimise Ageing (DYNOPTA)
project’, Quality of Life Research, 20 1227-
1236 (2011)
Bayley Sarah A, Magin Parker John,
Sweatman Jennifer M, Regan
Catherine M, ‘Effects of compulsory
rural vocational training for Australian
general practitioners: a qualitative study’,
Australian Health Review, 35 81-85 (2011)
Bellchambers Helen Lorraine, Levett-
Jones Tracy Lynn, ‘Health and illness in
the adult client’, Medical Surgical Nursing:
Critical Thinking in Client Care, Pearson
Australia, Frenchs Forest, NSW, 17-36
(2011)
Bembridge Elizabeth, Levett-Jones Tracy
Lynn, Jeong Yeun-Sim, ‘The transferability
of information and communication
technology skills from university to the
workplace: A qualitative descriptive study’,
Nurse Education Today, 31 245-252 (2011)
Bonevski Biljana, Bowman Jennifer Ann,
Richmond R, Bryant Jamie Lee, Wye
Paula Merise, Stockings Emily Alice,
Wilhelm K, Butler T, Indig D, Wodak A,
‘Turning of the tide: Changing systems to
address smoking for people with a mental
illness’, Mental Health and Substance Use,
4 116-129 (2011)
Bonevski Biljana, Bryant Jamie Lee, Paul
Christine Louise, ‘Encouraging smoking
cessation among disadvantaged groups:
A qualitative study of the financial aspects
of cessation’, Drug and Alcohol Review, 30
411-418 (2011)
Bonevski Biljana, Magin Parker John,
Horton Graeme Leonard, Foster Mark,
Girgis Afaf, ‘Response rates in GP surveys:
Trialling two recruitment strategies’,
Australian Family Physician, 40 427-430
(2011)
Bonevski Biljana, Paul Christine Louise,
D’Este Catherine Anne, Sanson-Fisher
Robert William, West Robert, Girgis Afaf,
Siahpush Mohammad, Carter Robert,
‘RCT of a client-centred, caseworkerdelivered
smoking cessation intervention
for a socially disadvantaged population’,
BMC Public Health, 11 70 (2011)
Bonevski Biljana, Paul Christine Louise,
Walsh Raoul Anthony, Bryant Jamie Lee,
Lecathelinais Louis Christophe, ‘Support
for smoke-free vocational education
settings: An exploratory survey of staff
behaviours, experiences and attitudes’,
Health Promotion Journal of Australia, 22
11-16 (2011)
Boughtwood Desiree, Shanley Chris,
Adams Jon, Santalucia Yvonne,
Kyriazopoulos Helena, Pond Constance
Dimity, Rowland Jeffery, ‘Culturally and
linguistically diverse (CALD) families
dealing with dementia: An examination
of the experiences and perceptions of
multicultural community link workers’,
Journal of Cross-Cultural Gerontology, 26
365-377 (2011)
Boyes Allison Wendy, Girgis Afaf, D’Este
Catherine Anne, Zucca Alison Cheree,
‘Flourishing or floundering? Prevalence
and correlates of anxiety and depression
among a population-based sample of
adult cancer survivors 6 months after
diagnosis’, Journal of Affective Disorders,
135 184-192 (2011)
Brown Leanne Julie, Mitchell Lana Jane,
Williams Lauren Therese, MacDonald-
Wicks Lesley Karen, Capra Sandra, ‘Private
practice in rural areas: An untapped
opportunity for dietitians’, Australian
Journal of Rural Health, 19 191-196 (2011)
Bryant Jamie Lee, Bonevski Biljana,
Paul Christine Louise, ‘A survey of
smoking prevalence and interest in
quitting among social and community
service organisation clients in Australia:
a unique opportunity for reaching the
disadvantaged’, BMC Public Health, 11 827
(2011)
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72
Bryant Jamie Lee, Bonevski Biljana, Paul
Christine Louise, McElduff Patrick, Attia John
Richard, ‘A systematic review and metaanalysis
of the effectiveness of behavioural
smoking cessation interventions in selected
disadvantaged groups’, Addiction, 106 1568-
1585 (2011)
Bryant Jamie Lee, Bonevski Biljana, Paul
Christine Louise, O’Brien Jon, Oakes
Wendy, ‘Developing cessation interventions
for the social and community service
setting: A qualitative study of barriers to
quitting among disadvantaged Australian
smokers’, BMC Public Health, 11 493 (2011)
Buckley N A, Eddleston M, Li Y, Bevan
Marc Daniel, Robertson Jane, ‘Oximes for
acute organophosphate pesticide poisoning’,
Cochrane Database of Systematic Reviews,
1-41 (2011)
Burns Lucy, Black Emma, Powers Jennifer
Robyn, Loxton Deborah Joanne, Elliott
Elizabeth, Shakeshaft Anthony, Dunlop
Adrian John, ‘Geographic and maternal
characteristics associated with alcohol use
in pregnancy’, Alcoholism: Clinical and
Experimental Research, 35 1-8 (2011)
Burrows Tracy Lee, Findlay Naomi Ann,
Killen Chloe Greentree, Dempsey Shane
Edward, Hunter Sharyn, Chiarelli Pauline
Elizabeth, Snodgrass Suzanne Nicole, ‘Using
nominal group technique to develop a
consensus derived model for peer review
of teaching across a multi-school faculty’,
Journal of University Teaching & Learning
Practice, 8 1-9 (2011)
Byles Julie Ellen, Dolja-Gore Xenia, Loxton
Deborah Joanne, Parkinson Lynne, Stewart
Williams Jennifer Anne, ‘Women’s uptake of
medicare benefits schedule mental health
items for general practitioners, psychologists
and other allied mental health professionals’,
Medical Journal of Australia, 194 175-179
(2011)
Campbell H Sharon, Sanson-Fisher
Robert William, Turner Donna, Hayward
Lynda, Wang X Sunny, Taylor-Brown Jill,
‘Psychometric properties of cancer survivors’
unmet needs survey’, Supportive Care in
Cancer, 19 221-230 (2011)
Carey Mariko Leanne, Clinton-Mcharg
Tara Lynne, Sanson-Fisher Robert William,
Campbell S, Douglas Heather Elaine,
‘Patient or treatment centre? Where are
efforts invested to improve cancer patients’
psychosocial outcomes?’, European Journal
of Cancer Care, 20 152-162 (2011)
Carey Mariko Leanne, Yoong Sze, Sanson-
Fisher Robert William, Paul Christine Louise,
Inder Kerry Jill, Makeham Meredith, ‘Efforts
to close the evidence-practice gap in the
management of cardiovascular risk factors
in general practice: Strategic or haphazard?’,
International Journal of Person Centered
Medicine, 1 660-667 (2011)
Carless Paul Anthony, Rubens Fraser
D, Anthony Danielle Marie, O’Connell
Dianne, Henry David A, ‘Platelet-richplasmapheresis
for minimising perioperative
allogeneic blood transfusion’,
Cochrane Database of Systematic Reviews,
Cd004172 (2011)
Carr Christine, Durrheim David N, Eastwood
Keith, Massey Peter, Jaggers Debbie,
Caelli Meredith, Nicholl Sonya, Winn
Linda, ‘Australia’s first pandemic influenza
mass vaccination clinic exercise: Hunter
New England Area Health Service, NSW,
Australia’, Australian Journal of Emergency
Management, 26 47-53 (2011)
Chandrajith Rohana, Nanayakkara Shanika,
Itai Kozuyoshi, Athuraliya Theresa Nimal,
Dissanayake C B, Abeysekera Thilak,
Harada Kouji, Watanabe Takao, Koizumi
Akio, ‘Chronic kidney diseases of uncertain
etiology (CKDue) in Sri Lanka: geographic
distribution and environmental implications’,
Environmental Geochemistry and Health, 33
267-278 (2011)
Chapman Kathy, Stacey Fiona Gai, Groves
Emma, Pratt Iain S, ‘After the storm:
Nutrition after cancer treatment’, Cancer
Forum, 35 97-101 (2011)
Clinton-Mcharg Tara Lynne, Carey Mariko
Leanne, Sanson-Fisher Robert William,
Tracey Elizabeth, ‘Recruitment of
representative samples for low incidence
cancer populations: Do registries deliver?’,
BMC Medical Research Methodology, 11 1-9
(2011)
Collins Clare Elizabeth, Patterson Amanda
Jane, Fitzgerald David, ‘Higher diet quality
does not predict lower medicare costs but
does predict number of claims in mid-aged
Australian women’, Nutrients, 3 40-48 (2011)
Cunningham John A, Kypri Kypros,
McCambridge Jim, ‘The use of emerging
technologies in alcohol treatment’, Alcohol
Research & Health, 33 320-326 (2011)
Czech Suzanne, Shakeshaft Anthony,
Sanson-Fisher Robert William, Breen
Courtney, ‘The development and application
of a proxy measure of alcohol-related traffic
crashes for rural communities’, Accident
Analysis and Prevention, 43 2160-2165 (2011)
Dalton Craig Brian, Merritt Tony David,
Unicomb L E, Kirk M D, Stafford R J,
Lalor K, Ozfoodnet Working Group, ‘A
national case-control study of risk factors
for listeriosis in Australia’, Epidemiology and
Infection, 139 437-445 (2011)
Dassanayake Waidyaratne Mudiyanselage,
Michie Patricia Therese, Carter Gregory
Leigh, Jones Alison, ‘Effects of
benzodiazepines, antidepressants and
opioids on driving: A systematic review
and meta-analysis of epidemiological and
experimental evidence’, Drug Safety, 34 125-
156 (2011)
Day Jennifer Lynn, Armitage Deborah Mary,
Jeong Yeun-Sim, Hunter Sharyn, Keatinge
Diana Rosemary, Higgins Isabel Johanna,
‘Community-based nursing care’, Medical
Surgical Nursing: Critical Thinking in Client
Care, Pearson Australia, Frenchs Forest, NSW,
37-52 (2011)
Day Jennifer Lynn, Higgins Isabel Johanna,
Keatinge Diana Rosemary, ‘Orientation
strategies during delirium: Are they helpful?’,
Journal of Clinical Nursing, 20 3285-3294
(2011)
De Brito-Ashurst I, Perry Linda, Sanders T
A B, Thomas J E, Yaqoob M M, Dobbie H,
‘Barriers and facilitators of dietary sodium
restriction amongst Bangladeshi chronic
kidney disease patients’, Journal of Human
Nutrition and Dietetics, 24 86-95 (2011)
Dempsey Shane Edward, Findlay Naomi Ann,
MacDonald-Wicks Lesley Karen, ‘Increasing
nutritional support for patients undergoing
radiation therapy: The radiation therapist
perspective’, Journal of Radiotherapy in
Practice, 10 181-189 (2011)
Dolja-Gore Xenia, Byles Julie Ellen, Loxton
Deborah Joanne, Hockey Richard L, Dobson
Annette J, ‘Increased bulk-billing for general
practice consultations in regional and
remote areas, 2002-2008’, Medical Journal of
Australia, 195 203-204 (2011)
Doran Evan, Robertson Jane, Salkeld Glenn,
‘Pharmaceutical Benefits Scheme cost
sharing, patient cost consciousness and
prescription affordability’, Australian Health
Review, 35 37-44 (2011)
Durrheim David N, ‘Using operational
research to ensure that immunisation
benefits are enjoyed by all’, NSW Public
Health Bulletin, 22 1-2 (2011)
Durrheim David N, Bashour Hyam, ‘Measles
eradication’, The Lancet, 377 808 (2011)
Ebert Lyn Maxine, Ferguson Alison Jean,
Bellchambers Helen Lorraine, ‘Working for
socially disadvantaged women’, Women and
Birth, 24 85-91 (2011)
Gidding Heather F, Law Matthew G, Amin
Janaki, MacDonald Graeme A, Sasadeusz
Joe J, Levett-Jones Tracy Lynn, Strasser
Simone I, George Jacob, Dore Gregory
J, ‘Predictors of deferral of treatment for
hepatitis C infection in Australian clinics’,
Medical Journal of Australia, 194 398-402
(2011)
Girgis Afaf, Lambert Sylvie, Lecathelinais
Louis Christophe, ‘The supportive care
needs survey for partners and caregivers
of cancer survivors: development and
psychometric evaluation’, Psycho-Oncology,
20 387-393 (2011)
Good Phillip David, Sneesby Ludmilla,
Higgins Isabel Johanna, Van Der Riet Pamela
Jane, ‘Medical officers in acute care settings:
Their views on medically assisted hydration
at the end of life’, Journal of Palliative Care,
27 303-309 (2011)
Guest Maya, Attia John Richard, D’Este
Catherine Anne, Boggess May M, Brown
Anthony M, Gibson Richard Edward,
Tavener Meredith A, Ross James, Gardner
Ian, Harrex Warren, ‘Peripheral neuropathy
in military aircraft maintenance workers
in Australia’, Journal of Occupational and
Environmental Medicine, 53 381-387 (2011)
Guest Maya, Boggess May M, D’Este
Catherine Anne, Attia John Richard, Brown
Anthony, ‘An observed relationship between
vestibular function and auditory thresholds
in aircraft-maintenance workers’, Journal of
Occupational and Environmental Medicine,
53 146-152 (2011)

Guest Maya, D’Este Catherine Anne,
Attia John Richard, Boggess May, Brown
Anthony, Tavener Meredith, Gibson
Richard Edward, Gardner Ian, Harrex
Warren, Ross James, ‘Impairment of color
vision in aircraft maintenance workers’,
International Archives of Occupational
and Environmental Health, 84 723-733
(2011)
Gwynn Josephine Diana, Flood Victoria
M, D’Este Catherine Anne, Attia John
Richard, Turner Nicole, Cochrane Janine,
Wiggers John Henry, ‘The reliability and
validity of a short FFQ among Australian
Aboriginal and Torres Strait Islander and
non-Indigenous rural children’, Public
Health Nutrition, 14 388-401 (2011)
Hall Robert, Durrheim David N, ‘One
Health: Much more than a slogan’, NSW
Public Health Bulletin, 22 97-98 (2011)
Hassani Mehraban A, Mackenzie Lynette
A, Byles Julie Ellen, ‘A self-report home
environment screening tool identified
older women at risk of falls’, Journal of
Clinical Epidemiology, 64 191-199 (2011)
Havard A, Shakeshaft A P, Conigrave K
M, Sanson-Fisher Robert William, ‘The
prevalence and characteristics of alcoholrelated
presentations to emergency
departments in rural Australia’, Emergency
Medicine Journal, 28 290-295 (2011)
Heard Todd Raymond, Daly Justine
Bernadette, Bowman Jennifer Ann, Freund
Megan Alberta, Wiggers John Henry, ‘A
cross-sectional survey of the prevalence
of environmental tobacco smoke
preventive care provision by child health
services in Australia’, BMC Public Health, 11
324 (2011)
Hess I M, Massey P D, Durrheim David
N, O’Connor S, Graves S R, ‘Preventing
Q fever endocarditis: a review of cardiac
assessment in hospitalised Q fever
patients’, Rural and Remote Health, 11 1763
(2011)
Hodder Rebecca Kate, Daly Justine
Bernadette, Freund Megan Alberta,
Bowman Jennifer Ann, Hazell Trevor,
Wiggers John Henry, ‘A school-based
resilience intervention to decrease
tobacco, alcohol and marijuana use in
high school students’, BMC Public Health,
11 722 (2011)
Hoffman Kerry Anne, ‘Shock and multiple
organ dysfunction syndrome’, Smeltzer
and Bare’s Textbook of Medical-Surgical
Nursing, Wolters Kluwer/Lippincott
Williams and Wilkins, Broadway, N.S.W.,
188-212 (2011)
Hoffman Kerry Anne, Dempsey Jennifer,
Levett-Jones Tracy Lynn, Noble Danielle
Iris, Hickey Noelene, Jeong Yeun-Sim,
Hunter Sharyn, Norton Carol Anne,
‘The design and implementation of
an Interactive Computerised Decision
Support Framework (ICDSF) as a strategy
to improve nursing students’ clinical
reasoning skills’, Nurse Education Today,
31 587-594 (2011)
Hope Kirsty Gai, Massey Peter D, Osbourn
Maggi, Durrheim David N, Kewley
Christopher Denis, Turner Catherine
Louise, ‘Senior clinical nurses effectively
contribute to the pandemic influenza
public health response’, Australian Journal
of Advanced Nursing, 28 47-53 (2011)
Huynh Dieu T T, Dibley Michael J,
Sibbritt David William, Tran Hanh T M,
Le Qui T K, ‘Influence of contextual and
individual level risk factors on adiposity in
a preschool child cohort in Ho Chi Minh
City, Vietnam’, International Journal of
Pediatric Obesity, 6 e487-e500 (2011)
Isbister Geoffrey Kennedy, Fan Hui Wen,
‘Spider bite’, The Lancet, 378 2039-2047
(2011)
Isbister Geoffrey Kennedy, Kumar Venkata
V Pavan, ‘Indications for single-dose
activated charcoal administration in acute
overdose’, Current Opinion in Critical Care,
17 351-357 (2011)
Isbister Geoffrey Kennedy, Page Colin B,
‘Early endoscopy or CT in caustic injuries:
A re-evaluation of clinical practice’, Clinical
Toxicology, 49 641-642 (2011)
James Carole Lesley, Southgate Erica
Lee, Kable Ashley Kathryn, Rivett Darren
Anthony, Guest Maya, Bohatko-Naismith
Joanna, ‘The Return-To-Work Coordinator
role: Qualitative insights for nursing’,
Journal of Occupational Rehabilitation, 21
220-227 (2011)
Jayasekera Himali, Carter Gregory
Leigh, Clover Kerrie, ‘Comparison of
the Composite International Diagnostic
Interview (CIDI-auto) with clinical
diagnosis in a suicidal population’,
Archives of Suicide Research, 15 43-55
(2011)
Jeong Yeun-Sim, Hickey Noelene,
Levett-Jones Tracy Lynn, Pitt Victoria
Lee, Hoffman Kerry Anne, Norton Carol
Anne, Ohr Se Ok, ‘Understanding and
enhancing the learning experiences of
culturally and linguistically diverse nursing
students in an Australian bachelor of
nursing program’, Nurse Education Today,
31 238-244 (2011)
Jeong Yeun-Sim, Higgins Isabel Johanna,
McMillan Margaret Anna, ‘Experiences
with advance care planning: Nurses’
perspective’, International Journal of Older
People Nursing, 6 165-175 (2011)
Jeong Yeun-Sim, Higgins Isabel Johanna,
McMillan Margaret Anna, ‘Experiences
with advance care planning: Older
people and family members’ perspective’,
International Journal of Older People
Nursing, 6 176-186 (2011)
Jiwa Moyez, Ping-Delfos Wendy Chan
She, Ross Jackie, Shaw Tim, Magin Parker
John, ‘Communities of practice: Quality
improvement or research in general
practice’, Australian Family Physician, 40
72-75 (2011)
Johnson Claire Elizabeth, Girgis Afaf,
Paul Christine Louise, Currow David
C, ‘Palliative care referral practices
and perceptions: The divide between
metropolitan and non-metropolitan
general practitioners’, Palliative and
Supportive Care, 9 181-189 (2011)
Johnson Claire Elizabeth, Girgis Afaf,
Paul Christine Louise, Currow David C,
Adams Jon, Aranda Sanchia, ‘Australian
palliative care providers’ perceptions and
experiences of the barriers and facilitators
to palliative care provision’, Supportive
Care in Cancer, 19 343-351 (2011)
Johnson Claire Elizabeth, Paul Christine
Louise, Girgis Afaf, Adams Jon, Currow
David C, ‘Australian general practitioners’
and oncology specialists’ perceptions
of barriers and facilitators of access to
specialist palliative care services’, Journal
of Palliative Medicine, 14 429-435 (2011)
Joyce Teresa Ann, Higgins Isabel Johanna,
Magin Parker John, Goode Susan May,
Pond Constance Dimity, Stone Teresa,
Elsom Stephen, O’Neill Kerry, ‘Nurses’
perceptions of a mental health education
programme for Australian nurses’,
International Journal of Mental Health
Nursing, 20 247-252 (2011)
Kable Ashley Kathryn, Bourgeois Sharon,
‘Nursing care of clients having surgery’,
Medical Surgical Nursing: Critical Thinking
in Client Care, Pearson Australia, Frenchs
Forest, NSW, 57-89 (2011)
Kable Ashley Kathryn, Guest Maya,
McLeod Mary, ‘Organizational risk
management and nurses’ perceptions
of workplace risk associated with sharps
including needlestick injuries in nurses
in New South Wales, Australia’, Nursing &
Health Sciences, 13 246-254 (2011)
Kalam Yasmean, Isbister Geoffrey
Kennedy, Mirtschin Peter, Hodgson
Wayne C, Konstantakopoulos Nicki,
‘Validation of a cell-based assay to
differentiate between the cytotoxic
effects of elapid snake venoms’, Journal
of Pharmacological and Toxicological
Methods, 63 137-142 (2011)
Kohlhagen Julie K, Massey Peter D,
Durrheim David N, ‘Meeting measles
elimination indicators: surveillance
performance in a regional area of
Australia’, Western Pacific Surveillance and
Response Journal, 2 1-5 (2011)
Kumar Venkata V Pavan, Isbister Geoffrey
Kennedy, Duffull Stephen B, ‘The effect
of decontamination procedures on the
pharmacodynamics of venlafaxine in
overdose’, British Journal of Clinical
Pharmacology, 72 125-132 (2011)
Kypri Kypros, Jones Craig, McElduff
Patrick, Barker Daniel Jacob, ‘Effects of
restricting pub closing times on nighttime
assaults in an Australian city’,
Addiction, 106 303-310 (2011)
Kypri Kypros, McCambridge Jim, Wilson
Amanda Jane, Attia John Richard,
Sheeran Paschal, Bowe Steve, Vater Tina,
‘Effects of study design and allocation
on participant behaviour- ESDA: Study
protocol for a randomized controlled trial’,
Trials, 12 42 (2011)
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74
Lambert Sylvie, Pallant Julie F, Girgis Afaf,
‘Rasch analysis of the Hospital Anxiety
and Depression Scale among caregivers of
cancer survivors: implications for its use in
psycho-oncology’, Psycho-Oncology, 20
919-925 (2011)
Lane J, O’Leary M A, Isbister Geoffrey
Kennedy, ‘Coagulant effects of black snake
(Pseudechis spp.) venoms and in-vitro
efficacy of commercial antivenom’, Toxicon,
58 239-246 (2011)
Lapkin Samuel, Levett-Jones Tracy Lynn, ‘A
cost-utility analysis of medium vs. highfidelity
human patient simulation manikins
in nursing education’, Journal of Clinical
Nursing, 20 3543?3552 (2011)
Lapkin Samuel, Levett-Jones Tracy Lynn,
Gilligan Conor, ‘The effectiveness of
interprofessional education in universitybased
health professional programs: A
systematic review’, Joanna Briggs Institute
Library of Systematic Reviews, 9 1917-1970
(2011)
Lawrence D J, Snodgrass Suzanne Nicole,
‘Posteroanterior thoracic spinal stiffness
does not change after manipulation in
asymptomatic subjects: Authors reply’,
Focus on Alternative and Complementary
Therapies, 16 153-154 (2011)
Lemone Priscilla, Burke Karen M, Dwyer
Trudy, Levett-Jones Tracy Lynn, Moxham
Lorna, Reid-Searl Kerry, Berry Kamaree,
Carville Kerlyn, Hales Majella, Knox Nicole,
Luxford Yoni, Raymond Debra, Medical
Surgical Nursing: Critical Thinking in Client
Care, Pearson Australia, Frenchs Forest, NSW,
1902 (2011)
Levett-Jones Tracy Lynn, Bellchambers
Helen Lorraine, ‘Medical-surgical nursing’,
Medical Surgical Nursing: Critical Thinking
in Client Care, Pearson Australia, Frenchs
Forest, NSW, 3-16 (2011)
Levett-Jones Tracy Lynn, Bellchambers
Helen Lorraine, ‘Medical-surgical nursing’,
Medical Surgical Nursing: Critical Thinking
in Client Care, Pearson Australia, Frenchs
Forest, NSW, 3-16 (2011)
Levett-Jones Tracy Lynn, Bourgeois Sharon,
The Clinical Placement : An Essential Guide
for Nursing Students, Elsevier Australia,
Chatswood, NSW, 251 (2011)
Levett-Jones Tracy Lynn, Gersbach Jean,
Arthur Carol, Roche Janiece Margaret,
‘Implementing a clinical competency
assessment model that promotes critical
reflection and ensures nursing graduates’
readiness for professional practice’, Nurse
Education in Practice, 11 64-69 (2011)
Levett-Jones Tracy Lynn, Lapkin Samuel,
Hoffman Kerry Anne, Arthur Carol, Roche
Janiece Margaret, ‘Examining the impact
of high and medium fidelity simulation
experiences on nursing students’ knowledge
acquisition’, Nurse Education in Practice, 11
380-383 (2011)
Levett-Jones Tracy Lynn, McCoy Michelle
Anne, Lapkin Samuel, Noble Danielle Iris,
Hoffman Kerry Anne, Dempsey Jennifer,
Arthur Carol, Roche Janiece Margaret, ‘The
development and psychometric testing of
the Satisfaction with Simulation Experience
Scale’, Nurse Education Today, 31 705-710
(2011)
Lopez Derrick, McCaul Kieran A, Hankey
Graeme J, Norman Paul E, Almeida Osvaldo
P, Dobson Annette J, Byles Julie Ellen, Yeap
Bu B, Flicker Leon, ‘Falls, injuries from falls,
health related quality of life and mortality
in older adults with vision and hearing
impairment - Is there a gender difference?’,
Maturitas, 69 359-364 (2011)
Louie Jimmy Chun-Yu, Flood Victoria,
Turner Nicole, Everingham Christopher,
Gwynn Josephine Diana, ‘Methodology for
adding glycemic index values to 24-hour
recalls’, Nutrition, 27 59-64 (2011)
Lowe Michael, Nair Balakrishnan R,
‘Histories, note taking and clinical reasoning’,
Clinical Examination: A Problem Based
Approach, World Scientific Publishing,
Singapore, 1-16 (2011)
Lynagh Marita Clare, Bonevski Biljana,
Symonds Ian Martin, Sanson-Fisher Robert
William, ‘Paying women to quit smoking
during pregnancy? Acceptability among
pregnant women’, Nicotine & Tobacco
Research, 13 1029-1036 (2011)
Macartney Kristine K, Durrheim David
N, ‘NSW immunisation performance:
continuing progress but no room for
complacency’, NSW Public Health Bulletin,
22 1-2 (2011)
Maclennan Brett, Langley John, Kypri
Kypros, ‘Distributing surveys: Postal versus
drop-and-collect’, Epidemiology, 22 443-444
(2011)
Magin Parker John, Adams Jon, Heading
Gaynor, Pond Constance Dimity, ‘’Perfect
skin’, the media and patients with skin
disease: A qualitative study of patients
with acne, psoriasis and atopic eczema’,
Australian Journal of Primary Health, 17 181-
185 (2011)
Magin Parker John, Marshall Melanie J,
Goode Susan M, Cotter Georgina Lorraine,
Pond Constance Dimity, Zwar Nicholas
A, ‘How generalisable are results of studies
conducted in practice-based research
networks? A cross-sectional study of general
practitioner demographics in two New
South Wales networks’, Medical Journal of
Australia, 195 210-213 (2011)
Magin Parker John, May Jenny, McElduff
Patrick, Goode Susan May, Adams Jon,
Cotter Georgina L, ‘Occupational violence
in general practice: A whole-of-practice
problem. Results of a cross-sectional study’,
Australian Health Review, 35 75-80 (2011)
Massey Peter D, Miller Adrian, Saggers
Sherry, Durrheim David N, Speare Richard,
Taylor Kylie, Pearce Glenn, Odo Travis,
Broome Jennifer, Judd Jenni, Kelly
Jenny, Blackley Magdalena, Clough Alan,
‘Australian Aboriginal and Torres Strait
Islander communities and the development
of pandemic influenza containment
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community control’, Health Policy, 103 184-
190 (2011)
Massey Peter D, Todd Kerry, Osbourn
Maggi, Taylor Kylie, Durrheim David N,
‘Invasive pneumococcal disease in New
South Wales, Australia: Reporting Aboriginal
and Torres Strait Islander status improves
epidemiology’, Western Pacific Surveillance
and Response, 2 1-4 (2011)
Massey Peter D, Viney Kerri, Kienene
Takeieta, Tagaro Markleen, Itogo Noel,
Ituaso-Conway Nese, Durrheim David N,
‘Ten years on: Highlights and challenges of
directly observed treatment short-course
as the recommended TB control strategy in
four Pacific Island nations’, Journal of Rural
and Tropical Public Health, 10 44-47 (2011)
McGarvey Aoife, Chiarelli Pauline Elizabeth,
Osmotherly Peter Grant, Hoffman Gary R,
‘Physiotherapy for accessory nerve shoulder
dysfunction following neck dissection
surgery: A literature review’, Head and Neck-
Journal for the Sciences and Specialties of
the Head and Neck, 33 274-280 (2011)
McKiernan Sharmaine Therese, Chiarelli
Pauline Elizabeth, Warren-Forward Helen, ‘A
survey of diagnostic ultrasound within the
physiotherapy profession for the design of
future training tools’, Radiography, 17 121-125
(2011)
McLaughlin Deirdre, Leung Janni, Byles
Julie Ellen, Dobson Annette, ‘Living with
stairs: Functioning in a large cohort of older
Australian adults (Letter)’, Journal of the
American Geriatrics Society, 59 1560-1562
(2011)
McNamara Bridgette J, Sanson-Fisher
Robert William, D’Este Catherine Anne, Eades
Sandra, ‘Type 2 diabetes in Indigenous
populations: Quality of intervention research
over 20 years’, Preventive Medicine, 52 3-9
(2011)
Miller Peter, Sonderlund Anders, Coomber
Kerri, Palmer Darren, Gillham Karen,
Tindall Jennifer, Wiggers John Henry, ‘Do
community interventions targeting licensed
venues reduce alcohol-related emergency
department presentations?’, Drug and
Alcohol Review, 30 546-553 (2011)
Milne Elizabeth, Royle Jill A, Bennett
Lisa C, De Klerk Nicholas H, Bailey Helen
D, Bower Carol, Miller Margaret, Attia
John Richard, Scott Rodney, Kirby Maria,
Armstrong Bruce K, ‘Maternal consumption
of coffee and tea during pregnancy and risk
of childhood ALL: Results from an Australian
case-control study’, Cancer Causes &
Control, 22 207-218 (2011)
Moxey Annette Jane, McEvoy Mark Anthony,
Bowe Steven John, Attia John Richard,
‘Spirituality, religion, social support and
health among older Australian adults’,
Australasian Journal on Ageing, 30 82-88
(2011)
Nair Balakrishnan R, Clinical Examination:
A Problem Based Approach, World Scientific
Publishing, Singapore, 376 (2011)
Nair Balakrishnan R, Heim Christian,
Krishnan Chitra, D’Este Catherine Anne,
Marley John, Attia John Richard, ‘The
effect of Baroque music on behavioural
disturbances in patients with dementia’,
Australasian Journal on Ageing, 30 11-15
(2011)

Nair Balakrishnan R, Kinlay Scott, Browne
William, ‘Cardiovascular examination’,
Clinical Examination: A Problem Based
Approach, World Scientific Publishing,
Singapore, 41-91 (2011)
Nathan Nicole Kathryn, Wolfenden Luke,
Butler Michelle, Bell Andrew Colin, Wyse
Rebecca, Campbell Elizabeth Maclean,
Milat Andrew J, Wiggers John Henry,
‘Vegetable and fruit breaks in Australian
primary schools: prevalence, attitudes,
barriers and implementation strategies’,
Health Education Research, 26 722-731
(2011)
Ngamjanyaporn Pintip, Thakkinstian
Ammarin, Verasertniyom Oravan,
Chatchaipun Porntip, Vanichapuntu
Monchand, Nantiruj Kanokrat,
Totemchokchyakarn Kitti, Attia John
Richard, Janwityanujit Suchela,
‘Pharmacogenetics of cyclophosphamide
and CYP2C19 polymorphism in
Thai systemic lupus erythematosus’,
Rheumatology International, 31 1215-1218
(2011)
Numthavaj Pawin, Thakkinstian
Ammarin, Dejthevaporn Charungthai,
Attia John Richard, ‘Corticosteroid and
antiviral therapy for Bell’s palsy: A network
meta-analysis’, BMC Neurology, 11 1 (2011)
Ongugo Kindin, Hall John Joseph, Attia
John Richard, ‘Implementing tuberculosis
control in Papua New Guinea: A clash
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Community Health, 36 423-430 (2011)
Osmotherly Peter Grant, McElduff Patrick,
Attia John Richard, ‘In response: Factor
structure of the Neck Disability Index’,
Spine, 36 1816 (2011)
Osmotherly Peter Grant, Rawson Olivia
Anne, Rowe Lindsay J, ‘The relationship
between dens height and alar ligament
orientation: A radiologic study’, Journal
of Manipulative and Physiological
Therapeutics, 34 181-187 (2011)
Osmotherly Peter Grant, Rivett Darren
Anthony, ‘Knowledge and use of
craniovertebral instability testing by
Australian physiotherapists’, Manual
Therapy, 16 357-363 (2011)
Palmer Michelle A, Capra Sandra, Baines
Surinder Kaur, ‘To snack or not to snack:
What should we advise for weight
management?’, Nutrition & Dietetics, 68
60-64 (2011)
Parkinson Lynne, ‘Ageing and spirituality
across faiths and cultures (book review)’,
Australasian Journal on Ageing, 30 49
(2011)
Paterson Beverley Joyce, Caddis Richard,
Durrheim David N, ‘Use of workplace
absenteeism surveillance data for
outbreak detection’, Emerging Infectious
Diseases, 17 1963-1964 (2011)
Paterson Beverley Joyce, Mackenzie
John S, Durrheim David N, Smith David,
‘A review of the epidemiology and
surveillance of viral zoonotic encephalitis
and the impact on human health in
Australia’, NSW Public Health Bulletin, 22
99-104 (2011)
Paul Christine Louise, Carey Mariko
Leanne, Hall Alix Edna, Lynagh Marita
Clare, Sanson-Fisher Robert William,
Henskens Frans Alexander, ‘Improving
access to information and support for
patients with less common cancers:
hematologic cancer patients’ views
about web-based approaches’, Journal of
Medical Internet Research, 13 e112 (2011)
Paul Christine Louise, Paras Lorraine
Elizabeth, Harper Ainsley, Coppa Kay,
‘Harm minimization in tan seekers: An
exploration of tanning behaviour and the
potential for substitutional use of sunless
tanning products’, Journal of Health
Psychology, 16 929-937 (2011)
Paul Christine Louise, Sanson-Fisher
Robert William, Douglas Heather Elaine,
Clinton-Mcharg Tara Lynne, Williamson
A, Barker Daniel Jacob, ‘Cutting
the research pie: A value-weighting
approach to explore perceptions about
psychosocial research priorities for adults
with haematological cancers’, European
Journal of Cancer Care, 20 345-353 (2011)
Perkins David A, Barclay Lesley, Browne
Kim M, Blunden Lou-Anne, Fragar Lyn
J, Kelly Brian Joseph, Lower Tony, Lyle
David M, Saberi Vahid, Stain Helen Joy,
Sidford Jan R, ‘The Australian Rural
Health Research Collaboration: Building
collaborative population health research in
rural and remote NSW’, NSW Public Health
Bulletin, 22 23-26 (2011)
Perry Lin, Bellchambers Helen Lorraine,
Howie Andrew John, Moxey Annette
Jane, Parkinson Lynne, Capra Sandra,
Byles Julie Ellen, ‘Examination of the
utility of the Promoting Action on
Research Implementation in Health
Services framework for implementation
of evidence based practice in residential
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Nursing, 67 2139-2150 (2011)
Pich Jacqueline Vivienne, Hazelton
Michael John, Sundin Deborah Jane, Kable
Ashley Kathryn, ‘Patient-related violence
at triage: A qualitative descriptive study’,
International Emergency Nursing, 19 12-19
(2011)
Pickering Phillip M, Osmotherly Peter
Grant, Attia John Richard, McElduff Patrick,
‘An examination of outcome measures for
pain and dysfunction in the cervical spine:
A factor analysis’, Spine, 36 581-588 (2011)
Ramsay Emmae N, Roughead Elizabeth
E, Ewald Benjamin David, Pratt Nicole
L, Ryan Philip, ‘A self-controlled case
series to assess the effectiveness of beta
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hospitalisations in the elderly’, BMC
Medical Research Methodology, 11 1-7
(2011)
Ranasinghe Weranja K B, Wright Timothy
Andrew, Attia John Richard, McElduff
Patrick, Doyle Terrence, Bartholomew
Meegan, Hurley Katrina, Persad Rajendra
A, ‘Effects of bariatric surgery on urinary
and sexual function’, BJU International,
107 88-94 (2011)
Rennick Janet E, Lambert Sylvie,
Childerhose Janet, Campbell-Yeo Marsha,
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‘Mothers’ experiences of a Touch and Talk
nursing intervention to optimise pain
management in the PICU: A qualitative
descriptive study’, Intensive and Critical
Care Nursing, 27 151-157 (2011)
Robertson Jane, Moxey Annette Jane,
Newby David Andrew, Gillies Malcolm
B, Williamson Margaret, Pearson Sallie-
Anne, ‘Electronic information and clinical
decision support for prescribing: State of
play in Australian general practice’, Family
Practice, 28 93-101 (2011)
Robertson Jane, Walkom Emily Jane,
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6 e19222 (2011)
Rotter Thomas, Kinsman Leigh, James
Erica Lyn, Machotta Andreas, Willis Jon,
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drawn the wrong conclusions about the
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review appropriate?: Response to the
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Shen Finna, Coulter Carolyn V, Isbister
Geoffrey Kennedy, Duffull Stephen
B, ‘A dosing regimen for immediate
N-acetylcysteine treatment for acute
paracetamol overdose’, Clinical Toxicology,
49 643-647 (2011)
Shin Dong Wook, Kim So Young, Cho
Juhee, Sanson-Fisher Robert William,
Guallar Eliseo, Chai Gyu Young, Kim
Hak-Soon, Park Bo Ram, Park Eun-
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in perceived needs between patients
and physicians in oncology practice: A
nationwide survey in Korea’, Journal of
Clinical Oncology, 29 4424-4429 (2011)
Sibbritt David William, Adams Jon,
Lui Chi-Wai, ‘A longitudinal analysis of
complementary and alternative medicine
use by a representative cohort of young
Australian women with asthma, 1996-
2006’, Journal of Asthma, 48 380-386
(2011)
Sibbritt David William, Adams Jon,
Lui Ch-Wai, ‘Health service utilisation
by pregnant women over a seven-year
period’, Midwifery, 27 474-476 (2011)
Sibbritt David William, Adams Jon,
Moxey Annette Jane, ‘Mid-age women’s
consultations with acupuncturists: A
longitudinal analysis of 11,200 Women,
2001-2007’, Journal of Alternative and
Complementary Medicine, 17 735-740
(2011)
Sibbritt David William, Adams Jon, Van
Der Riet Pamela Jane, ‘The prevalence
and characteristics of young and mid-age
women who use yoga and meditation:
Results of a nationally representative
survey of 19,209 Australian women’,
Complementary Therapies in Medicine, 19
71-77 (2011)
Sinclair Peter Michael, Levett-Jones Tracy
Lynn, ‘The evolution of the Nephrology
Educators’ Network’, Journal of Renal
Care, 37 40-46 (2011)
75

76
Skov Steven J, Chikritzhs Tanya N, Kypri
Kypros, Miller Peter G, Hall Wayne D, Daube
Michael M, Moodie A Rob, ‘Is the ‘alcopops’
tax working?: Probably yes but there is a
bigger picture’, Medical Journal of Australia,
195 84-86 (2011)
Sneesby Ludmilla, Satchell Ruth, Good
Phillip, Van Der Riet Pamela Jane, ‘Death and
dying in Australia: Perceptions of a Sudanese
community’, Journal of Advanced Nursing,
67 2696-2702 (2011)
Snodgrass Suzanne Nicole, ‘Wiki activities
in blended learning for health professional
students: Enhancing critical thinking and
clinical reasoning skills’, Australasian Journal
of Educational Technology, 27 563-580
(2011)
Southgate Erica Lee, James Carole Lesley,
Kable Ashley Kathryn, Bohatko-Naismith
Joanna, Rivett Darren Anthony, Guest Maya,
‘Workplace injury and nurses: Insights from
focus groups with Australian return-to-work
coordinators’, Nursing & Health Sciences, 13
192-198 (2011)
Stewart Williams Jennifer Anne, ‘Assessing
the suitability of fractional polynomial
methods in health services research: a
perspective on the categorization epidemic’,
Journal of Health Services Research, 16 147-
152 (2011)
Sylvester Stephen, Magin Parker John,
Sweeney Kevin Plunkett, Morgan Simon,
Henderson Kim, ‘Procedural skills in general
practice vocational training: What should
be taught?’, Australian Family Physician, 40
50-54 (2011)
Thakkinstian Ammarin, McKay Gareth
J, McEvoy Mark Anthony, Chakravarthy
Usha, Chakrabarti Subhabrata, Silvestri
Guiliana, Kaur Inderjeet, Li Xiaoxin, Attia
John Richard, ‘Systematic review and
meta-analysis of the association between
complement component 3 and age-related
macular degeneration: A HuGE review
and meta-analysis’, American Journal of
Epidemiology, 173 1365-1379 (2011)
Thompson John R, Attia John Richard,
Minelli Cosetta, ‘The meta-analysis of
genome-wide association studies’, Briefings
in Bioinformatics, 12 259-269 (2011)
Tzelepis Flora, Paul Christine Louise,
Walsh Raoul Anthony, McElduff Patrick,
Knight Jennifer Jane, ‘Proactive telephone
counseling for smoking cessation: Metaanalyses
by recruitment channel and
methodological quality’, Journal of the
National Cancer Institute, 103 922-941 (2011)
Tzelepis Flora, Paul Christine Louise,
Wiggers John Henry, Walsh Raoul Anthony,
Knight Jennifer Jane, Duncan Sarah Lee,
Lecanthelinais Christophe, Girgis Afaf,
Daly Justine Bernadette, ‘A randomised
controlled trial of proactive telephone
counselling on cold-called smokers’
cessation rates’, Tobacco Control, 20 40-46
(2011)
Van Der Riet Pamela Jane, ‘Complementary
therapies in health care’, Nursing & Health
Sciences, 13 4-8 (2011)
Van Der Riet Pamela Jane, ‘Exemplar:
Effleurage and petrissage: Holistic practice in
Thailand’, Contemporary Nurse, 37 227-228
(2011)
Van Der Riet Pamela Jane, ‘Vipassana
meditation: One woman’s narrative’,
Collegian, 18 36-42 (2011)
Van Der Riet Pamela Jane, Francis
Lyn Marie, Levett-Jones Tracy Lynn,
‘Complementary therapies in healthcare:
Design, implementation and evaluation of an
elective course for undergraduate students’,
Nurse Education in Practice, 11 146-152
(2011)
Van Der Riet Pamela Jane, Pitt Victoria Lee,
Blyton Greg Michael, ‘Nursing care of clients
experiencing loss, grief and death’, Medical
Surgical Nursing: Critical Thinking in Client
Care, Pearson Australia, Frenchs Forest, NSW,
90-106 (2011)
Walsh Raoul Anthony, ‘Australia’s experience
with varenicline: Usage, costs and adverse
reactions’, Addiction, 106 451-452 (2011)
Walsh Raoul Anthony, Paul Christine Louise,
Paras Lorraine Elizabeth, Stacey Fiona Gai,
Tzelepis Flora, ‘Workplace-related smoking
in New South Wales: Extent of bans, public
attitudes and relationships with relapse’,
Health Promotion Journal of Australia, 22
85-90 (2011)
Wardle Jon, Adams Jon, Magalhaes
Ricardo J Soares, Sibbritt David William,
‘Distribution of complementary and
alternative medicine (CAM) providers in rural
New South Wales, Australia: A step towards
explaining high CAM use in rural health?’,
Australian Journal of Rural Health, 19 197-
204 (2011)
Wolfenden Luke, Hardy Louise L, Wiggers
John Henry, Milat Andrew J, Bell Colin,
Sutherland Rachel Louise, ‘Prevalence
and socio-demographic associations of
overweight and obesity among children
attending child-care services in rural and
regional Australia’, Nutrition & Dietetics, 68
15-20 (2011)
Wolfenden Luke, Neve Melinda, Farrell
Louise, Lecathelinais Christophe, Bell
Colin, Milat Andrew, Wiggers John Henry,
Sutherland Rachel, ‘Physical activity
policies and practices of childcare centres
in Australia’, Journal of Paediatrics and Child
Health, 47 73-76 (2011)
Wolfenden Luke, Stojanovski Elizabeth,
Wiggers John Henry, Gillham Karen,
Bowman Jennifer Ann, Richie Chris,
‘Demographic, smoking, and clinical
characteristics associated with smoking
cessation care provided to patients preparing
for surgery’, Journal of Addictions Nursing,
22 171-175 (2011)
Wye Paula Merise, Bowman Jennifer
Ann, Wiggers John Henry, Freund Megan
Alberta, Wolfenden Luke, Stockings Emily
Alice, ‘Treating nicotine dependence in
mental health hospitals’, Mental Health and
Substance Use: Dual Diagnosis, 4 130-143
(2011)
Wyse Rebecca, Wolfenden Luke, Campbell
Elizabeth Maclean, Campbell Karen,
Brennan Leah, Fletcher Amanda, Bowman
Jennifer Ann, Heard Todd Raymond, Wiggers
John Henry, ‘A pilot study of a telephonebased
parental intervention to increase fruit
and vegetable consumption in 3-5-year-old
children’, Public Health Nutrition, 14 2245-
2253 (2011)
Zhao Feili, Yue Ming, Yang Hua, Wang Tian
A, Wu Jiu-Hong, Li Shu Chuen, ‘Willingness
to pay per quality-adjusted life year: Is one
threshold enough for decision-making?
Results from a study in patients with chronic
prostatitis’, Medical Care, 49 267-272 (2011)
Zucca Alison Cheree, Boyes Allison Wendy,
Newling Graham, Hall Alix Edna, Girgis Afaf,
‘Travelling all over the countryside: Travelrelated
burden and financial difficulties
reported by cancer patients in New South
Wales and Victoria’, Australian Journal of
Rural Health, 19 298-305 (2011)
Viruses, Infections /
Immunity, Vaccines and
Asthma (VIVA)
Antic Nick A, Catcheside Peter, Buchan
Catherine, Hensley Michael John, Naughton
Matthew T, Rowland Sharn, Williamson
Bernadette, Windler Samantha, McEvoy R
Doug, ‘The effect of CPAP in normalizing
daytime sleepiness, quality of life, and
neurocognitive function in patients with
moderate to severe OSA’, Sleep, 34 111-119
(2011)
Au Gough Geoffrey, Beagley Leone G,
Haley Erin Susannah, Barry Richard D,
Shafren Darren Raymond, ‘Oncolysis of
malignant human melanoma tumors by
Coxsackieviruses A13, A15 and A18’, Virology
Journal, 8 1-6 (2011)
Baines Katherine Joanne, Simpson Jodie
Louise, Gibson Peter Gerard, ‘Innate
immune responses are increased in chronic
obstructive pulmonary disease’, PLoS ONE,
36 e18426 (2011)
Baines Katherine Joanne, Simpson Jodie
Louise, Wood Lisa Gai, Scott Rodney, Gibson
Peter Gerard, ‘Systemic upregulation of
neutrophil α-defensins and serine proteases
in neutrophilic asthma’, Thorax, 66 942-947
(2011)
Baines Katherine Joanne, Simpson Jodie
Louise, Wood Lisa Gai, Scott Rodney, Gibson
Peter Gerard, ‘Transcriptional phenotypes of
asthma defined by gene expression profiling
of induced sputum samples’, Journal of
Allergy and Clinical Immunology, 127 153-
160.e9 (2011)
Cheng Allen C, Kotsimbos Tom, Kelly
Heath A, Irving Louis B, Bowler Simon D,
Brown Simon G A, Holmes Mark, Jenkins
Christine R, Thompson Philip, Simpson
Graham, Wood-Baker Richard, Senanayake
Sanjaya N, Brady Stephen J, Paterson David
L, Wark Peter Alexander, Upham John W,
Korman Tony M, Dwyer Dominic E, Waterer
Grant W, Kelly Paul M, ‘Effectiveness of
H1N1/09 monovalent and trivalent influenza
vaccines against hospitalization with

laboratory-confirmed H1N1/09 influenza
in Australia: A test-negative case control
study’, Vaccine, 29 7320-7325 (2011)
Clancy Robert Llewellyn, Dunkley
Margaret Lorraine, ‘A vaccine to prevent
exacerbations in COPD’, Medical Journal
of Australia, 195 99-100 (2011)
Davidson Sophia Kate, Kaiko Gerard
Emil, Loh Zhixuan, Lalwani Amit, Zhang
Vivian, Spann Kirsten, Foo Adeline,
Hansbro Nicole Gower, Uematsu Satoshi,
Akira Shizuo, Matthaei Klaus I, Rosenberg
Helene F, Foster Paul Stephen, Phipps
Simon, ‘Plasmacytoid Dendritic Cells
promote host defense against Acute
Pneumovirus infection via the TLR7-
MyD88-Dependent signaling pathway’,
Journal of Immunology, 186 5938-5948
(2011)
Ferguson John Kenneth, Cheng Allen C,
Gilbert Gwendolyn L, Gottlieb Thomas,
Korman Tony, McGregor Alistair, Richards
Michael, Roberts Sally, Robson Jenny,
Van Gessel Helen, Riley Thomas V,
‘Clostridium difficile laboratory testing
in Australia and New Zealand: National
survey results and Australasian Society for
Infectious Diseases recommendations for
best practice’, Pathology, 43 482-487 (2011)
Gaga M, Zervas E, Gibson Peter Gerard,
‘Allergic and nonallergic factors in severe
asthma’, Difficult-to-Treat Severe Asthma,
European Respiratory Society, Sheffield,
UK, 107-119 (2011)
Gibson Peter Gerard, ‘Asthma phenotypes
in childhood’, Paediatric Respiratory
Reviews, 12 151 (2011)
Gibson Peter Gerard, Wang F, He Xiao Yan,
Brightling C E, ‘Noninvasive assessment of
inflammation in severe asthma’, Difficultto-Treat
Severe Asthma, European
Respiratory Society, Sheffield, UK, 208-217
(2011)
Hansbro Philip Michael, Hurt Aeron C,
‘Influenza surveillance in wild birds in
Australia’, Microbiology Australia, 32 48-51
(2011)
Hansbro Philip Michael, Kaiko Gerard
Emil, Foster Paul Stephen, ‘Cytokine/anticytokine
therapy - Novel treatments for
asthma?’, British Journal of Pharmacology,
163 81-95 (2011)
Hazlewood Leia Claire, Wood Lisa
Gai, Hansbro Philip Michael, Foster
Paul Stephen, ‘Dietary lycopene
supplementation suppresses Th2 responses
and lung eosinophilia in a mouse model
of allergic asthma’, Journal of Nutritional
Biochemistry, 22 95-100 (2011)
He Xiao Yan, Simpson Jodie Louise, Wang
Fang, ‘Inflammatory phenotypes in stable
and acute childhood asthma’, Paediatric
Respiratory Reviews, 12 165-169 (2011)
Hodyl Nicolette A, Stark Michael J, Osei-
Kumah Annette, Bowman Maria, Gibson
Peter Gerard, Clifton Vicki Lee, ‘Fetal
glucocorticoid-regulated pathways are
not affected by inhaled corticosteroid use
for asthma during pregnancy’, American
Journal of Respiratory and Critical Care
Medicine, 183 716-722 (2011)
Hsu Alan, Barr Ian, Hansbro Philip
Michael, Wark Peter Alexander, ‘Human
influenza is more effective than Avian
influenza at antiviral suppression in airway
cells’, American Journal of Respiratory Cell
and Molecular Biology, 44 906-913 (2011)
Jensen Megan Elizabeth, Collins Clare
Elizabeth, Gibson Peter Gerard, Wood Lisa
Gai, ‘The obesity phenotype in children
with asthma’, Paediatric Respiratory
Reviews, 12 152-159 (2011)
Kaiko Gerard Emil, Foster Paul Stephen,
‘New insights into the generation of
Th2 immunity and potential therapeutic
targets for the treatment of asthma’,
Current Opinion in Allergy and Clinical
Immunology, 11 39-45 (2011)
Keely Simon, Feighery Linda, Campion
Deirdre P, O’Brien Leah, Brayden David
J, Baird Alan W, ‘Chloride-led disruption
of the intestinal mucous layer impedes
salmonella invasion: Evidence for an
‘enteric tear’ mechanism’, Cellular
Physiology and Biochemistry, 28 743-752
(2011)
Lousberg Erin L, Diener Kerrilyn R,
Fraser Cara K, Phipps Simon, Foster Paul
Stephen, Chen Weisan, Uematsu Satoshi,
Akira Shizuo, Robertson Sarah A, Brown
Michael P, Hayball John D, ‘Antigenspecific
T-Cell responses to a recombinant
fowlpox virus are dependent on MyD88
and Interleukin-18 and Independent of
Toll-Like Receptor 7 (TLR7)- and TLR9-
Mediated innate immune recognition’,
Journal of Virology, 85 3385-3396 (2011)
McDonald Vanessa Marie, Higgins Isabel
Johanna, Simpson Jodie Louise, Gibson
Peter Gerard, ‘The importance of clinical
management problems in older people
with COPD and asthma: Do patients
and physicians agree?’, Primary Care
Respiratory Journal, 20 389-395 (2011)
McDonald Vanessa Marie, Simpson
Jodie Louise, Higgins Isabel Johanna,
Gibson Peter Gerard, ‘Multidimensional
assessment of older people with asthma
and COPD: Clinical management and
health status’, Age and Ageing, 40 42-49
(2011)
McDonald Vanessa Marie, Vertigan
Anne Elizabeth, Gibson Peter Gerard,
‘How to set up a severe asthma service’,
Respirology, 16 900-911 (2011)
Murphy Vanessa Evonne, Namazy J A,
Powell Helen Gaye, Schatz M, Chambers
C, Attia John Richard, Gibson Peter Gerard,
‘A meta-analysis of adverse perinatal
outcomes in women with asthma’, BJOG:
An International Journal of Obstetrics and
Gynaecology, 118 1314-1323 (2011)
Otczyk Diana C, Clancy Robert Llewellyn,
Cripps Allan W, ‘Haemophilus influenzae
and smoking-related obstructive airways
disease’, International Journal of Chronic
Obstructive Pulmonary Disease, 6 345-351
(2011)
Powell Gillian Heather, Murphy Vanessa
Evonne, Taylor D Robin, Hensley Michael
John, McCaffery Kirsten, Giles Warwick,
Clifton Vicki L, Gibson Peter Gerard,
‘Management of asthma in pregnancy
guided by measurement of fraction of
exhaled nitric oxide: A double-blind,
randomised controlled trial’, The Lancet,
378 983-990 (2011)
Preston Julie Anne, Thorburn Alison
Nicole, Starkey Malcolm Ronald, Beckett
Emma Louise, Horvat Jay Christopher,
Wade Margaret Ann, O’Sullivan B J,
Thomas R, Beagley Kenneth William,
Gibson Peter Gerard, Foster Paul Stephen,
Hansbro Philip Michael, ‘Streptococcus
pneumoniae infection suppresses allergic
airways disease by inducing regulatory
T-cells’, European Respiratory Journal, 37
53-64 (2011)
Ranasinghe Charani, Eyers Fiona
Margaret, Stambas John, Boyle David
B, Ramshaw Ian A, Ramsay Alistair J,
‘A comparative analysis of HIV-specific
mucosal/systemic T cell immunity and
avidity following rDNA/rFPV and poxviruspoxvirus
prime boost immunisations’,
Vaccine, 29 3008-3020 (2011)
Scott Hayley Ann, Gibson Peter Gerard,
Garg Manohar Lal, Wood Lisa Gai, ‘Airway
inflammation is augmented by obesity
and fatty acids in asthma’, European
Respiratory Journal, 38 594-602 (2011)
Siegle J S, Hansbro Nicole Gower,
Dong C, Angkasekwinai P, Foster
Paul Stephen, Kumar R K, ‘Blocking
induction of T helper type 2 responses
prevents development of disease in a
model of childhood asthma’, Clinical and
Experimental Immunology, 165 19-28
(2011)
Tran Huy A, Jones Tracey L, Gibson
Robert, Reeves Glenn E, ‘Thyroid disease
is a favorable prognostic factor in
achieving sustained virologic response
in chronic hepatitis C undergoing
combination therapy: A nested case
control study’, BMC Endocrine Disorders,
11 10 (2011)
Tran Huy A, Jones Tracey L, Ianna
Elizabeth A, Reeves Glenn E, ‘The natural
history of interferon-α; induced thyroiditis
in chronic hepatitis c patients: A long term
study’, Thyroid Research, 4 1-5 (2011)
Verrills Nicole Margaret, Irwin Jennifer
Anne, He Xiao Yan, Wood Lisa Gai, Powell
Heather, Simpson Jodie Louise, McDonald
Vanessa Marie, Sim Alistair Thomas,
Gibson Peter Gerard, ‘Identification of
novel diagnostic biomarkers for asthma
and chronic obstructive pulmonary
disease’, American Journal of Respiratory
and Critical Care Medicine, 183 1633-1643
(2011)
Vertigan Anne Elizabeth, Gibson Peter
Gerard, ‘Chronic refractory cough as a
sensory neuropathy: Evidence from a
reinterpretation of cough triggers’, Journal
of Voice, 25 596-601 (2011)
Vertigan Anne Elizabeth, Gibson Peter
Gerard, ‘Urge to cough and its application
to the behavioural treatment of cough’,
Bratislavske Lekarske Listy, 112 102-8
(2011)
77

78
Walsh Neil P, Gleeson Michael, Shephard
Roy J, Gleeson Maree, Woods Jeffrey A,
Bishop Nicolette C, Fleshner Monika, Green
Charlotte, Pedersen Bente K, Hoffman-
Goete Laurie, Rogers Connie J, Northoff
Hinnak, Abbasi Ashgar, Simon Perikles,
‘Position statement part one: Immune
function and exercise’, Exercise Immunology
Review, 17 6-63 (2011)
Wang F, Gibson Peter Gerard, ‘Respiratory
Chlamydophyla pneumoniae resides
primarily in the lower airway’, European
Respiratory Journal, 38 995 (2011)
Wang F, He Xiao Yan, Baines Katherine
Joanne, Gunawardhana Lakshitha Prabhath,
Simpson Jodie Louise, Li F, Gibson Peter
Gerard, ‘Different inflammatory phenotypes
in adults and children with acute asthma’,
European Respiratory Journal, 38 567-574
(2011)
Wang Gang, Zhou Ting, Wang Lan, Wang
Lei, Fu Juanjuan, Zhang Hong-Ping, Ji
Yu-Lin, ‘Relationship between current
psychological symptoms and future risk of
asthma outcomes: A 12-month prospective
cohort study’, Journal of Asthma, 48 1041-
1050 (2011)
Wang Wan, Hansbro Philip Michael, Foster
Paul Stephen, Yang Ming, ‘An alternate
STAT6-independent pathway promotes
eosinophil influx into blood during allergic
airway inflammation’, PLoS ONE, 6 e17766
(2011)
Wark Peter Alexander, Hayes Michael,
‘Respiratory examination’, Clinical
Examination: A Problem Based Approach,
World Scientific Publishing, Singapore, 17-40
(2011)
Weckmann Markus, Kopp Matthias V,
Heinzmann Andrea, Mattes Joerg,
‘Haplotypes covering the TNFSF10 gene are
associated with bronchial asthma’, Pediatric
Allergy and Immunology, 22 25-30 (2011)
Wood Lisa Gai, Garg Manohar Lal, Gibson
Peter Gerard, ‘A high-fat challenge
increases airway inflammation and impairs
bronchodilator recovery in asthma’, Journal
of Allergy and Clinical Immunology, 127
1133-1140 (2011)
Wood Lisa Gai, Powell Heather, Grissell
Terry Vincent, Davies Bronwyn Lee, Shafren
Darren Raymond, Whitehead Bruce Foster,
Hensley Michael John, Gibson Peter Gerard,
‘Persistence of rhinovirus RNA and IP-
10 gene expression after acute asthma’,
Respirology, 16 291-299 (2011)
Wood Lisa Gai, Simpson Jodie Louise,
Wark Peter Alexander, Powell Helen Gaye,
Gibson Peter Gerard, ‘Characterization
of innate immune signalling receptors in
virus-induced acute asthma’, Clinical and
Experimental Allergy, 41 640-648 (2011)
Wright Anthony D, McCluskey Adam,
Robertson Mark James, Macgregor
Kylie Anne, Gordon Christopher Peter,
Guenther Jana, ‘Anti-malarial, anti-algal,
anti-tubercular, anti-bacterial, antiphotosynthetic,
and anti-fouling activity of
diterpene and diterpene isonitriles from the
tropical marine sponge Cymbastela hooperi’,
Organic and Biomolecular Chemistry, 9 400-
407 (2011)
Wu David, Ahrens Richard, Osterfeld
Heather, Noah Taeko K, Groschwitz
Katherine, Foster Paul Stephen, Steinbrecher
Kris A, Rothenberg Marc E, Shroyer Noah
F, Matthaei Klaus I, Finkelman Fred D,
Hogan Simon P, ‘Interleukin-13 (IL-13)/
IL-13 receptor α1 (IL-13Rα1) signaling
regulates intestinal epithelial cystic fibrosis
transmembrane conductance regulator
channel-dependent Cl- secretion’, Journal of
Biological Chemistry, 286 13357-13369 (2011)
Wynne Olivia Lee, Horvat Jay Christopher,
Kim Richard Yong, Ong Lin Kooi, Smith
Roger, Hansbro Philip Michael, Clifton
Vicki Lee, Hodgson Deborah Maree,
‘Neonatal respiratory infection and adult
re-infection: Effect on glucocorticoid
and mineralocorticoid receptors in the
hippocampus in BALB/c mice’, Brain Behavior
and Immunity, 25 1214-1222 (2011)
Wynne Olivia Lee, Horvat Jay Christopher,
Osei-Kumah A, Smith Roger, Hansbro Philip
Michael, Clifton Vicki Lee, Hodgson Deborah
Maree, ‘Early life infection alters adult
BALB/c hippocampal gene expression in a
sex specific manner’, Stress-the International
Journal on the Biology of Stress, 14 247-261
(2011)
Zhong Yunqing, Zhou Wei, Jiang Hongli,
Fan Tao, Diao Xiang, Yang Hongmei, Min
Jie, Wang Gang, Fu Juanjuan, Mao Bing,
‘Quality of reporting of two-group parallel
randomized controlled clinical trials of multiherb
formulae: A survey of reports indexed
in the Science Citation Index Expanded’,
European Journal of Integrative Medicine, 3
e303-e310 (2011)

Acknowledgements
Produced April 2011.
Written and produced by Robbie Macaulay, Mark Rothfield and Ellie McNamara -
HMRI Communications.
Concept design by John Church Advertising.
Photography by Thierry Boudan Photography, with additional images by
Ellie McNamara and Mark Rothfield.
Thank you to the following researchers for their participation in the photography:
Amanda Baker
Alexis Hure
Mark Baker
Daniel Johnstone
Natalie Beveridge
Heather Murray
Tim Budden
Nicole Ryan
Nick Buckley
Malcolm Starkey
Erin Gardiner
Judith Weidenhofer
Andrew Gardner
Michelle Wong
Liz Holliday
Thank you to the following community members for sharing their stories:
Desmond Barton &
Biraban Public School
Emma & Kim Burns
Vic Carroll
Cyril Edwards
Fiona Feltrin
Amanda & Zander Grahman
Peter Lynn
Thank you to former HMRI Director Emeritus Professor Maree Gleeson OAM, and
and HMRI Acting Director Emeritus Professor Peter Dunkley for their input.
HMRI is committed to reducing its impact on the environment and limited copies
of this report have been produced. An electronic copy can be accessed online at
www.hmri.net.au or by phoning (+61 2) 4921 4030.

Hunter Medical Research Institute
Locked Bag 1, HRMC NSW 2310
T +61 2 4921 4030
F +61 2 4985 5909
info@hmri.net.au
www.hmri.net.au